TGF-β1-induced regulatory T cells

Human Immunology

Volumn 76, Issue 8, 2015, Pages 561-564

  Hadaschik, Eva N ^a   Enk, Alexander H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Autoimmunity; Immunotherapy; Regulatory T cells; TGF 1; Tolerance

Indexed keywords

EPITOPE; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; AUTOIMMUNE DISEASES; CELL COMMUNICATION; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; METABOLISM; PROCEDURES; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; AUTOIMMUNE DISEASES; CELL COMMUNICATION; CELL DIFFERENTIATION; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNOMODULATION; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84953363027     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2015.06.015     Document Type: Article

References (44)

1. Bonertz A., Weitz J., Pietsch D.H., Rahbari N.N., Schlude C., Ge Y., et al. Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J. Clin. Investig. 2009, 119(11):3311-3321.
2. Muller-Berghaus J., Ehlert K., Ugurel S., Umansky V., Bucur M., Schirrmacher V., et al. Melanoma-reactive T cells in the bone marrow of melanoma patients: association with disease stage and disease duration. Cancer Res. 2006, 66(12):5997-6001.
3. Schmitz-Winnenthal F.H., Volk C., Z'Graggen K., Galindo L., Nummer D., Ziouta Y., et al. High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res. 2005, 65(21):10079-10087.
4. Edinger M., Powrie F., Chakraverty R. Regulatory mechanisms in graft-versus-host responses. Biol. Blood Marrow Transplant.: J. Am. Soc. Blood Marrow Transplant. 2009, 15(1 Suppl.):2-6.
5. + regulatory T cells approach the clinic. Cytotherapy 2008, 10(7):655-656.
6. +CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006, 108(13):4260-4267.
7. + regulatory T cells for clinical trials. Biol. Blood Marrow Transplant.: J. Am. Soc. Blood Marrow Transplant. 2006, 12(3):267-274.
8. Hoffmann P., Eder R., Edinger M. Polyclonal expansion of human CD4(+)CD25(+) regulatory T cells. Methods Mol. Biol. 2011, 677:15-30.
9. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003, 198(12):1875-1886.
10. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002, 2(6):389-400.
11. + regulatory T cells induces a scurfy-like disease. J. Exp. Med. 2007, 204(1):57-63.
12. Kim J.M., Rasmussen J.P., Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 2007, 8(2):191-197.
13. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155(3):1151-1164.
14. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998, 188(2):287-296.
15. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000, 164(1):183-190.
16. Vignali D. How many mechanisms do regulatory T cells need?. Eur. J. Immunol. 2008, 38(4):908-911.
17. Vignali D.A., Collison L.W., Workman C.J. How regulatory T cells work. Nat. Rev. Immunol. 2008, 8(7):523-532.
18. + regulatory T cells. Nat. Immunol. 2003, 4(4):330-336.
19. Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001, 27(1):20-21.
20. Wildin R.S., Ramsdell F., Peake J., Faravelli F., Casanova J.L., Buist N., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 2001, 27(1):18-20.
21. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., Rudensky A.Y. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22(3):329-341.
22. Shevach E.M. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006, 25(2):195-201.
23. Jonuleit H., Schmitt E., Schuler G., Knop J., Enk A.H. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 2000, 192(9):1213-1222.
24. Steinbrink K., WolflM., Jonuleit H., Knop J., Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 1997, 159(10):4772-4780.
25. Weiner H.L. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J. Clin. Investig. 2000, 106(8):935-937.
26. Weiner H.L. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect. 2001, 3(11):947-954.
27. + regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 2007, 204(8):1757-1764.
28. Jaensson E., Uronen-Hansson H., Pabst O., Eksteen B., Tian J., Coombes J.L., et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 2008, 205(9):2139-2149.
29. Tone Y., Furuuchi K., Kojima Y., Tykocinski M.L., Greene M.I., Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. [Research Support, N.I.H., Extramural] 2008, 9(2):194-202.
30. + T regulatory cells. J. Immunol. 2007, 178(7):4022-4026.
31. + regulatory T cells upon repetitive in vitro stimulation. Eur. J. Immunol. 2009, 39(4):1088-1097.
32. Selvaraj R.K., Geiger T.L. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta. J. Immunol. 2007, 178(12):7667-7677.
33. Hill J.A., Feuerer M., Tash K., Haxhinasto S., Perez J., Melamed R., et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 2007, 27(5):786-800.
34. + regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006, 55(5):671-680.
35. + regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. J. Immunol. 2007, 179(7):4685-4693.
36. Stummvoll G.H., DiPaolo R.J., Huter E.N., Davidson T.S., Glass D., Ward J.M., et al. Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J. Immunol. 2008, 181(3):1908-1916.
37. Huter E.N., Stummvoll G.H., DiPaolo R.J., Glass D.D., Shevach E.M. Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J. Immunol. 2008, 181(12):8209-8213.
38. Huter E.N., Stummvoll G.H., DiPaolo R.J., Glass D.D., Shevach E.M. Pre-differentiated Th1 and Th17 effector T cells in autoimmune gastritis: Ag-specific regulatory T cells are more potent suppressors than polyclonal regulatory T cells. Int. Immunopharmacol. 2009, 9(5):540-545.
39. Rao P.E., Petrone A.L., Ponath P.D. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-. J. Immunol. 2005, 174(3):1446-1455.
40. +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007, 110(8):2983-2990.
41. Lee Y.K., Mukasa R., Hatton R.D., Weaver C.T. Developmental plasticity of Th17 and Treg cells. Curr. Opin. Immunol. 2009, 21(3):274-280.
42. Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004, 10(9):942-949.
43. + regulatory T cells rescue scurfy mice. Eur. J. Immunol. 2008, 38(7):1814-1821.
44. Brunstein C.G., Miller J.S., Cao Q., McKenna D.H., Hippen K.L., Curtsinger J., et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117(3):1061-1070.