Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: Crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex

Cellular and Molecular Immunology

Volumn 13, Issue 1, 2016, Pages 47-56

  Wyszynski, Rafal W ^a   Gibbs, Bernhard F ^a   Varani, Luca ^b   Iannotta, Daniela ^b   Sumbayev, Vadim V ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Hypoxia; Inflammation; Leukaemia; Stem cell factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; INTERLEUKIN 1BETA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; STEM CELL FACTOR; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MTOR PROTEIN, HUMAN; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

ARTICLE; BREAST EPITHELIUM CELL; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MCF 7 CELL LINE; MTS ASSAY; NORMAL HUMAN; PROTEIN BLOOD LEVEL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ADAPTIVE IMMUNITY; CELL HYPOXIA; CELL LINE; CYTOLOGY; DRUG EFFECTS; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; MACROPHAGE; MCF-7 CELL LINE; METABOLISM; MOLECULAR CLONING; SIGNAL TRANSDUCTION;

ADAPTIVE IMMUNITY; CELL HYPOXIA; CELL LINE; CLONING, MOLECULAR; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNITY, INNATE; INTERLEUKIN-1BETA; MACROPHAGES; MCF-7 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STEM CELL FACTOR; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC;

EID: 84954203482     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2014.113     Document Type: Article

References (29)

1. Broudy VC. Stem cell factor and hematopoiesis. Blood 1997; 90: 1345-1364.
2. Lee SJ, Yoon JH, Song KS. Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells. Biochem Pharmacol 2007; 74: 215-225.
3. Gibbs BF, Yasinska IM, Oniku AE, Sumbayev VV. Effects of stem cell factor on hypoxia-inducible factor 1 alpha accumulation in human acute myeloid leukaemia and LAD2 mast cells. PLoS One 2011; 6: e22502.
4. Han ZB, Ren H, Zhao H, Chi Y, Chen K, ZhouBet al. Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis 2008; 29: 1853-1861.
5. Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 2002; 8: S62-S67.
6. Sumbayev VV. LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein. FEBS Lett 2008; 582: 319-326.
7. Lall H, Coughlan K, Sumbayev VV. HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6. Mol Immunol 2008; 45: 3045-3049.
8. Nicholas SA, Sumbayev VV. The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response. Cell Res 2009; 19: 973-983.
9. Sumbayev VV, Nicholas SA. Hypoxia-inducible factor 1 as one of the "signaling drivers" of Toll-like receptor-dependent and allergic inflammation. Arch Immunol Ther Exp (Warsz) 2010; 58: 287-294.
10. da Silva CA, Kassel O, Mathieu E, Massard G, Gasser B, Frossard N. Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF. Brit J Pharmacol 2002; 135: 1634-1640.
11. Da Silva CA, Heilbock C, Kassel O, Frossard N. Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element FASEB J 2003; 17: 2334-2336.
12. Reber L, Vermeulen L, Haegeman G, Frossard N. Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. PLoS One 2009; 4: e4393.
13. Sims JE, Gayle MA, Slack JL, Alderson MR, Bird TA, Giri JG et al. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci USA 1993; 90: 6155-6159.
14. Nehme A, Edelman J. Dexamethasone inhibits high glucose-, TNFalpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes. Invest Ophthalmol Vis Sci 2008; 49: 2030-2038.
15. Sumbayev VV, Yasinska IM, Garcia CP, Gilliland D, Lall GS, Gibbs BF et al. Gold nanoparticles downregulate interleukin-1beta-induced pro-inflammatory responses. Small 2013; 9: 472-477.
16. Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1b mediated upregulation of HIF-1a via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003; 17: 2115-2117.
17. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow Lancet 2001; 357: 539-545.
18. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860-867.
19. Frenz AM, Gibbs BF, Pearce FL. The effect of recombinant stem cell factor on human skin and lung mast cells and basophil leukocytes. Inflamm Res 1997; 46: 35-39.
20. Wang C, Liu, J, Wang L, Geng X. Solubilization and refolding with simultaneous purification of recombinant human stem cell factor. Appl Biochem Biotechnol 2008; 144: 181-189.
21. Hanze J, Eul BG, Savai R, Krick S, Goyal P, Grimminger F, Seeger W, Rose F. RNA interference for HIF-1 inhibits its downstream signalling and affects cellular proliferation. Biochem Biophys Res Commun 2003; 312: 571-577.
22. Yasinska IM, Gibbs BF, Lall GS, Sumbayev VV. The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation. Cell Mol Life Sci 2014; 71: 699-710.
23. Wiesner C, Nabha SM, dos Santos EB, Yamamoto H, Meng H, Melchior SW et al. C-kit and its ligand stem cell factor: potential contribution to prostate cancer bone metastasis. Neoplasia 2008; 10: 996-1003.
24. Abooali M, Lall GS, Coughlan K, Lall HS, Gibbs BF, Sumbayev VV. Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function. Sci Rep 2014; 4: 6307.
25. Sumbayev VV. PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPSinduced Toll-like receptor 4 signalling. Immunol Lett 2008; 115: 126-130.
26. Schneiter R, Daum G. Analysis of yeast lipids. In: Methods in Molecular Biology, 313: Yeast Protocols. 2nd ed. Totowa, NJ: Humana Press Inc., 2006: 75-84.
27. Oehme F, Jonghaus W, Narouz-Ott L, Huetter J, Flamme I. A nonradioactive 96-well plate assay for the detection of hypoxiainducible factor prolyl hydroxylase activity. Anal Biochem 2004; 330: 74-80.
28. Nicholas SA, Sumbayev VV. The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation. Immunol Cell Biol 2010; 88: 180-186.
29. Nicholas SA, Oniku AE, Sumbayev VV. Myeloid cell death associated with Toll-like receptor 7/8-mediated inflammatory response. Implication of ASK1, HIF-1 alpha, IL-1 beta and TNF-alpha. Mol Immunol 2010; 48: 240-247.