Accelerated aging, decreased white matter integrity, & associated neuropsychological dysfunction 25 years after pediatric lymphoid malignancies

Journal of Clinical Oncology

Volumn 31, Issue 27, 2013, Pages 3378-3388

  Schuitema, Ilse ^a,b   Deprez, Sabine ^d   Van Hecke, Wim ^e   Daams, Marita ^b   Uyttebroeck, Anne ^d   Sunaert, Stefan ^d   Barkhof, Frederik ^b   Van Dulmen den Broeder, Eline ^b   Van Der Pal, Helena J ^c   Van Den Bos, Cor ^c   Veerman, Anjo J P ^b   De Sonneville, Leo M J ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^e R D   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; BRAIN DEVELOPMENT; BRAIN SIZE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVOR; CHILDHOOD CANCER; COGNITIVE DEFECT; CONFERENCE PAPER; CONTROLLED STUDY; DEMENTIA; DIFFUSION TENSOR IMAGING; FEMALE; FRACTIONAL ANISOTROPY; FRONTAL LOBE; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NEUROTOXICITY; PARIETAL LOBE; PRIORITY JOURNAL; QUALITY OF LIFE; RISK ASSESSMENT; SKULL IRRADIATION; TEMPORAL LOBE; VOXEL BASED MORPHOMETRY; WHITE MATTER; ADOLESCENT; BRAIN; CASE CONTROL STUDY; CHEMORADIOTHERAPY; DIFFUSION WEIGHTED IMAGING; DRUG EFFECTS; MYELINATED NERVE; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROCEDURES; RADIATION RESPONSE; SURVIVOR; YOUNG ADULT;

ADOLESCENT; ADULT; BRAIN; CASE-CONTROL STUDIES; CHEMORADIOTHERAPY; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; LYMPHOMA; MALE; NERVE FIBERS, MYELINATED; NEUROPSYCHOLOGICAL TESTS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SURVIVORS; YOUNG ADULT;

EID: 84893086263     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2012.46.7050     Document Type: Conference Paper

References (82)

1. Cole PD, Kamen BA: Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Ment Retard Dev Disabil Res Rev 12:174-183, 2006.
2. Veerman AJ, Hählen K, Kamps WA, et al: High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group. J Clin Oncol 14:911-918, 1996.
3. Veerman AJ, Kamps WA, van den Berg H, et al: Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: Results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004). Lancet Oncol 10:957-966, 2009.
4. Pui CH, Campana D, Pei D, et al: Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 360:2730-2741, 2009.
5. Jenney ME, Levitt GA: The quality of survival after childhood cancer. Eur J Cancer 38:1241-1250, 2002.
6. Reddick WE, Shan ZY, Glass JO, et al: Smaller white-matter volumes are associated with larger deficits in attention and learning among long-Term survivors of acute lymphoblastic leukemia. Cancer 106:941-949, 2006.
7. Carey ME, Haut MW, Reminger SL, et al: Reduced frontal white matter volume in long-Term childhood leukemia survivors: A voxel-based morphometry study. Am J Neuroradiol 29:792-797, 2008.
8. Brown RT, Madan-Swain A, Walco GA, et al: Cognitive and academic late effects among children previously treated for acute lymphocytic leukemia receiving chemotherapy as CNS prophylaxis. J Pediatr Psychol 23:333-340, 1998.
9. Buizer AI, de Sonneville LM, Veerman AJ: Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Pediatr Blood Cancer 52:447-454, 2009.
10. Kingma A, Van Dommelen RI, Mooyaart EL, et al: No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: A prospective longitudinal study. J Pediatr Hematol Oncol 24:106-114, 2002.
11. Copeland DR, Moore BD 3rd, Francis DJ, et al: Neuropsychologic effects of chemotherapy on children with cancer: A longitudinal study. J Clin Oncol 14:2826-2835, 1996.
12. Mennes M, Stiers P, Vandenbussche E, et al: Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. Pediatr Blood Cancer 44: 478-486, 2005.
13. Buizer AI, de Sonneville LM, van den Heuvel- Eibrink MM, et al: Chemotherapy and attentional dysfunction in survivors of childhood acute lymphoblastic leukemia: Effect of treatment intensity. Pediatr Blood Cancer 45:281-290, 2005.
14. Porto L, Preibisch C, Hattingen E, et al: Voxelbased morphometry and diffusion-Tensor MR imaging of the brain in long-Term survivors of childhood leukemia. Eur Radiol 18:2691-2700, 2008.
15. Koppelmans V, Breteler MM, Boogerd W, et al: Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. J Clin Oncol 30:1080-1086, 2012.
16. Ball WS Jr, Prenger EC, Ballard ET: Neurotoxicity of radio/chemotherapy in children: Pathologic and MR correlation. Am J Neuroradiol 13:761-776, 1992.
17. Jain R, Robertson PL, Gandhi D, et al: Radiation-induced cavernomas of the brain. Am J Neuroradiol 26:1158-1162, 2005.
18. Hijiya N, Hudson MM, Lensing S, et al: Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia. JAMA 297:1207-1215, 2007.
19. Brouwers P, Poplack D: Memory and learning sequelae in long-Term survivors of acute lymphoblastic leukemia: Association with attention deficits. Am J Pediatr Hematol Oncol 12:174-181, 1990.
20. Butler RW, Copeland DR: Neuropsychological effects of central nervous system prophylactic treatment in childhood leukemia: Methodological considerations. J Pediatr Psychol 18:319-338, 1993.
21. Butler RW, Copeland DR: Attentional processes and their remediation in children treated for cancer: A literature review and the development of a therapeutic approach. J Int Neuropsychol Soc 8:115- 124, 2002.
22. Precourt S, Robaey P, Lamothe I, et al: Verbal cognitive functioning and learning in girls treated for acute lymphoblastic leukemia by chemotherapy with or without cranial irradiation. Dev Neuropsychol 21:173-195, 2002.
23. Mulhern RK, Palmer SL: Neurocognitive late effects in pediatric cancer. Curr Probl Cancer 27: 177-197, 2003.
24. Butler JM, Rapp SR, Shaw EG: Managing the cognitive effects of brain tumor radiation therapy. Curr Treat Options Oncol 7:517-523, 2006.
25. Pierpaoli C, Basser PJ: Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36:893-906, 1996.
26. Leung LH, Ooi GC, Kwong DL, et al: Whitematter diffusion anisotropy after chemo-irradiation: A statistical parametric mapping study and histogram analysis. Neuroimage 21:261-268, 2004.
27. Khong PL, Leung LH, Fung AS, et al: White matter anisotropy in post-Treatment childhood cancer survivors: Preliminary evidence of association with neurocognitive function. J Clin Oncol 24:884- 890, 2006.
28. de Ruiter MB, Reneman L, Boogerd W, et al: Late effects of high-dose chemotherapy on white and gray matter in breast cancer survivors: Converging results from multimodal magnetic resonance imaging. Hum Brain Mapp 33:2971-2983, 2012.
29. Deprez S, Amant F, Yigit R, et al: Chemotherapy- induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients. Hum Brain Mapp 32:480-493, 2011.
30. Deprez S, Amant F, Smeets A, et al: Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning. J Clin Oncol 30:274-281, 2012.
31. Dellani PR, Eder S, Gawehn J, et al: Late structural alterations of cerebral white matter in long-Term survivors of childhood leukemia. J Magn Reson Imaging 27:1250-1255, 2008.
32. Davis PC, Hoffman JC Jr, Pearl GS, et al: CT evaluation of effects of cranial radiation therapy in children. AJR Am J Roentgenol 147:587-592, 1986.
33. Suc E, Kalifa C, Brauner R, et al: Brain tumours under the age of three: The price of survival-A retrospective study of 20 long-Term survivors. Acta Neurochir (Wien) 106:93-98, 1990.
34. Mulhern RK, Palmer SL, Reddick WE, et al: Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. J Clin Oncol 19:472-479, 2001.
35. Spiegler BJ, Bouffet E, Greenberg ML, et al: Change in neurocognitive functioning after treatment with cranial radiation in childhood. J Clin Oncol 22:706-713, 2004.
36. Chan YL, Roebuck DJ, Yuen MP, et al: Longterm cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis. Int J Radiat Oncol Biol Phys 50:759-763, 2001.
37. Khong PL, Kwong DL, Chan GC, et al: Diffusion-Tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: A pilot study. AJNR Am J Neuroradiol 24:734-740, 2003.
38. Bleyer WA: Neurologic sequelae of methotrexate and ionizing radiation: A new classification. Cancer Treat Rep 65:89-98, 1981.
39. D'Ambrosio DJ, Cohen RB, Glass J, et al: Unexpected dementia following prophylactic cranial irradiation for small cell lung cancer: Case report. J Neurooncol 85:77-79, 2007.
40. Einhorn LH 3rd: The case against prophylactic cranial irradiation in limited small cell lung cancer. Semin Radiat Oncol 5:57-60, 1995.
41. Pedersen AG, Kristjansen PE, Hansen HH: Prophylactic cranial irradiation and small cell lung cancer. Cancer Treat Rev 15:85-103, 1988.
42. Edelstein K, Spiegler BJ, Fung S, et al: Early aging in adult survivors of childhood medulloblastoma: Long-Term neurocognitive, functional, and physical outcomes. Neuro Oncol 13:536-545, 2011.
43. Maccormick RE: Possible acceleration of aging by adjuvant chemotherapy: A cause of early onset frailty? Med Hypotheses 67:212-215, 2006.
44. Riehm H, Gadner H, Henze G, et al: Results and significance of six randomized trials in four consecutive ALL-BFM studies. Haematol Blood Transfus 33:439-450, 1990.
45. Vilmer E, Suciu S, Ferster A, et al: Long-Term results of three randomized trials (58831, 58832, 58881) in childhood lymphoblastic leukemia: A CLCG-EORTC report-Children Leukemia Cooperative Group. Leukemia 14:2257-2266, 2000.
46. Reese TG, Heid O, Weisskoff RM, et al: Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med 49:177-182, 2003.
47. Leemans A, Jones DK: The B-matrix must be rotated when correcting for subject motion in DTI data. Magn Reson Med 61:1336-1349, 2009.
48. Van Hecke W, Sijbers J, D'Agostino E, et al: On the construction of an inter-subject diffusion tensor magnetic resonance atlas of the healthy human brain. Neuroimage 43:69-80, 2008.
49. Van Hecke W, Leemans A, Sage CA, et al: The effect of template selection on diffusion tensor voxel-based analysis results. Neuroimage 55:566- 573, 2011.
50. Van Hecke W, Leemans A, De Backer S, et al: Comparing isotropic and anisotropic smoothing for voxel-based DTI analyses: A simulation study. Hum Brain Mapp 31:98-114, 2010.
51. Ashburner J, Friston KJ: Statistical Parametric Mapping (SPM). http://www.fil.ion.ucl.ac.uk/spm/software/spm8.
52. De Sonneville LMJ: Amsterdam Neuropsychological Tasks: A computer-Aided assessment program, in Den Brinker BPLM, Beek PJ, Brand AN, et al (eds): Cognitive Ergonomics, Clinical Assessment, and Computer-Assisted Learning. Lisse, the Netherlands, Swets & Zeitlinger, 1999, pp 187-203.
53. Burgard P, Rey F, Rupp A, et al: Neuropsychologic functions of early treated patients with phenylketonuria, on and off diet: Results of a cross-national and cross-sectional study. Pediatr Res 41:368-374, 1997.
54. Huijbregts S, de Sonneville L, Licht R, et al: Inhibition of prepotent responding and attentional flexibility in treated phenylketonuria. Dev Neuropsychol 22:481-499, 2002.
55. Huijbregts SC, de Sonneville LM, Licht R, et al: Sustained attention and inhibition of cognitive interference in treated phenylketonuria: Associations with concurrent and lifetime phenylalanine concentrations. Neuropsychologia 40:7-15, 2002.
56. De Sonneville LM, Boringa JB, Reuling IE, et al: Information processing characteristics in subtypes of multiple sclerosis. Neuropsychologia 40: 1751-1765, 2002.
57. Rowbotham I, Pit-Ten Cate IM, Sonuga-Barke EJ, et al: Cognitive control in adolescents with neurofibromatosis type 1. Neuropsychology 23:50- 60, 2009.
58. Huijbregts S, Swaab H, de Sonneville L: Cognitive and motor control in neurofibromatosis type I: Influence of maturation and hyperactivityinattention. Dev Neuropsychol 35:737-751, 2010.
59. Gunther T, Herpertz-Dahlmann B, Konrad K: [Reliability of attention and verbal memory tests with normal children and adolescents: Clinical implications]. [In German]. Z Kinder Jugendpsychiatrd Psychother 33:169-179, 2005.
60. De Sonneville LM: [Amsterdam Neuropsychological tasks: Scientific and clinical applications]. [In Dutch]. Tijdschr Neuropsychol 0:27-41, 2005.
61. Silverstein AB: Two-subtest and four-subtest short forms of the Wechsler adult intelligence scalerevised. J Consult Clin Psychol 50:415-418, 1982.
62. Reference deleted.
63. Westlye LT, Walhovd KB, Dale AM, et al: Life-span changes of the human brain white matter: Diffusion tensor imaging (DTI) and volumetry. Cereb Cortex 20:2055-2068, 2010.
64. Neter J, Kutner MH, Wasserman W, et al: Applied Linear Statistical Models (ed 4). New York, NY, WCB McGraw-Hill, 1996.
65. Mulhern RK, Kepner JL, Thomas PR, et al: Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced dose cranospinal irradiation: A Pediatric Oncology Group study. J Clin Oncol 16: 1723-1728, 1998.
66. Parente DB, Gasparetto EL, da Cruz LC Jr, et al: Potential role of diffusion tensor MRI in the differential diagnosis of mild cognitive impairment and Alzheimer's disease. AJR Am J Roentgenol 190:1369-1374, 2008.
67. Daams M, Schuitema I, van Dijk BW, et al: Longterm effects of cranial irradiation and intrathecal chemotherapy in treatment of childhood leukemia: A MEG study of power spectrum and correlated cognitive dysfunction. BMC Neurol 12:84, 2012.
68. O'Sullivan M, Morris RG, Huckstep B, et al: Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis. J Neurol Neurosurg Psychiatry 75:441-447, 2004.
69. Turken A, Whitfield-Gabrieli S, Bammer R, et al: Cognitive processing speed and the structure of white matter pathways: Convergent evidence from normal variation and lesion studies. Neuroimage 42:1032-1044, 2008.
70. Kurita H, Kawahara N, Asai A, et al: Radiationinduced apoptosis of oligodendrocytes in the adult rat brain. Neurol Res 23:869-874, 2001.
71. Smith B: Brain damage after intrathecal methotrexate. J Neurol Neurosurg Psychiatr 38:810-815, 1975.
72. Schultheiss TE, Kun LE, Ang KK, et al: Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 31:1093-1112, 1995.
73. Tofilon PJ, Fike JR: The radioresponse of the central nervous system: A dynamic process. Radiat Res 153:357-370, 2000.
74. Monje ML, Mizumatsu S, Fike JR, et al: Irradiation induces neural precursor-cell dysfunction. Nat Med 8:955-962, 2002.
75. Fukuda A, Fukuda H, Swanpalmer J, et al: Agedependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells. J Neurochem 92:569-584, 2005.
76. Dietrich J, Monje M, Wefel J, et al: Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist 13:1285-1295, 2008.
77. Han R, Yang YM, Dietrich J, et al: Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system. J Biol 7:12, 2008.
78. Dietrich J, Han R, Yang Y, et al: CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol 5:22, 2006.
79. Tau GZ, Peterson BS: Normal development of brain circuits. Neuropsychopharmacology 35:147- 168, 2010.
80. Shuper A, Stark B, Kornreich L, et al: Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia. Isr Med Assoc J 4:1050-1053, 2002.
81. Reddick WE, Glass JO, Johnson DP, et al: Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia. Am J Neuroradiol 30:1947-1954, 2009.
82. Mangialasche F, Kivipelto M, Solomon A, et al: Dementia prevention: Current epidemiological evidence and future perspective. Alzheimers Res Ther 4:6, 2012.