RNA interference targeting the platelet-derived growth factor receptor β subunit ameliorates experimental hepatic fibrosis in rats

Liver International

Volumn 28, Issue 10, 2008, Pages 1446-1457

  Chen, Si Wen ^a   Zhang, Xing Rong ^a   Wang, Chong Ze ^b   Chen, Wei Zhong ^a   Xie, Wei Fen ^a   Chen, Yue Xiang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cell proliferation; Gene therapy; Hepatic fibrosis; Hepatic stellate cells; Platelet derived growth factor receptor subunit (PDGFR ); RNA interference

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG EFFICACY; EXPRESSION VECTOR; FIBROGENESIS; GENE LOCATION; GENE SILENCING; GENE THERAPY; HYDRODYNAMICS; IMMUNOFLUORESCENCE; LIVER; LIVER FIBROSIS; LIVER FUNCTION; MALE; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STELLATE CELL; TISSUE DISTRIBUTION; TRANSGENE;

ANIMALS; BLOTTING, WESTERN; BROMODEOXYURIDINE; CELL LINE; CELL PROLIFERATION; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENE THERAPY; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 54049117220     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01759.x     Document Type: Article

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