Safety assessment of liver-targeted hydrodynamic gene delivery in dogs

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Kamimura, Kenya ^a   Kanefuji, Tsutomu ^a   Yokoo, Takeshi ^a   Abe, Hiroyuki ^a   Suda, Takeshi ^a   Kobayashi, Yuji ^a   Zhang, Guisheng ^b   Aoyagi, Yutaka ^a   Liu, Dexi ^b  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; BLOOD CLOTTING FACTOR 9; CYTOKINE; LIVER ENZYME; PLASMID DNA; INTERLEUKIN 10; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BALLOON CATHETER; BLOOD PRESSURE; BODY TEMPERATURE; BODY WEIGHT; COMPUTER ASSISTED DRUG THERAPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOG; ELECTROCARDIOGRAM; FEMALE; GENE TARGETING; GENE THERAPY; GUIDE WIRE; HEART RATE; HYDRODYNAMICS; LIVER; LIVER CIRCULATION; LIVER SINUSOID; MEDICAL DEVICE; MICROCIRCULATION; NONHUMAN; OXYGEN SATURATION; PRESSURE TRANSDUCER; PROMOTER REGION; RAT; RISK ASSESSMENT; SPECTROPHOTOMETRY; ADVERSE EFFECTS; ANIMAL; BLOOD; ELECTROCARDIOGRAPHY; GENE TRANSFER; INJECTION; METABOLISM; PHYSIOLOGIC MONITORING; PROCEDURES; REPRODUCIBILITY; VASCULARIZATION;

CANIS FAMILIARIS;

ANIMALS; CHEMOKINE CCL2; DOGS; ELECTROCARDIOGRAPHY; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HYDRODYNAMICS; INJECTIONS; INTERLEUKIN-10; INTERLEUKIN-6; LIVER; LIVER CIRCULATION; MONITORING, PHYSIOLOGIC; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907450567     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107203     Document Type: Article

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