Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice

Hepatology

Volumn 45, Issue 1, 2007, Pages 213-222

  Higashiyama, Reiichi ^a   Inagaki, Yutaka ^a   Hong, Yun Yu ^a   Kushida, Miwa ^a   Nakao, Sachie ^a   Niioka, Maki ^a   Watanabe, Tetsu ^a   Okano, Hideyuki ^b   Matsuzaki, Yumi ^b   Shiota, Goshi ^c   Okazaki, Isao ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; COLLAGENASE 3; ENHANCED GREEN FLUORESCENT PROTEIN; GELATINASE B; GRANULOCYTE COLONY STIMULATING FACTOR; SCATTER FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL THERAPY; CONTROLLED STUDY; DRUG POTENTIATION; LIVER FIBROSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMISSION;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CARBON TETRACHLORIDE; CELL DIFFERENTIATION; CELL MOVEMENT; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; GREEN FLUORESCENT PROTEINS; HEPATOCYTE GROWTH FACTOR; LIVER; LIVER CIRRHOSIS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REMISSION, SPONTANEOUS; TISSUE THERAPY;

EID: 33846453528     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21477     Document Type: Article

References (31)

1. Rojkind M, Dunn MA. Hepatic fibrosis. Gastroenterology 1979;76:849-863.
2. Dufour JF, DeLellis R, Kaplan MM. Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann Intern Med 1997;127:981-985.
3. Hammel P, Couvelard A, O'Toole D, Ratouis A, Sauvanet A, Flejou JF, et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med 2001; 344:418-423.
4. Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, et al. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med 2000; 132: 517-524.
5. Poynard T, McHutchison J, Manns M, Trepo C, Lindsay K, Goodman Z, et al. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002; 122:1303-1313.
6. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102:538-549.
7. Okazaki I, Maruyama K. Collagenase activity in experimental hepatic fibrosis. Nature 1974;252:49-50.
8. Okazaki I, Watanabe T, Hozawa S, Niioka M, Arai M, Maruyama K. Hepatic fibrolysis and hepatic sinusoidal cells. In: Tanikawa K, Ueno T, eds. Liver Diseases and Hepatic Sinusoidal Cells. Tokyo: Springer-Verlag, 1999:242-251.
9. Okazaki I, Yonezawa T, Watanabe T, Mayne R, Ninomiya Y. New insights into the extracellular matrix. In: Okazaki I, Ninomiya Y, Friedman SL, Tanikawa K, eds. Extracellular Matrix and The Liver-Approach to Gene Therapy. New York: Academic Press, 2003:3-22.
10. Watanabe T, Niioka M, Hozawa S, Kameyama K, Hayashi T, Arai M, et al. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride. J Hepatol 2000;33:224-235.
11. Watanabe T, Niioka M, Hozawa S, Sugioka Y, Arai M, Maruyama K, et al. Stem cells expressing MMP-13 mRNA appear during regression reversal of hepatic cirrhosis. In: Okazaki I, Ninomiya Y, Friedman SL, Tanikawa K, eds. Extracellular Matrix and The Liver-Approach to Gene Therapy. New York: Academic Press, 2003:361-388.
12. Shiota G, Wang TC, Nakamura T, Schmidt EV. Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression. HEPATOLOGY 1994;19:962-972.
13. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 1997;407:313-319.
14. Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, et al. Cell type-specific intervention of transforming growth factor β/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology 2005;129:259-268.
15. Lopez-De Leon A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 1985;33:737-743.
16. Matsumura S, Iwanaga S, Mochizuki S, Okamoto H, Ogawa S, Okada Y. Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. J Clin Invest 2005;115: 599-609.
17. Usuku T, Nishi M, Morimoto M, Brewer JA, Muglia LJ, Sugimoto T, et al. Visualization of glucocorticoid receptor in the brain of green fluorescent protein-glucocorticoid receptor knockin mice. Neuroscience 2005;135: 1119-1128.
18. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK, et al. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology 2003;124:445-458.
19. Siller-Lopez F, Sandoval A, Salgado S, Salazar A, Bueno M, Garcia J, et al. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology 2004;126:1122-1133.
20. McTaggart RA, Feng S. An uncomfortable silence while we all search for a better reporter gene in adult stem cell biology. HEPATOLOGY 2004;39: 1143-1146.
21. Shackel N, Rockey D. In pursuit of the "Holy Grail"-stem cells, hepatic injury, fibrogenesis and repair. HEPATOLOGY 2005;41:16-18.
22. Gao Z, McAlister VC, Williams GM. Repopulation of liver endothelium by bone-marrow-derived cells. Lancet 2001;357:932-933.
23. Fujii H, Hirose T, Oe S, Yasuchika K, Azuma H, Fujikawa T, et al. Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice. J Hepatol 2002;36:653-659.
24. Takezawa R, Watanabe Y, Akaike T. Direct evidence of macrophage differentiation from bone marrow cells in the liver: a possible origin of Kupffer cells. J Biochem 1995;118:1175-1183.
25. Baba S, Fujii H, Hirose T, Yasuchika K, Azuma H, Hoppo T, et al. Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol 2004;40:255-260.
26. Forbes SJ, Russo FP, Rey V, Burra P, Rugge M, Wright NA, et al. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004;126:955-963.
27. Russo FP, Alison MR, Bigger BW, Amorah E, Florou A, Amin F, et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006;130:1807-1821.
28. + stem cell recruitment to the liver. J Clin Invest 2003;112:160-169.
29. Watanabe Y, Haruyama T, Akaike T. Liver-derived matrix metalloproteinase-9 (gelatinase B) recruits progenitor cells from bone marrow into the blood circulation. Biol Pharm Bull 2003;26:564-568.
30. Yannaki E, Athanasiou E, Xagorari A, Constantinou V, Batsis I, Kaloyannidis P, et al. G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs. Exp Hematol 2005;33:108-119.
31. Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, et al. Transplantation of bone marrow cells reduces CCM-induced liver fibrosis in mice. HEPATOLOGY 2004;40:1304-1311.