Effective prevention of liver fibrosis by liver-targeted hydrodynamic gene delivery of matrix metalloproteinase-13 in a rat liver fibrosis model

Molecular Therapy Nucleic Acids

Volumn 5, Issue , 2016, Pages e276-

  Abe, Hiroyuki ^a   Kamimura, Kenya ^a   Kobayashi, Yuji ^a   Ohtsuka, Masato ^b   Miura, Hiromi ^b   Ohashi, Riuko ^c   Yokoo, Takeshi ^a   Kanefuji, Tsutomu ^a   Suda, Takeshi ^a   Tsuchida, Masanori ^a   Aoyagi, Yutaka ^a   Zhang, Guisheng ^d   Liu, Dexi ^d   Terai, Shuji ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^d UNIVERSITY OF GEORGIA   (United States)

Author keywords

gene therapy; hydrodynamic gene delivery; liver cirrhosis; MMP13; nucleic acids delivery

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGENASE 3; LACTATE DEHYDROGENASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; EMBRYO; FEMALE; GENE OVEREXPRESSION; GENE THERAPY; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDRODYNAMICS BASED TRANSFECTION; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER CELL; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; RAT;

EID: 84953725793     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2015.49     Document Type: Article

References (37)

1. Nusrat, S, Khan, MS, Fazili, J and Madhoun, MF (2014). Cirrhosis and its complications: evidence based treatment. World J Gastroenterol 20: 5442-5460
2. Iimuro Yuji, Brenner David A (2008). Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res 25: 249-258
3. Siller-López, F, Sandoval, A, Salgado, S, Salazar, A, Bueno, M, Garcia, J et al. (2004). Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology 126: 1122-33; discussion 949
4. Sato, Y, Murase, K, Kato, J, Kobune, M, Sato, T, Kawano, Y et al. (2008). Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 26: 431-442
5. Adrian, JE, Poelstra, K, Scherphof, GL, Meijer, DK, Van Loenen-Weemaes, AM, Reker-Smit, C et al. (2007). Effects of a new bioactive lipid-based drug carrier on cultured hepatic stellate cells and liver fibrosis in bile duct-ligated rats. J Pharmacol Exp Ther 321: 536-543
6. Sobrevals, L, Enguita, M, Rodriguez, C, Gonzalez-Rojas, J, Alzaguren, P, Razquin, N et al. (2012). AAV vectors transduce hepatocytes in vivo as efficiently in cirrhotic as in healthy rat livers. Gene Ther 19: 411-417
7. Abe H, Kamimura K, Yokoo T, Suda T, Kobayashi Y, Aoyagi Y (2014). Gene therapy for liver fibrosis. JSM Gastroenterol Hepatol 2: 1028
8. Terai, S, Tanimoto, H, Maeda, M, Zaitsu, J, Hisanaga, T, Iwamoto, T et al. (2012). Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy. J Gastroenterol 47: 491-497
9. Quinn, CO, Scott, DK, Brinckerhoff, CE, Matrisian, LM, Jeffrey, JJ and Partridge, NC (1990). Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J Biol Chem 265: 22342-22347
10. Endo, H, Niioka, M, Sugioka, Y, Itoh, J, Kameyama, K, Okazaki, I et al. (2011). Matrix metalloproteinase-13 promotes recovery from experimental liver cirrhosis in rats. Pathobiology 78: 239-252
11. Watanabe, T, Niioka, M, Hozawa, S, Kameyama, K, Hayashi, T, Arai, M et al. (2000). Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride. J Hepatol 33: 224-235
12. Yokoo, T, Kamimura, K, Suda, T, Kanefuji, T, Oda, M, Zhang, G et al. (2013). Novel electric power-driven hydrodynamic injection system for gene delivery: safety and efficacy of human factor IX delivery in rats. Gene Ther 20: 816-823
13. Bataller, R and Brenner, DA (2001). Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 21: 437-451
14. Granzow, M, Schierwagen, R, Klein, S, Kowallick, B, Huss, S, Linhart, M et al. (2014). Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology 60: 334-348
15. Zhang, Y, Zhang, QQ, Guo, XH, Zhang, HY and Liu, LX (2014). IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling. World J Gastroenterol 20: 6523-6533
16. Sakaida, I, Terai, S, Yamamoto, N, Aoyama, K, Ishikawa, T, Nishina, H et al. (2004). Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40: 1304-1311
17. Iimuro, Y, Nishio, T, Morimoto, T, Nitta, T, Stefanovic, B, Choi, SK et al. (2003). Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology 124: 445-458
18. Kim, EJ, Cho, HJ, Park, D, Kim, JY, Kim, YB, Park, TG et al. (2011). Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid. Mol Ther 19: 355-361
19. Ueki, T, Kaneda, Y, Tsutsui, H, Nakanishi, K, Sawa, Y, Morishita, R et al. (1999). Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 5: 226-230
20. Patel, K, Remlinger, KS, Walker, TG, Leitner, P, Lucas, JE, Gardner, SD et al. (2014). Multiplex protein analysis to determine fibrosis stage and progression in patients with chronic hepatitis C. Clin Gastroenterol Hepatol 12: 2113-20.e1
21. Yang, L, Kwon, J, Popov, Y, Gajdos, GB, Ordog, T, Brekken, RA et al. (2014). Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology 146: 1339-50.e1
22. Liu, F, Song, Y and Liu, D (1999). Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 6: 1258-1266
23. Zhang, G, Budker, V and Wolff, JA (1999). High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 10: 1735-1737
24. Zhang, G, Song, YK and Liu, D (2000). Long-term expression of human alpha1-antitrypsin gene in mouse liver achieved by intravenous administration of plasmid DNA using a hydrodynamics-based procedure. Gene Ther 7: 1344-1349
25. Kamimura, K and Liu, D (2008). Physical approaches for nucleic acid delivery to liver. AAPS J 10: 589-595
26. Kamimura, K, Suda, T, Zhang, G and Liu, D (2011). Advances in gene delivery systems. Pharmaceut Med 25: 293-306
27. Kamimura, K, Suda, T, Xu, W, Zhang, G and Liu, D (2009). Image-guided, lobe-specific hydrodynamic gene delivery to swine liver. Mol Ther 17: 491-499
28. Kamimura, K, Suda, T, Zhang, G, Aoyagi, Y and Liu, D (2013). Parameters affecting image-guided, hydrodynamic gene delivery to swine liver. Mol Ther Nucleic Acids 2: e128
29. Kamimura, K, Kanefuji, T, Yokoo, T, Abe, H, Suda, T, Kobayashi, Y et al. (2014). Safety assessment of liver-targeted hydrodynamic gene delivery in dogs. PLoS One 9: e107203
30. Kamimura K, Abe H, Suda T, Aoyagi Y, Liu D (2013). Liver-directed gene therapy. JSM Gastroenterol Hepatol 1: 1005
31. Kamimura, K, Zhang, G and Liu, D (2010). Image-guided, intravascular hydrodynamic gene delivery to skeletal muscle in pigs. Mol Ther 18: 93-100
32. Chen, SW, Zhang, XR, Wang, CZ, Chen, WZ, Xie, WF and Chen, YX (2008). RNA interference targeting the platelet-derived growth factor receptor beta subunit ameliorates experimental hepatic fibrosis in rats. Liver Int 28: 1446-1457
33. Du, SL, Pan, H, Lu, WY, Wang, J, Wu, J and Wang, JY (2007). Cyclic Arg-Gly-Asp peptide-labeled liposomes for targeting drug therapy of hepatic fibrosis in rats. J Pharmacol Exp Ther 322: 560-568
34. Tag CG, Sauer-Lehnen S, Weiskirchen S, Borkham-Kamphorst E, Tolba RH, Tacke F, et al. (2015). Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J Vis Exp 96: 52438
35. Higashiyama, R, Inagaki, Y, Hong, YY, Kushida, M, Nakao, S, Niioka, M et al. (2007). Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45: 213-222
36. Wolff, LJ, Wolff, JA and Sebestyén, MG (2009). Effect of tissue-specific promoters and microRNA recognition elements on stability of transgene expression after hydrodynamic naked plasmid DNA delivery. Hum Gene Ther 20: 374-388
37. Vrekoussis, T, Chaniotis, V, Navrozoglou, I, Dousias, V, Pavlakis, K, Stathopoulos, EN et al. (2009). Image analysis of breast cancer immunohistochemistry-stained sections using ImageJ: an RGB-based model. Anticancer Res 29: 4995-4998