Methamphetamine induces trace amineassociated receptor 1 (TAAR1) expression in human t lymphocytes: Role in immunomodulation

Journal of Leukocyte Biology

Volumn 99, Issue 1, 2016, Pages 213-223

  Sriram, Uma ^a   Cenna, Jonathan M ^a   Haldar, Bijayesh ^a   Fernandes, Nicole C ^a   Razmpour, Roshanak ^a   Fan, Shongshan ^a   Ramirez, Servio H ^a   Potula, Raghava ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drug abuse; HIV infection; Immune response; T cells

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 2; MESSENGER RNA; METHAMPHETAMINE; TRACE AMINE ASSOCIATED RECEPTOR 1; UNCLASSIFIED DRUG; TRACE AMINE-ASSOCIATED RECEPTOR 1;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IN VITRO STUDY; METHAMPHETAMINE DEPENDENCE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; CELL CULTURE; CELL CYCLE; DRUG DEPENDENCE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; METABOLISM;

CELL CYCLE; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; GENE EXPRESSION REGULATION; HIV INFECTIONS; HUMANS; IMMUNOMODULATION; INTERLEUKIN-2; METHAMPHETAMINE; RECEPTORS, G-PROTEIN-COUPLED; SUBSTANCE-RELATED DISORDERS; T-LYMPHOCYTES;

EID: 84953387232     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.4A0814-395RR     Document Type: Article

References (57)

1. Gold, M. S., Kobeissy, F. H., Wang, K. K., Merlo, L. J., Bruijnzeel, A. W., Krasnova, I. N., Cadet, J. L. (2009) Methamphetamine- and traumainduced brain injuries: comparative cellular and molecular neurobiological substrates. Biol. Psychiatry 66, 118–127
2. Panenka, W. J., Procyshyn, R. M., Lecomte, T., MacEwan, G. W., Flynn, S. W., Honer, W. G., Barr, A. M. (2013) Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings. Drug Alcohol Depend. 129, 167–179
3. Rawson, R. A., Anglin, M. D., Ling, W. (2002) Will the methamphetamine problem go away? J. Addict. Dis. 21, 5–19
4. Freese, T. E., Obert, J., Dickow, A., Cohen, J., Lord, R. H. (2000) Methamphetamine abuse: issues for special populations. J. Psychoactive Drugs 32, 177–182
5. Boddiger, D. (2005) Metamphetamine use linked to rising HIV transmission. Lancet 365, 1217–1218
6. Martinez, L. R., Mihu, M. R., Gácser, A., Santambrogio, L., Nosanchuk, J. D. (2009) Methamphetamine enhances histoplasmosis by immunosuppression of the host. J. Infect. Dis. 200, 131–141
7. Potula, R., Hawkins, B. J., Cenna, J. M., Fan, S., Dykstra, H., Ramirez, S. H., Morsey, B., Brodie, M. R., Persidsky, Y. (2010) Methamphetamine causes mitrochondrial oxidative damage in human T lymphocytes leading to functional impairment. J. Immunol. 185, 2867–2876
8. Cabral, G. A. (2006) Drugs of abuse, immune modulation, and AIDS. J. Neuroimmune Pharmacol. 1, 280–295
9. Borowsky, B., Adham, N., Jones, K. A., Raddatz, R., Artymyshyn, R., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F. Y., Branchek, T. A., Gerald, C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. USA 98, 8966–8971
10. Bunzow, J. R., Sonders, M. S., Arttamangkul, S., Harrison, L. M., Zhang, G., Quigley, D. I., Darland, T., Suchland, K. L., Pasumamula, S., Kennedy, J. L., Olson, S. B., Magenis, R. E., Amara, S. G., Grandy, D. K. (2001) Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol. 60, 1181–1188
11. Lindemann, L., Hoener, M. C. (2005) A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol. Sci. 26, 274–281
12. Lindemann, L., Ebeling, M., Kratochwil, N. A., Bunzow, J. R., Grandy, D. K., Hoener, M. C. (2005) Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G proteincoupled receptors. Genomics 85, 372–385
13. Berry, M. D. (2004) Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J. Neurochem. 90, 257–271
14. Berry, M. D. (2007) The potential of trace amines and their receptors for treating neurological and psychiatric diseases. Rev. Recent Clin. Trials 2, 3–19
15. Miller, G. M., Verrico, C. D., Jassen, A., Konar, M., Yang, H., Panas, H., Bahn, M., Johnson, R., Madras, B. K. (2005) Primate trace amine receptor 1 modulation by the dopamine transporter. J. Pharmacol. Exp. Ther. 313, 983–994
16. Miller, G. M. (2011) The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J. Neurochem. 116, 164–176
17. Xie, Z., Westmoreland, S. V., Miller, G. M. (2008) Modulation of monoamine transporters by common biogenic amines via trace amineassociated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes. J. Pharmacol. Exp. Ther. 325, 629–640
18. Nelson, D. A., Tolbert, M. D., Singh, S. J., Bost, K. L. (2007) Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes. J. Neuroimmunol. 192, 21–30
19. Qian, H. Z., Stinnette, S. E., Rebeiro, P. F., Kipp, A. M., Shepherd, B. E., Samenow, C. P., Jenkins, C. A., No, P., McGowan, C. C., Hulgan, T., Sterling, T. R. (2011) The relationship between injection and noninjection drug use and HIV disease progression. J. Subst. Abuse Treat. 41, 14–20
20. Kipp, A. M., Desruisseau, A. J., Qian, H. Z. (2011) Non-injection drug use and HIV disease progression in the era of combination antiretroviral therapy. J. Subst. Abuse Treat. 40, 386–396
21. Friedman, H., Pross, S., Klein, T. W. (2006) Addictive drugs and their relationship with infectious diseases. FEMS Immunol. Med. Microbiol. 47, 330–342
22. Cofrancesco, Jr., J., Scherzer, R., Tien, P. C., Gibert, C. L., Southwell, H., Sidney, S., Dobs, A., Grunfeld, C. (2008) Illicit drug use and HIV treatment outcomes in a US cohort. AIDS 22, 357–365
23. Shoptaw, S., Reback, C. J., Freese, T. E. (2002) Patient characteristics, HIV serostatus, and risk behaviors among gay and bisexual males seeking treatment for methamphetamine abuse and dependence in Los Angeles. J. Addict. Dis. 21, 91–105
24. Li, L., Assanangkornchai, S., Duo, L., McNeil, E., Li, J. (2014) Crossborder activities and association with current methamphetamine use among Chinese injection drug users (IDUs) in a China-Myanmar border region. Drug Alcohol Depend. 138, 48–53
25. Ghimire, B., Suguimoto, S. P., Zamani, S., Ono-Kihara, M., Kihara, M. (2013) Vulnerability to HIV infection among female drug users in Kathmandu Valley, Nepal: a cross-sectional study. BMC Public Health 13, 1238
26. Cisneros, I. E., Ghorpade, A. (2012) HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS. Curr. HIV Res. 10, 392–406
27. Persidsky, Y., Heilman, D., Haorah, J., Zelivyanskaya, M., Persidsky, R., Weber, G. A., Shimokawa, H., Kaibuchi, K., Ikezu, T. (2006) Rhomediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 107, 4770–4780
28. Ellis, R. J., Childers, M. E., Cherner, M., Lazzaretto, D., Letendre, S., Grant, I.; HIV Neurobehavioral Research Center Group. (2003) Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy. J. Infect. Dis. 188, 1820–1826
29. Smith, D. M., Wong, J. K., Hightower, G. K., Ignacio, C. C., Koelsch, K. K., Petropoulos, C. J., Richman, D. D., Little, S. J. (2005) HIV drug resistance acquired through superinfection. AIDS 19, 1251–1256
30. Colfax, G. N., Vittinghoff, E., Grant, R., Lum, P., Spotts, G., Hecht, F. M. (2007) Frequent methamphetamine use is associated with primary nonnucleoside reverse transcriptase inhibitor resistance. AIDS 21, 239–241
31. Moore, R. D., Keruly, J. C., Chaisson, R. E. (2004) Differences in HIV disease progression by injecting drug use in HIV-infected persons in care. J. Acquir. Immune Defic. Syndr. 35, 46–51
32. Francis, S. H., Corbin, J. D. (1994) Structure and function of cyclic nucleotide-dependent protein kinases. Annu. Rev. Physiol. 56, 237–272
33. Babusyte, A., Kotthoff, M., Fiedler, J., Krautwurst, D. (2013) Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2. J. Leukoc. Biol. 93, 387–394
34. Gendelman, H. E., Orenstein, J. M., Martin, M. A., Ferrua, C., Mitra, R., Phipps, T., Wahl, L. A., Lane, H. C., Fauci, A. S., Burke, D. S. (1988) Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J. Exp. Med. 167, 1428–1441
35. Abbas-Terki, T., Blanco-Bose, W., Déglon, N., Pralong, W., Aebischer, P. (2002) Lentiviral-mediated RNA interference. Hum. Gene Ther. 13, 2197–2201
36. Potula, R., Persidsky, Y. (2008) Adding fuel to the fire: methamphetamine enhances HIV infection. Am. J. Pathol. 172, 1467–1470
37. D’Andrea, G., Terrazzino, S., Fortin, D., Farruggio, A., Rinaldi, L., Leon, A. (2003) HPLC electrochemical detection of trace amines in human plasma and platelets and expression of mRNA transcripts of trace amine receptors in circulating leukocytes. Neurosci. Lett. 346, 89–92
38. Panas, M. W., Xie, Z., Panas, H. N., Hoener, M. C., Vallender, E. J., Miller, G. M. (2012) Trace amine associated receptor 1 signaling in activated lymphocytes. J. Neuroimmune Pharmacol. 7, 866–876
39. Wasik, A. M., Millan, M. J., Scanlan, T., Barnes, N. M., Gordon, J. (2012) Evidence for functional trace amine associated receptor-1 in normal and malignant B cells. Leuk. Res. 36, 245–249
40. Mantri, C. K., Mantri, J. V., Pandhare, J., Dash, C. (2014) Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. Am. J. Pathol. 184, 92–100
41. Lane, H. C. (2010) Pathogenesis of HIV infection: total CD4+ T-cell pool, immune activation, and inflammation. Top. HIV Med. 18, 2–6
42. Cisneros, I. E., Ghorpade, A. (2014) Methamphetamine and HIV-1- induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology 85, 499–507
43. Nair, M. P., Saiyed, Z. M., Nair, N., Gandhi, N. H., Rodriguez, J. W., Boukli, N., Provencio-Vasquez, E., Malow, R. M., Miguez-Burbano, M. J. (2009) Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells. J. Neuroimmune Pharmacol. 4, 129–139
44. Zucchi, R., Chiellini, G., Scanlan, T. S., Grandy, D. K. (2006) Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149, 967–978
45. Espinoza, S., Salahpour, A., Masri, B., Sotnikova, T. D., Messa, M., Barak, L. S., Caron, M. G., Gainetdinov, R. R. (2011) Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol. Pharmacol. 80, 416–425
46. [No authors listed] (2005) HIV & drugs. Meth use develops stronger link to HIV risk. AIDS Policy Law 20, 5
47. Liang, H., Wang, X., Chen, H., Song, L., Ye, L., Wang, S. H., Wang, Y. J., Zhou, L., Ho, W. Z. (2008) Methamphetamine enhances HIV infection of macrophages. Am. J. Pathol. 172, 1617–1624
48. Miller, G. M. (2012) Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1). J. Med. Chem. 55, 1809–1814
49. Lindemann, L., Meyer, C. A., Jeanneau, K., Bradaia, A., Ozmen, L., Bluethmann, H., Bettler, B., Wettstein, J. G., Borroni, E., Moreau, J. L., Hoener, M. C. (2008) Trace amine-associated receptor 1 modulates dopaminergic activity. J. Pharmacol. Exp. Ther. 324, 948–956
50. Stäubert, C., Böselt, I., Bohnekamp, J., Römpler, H., Enard, W., Schöneberg, T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS One 5, e11133
51. Vallender, E. J., Xie, Z., Westmoreland, S. V., Miller, G. M. (2010) Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs. BMC Evol. Biol. 10, 51
52. Tallóczy, Z., Martinez, J., Joset, D., Ray, Y., Gácser, A., Toussi, S., Mizushima, N., Nosanchuk, J. D., Goldstein, H., Loike, J., Sulzer, D., Santambrogio, L. (2008) Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS Pathog. 4, e28
53. Harms, R., Morsey, B., Boyer, C. W., Fox, H. S., Sarvetnick, N. (2012) Methamphetamine administration targets multiple immune subsets and induces phenotypic alterations suggestive of immunosuppression. PLoS One 7, e49897
54. Rahmouni, S., Aandahl, E. M., Trebak, M., Boniver, J., Tasken, K., Moutschen, M. (2001) Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirusinduced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing. FASEB J. 15, 1466–1468
55. Matsuda, S., Kominato, K., Koide-Yoshida, S., Miyamoto, K., Isshiki, K., Tsuji, A., Yuasa, K. (2014) PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A. J. Biol. Chem. 289, 18387–18400
56. White, P. C., Shore, A. M., Clement, M., McLaren, J., Soeiro, I., Lam, E. W., Brennan, P. (2006) Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25, 2170–2180
57. Wires, E. S., Alvarez, D., Dobrowolski, C., Wang, Y., Morales, M., Karn, J., Harvey, B. K. (2012) Methamphetamine activates nuclear factor kappalight- chain-enhancer of activated B cells (NF-kB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells. J. Neurovirol. 18, 400–410.