메뉴 건너뛰기




Volumn 67, Issue 5, 2012, Pages 1228-1237

Differential alterations of the CD4 and CD8 T cell subsets in HIV-infected patients on highly active antiretroviral therapy with low CD4 t cell restoration

Author keywords

CD34; HsCRP; Immune reconstitution; Immunosenescence; Naive CD4 T cells; SCD14

Indexed keywords

C REACTIVE PROTEIN; CD14 ANTIGEN; CD34 ANTIGEN; INTERLEUKIN 7 RECEPTOR;

EID: 84859618903     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr594     Document Type: Article
Times cited : (32)

References (39)
  • 1
    • 7144229335 scopus 로고    scopus 로고
    • Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease
    • Piketty C, Castiel P, Belec L et al. Discrepant responses to triple combination antiretroviral therapy in advanced HIV disease. AIDS 1998; 12: 745-50.
    • (1998) AIDS , vol.12 , pp. 745-750
    • Piketty, C.1    Castiel, P.2    Belec, L.3
  • 2
    • 69049092011 scopus 로고    scopus 로고
    • Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation
    • Molina-Pinelo S, Vallejo A, Díaz L et al. Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation. J Antimicrob Chemother 2009; 64: 579-88.
    • (2009) J Antimicrob Chemother , vol.64 , pp. 579-588
    • Molina-Pinelo, S.1    Vallejo, A.2    Díaz, L.3
  • 3
    • 73949156929 scopus 로고    scopus 로고
    • Risk factors, CD4 long-term evolution and mortality of HIV-infected patients who persistently maintain low CD4 counts, despite virological response to HAART
    • Pacheco YM, Jarrín I, Del Amo J et al. Risk factors, CD4 long-term evolution and mortality of HIV-infected patients who persistently maintain low CD4 counts, despite virological response to HAART. Curr HIV Res 2009; 7: 612-9.
    • (2009) Curr HIV Res , vol.7 , pp. 612-619
    • Pacheco, Y.M.1    Jarrín, I.2    Del Amo, J.3
  • 4
    • 77958572990 scopus 로고    scopus 로고
    • Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study
    • Engsig FN, Gerstoft J, Kronborg G et al. Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study. BMC Infect Dis 2010; 10: 318.
    • (2010) BMC Infect Dis , vol.10 , pp. 318
    • Engsig, F.N.1    Gerstoft, J.2    Kronborg, G.3
  • 5
    • 78649375201 scopus 로고    scopus 로고
    • A CD4+ cell count < 200 cells per cubic millimeter at 2 years after initiation of combination antiretroviral therapy is associated with increased mortality in HIV-infected individuals with viral suppression
    • Loutfy MR, Genebat M, Moore D et al. A CD4+ cell count <200 cells per cubic millimeter at 2 years after initiation of combination antiretroviral therapy is associated with increased mortality in HIV-infected individuals with viral suppression. J Acquir Immune Defic Syndr 2010; 55: 451-9.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , pp. 451-459
    • Loutfy, M.R.1    Genebat, M.2    Moore, D.3
  • 6
    • 70350441282 scopus 로고    scopus 로고
    • Interleukin-2 therapy in patients with HIV infection
    • Abrams D, Lévy Y, Losso MH et al. Interleukin-2 therapy in patients with HIV infection. N Engl J Med 2009; 361: 1548-59.
    • (2009) N Engl J Med , vol.361 , pp. 1548-1559
    • Abrams, D.1    Lévy, Y.2    Losso, M.H.3
  • 7
    • 58749087048 scopus 로고    scopus 로고
    • The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options
    • Gazzola L, Tincati C, Bellistrì GM et al. The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options. Clin Infect Dis 2009; 48: 328-37.
    • (2009) Clin Infect Dis , vol.48 , pp. 328-337
    • Gazzola, L.1    Tincati, C.2    Bellistrì, G.M.3
  • 8
    • 0035816396 scopus 로고    scopus 로고
    • Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis
    • Pitrak DL, Bolaños J, Hershow R et al. Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis. AIDS 2001; 15: 1317-9.
    • (2001) AIDS , vol.15 , pp. 1317-1319
    • Pitrak, D.L.1    Bolaños, J.2    Hershow, R.3
  • 9
    • 0037076716 scopus 로고    scopus 로고
    • Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss
    • Hazenberg MD, Otto SA, Wit FW et al. Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell loss. AIDS 2002; 16: 1287-9.
    • (2002) AIDS , vol.16 , pp. 1287-1289
    • Hazenberg, M.D.1    Otto, S.A.2    Wit, F.W.3
  • 10
    • 33746085971 scopus 로고    scopus 로고
    • Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function
    • Fernandez S, Price P, McKinnon EJ et al. Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function. Clin Immunol 2006; 120: 163-70.
    • (2006) Clin Immunol , vol.120 , pp. 163-170
    • Fernandez, S.1    Price, P.2    McKinnon, E.J.3
  • 11
    • 70449411747 scopus 로고    scopus 로고
    • HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy
    • Mavigner M, Delobel P, Cazabat M et al. HIV-1 residual viremia correlates with persistent T-cell activation in poor immunological responders to combination antiretroviral therapy. PLoS ONE 2009; 4: e7658.
    • (2009) PLoS ONE , vol.4
    • Mavigner, M.1    Delobel, P.2    Cazabat, M.3
  • 12
    • 33749491636 scopus 로고    scopus 로고
    • Naïve T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy
    • Delobel P, Nugeyre MT, Cazabat M et al. Naïve T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy. J Virol 2006; 80: 10229-36.
    • (2006) J Virol , vol.80 , pp. 10229-10236
    • Delobel, P.1    Nugeyre, M.T.2    Cazabat, M.3
  • 13
    • 33748052966 scopus 로고    scopus 로고
    • Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART
    • Marchetti G, Gori A, Casabianca A et al. Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART. AIDS 2006; 20: 1727-36.
    • (2006) AIDS , vol.20 , pp. 1727-1736
    • Marchetti, G.1    Gori, A.2    Casabianca, A.3
  • 14
    • 33750267084 scopus 로고    scopus 로고
    • T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART
    • Marziali M, De Santis W, Carello R et al. T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART. AIDS 2006; 20: 2033-41.
    • (2006) AIDS , vol.20 , pp. 2033-2041
    • Marziali, M.1    De Santis, W.2    Carello, R.3
  • 15
    • 53549129725 scopus 로고    scopus 로고
    • Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
    • Marchetti G, Bellistrì GM, Borghi E et al. Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. AIDS 2008; 22: 2035-8.
    • (2008) AIDS , vol.22 , pp. 2035-2038
    • Marchetti, G.1    Bellistrì, G.M.2    Borghi, E.3
  • 16
    • 77950947891 scopus 로고    scopus 로고
    • CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART
    • Massanella M, Negredo E, Pérez-Álvarez N et al. CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART. AIDS 2010; 24: 959-68.
    • (2010) AIDS , vol.24 , pp. 959-968
    • Massanella, M.1    Negredo, E.2    Pérez-Álvarez, N.3
  • 17
    • 79952335046 scopus 로고    scopus 로고
    • Plasma levels of soluble CD14 independently predict mortality in HIV infection
    • Sandler NG, Wand H, Roque A et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011; 203: 780-90.
    • (2011) J Infect Dis , vol.203 , pp. 780-790
    • Sandler, N.G.1    Wand, H.2    Roque, A.3
  • 18
    • 0032530736 scopus 로고    scopus 로고
    • Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events
    • Lien E, Aukrust P, Sundan A et al. Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood 1998; 92: 2084-92.
    • (1998) Blood , vol.92 , pp. 2084-2092
    • Lien, E.1    Aukrust, P.2    Sundan, A.3
  • 19
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TWet al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12: 1365-71.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 20
    • 79959563324 scopus 로고    scopus 로고
    • Age-related deregulation of naive T cell homeostasis in elderly humans
    • Ferrando-Martínez S, Ruiz-Mateos E, Hernández A et al. Age-related deregulation of naive T cell homeostasis in elderly humans. Age 2011; 33: 197-207.
    • (2011) Age , vol.33 , pp. 197-207
    • Ferrando-Martínez, S.1    Ruiz-Mateos, E.2    Hernández, A.3
  • 21
    • 77149147486 scopus 로고    scopus 로고
    • Pediatric HIV BioBank: a new role of the Spanish HIV BioBank in pediatric HIV research
    • García-Merino I, de Las Cuevas N, Jiménez JL et al. Pediatric HIV BioBank: a new role of the Spanish HIV BioBank in pediatric HIV research. AIDS Res Hum Retroviruses 2010; 26: 241-4.
    • (2010) AIDS Res Hum Retroviruses , vol.26 , pp. 241-244
    • García-Merino, I.1    de Las Cuevas, N.2    Jiménez, J.L.3
  • 22
    • 71649094328 scopus 로고    scopus 로고
    • CD27 and CCR7 expression on naïve T cells, are both necessary
    • Ferrando-Martinez S, Ruiz-Mateos E, Leal M. CD27 and CCR7 expression on naïve T cells, are both necessary? Immunol Lett 2010; 127: 157-8.
    • (2010) Immunol Lett , vol.127 , pp. 157-158
    • Ferrando-Martinez, S.1    Ruiz-Mateos, E.2    Leal, M.3
  • 23
    • 77649222712 scopus 로고    scopus 로고
    • T-cell dysfunction in HIV-1-infected patients with impaired recovery of CD4 cells despite suppression of viral replication
    • Erikstrup C, Kronborg G, Lohse N et al. T-cell dysfunction in HIV-1-infected patients with impaired recovery of CD4 cells despite suppression of viral replication. J Acquir Immune Defic Syndr 2010; 53: 303-10.
    • (2010) J Acquir Immune Defic Syndr , vol.53 , pp. 303-310
    • Erikstrup, C.1    Kronborg, G.2    Lohse, N.3
  • 24
    • 33646203680 scopus 로고    scopus 로고
    • Development of human lymphoid cells
    • Blom B, Spits H. Development of human lymphoid cells. Ann Rev Immunol 2006; 24: 287-320.
    • (2006) Ann Rev Immunol , vol.24 , pp. 287-320
    • Blom, B.1    Spits, H.2
  • 25
    • 34248592702 scopus 로고    scopus 로고
    • A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood
    • Duda DG, Cohen KS, Scadden DT et al. A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nat Protoc 2007; 2: 805-10.
    • (2007) Nat Protoc , vol.2 , pp. 805-810
    • Duda, D.G.1    Cohen, K.S.2    Scadden, D.T.3
  • 26
    • 0028784287 scopus 로고
    • Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset
    • Galy A, Travis M, Cen D et al. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 1995; 3: 459-73.
    • (1995) Immunity , vol.3 , pp. 459-473
    • Galy, A.1    Travis, M.2    Cen, D.3
  • 27
    • 32244444536 scopus 로고    scopus 로고
    • Dynamics of thymus-colonizing cells during human development
    • Haddad R, Guimiot F, Six E et al. Dynamics of thymus-colonizing cells during human development. Immunity 2006; 24: 217-30.
    • (2006) Immunity , vol.24 , pp. 217-230
    • Haddad, R.1    Guimiot, F.2    Six, E.3
  • 28
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • Hunt PW, Brenchley J, Sinclair E et al. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 2008; 197: 126-33.
    • (2008) J Infect Dis , vol.197 , pp. 126-133
    • Hunt, P.W.1    Brenchley, J.2    Sinclair, E.3
  • 29
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009; 199: 1177-85.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 30
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Ridker PM, Danielson E, Fonseca FA et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359: 2195-207.
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 31
    • 71749119317 scopus 로고    scopus 로고
    • A reliable and simplified sj/β-TREC ratio quantification method for human thymic output measurement
    • Ferrando-Martínez S, Franco JM, Ruiz-Mateos E et al. A reliable and simplified sj/β-TREC ratio quantification method for human thymic output measurement. J Immunol Methods 2010; 352: 111-7.
    • (2010) J Immunol Methods , vol.352 , pp. 111-117
    • Ferrando-Martínez, S.1    Franco, J.M.2    Ruiz-Mateos, E.3
  • 32
    • 84859614297 scopus 로고    scopus 로고
    • Severe immune dysregulation affects CD4+CD25hiFoxP3+ regulatory T-cells in HIV infected patients with low-level CD4 T-cell repopulation despite suppressive HAART
    • (in press)
    • Mendez-Lagares G, Pozo-Balado MM, Genebat M et al. Severe immune dysregulation affects CD4+CD25hiFoxP3+ regulatory T-cells in HIV infected patients with low-level CD4 T-cell repopulation despite suppressive HAART. J Infect Dis (in press).
    • J Infect Dis
    • Mendez-Lagares, G.1    Pozo-Balado, M.M.2    Genebat, M.3
  • 33
    • 77953915528 scopus 로고    scopus 로고
    • Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART
    • Marchetti G, Gazzola L, Trabattoni D et al. Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART. AIDS 2010; 24: 1455-60.
    • (2010) AIDS , vol.24 , pp. 1455-1460
    • Marchetti, G.1    Gazzola, L.2    Trabattoni, D.3
  • 35
    • 46249104669 scopus 로고    scopus 로고
    • Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART
    • Isgrò A, Leti W, De Santis W et al. Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART. Clin Infect Dis 2008; 46: 1902-10.
    • (2008) Clin Infect Dis , vol.46 , pp. 1902-1910
    • Isgrò, A.1    Leti, W.2    De Santis, W.3
  • 36
    • 37549001261 scopus 로고    scopus 로고
    • A human postnatal lymphoid progenitor capable of circulating and seeding the thymus
    • Six EM, Bonhomme D, Monteiro M et al. A human postnatal lymphoid progenitor capable of circulating and seeding the thymus. J Exp Med 2007; 204: 3085-93.
    • (2007) J Exp Med , vol.204 , pp. 3085-3093
    • Six, E.M.1    Bonhomme, D.2    Monteiro, M.3
  • 37
    • 0035471754 scopus 로고    scopus 로고
    • Interleukin-7: master regulator of peripheral T-cell homeostasis?
    • Fry TJ, Mackall CL. Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol 2001; 22: 564-71.
    • (2001) Trends Immunol , vol.22 , pp. 564-571
    • Fry, T.J.1    Mackall, C.L.2
  • 38
    • 0035138982 scopus 로고    scopus 로고
    • Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis
    • Napolitano LA, Grant RM, Deeks SG et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 2001; 7: 73-9.
    • (2001) Nat Med , vol.7 , pp. 73-79
    • Napolitano, L.A.1    Grant, R.M.2    Deeks, S.G.3
  • 39
    • 0038216950 scopus 로고    scopus 로고
    • Endogenous IL-7 is associated with increased thymic volume in adult HIV-infected patients under highly active antiretroviral therapy
    • Ruiz-Mateos E, de la Rosa R, Franco JM et al. Endogenous IL-7 is associated with increased thymic volume in adult HIV-infected patients under highly active antiretroviral therapy. AIDS 2003; 17: 947-54.
    • (2003) AIDS , vol.17 , pp. 947-954
    • Ruiz-Mateos, E.1    de la Rosa, R.2    Franco, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.