Late Effects of Treatment of Pediatric Central Nervous System Tumors

Journal of Child Neurology

Volumn 31, Issue 2, 2016, Pages 237-254

  Roddy, E R I K A ^a   Mueller, Sabine ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

brain tumor; chemotherapy; late effect; radiation therapy; stroke

Indexed keywords

GROWTH HORMONE;

ACADEMIC ACHIEVEMENT; ATTENTION; BRAIN DEVELOPMENT; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURGERY; CANCER SURVIVAL; CANCER SURVIVOR; CANCER THERAPY; CENTRAL NERVOUS SYSTEM TUMOR; CEREBROVASCULAR ACCIDENT; CHILD; CHILDHOOD CANCER; EXECUTIVE FUNCTION; FOLLOW UP; GONAD FUNCTION; HUMAN; HYPERFRACTIONATED RADIOTHERAPY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTELLIGENCE QUOTIENT; LANGUAGE; META ANALYSIS (TOPIC); MORBIDITY; OBESITY; OTOTOXICITY; OUTCOME ASSESSMENT; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RADIATION DOSE; REVIEW; RISK FACTOR; RISK REDUCTION; SURVIVAL RATE; THYROID FUNCTION; WORKING MEMORY; ANIMAL; CENTRAL NERVOUS SYSTEM NEOPLASMS; COMORBIDITY; COMPLICATION; PATHOPHYSIOLOGY;

ANIMALS; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHILD; COMORBIDITY; HUMANS;

EID: 84954128210     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073815587944     Document Type: Review

References (251)

1. Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014; 16 (suppl 4): iv1-iv63.
2. Mariotto AB, Rowland JH, Yabroff KR, et al. Long-term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev. 2009; 18: 1033-1040.
3. Linabery AM, Ross JA,. Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975-1999. Cancer. 2008; 113: 2575-2596.
4. Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006; 355: 1572-1582.
5. Hudson MM, Ness KK, Gurney JG, et al. Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA. 2013; 309: 2371-2381.
6. Duffner PK,. Risk factors for cognitive decline in children treated for brain tumors. Eur J Paediatr Neurol. 2010; 14: 106-115.
7. Padovani L, Andre N, Constine LS, Muracciole X,. Neurocognitive function after radiotherapy for paediatric brain tumours. Nat Rev Neurol. 2012; 8: 578-588.
8. Reimers TS, Ehrenfels S, Mortensen EL, et al. Cognitive deficits in long-term survivors of childhood brain tumors: identification of predictive factors. Med Pediatr Oncol. 2003; 40: 26-34.
9. Armstrong GT,. Long-term survivors of childhood central nervous system malignancies: the experience of the Childhood Cancer Survivor Study. Eur J Paediatr Neurol. 2010; 14: 298-303.
10. Armstrong GT, Liu Q, Yasui Y, et al. Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study. J Clin Oncol. 2009; 27: 2328-2338.
11. Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long-term survivors of childhood CNS malignancies: a report from the Childhood Cancer Survivor Study. Neuropsychology. 2009; 23: 705-717.
12. Robinson KE, Kuttesch JF, Champion JE, et al. A quantitative meta-analysis of neurocognitive sequelae in survivors of pediatric brain tumors. Pediatr Blood Cancer. 2010; 55: 525-531.
13. Mulhern RK, Hancock J, Fairclough D, Kun L,. Neuropsychological status of children treated for brain tumors: a critical review and integrative analysis. Med Pediatr Oncol. 1992; 20: 181-191.
14. Copeland DR, deMoor C, Moore BD 3rd, Ater JL,. Neurocognitive development of children after a cerebellar tumor in infancy: a longitudinal study. J Clin Oncol. 1999; 17: 3476-3486.
15. Mulhern RK, Palmer SL, Reddick WE, et al. Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. J Clin Oncol. 2001; 19: 472-479.
16. Maddrey AM, Bergeron JA, Lombardo ER, et al. Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. J Neurooncol. 2005; 72: 245-253.
17. Spiegler BJ, Bouffet E, Greenberg ML, Rutka JT, Mabbott DJ,. Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol. 2004; 22: 706-713.
18. Armstrong GT, Reddick WE, Petersen RC, et al. Evaluation of memory impairment in aging adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiotherapy. J Natl Cancer Inst. 2013; 105: 899-907.
19. Schuitema I, Deprez S, Van Hecke W, et al. Accelerated aging, decreased white matter integrity, and associated neuropsychological dysfunction 25 years after pediatric lymphoid malignancies. J Clin Oncol. 2013; 31: 3378-3388.
20. Palmer SL, Armstrong C, Onar-Thomas A, et al. Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. J Clin Oncol. 2013; 31: 3494-3500.
21. Conklin HM, Ashford JM, Howarth RA, et al. Working memory performance among childhood brain tumor survivors. J Int Neuropsychol Soc. 2012; 18: 996-1005.
22. Palmer SL, Goloubeva O, Reddick WE, et al. Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. J Clin Oncol. 2001; 19: 2302-2308.
23. Mulhern RK, Reddick WE, Palmer SL, et al. Neurocognitive deficits in medulloblastoma survivors and white matter loss. Ann Neurol. 1999; 46: 834-841.
24. Fry AF, Hale S,. Relationships among processing speed, working memory, and fluid intelligence in children. Biol Psychol. 2000; 54: 1-34.
25. Ullrich NJ, Embry L,. Neurocognitive dysfunction in survivors of childhood brain tumors. Semin Pediatr Neurol. 2012; 19: 35-42.
26. Grill J, Renaux VK, Bulteau C, et al. Long-term intellectual outcome in children with posterior fossa tumors according to radiation doses and volumes. Int J Radiat Oncol Biol Phys. 1999; 45: 137-145.
27. Ris MD, Packer R, Goldwein J, Jones-Wallace D, Boyett JM,. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study. J Clin Oncol. 2001; 19: 3470-3476.
28. Mulhern RK, Kepner JL, Thomas PR, Armstrong FD, Friedman HS, Kun LE,. Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study. J Clin Oncol. 1998; 16: 1723-1728.
29. Chapman CA, Waber DP, Bernstein JH, et al. Neurobehavioral and neurologic outcome in long-term survivors of posterior fossa brain tumors: role of age and perioperative factors. J Child Neurol. 1995; 10: 209-212.
30. Tuli S, Drake J, Lawless J, Wigg M, Lamberti-Pasculli M,. Risk factors for repeated cerebrospinal shunt failures in pediatric patients with hydrocephalus. J Neurosurg. 2000; 92: 31-38.
31. Del Bigio MR,. Neuropathology and structural changes in hydrocephalus. Dev Disabil Res Rev. 2010; 16: 16-22.
32. Merchant TE, Mulhern RK, Krasin MJ, et al. Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol. 2004; 22: 3156-3162.
33. Hoppe-Hirsch E, Brunet L, Laroussinie F, et al. Intellectual outcome in children with malignant tumors of the posterior fossa: influence of the field of irradiation and quality of surgery. Childs Nerv Syst. 1995; 11: 340-345; discussion 345-346.
34. Fouladi M, Gilger E, Kocak M, et al. Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies. J Clin Oncol. 2005; 23: 7152-7160.
35. Netson KL, Conklin HM, Wu S, Xiong X, Merchant TE,. A 5-year investigation of children's adaptive functioning following conformal radiation therapy for localized ependymoma. Int J Radiat Oncol Biol Phys. 2012; 84: 217-223.e1.
36. Merchant TE, Conklin HM, Wu S, Lustig RH, Xiong X,. Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol. 2009; 27: 3691-3697.
37. Reddick WE, White HA, Glass JO, et al. Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer. 2003; 97: 2512-2519.
38. Jalali R, Mallick I, Dutta D, et al. Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2010; 77: 974-979.
39. Radcliffe J, Bunin GR, Sutton LN, Goldwein JW, Phillips PC,. Cognitive deficits in long-term survivors of childhood medulloblastoma and other noncortical tumors: age-dependent effects of whole brain radiation. Int J Dev Neurosci. 1994; 12: 327-334.
40. Walter AW, Mulhern RK, Gajjar A, et al. Survival and neurodevelopmental outcome of young children with medulloblastoma at St Jude Children's Research Hospital. J Clin Oncol. 1999; 17: 3720-3728.
41. Hoppe-Hirsch E, Renier D, Lellouch-Tubiana A, Sainte-Rose C, Pierre-Kahn A, Hirsch JF,. Medulloblastoma in childhood: progressive intellectual deterioration. Childs Nerv Syst. 1990; 6: 60-65.
42. Lannering B, Marky I, Lundberg A, Olsson E,. Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life. Med Pediatr Oncol. 1990; 18: 304-310.
43. Ris MD, Walsh K, Wallace D, et al. Intellectual and academic outcome following two chemotherapy regimens and radiotherapy for average-risk medulloblastoma: COG A9961. Pediatr Blood Cancer. 2013; 60: 1350-1357.
44. Mabbott DJ, Spiegler BJ, Greenberg ML, Rutka JT, Hyder DJ, Bouffet E,. Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. J Clin Oncol. 2005; 23: 2256-2263.
45. Moxon-Emre I, Bouffet E, Taylor MD, et al. Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma. J Clin Oncol. 2014; 32: 1760-1768.
46. Anderson FS, Kunin-Batson AS,. Neurocognitive late effects of chemotherapy in children: the past 10 years of research on brain structure and function. Pediatr Blood Cancer. 2009; 52: 159-164.
47. Conklin HM, Krull KR, Reddick WE, Pei D, Cheng C, Pui CH,. Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia. J Natl Cancer Inst. 2012; 104: 1386-1395.
48. Ashford J, Schoffstall C, Reddick WE, et al. Attention and working memory abilities in children treated for acute lymphoblastic leukemia. Cancer. 2010; 116: 4638-4645.
49. Mennes M, Stiers P, Vandenbussche E, et al. Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Pediatr Blood Cancer. 2005; 44: 478-486.
50. Moleski M,. Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia. Arch Clin Neuropsychol. 2000; 15: 603-30.
51. Riva D, Giorgi C, Nichelli F, et al. Intrathecal methotrexate affects cognitive function in children with medulloblastoma. Neurology. 2002; 59: 48-53.
52. Duffner PK,. Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia and brain tumors. The neurologist. 2004; 10: 293-310.
53. Korah MP, Esiashvili N, Mazewski CM, et al. Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys. 2010; 77: 106-112.
54. Palmer SL, Hassall T, Evankovich K, et al. Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro Oncol. 2010; 12: 1311-1317.
55. Robertson PL, Muraszko KM, Holmes EJ, et al. Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group. J Neurosurg. 2006; 105 (6 suppl): 444-451.
56. Catsman-Berrevoets CE, Aarsen FK,. The spectrum of neurobehavioural deficits in the Posterior Fossa Syndrome in children after cerebellar tumour surgery. Cortex. 2010; 46: 933-946.
57. Baillieux H, De Smet HJ, Paquier PF, De Deyn PP, Marien P,. Cerebellar neurocognition: insights into the bottom of the brain. Clin Neurol Neurosurg. 2008; 110: 763-773.
58. Morris EB, Phillips NS, Laningham FH, et al. Proximal dentatothalamocortical tract involvement in posterior fossa syndrome. Brain. 2009; 132 (pt 11): 3087-3095.
59. Miller NG, Reddick WE, Kocak M, et al. Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors. AJNR Am J Neuroradiol. 2010; 31: 288-294.
60. Law N, Bouffet E, Laughlin S, et al. Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: impact on working memory. NeuroImage. 2011; 56: 2238-2248.
61. Wells EM, Khademian ZP, Walsh KS, et al. Postoperative cerebellar mutism syndrome following treatment of medulloblastoma: neuroradiographic features and origin. J Neurosurg Pediatr. 2010; 5: 329-334.
62. Brunamonti E, Chiricozzi FR, Clausi S, et al. Cerebellar damage impairs executive control and monitoring of movement generation. PLoS One. 2014; 9: e85997.
63. Cardoso Cde O, Branco LD, Cotrena C, Kristensen CH, Schneider Bakos DD, Fonseca RP,. The impact of frontal and cerebellar lesions on decision making: evidence from the Iowa Gambling Task. Front Neurosci. 2014; 8: 61.
64. Cooper FE, Grube M, Von Kriegstein K, et al. Distinct critical cerebellar subregions for components of verbal working memory. Neuropsychologia. 2012; 50: 189-197.
65. Passamonti L, Novellino F, Cerasa A, et al. Altered cortical-cerebellar circuits during verbal working memory in essential tremor. Brain. 2011; 134 (pt 8): 2274-2286.
66. Riva D, Cazzaniga F, Esposito S, Bulgheroni S,. Executive functions and cerebellar development in children. Appl Neuropsychol Child. 2013; 2: 97-103.
67. Jacola LM, Ashford JM, Reddick WE, et al. The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy. J Neurooncol. 2014; 119: 197-205.
68. Nagel BJ, Delis DC, Palmer SL, Reeves C, Gajjar A, Mulhern RK,. Early patterns of verbal memory impairment in children treated for medulloblastoma. Neuropsychology. 2006; 20: 105-112.
69. Mulhern RK, White HA, Glass JO, et al. Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood. J Int Neuropsychol Soc. 2004; 10: 180-189.
70. Belka C, Budach W, Kortmann RD, Bamberg M,. Radiation induced CNS toxicity-molecular and cellular mechanisms. Br J Cancer. 2001; 85: 1233-1239.
71. Kim JH, Brown SL, Jenrow KA, Ryu S,. Mechanisms of radiation-induced brain toxicity and implications for future clinical trials. J Neurooncol. 2008; 87: 279-286.
72. Soussain C, Ricard D, Fike JR, Mazeron JJ, Psimaras D, Delattre JY,. CNS complications of radiotherapy and chemotherapy. Lancet. 2009; 374: 1639-1651.
73. Gondi V, Tome WA, Mehta MP,. Why avoid the hippocampus? A comprehensive review. Radiother Oncol. 2010; 97: 370-376.
74. Monje ML, Mizumatsu S, Fike JR, Palmer TD,. Irradiation induces neural precursor-cell dysfunction. Nat Med. 2002; 8: 955-962.
75. Raber J, Rola R, LeFevour A, et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res. 2004; 162: 39-47.
76. Redmond KJ, Mahone EM, Horska A,. Association between radiation dose to neuronal progenitor cell niches and temporal lobes and performance on neuropsychological testing in children: a prospective study. Neuro Oncol. 2013; 15: 1455.
77. Riggs L, Bouffet E, Laughlin S, et al. Changes to memory structures in children treated for posterior fossa tumors. J Int Neuropsychol Soc. 2014; 20: 168-180.
78. Abayomi OK,. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol. 1996; 35: 659-663.
79. Rueckriegel SM, Driever PH, Blankenburg F, Ludemann L, Henze G, Bruhn H,. Differences in supratentorial damage of white matter in pediatric survivors of posterior fossa tumors with and without adjuvant treatment as detected by magnetic resonance diffusion tensor imaging. Int J Radiat Oncol Biol Phys. 2010; 76: 859-866.
80. Reddick WE, Russell JM, Glass JO, et al. Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation. Magn Reson Imaging. 2000; 18: 787-793.
81. Khong PL, Kwong DL, Chan GC, Sham JS, Chan FL, Ooi GC,. Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: a pilot study. AJNR Am J Neuroradiol. 2003; 24: 734-740.
82. Schultheiss TE, Kun LE, Ang KK, Stephens LC,. Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys. 1995; 31: 1093-1112.
83. Beaulieu C,. The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed. 2002; 15: 435-455.
84. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH,. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. NeuroImage. 2002; 17: 1429-1436.
85. Mabbott DJ, Noseworthy MD, Bouffet E, Rockel C, Laughlin S,. Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: correlation with IQ. Neuro Oncol. 2006; 8: 244-252.
86. Khong PL, Leung LH, Fung AS, et al. White matter anisotropy in post-treatment childhood cancer survivors: preliminary evidence of association with neurocognitive function. J Clin Oncol. 2006; 24: 884-890.
87. Aukema EJ, Caan MW, Oudhuis N, et al. White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors. Int J Radiat Oncol Biol Phys. 2009; 74: 837-843.
88. Palmer SL, Glass JO, Li Y, et al. White matter integrity is associated with cognitive processing in patients treated for a posterior fossa brain tumor. Neuro Oncol. 2012; 14: 1185-1193.
89. Brinkman TM, Reddick WE, Luxton J, et al. Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. Neuro Oncol. 2012; 14 (suppl 4): iv25-iv36.
90. Qiu D, Kwong DL, Chan GC, Leung LH, Khong PL,. Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? Int J Radiat Oncol Biol Phys. 2007; 69: 846-851.
91. Reddick WE, Taghipour DJ, Glass JO, et al. Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Pediatr Blood Cancer. 2014; 61: 1074-1079.
92. Nagy Z, Westerberg H, Klingberg T,. Maturation of white matter is associated with the development of cognitive functions during childhood. J Cogn Neurosci. 2004; 16: 1227-1233.
93. Klingberg T, Vaidya CJ, Gabrieli JD, Moseley ME, Hedehus M,. Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. Neuroreport. 1999; 10: 2817-2821.
94. Paus T, Zijdenbos A, Worsley K, et al. Structural maturation of neural pathways in children and adolescents: in vivo study. Science. 1999; 283: 1908-1911.
95. Bunge SA, Wright SB,. Neurodevelopmental changes in working memory and cognitive control. Curr Opin Neurobiol. 2007; 17: 243-250.
96. Reddick WE, Mulhern RK, Elkin TD, Glass JO, Merchant TE, Langston JW,. A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors. Magn Reson Imaging. 1998; 16: 413-421.
97. Liu AK, Marcus KJ, Fischl B, et al. Changes in cerebral cortex of children treated for medulloblastoma. Int J Radiat Oncol Biol Phys. 2007; 68: 992-998.
98. Mostow EN, Byrne J, Connelly RR, Mulvihill JJ,. Quality of life in long-term survivors of CNS tumors of childhood and adolescence. J Clin Oncol. 1991; 9: 592-599.
99. Rutkowski S, Bode U, Deinlein F, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005; 352: 978-986.
100. Duffner PK, Horowitz ME, Krischer JP, et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993; 328: 1725-1731.
101. Marsh JC, Gielda BT, Herskovic AM, Abrams RA,. Cognitive sparing during the administration of whole brain radiotherapy and prophylactic cranial irradiation: current concepts and approaches. J Oncol. 2010; 2010: 198208.
102. Gupta T, Jalali R, Goswami S, et al. Early clinical outcomes demonstrate preserved cognitive function in children with average-risk medulloblastoma when treated with hyperfractionated radiation therapy. Int J Radiat Oncol Biol Phys. 2012; 83: 1534-1540.
103. Fossati P, Ricardi U, Orecchia R,. Pediatric medulloblastoma: toxicity of current treatment and potential role of protontherapy. Cancer Treat Rev. 2009; 35: 79-96.
104. Rosenstein BS, West CM, Bentzen SM, et al. Radiogenomics: radiobiology enters the era of big data and team science. Int J Radiat Oncol Biol Phys. 2014; 89: 709-713.
105. Butler RW, Copeland DR, Fairclough DL, et al. A multicenter, randomized clinical trial of a cognitive remediation program for childhood survivors of a pediatric malignancy. J Consult Clin Psychol. 2008; 76: 367-378.
106. Butler RW, Copeland DR,. Attentional processes and their remediation in children treated for cancer: a literature review and the development of a therapeutic approach. J Int Neuropsychol Soc. 2002; 8: 115-124.
107. Conklin HM, Reddick WE, Ashford J, et al. Long-term efficacy of methylphenidate in enhancing attention regulation, social skills, and academic abilities of childhood cancer survivors. J Clin Oncol. 2010; 28: 4465-4472.
108. Shaw EG, Rosdhal R, D'Agostino RB Jr., et al. Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. J Clin Oncol. 2006; 24: 1415-1420.
109. Castellino SM, Tooze JA, Flowers L, et al. Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Pediatr Blood Cancer. 2012; 59: 540-547.
110. Gurney JG, Kadan-Lottick NS, Packer RJ, et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study. Cancer. 2003; 97: 663-673.
111. Anderson DM, Rennie KM, Ziegler RS, Neglia JP, Robison LR, Gurney JG,. Medical and neurocognitive late effects among survivors of childhood central nervous system tumors. Cancer. 2001; 92: 2709-2719.
112. Livesey EA, Hindmarsh PC, Brook CG, et al. Endocrine disorders following treatment of childhood brain tumours. Br J Cancer. 1990; 61: 622-625.
113. Samaan NA, Vieto R, Schultz PN, et al. Hypothalamic, pituitary and thyroid dysfunction after radiotherapy to the head and neck. Int J Radiat Oncol Biol Phys. 1982; 8: 1857-1867.
114. Darzy KH, Shalet SM,. Hypopituitarism following radiotherapy revisited. Endocr Dev. 2009; 15: 1-24.
115. Merchant TE, Zhu Y, Thompson SJ, Sontag MR, Heideman RL, Kun LE,. Preliminary results from a phase II trail of conformal radiation therapy for pediatric patients with localised low-grade astrocytoma and ependymoma. Int J Radiat Oncol Biol Phys. 2002; 52: 325-332.
116. Shalet SM, Beardwell CG, Pearson D, Jones PH,. The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol. 1976; 5: 287-290.
117. Clayton PE, Shalet SM,. Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Pediatr. 1991; 118: 226-228.
118. Adan L, Sainte-Rose C, Souberbielle JC, Zucker JM, Kalifa C, Brauner R,. Adult height after growth hormone (GH) treatment for GH deficiency due to cranial irradiation. Med Pediatr Oncol. 2000; 34: 14-19.
119. Sklar CA, Mertens AC, Mitby P, et al. Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab. 2002; 87: 3136-3141.
120. Laughton SJ, Merchant TE, Sklar CA, et al. Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial. J Clin Oncol. 2008; 26: 1112-1118.
121. Paulino AC,. Hypothyroidism in children with medulloblastoma: a comparison of 3600 and 2340 cGy craniospinal radiotherapy. Int J Radiat Oncol Biol Phys. 2002; 53: 543-547.
122. Schmiegelow M, Feldt-Rasmussen U, Rasmussen AK, Poulsen HS, Muller J,. A population-based study of thyroid function after radiotherapy and chemotherapy for a childhood brain tumor. J Clin Endocrinol Metab. 2003; 88: 136-140.
123. Ricardi U, Corrias A, Einaudi S, et al. Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. Int J Radiat Oncol Biol Phys. 2001; 50: 1287-1294.
124. Brignardello E, Felicetti F, Castiglione A, et al. Endocrine health conditions in adult survivors of childhood cancer: the need for specialized adult-focused follow-up clinics. Eur J Endocrinol. 2013; 168: 465-472.
125. Sigurdson AJ, Ronckers CM, Mertens AC, et al. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet. 2005; 365: 2014-2023.
126. Meadows AT, Friedman DL, Neglia JP, et al. Second neoplasms in survivors of childhood cancer: findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009; 27: 2356-2362.
127. Green DM, Kawashima T, Stovall M, et al. Fertility of female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2009; 27: 2677-2685.
128. Barton SE, Najita JS, Ginsburg ES, et al. Infertility, infertility treatment, and achievement of pregnancy in female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort. Lancet Oncol. 2013; 14: 873-881.
129. Green DM, Kawashima T, Stovall M, et al. Fertility of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2010; 28: 332-339.
130. Rappaport R, Brauner R, Czernichow P, et al. Effect of hypothalamic and pituitary irradiation on pubertal development in children with cranial tumors. J Clin Endocrinol Metab. 1982; 54: 1164-1168.
131. Constine LS, Woolf PD, Cann D, et al. Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med. 1993; 328: 87-94.
132. Gleeson HK, Shalet SM,. The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours. Endocr Relat Cancer. 2004; 11: 589-602.
133. Chemaitilly W, Mertens AC, Mitby P, et al. Acute ovarian failure in the Childhood Cancer Survivor Study. J Clin Endocrinol Metab. 2006; 91: 1723-1728.
134. Sklar CA, Mertens AC, Mitby P, et al. Premature menopause in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2006; 98: 890-896.
135. Clayton PE, Shalet SM, Price DA, Jones PH,. Ovarian function following chemotherapy for childhood brain tumours. Med Pediatr Oncol. 1989; 17: 92-96.
136. Morgan S, Anderson RA, Gourley C, Wallace WH, Spears N,. How do chemotherapeutic agents damage the ovary? Hum Reprod update. 2012; 18: 525-535.
137. Meirow D, Dor J, Kaufman B, et al. Cortical fibrosis and blood-vessels damage in human ovaries exposed to chemotherapy. Potential mechanisms of ovarian injury. Hum Reprod. 2007; 22: 1626-1633.
138. Livesey EA, Brook CG,. Gonadal dysfunction after treatment of intracranial tumours. Arch Dis Child. 1988; 63: 495-500.
139. Schmiegelow M, Lassen S, Poulsen HS, et al. Gonadal status in male survivors following childhood brain tumors. J Clin Endocrinol Metab. 2001; 86: 2446-2452.
140. Thomson AB, Critchley HO, Kelnar CJ, Wallace WH,. Late reproductive sequelae following treatment of childhood cancer and options for fertility preservation. Best Pract Res Clin Endocrinol Metab. 2002; 16: 311-334.
141. Schover LR, Brey K, Lichtin A, Lipshultz LI, Jeha S,. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol. 2002; 20: 1880-1889.
142. Signorello LB, Mulvihill JJ, Green DM, et al. Congenital anomalies in the children of cancer survivors: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2012; 30: 239-245.
143. Sanders JE, Hawley J, Levy W, et al. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood. 1996; 87: 3045-3052.
144. Nicholson HS, Byrne J,. Fertility and pregnancy after treatment for cancer during childhood or adolescence. Cancer. 1993; 71 (10 suppl): 3392-3399.
145. Green DM, Sklar CA, Boice JD Jr, et al. Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. J Clin Oncol. 2009; 27: 2374-2381.
146. Goodwin T, Elizabeth Oosterhuis B, Kiernan M, Hudson MM, Dahl GV,. Attitudes and practices of pediatric oncology providers regarding fertility issues. Pediatr Blood Cancer. 2007; 48: 80-85.
147. Levine J, Canada A, Stern CJ,. Fertility preservation in adolescents and young adults with cancer. J Clin Oncol. 2010; 28: 4831-4841.
148. Rose SR, Danish RK, Kearney NS, et al. ACTH deficiency in childhood cancer survivors. Pediatr Blood Cancer. 2005; 45: 808-813.
149. Rohrer TR, Beck JD, Grabenbauer GG, Fahlbusch R, Buchfelder M, Dorr HG,. Late endocrine sequelae after radiotherapy of pediatric brain tumors are independent of tumor location. J Endocrinol Investig. 2009; 32: 294-297.
150. Lustig RH, Post SR, Srivannaboon K, et al. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab. 2003; 88: 611-616.
151. Talvensaari KK, Lanning M, Tapanainen P, Knip M,. Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. J Clin Endocrinol Metab. 1996; 81: 3051-3055.
152. Pietila S, Makipernaa A, Sievanen H, Koivisto AM, Wigren T, Lenko HL,. Obesity and metabolic changes are common in young childhood brain tumor survivors. Pediatr Blood Cancer. 2009; 52: 853-859.
153. Green DM, Cox CL, Zhu L, et al. Risk factors for obesity in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2012; 30: 246-255.
154. Heikens J, Ubbink MC, van der Pal HP, et al. Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. Cancer. 2000; 88: 2116-2121.
155. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG,. Central nervous system control of food intake. Nature. 2000; 404: 661-671.
156. Lustig RH, Hinds PS, Ringwald-Smith K, et al. Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2003; 88: 2586-2592.
157. Tataranni PA, Larson DE, Snitker S, Young JB, Flatt JP, Ravussin E,. Effects of glucocorticoids on energy metabolism and food intake in humans. Am J Physiol. 1996; 271 (2 pt 1): E317-E325.
158. Packer RJ, Gurney JG, Punyko JA, et al. Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: Childhood Cancer Survivor Study. J Clin Oncol. 2003; 21: 3255-3261.
159. Ness KK, Mertens AC, Hudson MM, et al. Limitations on physical performance and daily activities among long-term survivors of childhood cancer. Ann Intern Med. 2005; 143: 639-647.
160. Ness KK, Leisenring WM, Huang S, et al. Predictors of inactive lifestyle among adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Cancer. 2009; 115: 1984-1994.
161. Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V,. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res. 2007; 226: 157-167.
162. Li Y, Womer RB, Silber JH,. Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose. Eur J Cancer. 2004; 40: 2445-2451.
163. Kushner BH, Budnick A, Kramer K, Modak S, Cheung NK,. Ototoxicity from high-dose use of platinum compounds in patients with neuroblastoma. Cancer. 2006; 107: 417-422.
164. Kretschmar CS, Warren MP, Lavally BL, Dyer S, Tarbell NJ,. Ototoxicity of preradiation cisplatin for children with central nervous system tumors. J Clin Oncol. 1990; 8: 1191-1198.
165. Merchant TE, Gould CJ, Xiong X, et al. Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors. Int J Radiat Oncol Biol Phys. 2004; 58: 1194-1207.
166. Verstappen CC, Heimans JJ, Hoekman K, Postma TJ,. Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs. 2003; 63: 1549-1563.
167. Postma TJ, Benard BA, Huijgens PC, Ossenkoppele GJ, Heimans JJ,. Long-term effects of vincristine on the peripheral nervous system. J Neurooncol. 1993; 15: 23-27.
168. Brouwers EE, Huitema AD, Boogerd W, Beijnen JH, Schellens JH,. Persistent neuropathy after treatment with cisplatin and oxaliplatin. Acta Oncol. 2009; 48: 832-841.
169. Jaggi AS, Singh N,. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology. 2012; 291: 1-9.
170. Grisold W, Cavaletti G, Windebank AJ,. Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol. 2012; 14 (suppl 4): iv45-iv54.
171. Latiff ZA, Kamal NA, Jahendran J, et al. Vincristine-induced vocal cord palsy: case report and review of the literature. J Pediatr Hematol Oncol. 2010; 32: 407-410.
172. Ngamphaiboon N, Sweeney R, Wetzler M, Wang ES,. Pyridoxine treatment of vincristine-induced cranial polyneuropathy in an adult patient with acute lymphocytic leukemia: case report and review of the literature. Leuk Res. 2010; 34: e194-e196.
173. Rosenthal S, Kaufman S,. Vincristine neurotoxicity. Ann Intern Med. 1974; 80: 733-737.
174. Gilchrist L,. Chemotherapy-induced peripheral neuropathy in pediatric cancer patients. Semin Pediatr Neurol. 2012; 19: 9-17.
175. Reulen RC, Winter DL, Frobisher C, et al. Long-term cause-specific mortality among survivors of childhood cancer. JAMA. 2010; 304: 172-179.
176. Mertens AC, Liu Q, Neglia JP, et al. Cause-specific late mortality among 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2008; 100: 1368-1379.
177. Ullrich NJ, Robertson R, Kinnamon DD, et al. Moyamoya following cranial irradiation for primary brain tumors in children. Neurology. 2007; 68: 932-938.
178. Wang C, Roberts KB, Bindra RS, Chiang VL, Yu JB,. Delayed cerebral vasculopathy following cranial radiation therapy for pediatric tumors. Pediatr Neurol. 2014; 50: 549-556.
179. Kondoh T, Morishita A, Kamei M, Okamura Y, Tamaki M, Kohmura E,. Moyamoya syndrome after prophylactic cranial irradiation for acute lymphocytic leukemia. Pediatr Neurosurg. 2003; 39: 264-269.
180. Kestle JR, Hoffman HJ, Mock AR,. Moyamoya phenomenon after radiation for optic glioma. J Neurosurg. 1993; 79: 32-35.
181. Desai SS, Paulino AC, Mai WY, Teh BS,. Radiation-induced moyamoya syndrome. Int J Radiat Oncol Biol Phys. 2006; 65: 1222-1227.
182. Larson JJ, Ball WS, Bove KE, Crone KR, Tew JM Jr,. Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children. J Neurosurg. 1998; 88: 51-56.
183. Gross BA, Lin N, Du R, Day AL,. The natural history of intracranial cavernous malformations. Neurosurg Focus. 2011; 30: E24.
184. Al-Holou WN, O'Lynnger TM, Pandey AS, et al. Natural history and imaging prevalence of cavernous malformations in children and young adults. J Neurosurg Pediatr. 2012; 9: 198-205.
185. Gastelum E, Sear K, Hills N, et al. Rates and characteristics of radiographically detected intracerebral cavernous malformations after cranial radiation therapy in pediatric cancer patients. J Child Neurol. 2014.
186. Yates PA, Villemagne VL, Ellis KA, Desmond PM, Masters CL, Rowe CC,. Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Front Neurol. 2014; 4: 205.
187. Yeom KW, Lober RM, Partap S, et al. Increased focal hemosiderin deposition in pediatric medulloblastoma patients receiving radiotherapy at a later age. J Neurosurg Pediatr. 2013; 12: 444-451.
188. Lupo JM, Chuang CF, Chang SM, et al. 7-Tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma. Int J Radiat Oncol Biol Phys. 2012; 82: e493-e500.
189. Heringa SM, Reijmer YD, Leemans A, et al. Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease. J Alzheimers Dis. 2014; 38: 211-221.
190. van Norden AG, van den Berg HA, de Laat KF, Gons RA, van Dijk EJ, de Leeuw FE,. Frontal and temporal microbleeds are related to cognitive function: the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study. Stroke. 2011; 42: 3382-3386.
191. Krull KR, Sabin ND, Reddick WE, et al. Neurocognitive function and CNS integrity in adult survivors of childhood hodgkin lymphoma. J Clin Oncol. 2012; 30: 3618-3624.
192. Mueller S, Fullerton HJ, Stratton K, et al. Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the Childhood Cancer Survivor Study. Int J Radiat Oncol Biol Phys. 2013; 86: 649-655.
193. Campen CJ, Kranick SM, Kasner SE, et al. Cranial irradiation increases risk of stroke in pediatric brain tumor survivors. Stroke. 2012; 43: 3035-3040.
194. Mueller S, Sear K, Hills NK, et al. Risk of first and recurrent stroke in childhood cancer survivors treated with cranial and cervical radiation therapy. Int J Radiat Oncol Biol Phys. 2013; 86: 643-648.
195. Fullerton HJ, Wu YW, Sidney S, Johnston SC,. Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging. Pediatrics. 2007; 119: 495-501.
196. Nedeltchev K, der Maur TA, Georgiadis D, et al. Ischaemic stroke in young adults: predictors of outcome and recurrence. J Neurol Neurosurg Psychiatry. 2005; 76: 191-195.
197. Putaala J, Metso AJ, Metso TM, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke. 2009; 40: 1195-1203.
198. Vos J, Aarnoudse MW, Dijk F, Lamberts HB,. On the cellular origin and development of atheromatous plaques. A light and electron microscopic study of combined x-ray and hypercholesterolemia-induced atheromatosis in the carotid artery of the rabbit. Virchows Arch B Cell Pathol Incl Mol Pathol. 1983; 43: 1-16.
199. Stewart FA, Heeneman S, Te Poele J, et al. Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. Am J Pathol. 2006; 168: 649-658.
200. Meeske KA, Siegel SE, Gilsanz V, et al. Premature carotid artery disease in pediatric cancer survivors treated with neck irradiation. Pediatr Blood Cancer. 2009; 53: 615-621.
201. Lowe D, Raj K,. Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression. Aging cell. 2014; 13: 900-910.
202. Bowers DC, Liu Y, Leisenring W, et al. Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2006; 24: 5277-5282.
203. Mulrooney DA, Yeazel MW, Kawashima T, et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ. 2009; 339: b4606.
204. Thomas JD, Monson JP,. Adult GH deficiency throughout lifetime. Eur J Endocrinol. 2009; 161 (suppl 1): S97-S106.
205. Link K, Moell C, Garwicz S, et al. Growth hormone deficiency predicts cardiovascular risk in young adults treated for acute lymphoblastic leukemia in childhood. J Clin Endocrinol Metab. 2004; 89: 5003-5012.
206. Lipshultz SE, Lipsitz SR, Sallan SE, et al. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J Clin Oncol. 2005; 23: 2629-2636.
207. Lipshultz SE, Alvarez JA, Scully RE,. Anthracycline associated cardiotoxicity in survivors of childhood cancer. Heart. 2008; 94: 525-533.
208. Krischer JP, Epstein S, Cuthbertson DD, Goorin AM, Epstein ML, Lipshultz SE,. Clinical cardiotoxicity following anthracycline treatment for childhood cancer: the Pediatric Oncology Group experience. J Clin Oncol. 1997; 15: 1544-1552.
209. Adams MJ, Lipsitz SR, Colan SD, et al. Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapy. J Clin Oncol. 2004; 22: 3139-3148.
210. Geenen MM, Cardous-Ubbink MC, Kremer LC, et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA. 2007; 297: 2705-2715.
211. Tukenova M, Guibout C, Oberlin O, et al. Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol. 2010; 28: 1308-1315.
212. Lipshultz SE, Landy DC, Lopez-Mitnik G, et al. Cardiovascular status of childhood cancer survivors exposed and unexposed to cardiotoxic therapy. J Clin Oncol. 2012; 30: 1050-1057.
213. Steinberger J, Sinaiko AR, Kelly AS, et al. Cardiovascular risk and insulin resistance in childhood cancer survivors. J Pediatr. 2012; 160: 494-499.
214. Morris EB, Gajjar A, Okuma JO, et al. Survival and late mortality in long-term survivors of pediatric CNS tumors. J Clin Oncol. 2007; 25: 1532-1538.
215. Bhatia S, Sklar C,. Second cancers in survivors of childhood cancer. Nat Rev Cancer. 2002; 2: 124-132.
216. Friedman DL, Whitton J, Leisenring W, et al. Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2010; 102: 1083-1095.
217. Peterson KM, Shao C, McCarter R, MacDonald TJ, Byrne J,. An analysis of SEER data of increasing risk of secondary malignant neoplasms among long-term survivors of childhood brain tumors. Pediatr Blood Cancer. 2006; 47: 83-88.
218. Armstrong GT, Liu Q, Yasui Y, et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009; 101: 946-958.
219. Neglia JP, Robison LL, Stovall M, et al. New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2006; 98: 1528-1537.
220. Leone G, Mele L, Pulsoni A, Equitani F, Pagano L,. The incidence of secondary leukemias. Haematologica. 1999; 84: 937-945.
221. Felix CA,. Leukemias related to treatment with DNA topoisomerase II inhibitors. Med Pediatr Oncol. 2001; 36: 525-535.
222. Sandoval C, Pui CH, Bowman LC, et al. Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation. J Clin Oncol. 1993; 11: 1039-1045.
223. Pedersen-Bjergaard J, Daugaard G, Hansen SW, Philip P, Larsen SO, Rorth M,. Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours. Lancet. 1991; 338: 359-363.
224. Smith MA, Rubinstein L, Anderson JR, et al. Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins. J Clin Oncol. 1999; 17: 569-577.
225. Bowers DC, Nathan PC, Constine L, et al. Subsequent neoplasms of the CNS among survivors of childhood cancer: a systematic review. Lancet Oncol. 2013; 14: e321-e328.
226. Meeske KA, Patel SK, Palmer SN, Nelson MB, Parow AM,. Factors associated with health-related quality of life in pediatric cancer survivors. Pediatr Blood Cancer. 2007; 49: 298-305.
227. Zeltzer LK, Recklitis C, Buchbinder D, et al. Psychological status in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2009; 27: 2396-2404.
228. Zebrack BJ, Zevon MA, Turk N, et al. Psychological distress in long-term survivors of solid tumors diagnosed in childhood: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2007; 49: 47-51.
229. Zebrack BJ, Stuber ML, Meeske KA, et al. Perceived positive impact of cancer among long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Psychooncology. 2012; 21: 630-639.
230. Parry C, Chesler MA,. Thematic evidence of psychosocial thriving in childhood cancer survivors. Qual Health Res. 2005; 15: 1055-1073.
231. Zeltzer LK, Lu Q, Leisenring W, et al. Psychosocial outcomes and health-related quality of life in adult childhood cancer survivors: a report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2008; 17: 435-446.
232. Stuber ML, Meeske KA, Krull KR, et al. Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer. Pediatrics. 2010; 125: e1124-e1134.
233. Barrera M, Shaw AK, Speechley KN, Maunsell E, Pogany L,. Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Cancer. 2005; 104: 1751-1760.
234. Stam H, Grootenhuis MA, Last BF,. The course of life of survivors of childhood cancer. Psychooncology. 2005; 14: 227-238.
235. Rauck AM, Green DM, Yasui Y, Mertens A, Robison LL,. Marriage in the survivors of childhood cancer: a preliminary description from the Childhood Cancer Survivor Study. Med Pediatr Oncol. 1999; 33: 60-63.
236. Maurice-Stam H, Grootenhuis MA, Caron HN, Last BF,. Course of life of survivors of childhood cancer is related to quality of life in young adulthood. J Psychosoc Oncol. 2007; 25: 43-58.
237. Zebrack BJ, Gurney JG, Oeffinger K, et al. Psychological outcomes in long-term survivors of childhood brain cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2004; 22: 999-1006.
238. Coups EJ, Ostroff JS,. A population-based estimate of the prevalence of behavioral risk factors among adult cancer survivors and noncancer controls. Prev Med. 2005; 40: 702-711.
239. Pang JW, Friedman DL, Whitton JA, et al. Employment status among adult survivors in the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2008; 50: 104-110.
240. de Boer AG, Verbeek JH, van Dijk FJ,. Adult survivors of childhood cancer and unemployment: a metaanalysis. Cancer. 2006; 107: 1-11.
241. Gurney JG, Krull KR, Kadan-Lottick N, et al. Social outcomes in the Childhood Cancer Survivor Study cohort. J Clin Oncol. 2009; 27: 2390-2395.
242. Ness KK, Morris EB, Nolan VG, et al. Physical performance limitations among adult survivors of childhood brain tumors. Cancer. 2010; 116: 3034-3044.
243. Houtzager BA, Grootenhuis MA, Last BF,. Adjustment of siblings to childhood cancer: a literature review. Support Care Cancer. 1999; 7: 302-320.
244. French AE, Tsangaris E, Barrera M, et al. School attendance in childhood cancer survivors and their siblings. J Pediatr. 2013; 162: 160-165.
245. Kaplan LM, Kaal KJ, Bradley L, Alderfer MA,. Cancer-related traumatic stress reactions in siblings of children with cancer. Fam Syst Health. 2013; 31: 205-217.
246. Lown EA, Goldsby R, Mertens AC, et al. Alcohol consumption patterns and risk factors among childhood cancer survivors compared to siblings and general population peers. Addiction. 2008; 103: 1139-1148.
247. Lown EA, Mertens AC, Korcha RA, et al. Prevalence and predictors of risky and heavy alcohol consumption among adult siblings of childhood cancer survivors. Psychooncology. 2013; 22: 1134-1143.
248. Ach E, Gerhardt CA, Barrera M, et al. Family factors associated with academic achievement deficits in pediatric brain tumor survivors. Psychooncology. 2013; 22: 1731-1737.
249. Henderson TO, Hlubocky FJ, Wroblewski KE, Diller L, Daugherty CK,. Physician preferences and knowledge gaps regarding the care of childhood cancer survivors: a mailed survey of pediatric oncologists. J Clin Oncol. 2010; 28: 878-883.
250. Nathan PC, Daugherty CK, Wroblewski KE, et al. Family physician preferences and knowledge gaps regarding the care of adolescent and young adult survivors of childhood cancer. J Cancer Surviv. 2013; 7: 275-282.
251. Nathan PC, Greenberg ML, Ness KK, et al. Medical care in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol. 2008; 26: 4401-4409.