The role of the PI3K-AKT kinase pathway in T-cell development beyond the β checkpoint

European Journal of Immunology

Volumn 38, Issue 11, 2008, Pages 3200-3207

  Xue, Ling ^a   Chiang, Leslie ^a   Kang, Chulho ^a   Winoto, Astar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AKT; Apoptosis; Proliferation; PTEN; Thymocytes

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; T LYMPHOCYTE RECEPTOR BETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PTEN PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL COUNT; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THYMOCYTE; ANIMAL; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 58149347261     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838614     Document Type: Article

References (41)

1. Mora, A., Komander, D., van Aalten, D. M. and Alessi, D. R., PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell Dev. Biol. 2004. 15: 161-170.
2. Cully, M., You, H., Levine, A. J. and Mak, T. W., Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 2006. 6: 184-192.
3. Juntilla, M. M. and Koretzky, G. A., Critical roles of the PI3K/ Akt signaling pathway in T cell development. Immunol. Lett. 2008. 116: 104-110.
4. Manning, B. D. and Cantley, L. C., AKT/PKB signaling: Navigating downstream. Cell 2007. 129: 1261-1274.
5. Huang, H. and Tindall, D. J., Dynamic FoxO transcription factors. J. Cell Sci. 2007. 120: 2479-2487.
6. Rossi, D. J. and Weissman, I. L., Pten, tumorigenesis, and stem cell self-renewal. Cell 2006. 125: 229-231.
7. Hay, N., The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005. 8: 179-183.
8. Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H., Lindboe, C. F. et al., Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum. Mol. Genet. 1997. 6: 1383-1387.
9. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S. et al., Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet. 1997. 16: 64-67.
10. Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon-Cardo, C. et al., Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. USA 1999. 96: 1563-1568.
11. Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I., Ho, A. et al., High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 1998. 8: 1169-1178.
12. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. and Pandolfi, P. P., Pten is essential for embryonic development and tumour suppression. Nat. Genet. 1998. 19: 348-355.
13. Suzuki, A., Yamaguchi, M. T., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R. et al., T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 2001. 14: 523-534.
14. Hagenbeek, T. J. and Spits, H., T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus. Leukemia 2008. 22: 608-619.
15. Xue, L., Nolla, H., Suzuki, A., Mak, T. W. and Winoto, A., Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc. Natl. Acad. Sci. USA 2008. 105: 2022-2027.
16. Buckler, J. L., Walsh, P. T., Porrett, P. M., Choi, Y. and Turka, L. A., Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J. Immunol. 2006. 177: 4262-4266.
17. Rathmell, J. C., Elstrom, R. L., Cinalli, R. M. and Thompson, C. B., Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur. J. Immunol. 2003. 33: 2223-2232.
18. Anzelon, A. N., Wu, H. and Rickert, R. C., Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat. Immunol. 2003. 4: 287-294.
19. Hinton, H. J., Alessi, D. R. and Cantrell, D. A., The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development. Nat. Immunol. 2004. 5: 539-545.
20. Juntilla, M. M., Wofford, J. A., Birnbaum, M. J., Rathmell, J. C. and Koretzky, G. A., Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc. Natl. Acad. Sci. USA 2007. 104: 12105-12110.
21. Swat, W., Montgrain, V., Doggett, T. A., Douangpanya, J., Puri, K., Vermi, W. and Diacovo, T. G., Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival. Blood 2006. 107: 2415-2422.
22. Adlam, M. and Siu, G., Hierarchical interactions control CD4 gene expression during thymocyte development. Immunity 2003. 18: 173-184.
23. MacDonald, H. R., Budd, R. C. and Howe, R. C., A CD3- subset of CD4-8+ thymocytes: A rapidly cycling intermediate in the generation of CD4+8+ cells. Eur. J. Immunol. 1988. 18: 519-523.
24. Winoto, A. and Littman, D. R., Nuclear hormone receptors in T lymphocytes. Cell 2002. 109: S57-S66.
25. Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L. et al., Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004. 427: 355-360.
26. Carlson, C. M., Endrizzi, B. T., Wu, J., Ding, X., Weinreich, M. A.,Walsh, E. R.,Wani, M. A. et al., Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 2006. 442: 299-302.
27. Jones, R. G., Elford, A. R., Parsons, M. J., Wu, L., Krawczyk, C. M., Yeh, W. C. Hakem, R. et al., CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J. Exp. Med. 2002. 196: 335-348.
28. Yu, Q., Erman, B., Park, J. H., Feigenbaum, L. and Singer, A., IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: Impact on thymocyte development. J. Exp. Med. 2004. 200: 797-803.
29. Verbeek, S., Izon, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M. et al., An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 1995. 374: 70-74.
30. Okamura, R. M., Sigvardsson, M., Galceran, J., Verbeek, S., Clevers, H. and Grosschedl, R., Redundant regulation of T cell differentiation and TCR gene expression by the transcription factors LEF-1 and TCF-1. Immunity 1998. 8: 11-20.
31. He, Y., Deftos, M. L., Ojala, E. W. and Bevan, M. J., RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T Cells. Immunity 1998. 9: 797-806.
32. Sun, Z., Unutmaz, D., Zou, Y. R., Sunshine, M. J., Pierani, A., Brenner-Morton, S., Mebius, R. E. and Littman, D. R., Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 2000. 288: 2369-2373.
33. Stiles, B., Groszer, M., Wang, S., Jiao, J. and Wu, H., PTENless means more. Dev. Biol. 2004. 273: 175-184.
34. Cunningham, N. R., Artim, S. C., Fornadel, C. M., Sellars, M. C., Edmonson, S. G., Scott, G., Albino, F. et al., Immature CD4+CD8+ thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation. J. Immunol. 2006. 177: 6660-6666.
35. Jones, R. G., Parsons, M., Bonnard, M., Chan, V. S., Yeh, W. C., Woodgett, J. R. and Ohashi, P. S., Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J. Exp. Med. 2000. 191: 1721-1734.
36. Huang, C. Y., Bredemeyer, A. L., Walker, L. M., Bassing, C. H. and Sleckman, B. P., Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur. J. Immunol. 2008. 38: 342-349.
37. Haxhinasto, S., Mathis, D. and Benoist, C., The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J. Exp. Med. 2008. 205: 565-574.
38. Na, S. Y., Patra, A., Scheuring, Y., Marx, A., Tolaini, M., Kioussis, D., Hemmings, B. et al., Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation. J. Immunol. 2003. 171: 1285-1296.
39. Webster, M. K., Goya, L., Ge, Y., Maiyar, A. C. and Firestone, G. L., Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell. Biol. 1993. 13: 2031-2040.
40. Allen, J. M., Forbush, K. A. and Perlmutter, R. M., Functional dissection of the lck proximal promoter. Mol. Cell. Biol. 1992. 12: 2758-2768.
41. Krutzik, P. O., Clutter, M. R. and Nolan, G. P., Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J. Immunol. 2005. 175: 2357-2365.