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Volumn 15, Issue 1, 2015, Pages

Shifts in subsets of CD8+ T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: An observational case-control study

Author keywords

Cellular senescence; Chemotherapy; Immune risk profile; Immunosenescence; Lung cancer

Indexed keywords

CD28 ANTIGEN; CD57 ANTIGEN; CISPLATIN; DOCETAXEL; ETOPOSIDE; GEMCITABINE; NAVELBINE; PEMETREXED; ANTINEOPLASTIC AGENT;

EID: 84953717390     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-2013-3     Document Type: Article
Times cited : (30)

References (60)
  • 1
    • 0037561928 scopus 로고    scopus 로고
    • Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    • Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003;101(7):2711-20.
    • (2003) Blood , vol.101 , Issue.7 , pp. 2711-2720
    • Brenchley, J.M.1    Karandikar, N.J.2    Betts, M.R.3    Ambrozak, D.R.4    Hill, B.J.5    Crotty, L.E.6
  • 4
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    • Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol. 2002;37(2-3):445-53.
    • (2002) Exp Gerontol , vol.37 , Issue.2-3 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.6
  • 7
    • 77955236931 scopus 로고    scopus 로고
    • Rheumatoid arthritis: a role for immunosenescence?
    • Lindstrom TM, Robinson WH. Rheumatoid arthritis: a role for immunosenescence? J Am Geriatr Soc. 2010;58(8):1565-75.
    • (2010) J Am Geriatr Soc , vol.58 , Issue.8 , pp. 1565-1575
    • Lindstrom, T.M.1    Robinson, W.H.2
  • 8
    • 34547828312 scopus 로고    scopus 로고
    • Interleukin-15 selectively expands CD57+ CD28-CD4+ T cells, which are increased in active rheumatoid arthritis
    • Yamada H, Kaibara N, Okano S, Maeda T, Shuto T, Nakashima Y, et al. Interleukin-15 selectively expands CD57+ CD28-CD4+ T cells, which are increased in active rheumatoid arthritis. Clin Immunol. 2007;124(3):328-35.
    • (2007) Clin Immunol , vol.124 , Issue.3 , pp. 328-335
    • Yamada, H.1    Kaibara, N.2    Okano, S.3    Maeda, T.4    Shuto, T.5    Nakashima, Y.6
  • 13
    • 19344370239 scopus 로고    scopus 로고
    • Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    • Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004;2(2):E20.
    • (2004) PLoS Biol , vol.2 , Issue.2 , pp. E20
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3    Salio, M.4    Rufer, N.5    Little, S.6
  • 16
    • 84895073832 scopus 로고    scopus 로고
    • Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions
    • Krone CL, van de Groep K, Trzcinski K, Sanders EA, Bogaert D. Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions. Lancet Respir Med. 2014;2(2):141-53.
    • (2014) Lancet Respir Med , vol.2 , Issue.2 , pp. 141-153
    • Krone, C.L.1    Groep, K.2    Trzcinski, K.3    Sanders, E.A.4    Bogaert, D.5
  • 17
    • 0032524932 scopus 로고    scopus 로고
    • Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
    • Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev. 1998;102(2-3):187-98.
    • (1998) Mech Ageing Dev , vol.102 , Issue.2-3 , pp. 187-198
    • Wikby, A.1    Maxson, P.2    Olsson, J.3    Johansson, B.4    Ferguson, F.G.5
  • 20
    • 71849084149 scopus 로고    scopus 로고
    • Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection
    • Chen IH, Lai YL, Wu CL, Chang YF, Chu CC, Tsai IF, et al. Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection. Cancer Immunol Immunother. 2010;59(2):323-34.
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.2 , pp. 323-334
    • Chen, I.H.1    Lai, Y.L.2    Wu, C.L.3    Chang, Y.F.4    Chu, C.C.5    Tsai, I.F.6
  • 21
    • 84886032038 scopus 로고    scopus 로고
    • Immune senescence and cancer in elderly patients: results from an exploratory study
    • Falci C, Gianesin K, Sergi G, Giunco S, De Ronch I, Valpione S, et al. Immune senescence and cancer in elderly patients: results from an exploratory study. Exp Gerontol. 2013;48(12):1436-42.
    • (2013) Exp Gerontol , vol.48 , Issue.12 , pp. 1436-1442
    • Falci, C.1    Gianesin, K.2    Sergi, G.3    Giunco, S.4    Ronch, I.5    Valpione, S.6
  • 22
    • 54849422416 scopus 로고    scopus 로고
    • Systemic immune effects of adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide and/or radiotherapy in breast cancer: a longitudinal study
    • Mozaffari F, Lindemalm C, Choudhury A, Granstam-Bjorneklett H, Lekander M, Nilsson B, et al. Systemic immune effects of adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide and/or radiotherapy in breast cancer: a longitudinal study. Cancer Immunol Immunother. 2009;58(1):111-20.
    • (2009) Cancer Immunol Immunother , vol.58 , Issue.1 , pp. 111-120
    • Mozaffari, F.1    Lindemalm, C.2    Choudhury, A.3    Granstam-Bjorneklett, H.4    Lekander, M.5    Nilsson, B.6
  • 23
    • 84864421972 scopus 로고    scopus 로고
    • Tumor-induced changes in the phenotype of blood-derived and tumor-associated T cells of early stage breast cancer patients
    • Poschke I, De Boniface J, Mao Y, Kiessling R. Tumor-induced changes in the phenotype of blood-derived and tumor-associated T cells of early stage breast cancer patients. Int J Cancer. 2012;131(7):1611-20.
    • (2012) Int J Cancer , vol.131 , Issue.7 , pp. 1611-1620
    • Poschke, I.1    Boniface, J.2    Mao, Y.3    Kiessling, R.4
  • 25
    • 52949152429 scopus 로고    scopus 로고
    • Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation
    • Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol. 2008;76(8):947-57.
    • (2008) Biochem Pharmacol , vol.76 , Issue.8 , pp. 947-957
    • Gewirtz, D.A.1    Holt, S.E.2    Elmore, L.W.3
  • 26
    • 0036709888 scopus 로고    scopus 로고
    • Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence
    • Dierick JF, Eliaers F, Remacle J, Raes M, Fey SJ, Larsen PM, et al. Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence. Biochem Pharmacol. 2002;64(5-6):1011-7.
    • (2002) Biochem Pharmacol , vol.64 , Issue.5-6 , pp. 1011-1017
    • Dierick, J.F.1    Eliaers, F.2    Remacle, J.3    Raes, M.4    Fey, S.J.5    Larsen, P.M.6
  • 27
    • 0036710468 scopus 로고    scopus 로고
    • Stress-induced premature senescence and tissue ageing
    • Toussaint O, Royer V, Salmon M, Remacle J. Stress-induced premature senescence and tissue ageing. Biochem Pharmacol. 2002;64(5-6):1007-9.
    • (2002) Biochem Pharmacol , vol.64 , Issue.5-6 , pp. 1007-1009
    • Toussaint, O.1    Royer, V.2    Salmon, M.3    Remacle, J.4
  • 28
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res. 2003;63(11):2705-15.
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2705-2715
    • Roninson, I.B.1
  • 30
    • 79851489810 scopus 로고    scopus 로고
    • Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management
    • Shakir DK, Rasul KI. Chemotherapy induced cardiomyopathy: pathogenesis, monitoring and management. J Clin Med Res. 2009;1(1):8-12.
    • (2009) J Clin Med Res , vol.1 , Issue.1 , pp. 8-12
    • Shakir, D.K.1    Rasul, K.I.2
  • 31
    • 0031472503 scopus 로고    scopus 로고
    • Loss of CD28 expression on T lymphocytes: a marker of replicative senescence
    • Effros RB. Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev Comp Immunol. 1997;21(6):471-8.
    • (1997) Dev Comp Immunol , vol.21 , Issue.6 , pp. 471-478
    • Effros, R.B.1
  • 32
    • 84943449487 scopus 로고    scopus 로고
    • Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes
    • Onyema OO, Njemini R, Forti LN, Bautmans I, Aerts JL, De Waele M, et al. Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes. Arch Gerontol Geriatr. 2015;61:494-502.
    • (2015) Arch Gerontol Geriatr , vol.61 , pp. 494-502
    • Onyema, O.O.1    Njemini, R.2    Forti, L.N.3    Bautmans, I.4    Aerts, J.L.5    Waele, M.6
  • 34
    • 0038375013 scopus 로고    scopus 로고
    • Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
    • Geginat J, Lanzavecchia A, Sallusto F. Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood. 2003;101(11):4260-6.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4260-4266
    • Geginat, J.1    Lanzavecchia, A.2    Sallusto, F.3
  • 36
    • 84924957319 scopus 로고    scopus 로고
    • Chemotherapy-induced changes and immunosenescence of CD8+ T-cells in patients with breast cancer
    • Onyema OO, Decoster L, Njemini R, Forti LN, Bautmans I, De Waele M, et al. Chemotherapy-induced changes and immunosenescence of CD8+ T-cells in patients with breast cancer. Anticancer Res. 2015;35(3):1481-9.
    • (2015) Anticancer Res , vol.35 , Issue.3 , pp. 1481-1489
    • Onyema, O.O.1    Decoster, L.2    Njemini, R.3    Forti, L.N.4    Bautmans, I.5    Waele, M.6
  • 41
    • 84866920006 scopus 로고    scopus 로고
    • Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies
    • McCoy MJ, Lake RA, van der Most RG, Dick IM, Nowak AK. Post-chemotherapy T-cell recovery is a marker of improved survival in patients with advanced thoracic malignancies. Br J Cancer. 2012;107(7):1107-15.
    • (2012) Br J Cancer , vol.107 , Issue.7 , pp. 1107-1115
    • McCoy, M.J.1    Lake, R.A.2    Most, R.G.3    Dick, I.M.4    Nowak, A.K.5
  • 42
    • 84877154621 scopus 로고    scopus 로고
    • Peripheral CD8(+) T cell proliferation is prognostic for patients with advanced thoracic malignancies
    • McCoy MJ, Nowak AK, van der Most RG, Dick IM, Lake RA. Peripheral CD8(+) T cell proliferation is prognostic for patients with advanced thoracic malignancies. Cancer Immunol Immunother. 2013;62(3):529-39.
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.3 , pp. 529-539
    • McCoy, M.J.1    Nowak, A.K.2    Most, R.G.3    Dick, I.M.4    Lake, R.A.5
  • 43
    • 41349120954 scopus 로고    scopus 로고
    • Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise
    • Simpson RJ, Cosgrove C, Ingram LA, Florida-James GD, Whyte GP, Pircher H, et al. Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain Behav Immun. 2008;22(4):544-51.
    • (2008) Brain Behav Immun , vol.22 , Issue.4 , pp. 544-551
    • Simpson, R.J.1    Cosgrove, C.2    Ingram, L.A.3    Florida-James, G.D.4    Whyte, G.P.5    Pircher, H.6
  • 44
    • 34447630844 scopus 로고    scopus 로고
    • High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects
    • Simpson RJ, Florida-James GD, Cosgrove C, Whyte GP, Macrae S, Pircher H, et al. High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. J Appl Physiol. 2007;103(1):396-401.
    • (2007) J Appl Physiol , vol.103 , Issue.1 , pp. 396-401
    • Simpson, R.J.1    Florida-James, G.D.2    Cosgrove, C.3    Whyte, G.P.4    Macrae, S.5    Pircher, H.6
  • 45
    • 84859618903 scopus 로고    scopus 로고
    • Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration
    • Mendez-Lagares G, Garcia-Perganeda A, del Mar del Pozo-Balado M, Genebat M, Ruiz-Mateos E, Garcia Garcia M, et al. Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 T cell restoration. J Antimicrob Chemother. 2012;67(5):1228-37.
    • (2012) J Antimicrob Chemother , vol.67 , Issue.5 , pp. 1228-1237
    • Mendez-Lagares, G.1    Garcia-Perganeda, A.2    Pozo-Balado, M.3    Genebat, M.4    Ruiz-Mateos, E.5    Garcia Garcia, M.6
  • 46
    • 84895736383 scopus 로고    scopus 로고
    • CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals
    • Pera A, Campos C, Corona A, Sanchez-Correa B, Tarazona R, Larbi A, et al. CMV latent infection improves CD8+ T response to SEB due to expansion of polyfunctional CD57+ cells in young individuals. PloS one. 2014;9(2):e88538.
    • (2014) PloS one , vol.9 , Issue.2 , pp. e88538
    • Pera, A.1    Campos, C.2    Corona, A.3    Sanchez-Correa, B.4    Tarazona, R.5    Larbi, A.6
  • 47
    • 10744223612 scopus 로고    scopus 로고
    • Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
    • Zanni F, Vescovini R, Biasini C, Fagnoni F, Zanlari L, Telera A, et al. Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol. 2003;38(9):981-7.
    • (2003) Exp Gerontol , vol.38 , Issue.9 , pp. 981-987
    • Zanni, F.1    Vescovini, R.2    Biasini, C.3    Fagnoni, F.4    Zanlari, L.5    Telera, A.6
  • 48
    • 33745083070 scopus 로고    scopus 로고
    • CD8+ T-cell memory in tumor immunology and immunotherapy
    • Klebanoff CA, Gattinoni L, Restifo NP. CD8+ T-cell memory in tumor immunology and immunotherapy. Immunol Rev. 2006;211:214-24.
    • (2006) Immunol Rev , vol.211 , pp. 214-224
    • Klebanoff, C.A.1    Gattinoni, L.2    Restifo, N.P.3
  • 49
    • 38649094605 scopus 로고    scopus 로고
    • Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise
    • Campbell JP, Guy K, Cosgrove C, Florida-James GD, Simpson RJ. Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain Behav Immun. 2008;22(3):375-80.
    • (2008) Brain Behav Immun , vol.22 , Issue.3 , pp. 375-380
    • Campbell, J.P.1    Guy, K.2    Cosgrove, C.3    Florida-James, G.D.4    Simpson, R.J.5
  • 50
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study
    • Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2000;121(1-3):187-201.
    • (2000) Mech Ageing Dev , vol.121 , Issue.1-3 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.G.6
  • 52
    • 84897859958 scopus 로고    scopus 로고
    • Relationship between radiation-induced apoptosis of T lymphocytes and chronic toxicity in patients with prostate cancer treated by radiation therapy: a prospective study
    • Foro P, Algara M, Lozano J, Rodriguez N, Sanz X, Torres E, et al. Relationship between radiation-induced apoptosis of T lymphocytes and chronic toxicity in patients with prostate cancer treated by radiation therapy: a prospective study. Int J Radiat Oncol Biol Phys. 2014;88(5):1057-63.
    • (2014) Int J Radiat Oncol Biol Phys , vol.88 , Issue.5 , pp. 1057-1063
    • Foro, P.1    Algara, M.2    Lozano, J.3    Rodriguez, N.4    Sanz, X.5    Torres, E.6
  • 53
    • 9644310524 scopus 로고    scopus 로고
    • Differential regulation of apoptotic cell death in senescent human cells
    • Hampel B, Malisan F, Niederegger H, Testi R, Jansen-Durr P. Differential regulation of apoptotic cell death in senescent human cells. Exp Gerontol. 2004;39(11-12):1713-21.
    • (2004) Exp Gerontol , vol.39 , Issue.11-12 , pp. 1713-1721
    • Hampel, B.1    Malisan, F.2    Niederegger, H.3    Testi, R.4    Jansen-Durr, P.5
  • 54
    • 0034598365 scopus 로고    scopus 로고
    • Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy
    • Newton K, Strasser A. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy. J Exp Med. 2000;191(1):195-200.
    • (2000) J Exp Med , vol.191 , Issue.1 , pp. 195-200
    • Newton, K.1    Strasser, A.2
  • 55
    • 0035892135 scopus 로고    scopus 로고
    • Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy
    • Stahnke K, Fulda S, Friesen C, Strauss G, Debatin KM. Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy. Blood. 2001;98(10):3066-73.
    • (2001) Blood , vol.98 , Issue.10 , pp. 3066-3073
    • Stahnke, K.1    Fulda, S.2    Friesen, C.3    Strauss, G.4    Debatin, K.M.5
  • 56
    • 70349170354 scopus 로고    scopus 로고
    • Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth
    • van der Most RG, Currie AJ, Cleaver AL, Salmons J, Nowak AK, Mahendran S, et al. Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth. PloS one. 2009;4(9):e6982.
    • (2009) PloS one , vol.4 , Issue.9 , pp. e6982
    • Most, R.G.1    Currie, A.J.2    Cleaver, A.L.3    Salmons, J.4    Nowak, A.K.5    Mahendran, S.6
  • 57
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
    • Wang E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res. 1995;55(11):2284-92.
    • (1995) Cancer Res , vol.55 , Issue.11 , pp. 2284-2292
    • Wang, E.1
  • 58
    • 0036237604 scopus 로고    scopus 로고
    • T-cell dynamics after high-dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T-cell compartments with distinct implications for immune competence
    • Fagnoni FF, Lozza L, Zibera C, Zambelli A, Ponchio L, Gibelli N, et al. T-cell dynamics after high-dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T-cell compartments with distinct implications for immune competence. Immunology. 2002;106(1):27-37.
    • (2002) Immunology , vol.106 , Issue.1 , pp. 27-37
    • Fagnoni, F.F.1    Lozza, L.2    Zibera, C.3    Zambelli, A.4    Ponchio, L.5    Gibelli, N.6
  • 59
    • 14744281718 scopus 로고    scopus 로고
    • Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Wurzner R, et al. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol. 2005;79(6):3675-83.
    • (2005) J Virol , vol.79 , Issue.6 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3    Keller, M.4    Herndler-Brandstetter, D.5    Wurzner, R.6
  • 60
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013;14(5):428-36.
    • (2013) Nat Immunol , vol.14 , Issue.5 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2


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