Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2/STAT5

Biochemical and Biophysical Research Communications

Volumn 469, Issue 3, 2016, Pages 716-722

  Xiao, Meifang ^a   Zhang, Liming ^a   Zhou, Yizheng ^a   Rajoria, Pasupati ^b   Wang, Changfu ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b YANGTZE UNIVERSITY   (China)

Author keywords

JAK2 STAT5; Lymphoma; Mitochondrial respiration; Pyrvinium

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; JANUS KINASE 2; PROTEIN BCL 2; PROTEIN MCL 1; PYRVINIUM EMBONATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STAT5 PROTEIN; ANTHELMINTIC AGENT; ANTINEOPLASTIC AGENT; JAK2 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; JURKAT CELL LINE; LYMPHOMA CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; T-CELL LYMPHOMA CELL LINE; CELL RESPIRATION; DOSE RESPONSE; DRUG EFFECTS; LYMPHOMA; METABOLISM; MITOCHONDRION; PATHOLOGY;

ANTHELMINTICS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL RESPIRATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; JANUS KINASE 2; JURKAT CELLS; LYMPHOMA; MITOCHONDRIA; PYRVINIUM COMPOUNDS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 84953636707     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.12.059     Document Type: Article

References (26)

1. M. Sakata-Yanagimoto, and S. Chiba Molecular pathogenesis of peripheral T cell lymphoma Curr. Hematol. Malig. Rep. 10 4 December 2015 429 437
2. M. Zhang, L.A. Mathews Griner, W. Ju, D.Y. Duveau, R. Guha, M.N. Petrus, B. Wen, M. Maeda, P. Shinn, M. Ferrer, K.D. Conlon, R.N. Bamford, J.J. O'Shea, C.J. Thomas, and T.A. Waldmann Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia Proc. Natl. Acad. Sci. U. S. A. 112 2015 12480 12485
3. A.M. Roncero, P. Lopez-Nieva, M.A. Cobos-Fernandez, M. Villa-Morales, L. Gonzalez-Sanchez, J.L. Lopez-Lorenzo, P. Llamas, C. Ayuso, S.M. Rodriguez-Pinilla, M.C. Arriba, M.A. Piris, P. Fernandez-Navarro, A.F. Fernandez, M.F. Fraga, J. Santos, and J. Fernandez-Piqueras Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development Leukemia 2015 10.1038/leu.2015.202
4. M. Jaras, and B.L. Ebert Power cut: inhibiting mitochondrial translation to target leukemia Cancer Cell 20 2011 555 556
5. R. Loureiro, K.A. Mesquita, P.J. Oliveira, and I. Vega-Naredo Mitochondria in cancer stem cells: a target for therapy Recent Pat. Endocr. Metab. Immune Drug Discov. 7 2013 102 114
6. E.D. Lagadinou, A. Sach, K. Callahan, R.M. Rossi, S.J. Neering, M. Minhajuddin, J.M. Ashton, S. Pei, V. Grose, K.M. O'Dwyer, J.L. Liesveld, P.S. Brookes, M.W. Becker, and C.T. Jordan BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells Cell Stem Cell 12 2013 329 341
7. M. Skrtic, S. Sriskanthadevan, B. Jhas, M. Gebbia, X. Wang, Z. Wang, R. Hurren, Y. Jitkova, M. Gronda, N. Maclean, C.K. Lai, Y. Eberhard, J. Bartoszko, P. Spagnuolo, A.C. Rutledge, A. Datti, T. Ketela, J. Moffat, B.H. Robinson, J.H. Cameron, J. Wrana, C.J. Eaves, M.D. Minden, J.C. Wang, J.E. Dick, K. Humphries, C. Nislow, G. Giaever, and A.D. Schimmer Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia Cancer Cell 20 2011 674 688
8. E. Samper, L. Morgado, J.C. Estrada, A. Bernad, A. Hubbard, S. Cadenas, and S. Melov Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas Free Radic. Biol. Med. 46 2009 387 396
9. W. Xu, L. Lacerda, B.G. Debeb, R.L. Atkinson, T.N. Solley, L. Li, D. Orton, J.S. McMurray, B.I. Hang, E. Lee, A.H. Klopp, N.T. Ueno, J.M. Reuben, S. Krishnamurthy, and W.A. Woodward The anthelmintic drug pyrvinium pamoate targets aggressive breast cancer PLoS One 8 2013 e71508
10. L. Deng, Y. Lei, R. Liu, J. Li, K. Yuan, Y. Li, Y. Chen, Y. Liu, Y. Lu, C.K. Edwards III, C. Huang, and Y. Wei Pyrvinium targets autophagy addiction to promote cancer cell death Cell Death Dis. 4 2013 e614
11. Y. Harada, I. Ishii, K. Hatake, and T. Kasahara Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3 Cancer Lett. 319 2012 83 88
12. D.H. Yu, J. Macdonald, G. Liu, A.S. Lee, M. Ly, T. Davis, N. Ke, D. Zhou, F. Wong-Staal, and Q.X. Li Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy PLoS One 3 2008 e3951
13. I. Ishii, Y. Harada, and T. Kasahara Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration Front. Oncol. 2 2012 137
14. C.A. Thorne, A.J. Hanson, J. Schneider, E. Tahinci, D. Orton, C.S. Cselenyi, K.K. Jernigan, K.C. Meyers, B.I. Hang, A.G. Waterson, K. Kim, B. Melancon, V.P. Ghidu, G.A. Sulikowski, B. LaFleur, A. Salic, L.A. Lee, D.M. Miller 3rd, and E. Lee Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha Nat. Chem. Biol. 6 2010 829 836
15. H. Esumi, J. Lu, Y. Kurashima, and T. Hanaoka Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation Cancer Sci. 95 2004 685 690
16. W. Xiang, J.K. Cheong, S.H. Ang, B. Teo, P. Xu, K. Asari, W.T. Sun, H. Than, R.M. Bunte, D.M. Virshup, and C. Chuah Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration Oncotarget 6 2015 33769 33780
17. K. Hashiguchi, and Q.M. Zhang-Akiyama Establishment of human cell lines lacking mitochondrial DNA Methods Mol. Biol. 554 2009 383 391
18. S. Varum, A.S. Rodrigues, M.B. Moura, O. Momcilovic, C.A.t Easley, J. Ramalho-Santos, B. Van Houten, and G. Schatten Energy metabolism in human pluripotent stem cells and their differentiated counterparts PLoS One 6 2011 e20914
19. L. Xue, L. Chiang, C. Kang, and A. Winoto The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint Eur. J. Immunol. 38 2008 3200 3207
20. R. Moriggl, V. Sexl, R. Piekorz, D. Topham, and J.N. Ihle Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells Immunity 11 1999 225 230
21. C.L. Batlevi, E. Matsuki, R.J. Brentjens, and A. Younes Novel immunotherapies in lymphoid malignancies Nat. Rev. Clin. Oncol. 2015, doi: 10.1038/nrclinonc.2015.187 10.1038/nrclinonc.2015.187
22. N. Li, K. Ragheb, G. Lawler, J. Sturgis, B. Rajwa, J.A. Melendez, and J.P. Robinson Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production J. Biol. Chem. 278 2003 8516 8525
23. M.E. Irwin, N. Rivera-Del Valle, and J. Chandra Redox control of leukemia: from molecular mechanisms to therapeutic opportunities Antioxid. Redox. Signal. 18 2013 1349 1383
24. P.S. Hole, R.L. Darley, and A. Tonks Do reactive oxygen species play a role in myeloid leukemias? Blood 117 2011 5816 5826
25. C. Li, Y. Li, L. He, A.R. Agarwal, N. Zeng, E. Cadenas, and B.L. Stiles PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes Free Radic. Biol. Med. 60 2013 29 40
26. J.A. Meier, and A.C. Larner Toward a new STATe: the role of STATs in mitochondrial function Semin. Immunol. 26 2014 20 28