메뉴 건너뛰기




Volumn 18, Issue 5, 2012, Pages 525-535

How do chemotherapeutic agents damage the ovary?

Author keywords

Cancer; Chemotherapy; Female infertility; Follicle development; Ovary

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; BLEOMYCIN; BUSULFAN; CARMUSTINE; CISPLATIN; CISPLATIN DERIVATIVE; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GONADORELIN AGONIST; HYDROXYUREA; IFOSFAMIDE; IMATINIB; IRINOTECAN; MELPHALAN; MERCAPTOPURINE; MESNA; METHOTREXATE; MITOXANTRONE; PACLITAXEL; PREDNISONE; PROCARBAZINE; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE; VINCRISTINE SULFATE;

EID: 84865094333     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dms022     Document Type: Review
Times cited : (331)

References (89)
  • 2
    • 64649101643 scopus 로고    scopus 로고
    • The current knowledge on radiosensitivity of ovarian follicle development stages
    • Adriaens I, Smitz J, Jacquet P. The current knowledge on radiosensitivity of ovarian follicle development stages. Hum Reprod Update 2009;15:359-377.
    • (2009) Hum Reprod Update , vol.15 , pp. 359-377
    • Adriaens, I.1    Smitz, J.2    Jacquet, P.3
  • 4
    • 79955661129 scopus 로고    scopus 로고
    • Pretreament serum Anti-müllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer
    • Anderson RA, Cameron DA. Pretreament serum Anti-müllerian hormone predicts long-term ovarian function and bone mass after chemotherapy for early breast cancer. J Clin Endocrinol Metab 2011;96:1336-1343.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1336-1343
    • Anderson, R.A.1    Cameron, D.A.2
  • 5
    • 80052540620 scopus 로고    scopus 로고
    • Fertility preservation in girls and young women
    • Anderson RA, Wallace WHB. Fertility preservation in girls and young women. Clin Endocrinol 2011;75:409-419.
    • (2011) Clin Endocrinol , vol.75 , pp. 409-419
    • Anderson, R.A.1    Wallace, W.H.B.2
  • 6
    • 33749601698 scopus 로고    scopus 로고
    • The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer
    • Anderson RA, Themmen APN, Al-Qahtani A, Groome NP, Cameron DA. The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer. Hum Reprod 2006;21:2583-2592.
    • (2006) Hum Reprod , vol.21 , pp. 2583-2592
    • Anderson, R.A.1    Themmen, A.P.N.2    Al-Qahtani, A.3    Groome, N.P.4    Cameron, D.A.5
  • 7
    • 0024409865 scopus 로고
    • Gonadotrophin-releasing hormone agonist inhibits physiologic ovarian folliclualr loss in rats
    • Ataya K, Tadros M, Ramahi A. Gonadotrophin-releasing hormone agonist inhibits physiologic ovarian folliclualr loss in rats. Acta Endocrinol 1989;121:55-60.
    • (1989) Acta Endocrinol , vol.121 , pp. 55-60
    • Ataya, K.1    Tadros, M.2    Ramahi, A.3
  • 9
    • 54449085899 scopus 로고    scopus 로고
    • GnRH agonist therapy as ovarian protectants in female patients undergoing chemotherapy: a review of the clinical data
    • Beck-Fruchter R, Weiss A, Shalev E. GnRH agonist therapy as ovarian protectants in female patients undergoing chemotherapy: a review of the clinical data. Hum Reprod Update 2008;14:553-561.
    • (2008) Hum Reprod Update , vol.14 , pp. 553-561
    • Beck-Fruchter, R.1    Weiss, A.2    Shalev, E.3
  • 11
    • 0029864362 scopus 로고    scopus 로고
    • Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer
    • Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996; 14:1718-1729.
    • (1996) J Clin Oncol , vol.14 , pp. 1718-1729
    • Bines, J.1    Oleske, D.M.2    Cobleigh, M.A.3
  • 12
    • 54449091950 scopus 로고    scopus 로고
    • GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy
    • Blumenfeld Z, von Wolff M. GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy. Hum Reprod Update 2008; 14:543-552.
    • (2008) Hum Reprod Update , vol.14 , pp. 543-552
    • Blumenfeld, Z.1    von Wolff, M.2
  • 13
    • 84878387082 scopus 로고    scopus 로고
    • Brougham MFH, Crofton PM, Johnson EJ, Evans N, Anderson RA, Wallace WHB. Anti-Müllerian hormone is a marker of gonadotoxicity in pre- and post pubertal girls treated for cancer: a prospective study. J Clin Endocrinol Metab, in press.
  • 18
    • 0033179502 scopus 로고    scopus 로고
    • Early menopause and infertility in females after treatment for childhood cancer diagnosed in 1964-1988 in Ontario
    • Chiarelli AM, Marrett LD, Darlington G. Early menopause and infertility in females after treatment for childhood cancer diagnosed in 1964-1988 in Ontario, Canada. Am J Epidemiol 1999;150:245-254.
    • (1999) Canada. Am J Epidemiol , vol.150 , pp. 245-254
    • Chiarelli, A.M.1    Marrett, L.D.2    Darlington, G.3
  • 19
    • 33751511183 scopus 로고    scopus 로고
    • Immunolocalization of gonadotropin-releasing Hormone (GnRH)-I, GnRH-II, and Type I GnRH receptor during follicular development in the human ovary
    • Choi JH, Gilks CB, Auersperg N, Leung PCK. Immunolocalization of gonadotropin-releasing Hormone (GnRH)-I, GnRH-II, and Type I GnRH receptor during follicular development in the human ovary. J Clin Endocrinol Metab 2006;91:4562-4570.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4562-4570
    • Choi, J.H.1    Gilks, C.B.2    Auersperg, N.3    Leung, P.C.K.4
  • 20
    • 77952112061 scopus 로고    scopus 로고
    • The role of autophagy in follicular development and atresia in rat granulosa cells
    • Choi JY, Jo MW, Lee EY, Yoon BK, Choi DS. The role of autophagy in follicular development and atresia in rat granulosa cells. Fertil Steril 2010;93:2532-2537.
    • (2010) Fertil Steril , vol.93 , pp. 2532-2537
    • Choi, J.Y.1    Jo, M.W.2    Lee, E.Y.3    Yoon, B.K.4    Choi, D.S.5
  • 22
    • 77649200868 scopus 로고    scopus 로고
    • Anti-Müllerian hormone follow-up in young women treated by chemotherapy for lymphoma: preliminary results
    • Decanter C, Morschhauser F, Pigny P, Lefebvre C, Gallo C, Dewailly D. Anti-Müllerian hormone follow-up in young women treated by chemotherapy for lymphoma: preliminary results. Reprod Biomed Online 2010;20:280-285.
    • (2010) Reprod Biomed Online , vol.20 , pp. 280-285
    • Decanter, C.1    Morschhauser, F.2    Pigny, P.3    Lefebvre, C.4    Gallo, C.5    Dewailly, D.6
  • 23
    • 79960545091 scopus 로고    scopus 로고
    • Effect of the gonadotrophin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer
    • Del Mastro L, Boni L, Michelotti A, Gamucci T, Olmeo N, Gori S, Giordano M, Garrone O, Pronzato P, Bighin C. Effect of the gonadotrophin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer. JAMA 2011;306:269-276.
    • (2011) JAMA , vol.306 , pp. 269-276
    • Del Mastro, L.1    Boni, L.2    Michelotti, A.3    Gamucci, T.4    Olmeo, N.5    Gori, S.6    Giordano, M.7    Garrone, O.8    Pronzato, P.9    Bighin, C.10
  • 24
    • 33645119762 scopus 로고    scopus 로고
    • characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries
    • Desmeules P, Devine PJ. characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries. Toxicol Sci 2006;90:500-509.
    • (2006) Toxicol Sci , vol.90 , pp. 500-509
    • Desmeules, P.1    Devine, P.J.2
  • 25
    • 79959818297 scopus 로고    scopus 로고
    • Preservation of fertility in females with haemotological malignancy
    • Donnez J, Dolmans MM. Preservation of fertility in females with haemotological malignancy. Br J Haematol 2011;154:175-184.
    • (2011) Br J Haematol , vol.154 , pp. 175-184
    • Donnez, J.1    Dolmans, M.M.2
  • 26
    • 0033007545 scopus 로고    scopus 로고
    • Metabolism of radiolabeled glucose by mouse oocytes and oocyte-cumulus cell complexes
    • Downs SM, Utecht AM. Metabolism of radiolabeled glucose by mouse oocytes and oocyte-cumulus cell complexes. Biol Reprod 1999;60:1446-1452.
    • (1999) Biol Reprod , vol.60 , pp. 1446-1452
    • Downs, S.M.1    Utecht, A.M.2
  • 30
    • 78649498783 scopus 로고    scopus 로고
    • DNA damage stress response in germ cells: role of c-Abl and clinical implications
    • Gonfloni S. DNA damage stress response in germ cells: role of c-Abl and clinical implications. Oncogene 2010;29:6193-6202.
    • (2010) Oncogene , vol.29 , pp. 6193-6202
    • Gonfloni, S.1
  • 34
    • 33846977746 scopus 로고    scopus 로고
    • Direct protection by a gonadotropin-releasing hormone analog from doxorubicin-induced granulosa cell damage
    • Imai A, Sugiyama M, Furui T, Tamaya T, Ohno T. Direct protection by a gonadotropin-releasing hormone analog from doxorubicin-induced granulosa cell damage. Gynecol Obstet Invest 2007;63:102-106.
    • (2007) Gynecol Obstet Invest , vol.63 , pp. 102-106
    • Imai, A.1    Sugiyama, M.2    Furui, T.3    Tamaya, T.4    Ohno, T.5
  • 35
    • 33847032042 scopus 로고    scopus 로고
    • Cardiovascular risk in women: the impact of hormone replacement therapy and prospects for new therapeutic approaches
    • Jeanes H, Newby D, Gray GA. Cardiovascular risk in women: the impact of hormone replacement therapy and prospects for new therapeutic approaches. Expert Opin Pharmacother 2007;8:279-288.
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 279-288
    • Jeanes, H.1    Newby, D.2    Gray, G.A.3
  • 36
    • 1642349298 scopus 로고    scopus 로고
    • Germline stem cells and follicular renewal in the postnatal mammalian ovary
    • Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL. Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature 2004;428:145-150.
    • (2004) Nature , vol.428 , pp. 145-150
    • Johnson, J.1    Canning, J.2    Kaneko, T.3    Pru, J.K.4    Tilly, J.L.5
  • 39
    • 0033316264 scopus 로고    scopus 로고
    • Involvement of the Fas/Fas ligand system in p53-mediated granulosa cell apoptosis during follicular development and atresia
    • Kim JM, Yoon YD, Tsang BK. Involvement of the Fas/Fas ligand system in p53-mediated granulosa cell apoptosis during follicular development and atresia. Endocrinology 1999;140:2307-2317.
    • (1999) Endocrinology , vol.140 , pp. 2307-2317
    • Kim, J.M.1    Yoon, Y.D.2    Tsang, B.K.3
  • 40
    • 30944466669 scopus 로고    scopus 로고
    • Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5
    • Kitajima Y, Endo T, Nagasawa K, Manase K, Honnma H, Baba T, Hayashi T, Chiba H, Sawada N, Saito T. Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5. Endocrinology 2006;147:694-699.
    • (2006) Endocrinology , vol.147 , pp. 694-699
    • Kitajima, Y.1    Endo, T.2    Nagasawa, K.3    Manase, K.4    Honnma, H.5    Baba, T.6    Hayashi, T.7    Chiba, H.8    Sawada, N.9    Saito, T.10
  • 43
    • 84857997531 scopus 로고    scopus 로고
    • Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer
    • Letourneau JM, Ebbel EE, Katz PP, Katz A, Ai WZ, Chien AJ, Melisko ME, Cedars MI, Rosen MP. Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer. Cancer 2012b; 118:1710-1717.
    • (2012) Cancer , vol.118 , pp. 1710-1717
    • Letourneau, J.M.1    Ebbel, E.E.2    Katz, P.P.3    Katz, A.4    Ai, W.Z.5    Chien, A.J.6    Melisko, M.E.7    Cedars, M.I.8    Rosen, M.P.9
  • 44
    • 0032736260 scopus 로고    scopus 로고
    • The risk of premature menopause induced by chemotherapy for early breast cancer
    • Lower EE, Blau R, Gazder P, Tummala R. The risk of premature menopause induced by chemotherapy for early breast cancer. J Womens Health Genet Based Med 1999;8:949-954.
    • (1999) J Womens Health Genet Based Med , vol.8 , pp. 949-954
    • Lower, E.E.1    Blau, R.2    Gazder, P.3    Tummala, R.4
  • 45
    • 0037646503 scopus 로고    scopus 로고
    • Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling
    • Mandic A, Hansson J, Linder S, Shoshan MC. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 2003; 278:9100-9106.
    • (2003) J Biol Chem , vol.278 , pp. 9100-9106
    • Mandic, A.1    Hansson, J.2    Linder, S.3    Shoshan, M.C.4
  • 47
    • 0037150650 scopus 로고    scopus 로고
    • Intercellular communication in the mammalian ovary: oocytes carry the conversation
    • Matzuk MM, Burns KH, Viveiros MM, Eppig JJ. Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 2002;296:2178-2180.
    • (2002) Science , vol.296 , pp. 2178-2180
    • Matzuk, M.M.1    Burns, K.H.2    Viveiros, M.M.3    Eppig, J.J.4
  • 48
    • 0034722210 scopus 로고    scopus 로고
    • Reproduction post-chemotherapy in young cancer patients
    • Meirow D. Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol 2000;169:123-131.
    • (2000) Mol Cell Endocrinol , vol.169 , pp. 123-131
    • Meirow, D.1
  • 49
    • 0035174750 scopus 로고    scopus 로고
    • The effects of radiotherapy and chemotherapy on female reproduction
    • Meirow D, Nugent D. The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update 2001;7:535-543.
    • (2001) Hum Reprod Update , vol.7 , pp. 535-543
    • Meirow, D.1    Nugent, D.2
  • 50
    • 0032772302 scopus 로고    scopus 로고
    • Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool
    • Meirow D, Lewis H, Nugent D, Epstein M. Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool. Hum Reprod 1999;14:1903-1907.
    • (1999) Hum Reprod , vol.14 , pp. 1903-1907
    • Meirow, D.1    Lewis, H.2    Nugent, D.3    Epstein, M.4
  • 53
    • 0034102433 scopus 로고    scopus 로고
    • Sphingolipid regulation of female gonadal cell apoptosis
    • Morita Y, Tilly JL. Sphingolipid regulation of female gonadal cell apoptosis. Ann N Y Acad Sci 2000;905:209-220.
    • (2000) Ann N Y Acad Sci , vol.905 , pp. 209-220
    • Morita, Y.1    Tilly, J.L.2
  • 56
    • 35948997339 scopus 로고    scopus 로고
    • A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve
    • Oktem O, Oktay K. A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve. Cancer Res 2007a; 67:10159-10162.
    • (2007) Cancer Res , vol.67 , pp. 10159-10162
    • Oktem, O.1    Oktay, K.2
  • 57
    • 36049006773 scopus 로고    scopus 로고
    • Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function
    • Oktem O, Oktay K. Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function. Cancer 2007b;110:2222-2229.
    • (2007) Cancer , vol.110 , pp. 2222-2229
    • Oktem, O.1    Oktay, K.2
  • 58
    • 84865081509 scopus 로고    scopus 로고
    • Cancer survival in England: one-year and five-year survival for 21 common cancers
    • ONS. Office for National Statistics
    • ONS. Cancer survival in England: one-year and five-year survival for 21 common cancers, by sex and age. Office for National Statistics, 2010.
    • (2010) by sex and age
  • 60
    • 34447272269 scopus 로고    scopus 로고
    • Age of menopause among women who remain premenopausal following treatment for early breast cancer: Long-term results from International Breast Cancer Study Group Trials V and VI
    • Partridge A, Gelber S, Gelber RD, Castiglione-Gertsch M, Goldhirsch A, Winder E. Age of menopause among women who remain premenopausal following treatment for early breast cancer: Long-term results from International Breast Cancer Study Group Trials V and VI. Eu J Cancer 2007;43: 1646-1653.
    • (2007) Eu J Cancer , vol.43 , pp. 1646-1653
    • Partridge, A.1    Gelber, S.2    Gelber, R.D.3    Castiglione-Gertsch, M.4    Goldhirsch, A.5    Winder, E.6
  • 61
    • 0030694255 scopus 로고    scopus 로고
    • Apoptosis-associated signalling pathways are required for chemotherapy-mediated female germ cell destruction
    • Perez GI, Knudson CM, Leykin L, Korsmeyer SJ, Tilly JL. Apoptosis-associated signalling pathways are required for chemotherapy-mediated female germ cell destruction. Nat Med 1997;3:1228-1232.
    • (1997) Nat Med , vol.3 , pp. 1228-1232
    • Perez, G.I.1    Knudson, C.M.2    Leykin, L.3    Korsmeyer, S.J.4    Tilly, J.L.5
  • 63
    • 79955603763 scopus 로고    scopus 로고
    • Detection of DNA damage in oocytes of small ovarian follicles following phosphoramide mustard exposures of cultured rodent ovaries in vitro
    • Petrillo SK, Desmeules P, Truong TQ, Devine PJ. Detection of DNA damage in oocytes of small ovarian follicles following phosphoramide mustard exposures of cultured rodent ovaries in vitro. Toxicol Appl Pharmacol 2011; 253:94-102.
    • (2011) Toxicol Appl Pharmacol , vol.253 , pp. 94-102
    • Petrillo, S.K.1    Desmeules, P.2    Truong, T.Q.3    Devine, P.J.4
  • 65
    • 0036773594 scopus 로고    scopus 로고
    • Possible direct cytotoxicity effects of cyclophosphamide on cultured human follicles: an electron microscopy study
    • Raz A, Fisch B, Okon E, Feldberg D, Nitke S, Raanani H, Abir R. Possible direct cytotoxicity effects of cyclophosphamide on cultured human follicles: an electron microscopy study. J Assist Reprod Genet 2002;19:500-506.
    • (2002) J Assist Reprod Genet , vol.19 , pp. 500-506
    • Raz, A.1    Fisch, B.2    Okon, E.3    Feldberg, D.4    Nitke, S.5    Raanani, H.6    Abir, R.7
  • 67
    • 79851489810 scopus 로고    scopus 로고
    • Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management
    • Shakir DK, Rasul KI. Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management. J Clin Med Res 2009;1:8-12.
    • (2009) J Clin Med Res , vol.1 , pp. 8-12
    • Shakir, D.K.1    Rasul, K.I.2
  • 68
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: mode of cytotoxic action and molecular basis of resistance
    • Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003;22:7265-7279.
    • (2003) Oncogene , vol.22 , pp. 7265-7279
    • Siddik, Z.H.1
  • 69
    • 20444486561 scopus 로고    scopus 로고
    • Maintenance of ovarian function and risk of premature menopause related to cancer treatment
    • Sklar C. Maintenance of ovarian function and risk of premature menopause related to cancer treatment. J Natl Cancer Inst Monogr 2005;34:25-27.
    • (2005) J Natl Cancer Inst Monogr , vol.34 , pp. 25-27
    • Sklar, C.1
  • 71
    • 77954295382 scopus 로고    scopus 로고
    • The 'two faces' of tumour supressor p53-revisited
    • Smith ML, Suresh Kumar MA. The 'two faces' of tumour supressor p53-revisited. Mol Cell Pharmacol 2010;2:117-119.
    • (2010) Mol Cell Pharmacol , vol.2 , pp. 117-119
    • Smith, M.L.1    Suresh Kumar, M.A.2
  • 72
    • 84857709131 scopus 로고    scopus 로고
    • Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise
    • Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K. Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. AGING 2011;3:782-793.
    • (2011) AGING , vol.3 , pp. 782-793
    • Soleimani, R.1    Heytens, E.2    Darzynkiewicz, Z.3    Oktay, K.4
  • 73
    • 33750287996 scopus 로고    scopus 로고
    • Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants
    • Stearns V, Schneider B, Henry NL, Hayes DF, Flockhart DA. Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants. Nat Rev Cancer 2006;6:886-893.
    • (2006) Nat Rev Cancer , vol.6 , pp. 886-893
    • Stearns, V.1    Schneider, B.2    Henry, N.L.3    Hayes, D.F.4    Flockhart, D.A.5
  • 76
    • 77958000116 scopus 로고    scopus 로고
    • Doxorubicin induces apoptosis in H9c2 cardiomyocytes: role of overexpressed eukaryotic translation initiation factor 5A
    • Tan X, Wang DB, Wei H, Zhu R, Zhu SS, Jiang H, Yang ZJ. Doxorubicin induces apoptosis in H9c2 cardiomyocytes: role of overexpressed eukaryotic translation initiation factor 5A. Biol Pharm Bull 2010;10:1666-1672.
    • (2010) Biol Pharm Bull , vol.10 , pp. 1666-1672
    • Tan, X.1    Wang, D.B.2    Wei, H.3    Zhu, R.4    Zhu, S.S.5    Jiang, H.6    Yang, Z.J.7
  • 79
    • 0030238334 scopus 로고    scopus 로고
    • Apoptosis and ovarian function
    • Tilly JL. Apoptosis and ovarian function. Rev Reprod 1996;1:162-172.
    • (1996) Rev Reprod , vol.1 , pp. 162-172
    • Tilly, J.L.1
  • 81
    • 45849151738 scopus 로고    scopus 로고
    • A novel molecular mechanism for anticancer drug-induced ovarian failure: irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apotosis
    • Utsunomiya T, Tanaka T, Utsunomiya H, Umesaki N. A novel molecular mechanism for anticancer drug-induced ovarian failure: irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apotosis. Intl J Oncol 2008; 32:991-1000.
    • (2008) Intl J Oncol , vol.32 , pp. 991-1000
    • Utsunomiya, T.1    Tanaka, T.2    Utsunomiya, H.3    Umesaki, N.4
  • 82
    • 77952508440 scopus 로고    scopus 로고
    • Human ovarian reserve from conception to the menopause
    • Wallace WHB, Kelsey TW. Human ovarian reserve from conception to the menopause. PLoS ONE 2010;5:e8772.
    • (2010) PLoS ONE , vol.5
    • Wallace, W.H.B.1    Kelsey, T.W.2
  • 85
    • 40749100654 scopus 로고    scopus 로고
    • Primary ovarian insufficiency: a more accurate term for premature ovarian failure
    • Welt C. Primary ovarian insufficiency: a more accurate term for premature ovarian failure. Clin Endocrinol 2008;68:499-509.
    • (2008) Clin Endocrinol , vol.68 , pp. 499-509
    • Welt, C.1
  • 89
    • 77953290799 scopus 로고    scopus 로고
    • GnRH antagonist cetrorelix inhibits mitochondria-dependant apoptosis triggered by chemotherapy in granulosa cells of rats
    • Zhao XI, Huang YH, Yu YC, Xin XY. GnRH antagonist cetrorelix inhibits mitochondria-dependant apoptosis triggered by chemotherapy in granulosa cells of rats. Gynecol Oncol 2010;118:69-75.
    • (2010) Gynecol Oncol , vol.118 , pp. 69-75
    • Zhao, X.I.1    Huang, Y.H.2    Yu, Y.C.3    Xin, X.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.