Myeloid cell death associated with Toll-like receptor 7/8-mediated inflammatory response. Implication of ASK1, HIF-1alpha, IL-1beta and TNF-alpha

Molecular Immunology

Volumn 48, Issue 1-3, 2010, Pages 240-247

  Nicholas, Sally A ^a   Oniku, Abraham E ^a   Sumbayev, Vadim V ^a  

^a MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

Author keywords

Apoptosis; ASK1; IL 1beta; Inflammation; TNF alpha; Toll like receptors

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; INTERLEUKIN 1BETA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN SECRETION;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; INTERLEUKIN-1BETA; MAP KINASE KINASE KINASE 5; MYELOID CELLS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR-ALPHA;

EBOLA VIRUS; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; ORTHOMYXOVIRIDAE;

EID: 78649521933     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.08.004     Document Type: Article

References (26)

1. Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
2. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004, 430:257-263.
3. Carneiro L.A.M., Magalhaes J.G., Tattoli I., Philpott D.J., Travassos L.H. Nod-like proteins in inflammation and disease. J. Pathol. 2008, 214:136-148.
4. Ferlito M., Romanenko O.G., Ashton S., Squadrito F., Halushka P.V., Cook J.A. Effect of cross-tolerance between endotoxin and TNF-α or IL-1β on cellular signalling and mediator production. J. Leukoc. Biol. 2001, 70:821-829.
5. Garedew, A., Henderson, S.O., Moncada, S., in press. Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death. Cell Death Differ.
6. Gay N.J., Gangloff M. Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem. 2007, 76:141-165.
7. Gonzalez-Mejia M.E., Doseff A.I. Regulation of monocytes and macrophages cell fate. Front. Biosci. 2009, 14:2413-2431.
8. Hanze J., Eul B.G., Savai R., Krick S., Goyal P., Grimminger F., Seeger W., Rose F. RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation. Biochem. Biophys. Res. Commun. 2003, 312:571-577.
9. Hayakawa T., Matsuzawa A., Noguchi T., Takeda K., Ichijo H. The ASK1-MAP kinase pathways in immune and stress responses. Microbes Infect. 2006, 8:1098-1107.
10. Jung Y.J., Isaacs J.S., Lee S., Trepel J., Neckers L. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 2003, 17:2115-2117.
11. Kaufmann T., Jost P., et al. Fatal hepatitis mediated by secreted TNFa requires caspase 8 and the two BH3-only proteins Bid and Bim. Proc. of 16th Euroconference on Apoptosis 2008, (Book of Abstracts, L-10).
12. Lall H., Coughlan K., Sumbayev V.V. HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6. Mol. Immunol. 2008, 45:3045-3049.
13. Matsuzawa A., Saegusa K., Noguchi T., Sadamitsu C., Nishitoh H., Nagai S., Koyasu S., Matsumoto K., Takeda K., Ichijo H. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat. Immunol. 2005, 6:587-592.
14. Medzhitov R., Janeway C. Innate immunity. N. Engl. J. Med. 2000, 343:338-344.
15. Nehme A., Edelman J. Dexamethasone inhibits high glucose-, TNF-α-, and IL-1β-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes. Invest. Ophthalmol. Vis. Sci. 2008, 49:2030-2038.
16. Nicholas S.A., Sumbayev V.V. The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation. Immunol. Cell Biol. 2010, 88:180-186.
17. Nicholas S.A., Sumbayev V.V. The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response. Cell Res. 2009, 19:973-983.
18. Saitoh M., Nishitoh H., Fujii M., Takeda K., Tobiume K., Sawada Y., Kawabata M., Miyazono K., Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 1998, 17:2596-2606.
19. Sims J.E., Gayle M.A., Slack J.L., Alderson M.R., Bird T.A., Giri J.G., Colotta F., Re F., Mantovani A., Shanebeck K., Grabstein K.H., Dower S.K. Interleukin 1 signalling occurs exclusively via type I receptor. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:6155-6159.
20. Sumbayev V.V. LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein. FEBS Lett. 2008, 582:319-326.
21. Sumbayev V.V., Bonefeld-Jorgensen E.C., Wind T., Andreasen P.A. A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding. FEBS Lett. 2005, 579:541-548.
22. Sumbayev V.V., Jensen J.K., Hansen J.A., Andreasen P.A. Novel modes of oestrogen receptor agonism and antagonism by hydroxylated and chlorinated biphenyls, revealed by conformation-specific peptide recognition patterns. Mol. Cell. Endocrinol. 2008, 287:30-39.
23. Sumbayev V.V., Sandau K.B., Brune B. Mesangial cells but not hepatocytes are protected against NO/O(2)(-) cogeneration: mechanistic considerations. Eur. J. Pharmacol. 2002, 444:1-11.
24. van Duin D., Medzhitov R., Shaw A.C. Triggering TLR signaling in vaccination. Trends Immunol. 2006, 27:49-55.
25. Walmsley S.R., Cadwallader K.A., Chilvers E.R. The role of HIF-1alpha in myeloid cell inflammation. Trends Immunol. 2005, 26:434-439.
26. Zhou G., Golden T., Aragon I.V., Honkanen R.E. Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. J. Biol. Chem. 2004, 279:46595-46605.