-
1
-
-
67649876115
-
New insights into the regulation of T cells by gamma(c) family cytokines
-
ROCHMAN Y, SPOLSKI R, LEONARD WJ: New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol 2009; 9: 480-490.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 480-490
-
-
Rochman, Y.1
Spolski, R.2
Leonard, W.J.3
-
2
-
-
77955890953
-
Interleukin-2 receptor signaling: at the interface between tolerance and immunity
-
MALEK TR, CASTRO I: Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 2010; 33: 153-65.
-
(2010)
Immunity
, vol.33
, pp. 153-165
-
-
Malek, T.R.1
Castro, I.2
-
3
-
-
84857646605
-
The role of interleukin-2 during homeostasis and activation of the immune system
-
BOYMAN O, SPRENT J: The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol 2012; 12: 180-90.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 180-190
-
-
Boyman, O.1
Sprent, J.2
-
4
-
-
84872790689
-
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
-
LIAO W, LIN JX, LEONARD WJ: Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 2013; 38: 13-25.
-
(2013)
Immunity
, vol.38
, pp. 13-25
-
-
Liao, W.1
Lin, J.X.2
Leonard, W.J.3
-
5
-
-
0027405991
-
The IL-2 receptor complex: its structure, function, and target genes
-
MINAMI Y, KONO T, MIYAZAKI T, TANIGUCHI T: The IL-2 receptor complex: its structure, function, and target genes. Annu Rev Immunol 1993; 11: 245-68.
-
(1993)
Annu Rev Immunol
, vol.11
, pp. 245-268
-
-
Minami, Y.1
Kono, T.2
Miyazaki, T.3
Taniguchi, T.4
-
6
-
-
0024349603
-
The multi-subunit interleukin-2 receptor
-
WALDMANN TA: The multi-subunit interleukin-2 receptor. Annu Rev Biochem 1989; 58: 875-911.
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 875-911
-
-
Waldmann, T.A.1
-
7
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
SAKAGUCHI S, SAKAGUCHI N, ASANO M, ITOH M, TODA M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-64.
-
(1995)
J Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
8
-
-
84878257969
-
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
-
ROEDIGER B, KYLE R, YIP KH et al.: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol 2013; 14: 564-73.
-
(2013)
Nat Immunol
, vol.14
, pp. 564-573
-
-
Roediger, B.1
Kyle, R.2
Yip, K.H.3
-
9
-
-
60149085254
-
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells
-
YU A, ZHU L, ALTMAN NH, MALEK TR: A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 2009; 30: 204-17.
-
(2009)
Immunity
, vol.30
, pp. 204-217
-
-
Yu, A.1
Zhu, L.2
Altman, N.H.3
Malek, T.R.4
-
10
-
-
84928591321
-
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
-
KLATZMANN D, ABBAS AK: The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol 2015; 15: 283-94.
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 283-294
-
-
Klatzmann, D.1
Abbas, A.K.2
-
11
-
-
84863565430
-
Homeostatic maintenance of T cells and natural killer cells
-
BOYMAN O, KRIEG C, HOMANN D, SPRENT J: Homeostatic maintenance of T cells and natural killer cells. Cell Mol Life Sci 2012; 69: 1597-608.
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 1597-1608
-
-
Boyman, O.1
Krieg, C.2
Homann, D.3
Sprent, J.4
-
12
-
-
33645465526
-
Selective stimulation of T cell subsets with antibody-cytokine immune complexes
-
BOYMAN O, KOVAR M, RUBINSTEIN MP, SURH CD, SPRENT J: Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006; 311: 1924-7.
-
(2006)
Science
, vol.311
, pp. 1924-1927
-
-
Boyman, O.1
Kovar, M.2
Rubinstein, M.P.3
Surh, C.D.4
Sprent, J.5
-
13
-
-
65549091509
-
In vivo expansion of T eg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
-
WEBSTER KE, WALTERS S, KOHLER RE et al.: In vivo expansion of T eg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 2009; 206: 751-60.
-
(2009)
J Exp Med
, vol.206
, pp. 751-760
-
-
Webster, K.E.1
Walters, S.2
Kohler, R.E.3
-
14
-
-
76649145452
-
IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor {alpha} subunit CD25
-
LETOURNEAU S, VAN LEEUWEN EM, KRIEG C et al.: IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor {alpha} subunit CD25. Proc Natl Acad Sci USA 2010; 107: 2171-6.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 2171-2176
-
-
Letourneau, S.1
Van Leeuwen, E.M.2
Krieg, C.3
-
15
-
-
77955345138
-
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
-
KRIEG C, LETOURNEAU S, PANTALEO G, BOYMAN O: Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci USA 2010; 107: 11906-11.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 11906-11911
-
-
Krieg, C.1
Letourneau, S.2
Pantaleo, G.3
Boyman, O.4
-
16
-
-
84862776988
-
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
-
LEVIN AM, BATES DL, RING AM et al.: Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature 2012; 484: 529-33.
-
(2012)
Nature
, vol.484
, pp. 529-533
-
-
Levin, A.M.1
Bates, D.L.2
Ring, A.M.3
-
17
-
-
1242295282
-
Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance
-
PICCIRILLO CA, SHEVACH EM: Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol 2004; 16: 81-8.
-
(2004)
Semin Immunol
, vol.16
, pp. 81-88
-
-
Piccirillo, C.A.1
Shevach, E.M.2
-
18
-
-
2442637772
-
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
-
THORNTON AM, DONOVAN EE, PICCIRILLO CA, SHEVACH EM: Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 2004; 172: 6519-23.
-
(2004)
J Immunol
, vol.172
, pp. 6519-6523
-
-
Thornton, A.M.1
Donovan, E.E.2
Piccirillo, C.A.3
Shevach, E.M.4
-
19
-
-
15444374646
-
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
-
SETOGUCHI R, HORI S, TAKAHASHI T, SAKAGUCHI S: Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005 201: 723-35.
-
(2005)
J Exp Med
, vol.201
, pp. 723-735
-
-
Setoguchi, R.1
Hori, S.2
Takahashi, T.3
Sakaguchi, S.4
-
20
-
-
16844365788
-
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
-
SAKAGUCHI S: Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345-52.
-
(2005)
Nat Immunol
, vol.6
, pp. 345-352
-
-
Sakaguchi, S.1
-
22
-
-
63449138020
-
IL-2-and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets
-
LETOURNEAU S, KRIEG C, PANTALEO G, BOYMAN O: IL-2-and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets. J Allergy Clin Immunol 2009; 123: 758-62.
-
(2009)
J Allergy Clin Immunol
, vol.123
, pp. 758-762
-
-
Letourneau, S.1
Krieg, C.2
Pantaleo, G.3
Boyman, O.4
-
23
-
-
78650668123
-
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells
-
BARRON L, DOOMS H, HOYER KK et al.: Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J Immunol 2010; 185: 6426-30.
-
(2010)
J Immunol
, vol.185
, pp. 6426-6430
-
-
Barron, L.1
Dooms, H.2
Hoyer, K.K.3
-
24
-
-
77957371028
-
Stability of the regulatory T cell lineage in vivo
-
RUBTSOV YP, NIEC RE, JOSEFOWICZ S et al.: Stability of the regulatory T cell lineage in vivo. Science 2010; 329: 1667-71.
-
(2010)
Science
, vol.329
, pp. 1667-1671
-
-
Rubtsov, Y.P.1
Niec, R.E.2
Josefowicz, S.3
-
25
-
-
77953308663
-
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice
-
SCHALLENBERG S, TSAI PY, RIEWALDT J, KRETSCHMER K: Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice. J Exp Med 2010; 207: 1393-407.
-
(2010)
J Exp Med
, vol.207
, pp. 1393-1407
-
-
Schallenberg, S.1
Tsai, P.Y.2
Riewaldt, J.3
Kretschmer, K.4
-
26
-
-
79958021546
-
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo
-
CHEN Q, KIM YC, LAURENCE A, PUNKOSDY GA, SHEVACH EM: IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol 2011; 186: 6329-37.
-
(2011)
J Immunol
, vol.186
, pp. 6329-6337
-
-
Chen, Q.1
Kim, Y.C.2
Laurence, A.3
Punkosdy, G.A.4
Shevach, E.M.5
-
27
-
-
82555168440
-
Interleukin-2 and regulatory T cells in graft-versus-host disease
-
KORETH J, MATSUOKA K, KIM HT et al.: Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 2011; 365: 2055-66.
-
(2011)
N Engl J Med
, vol.365
, pp. 2055-2066
-
-
Koreth, J.1
Matsuoka, K.2
Kim, H.T.3
-
28
-
-
84876012054
-
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
-
MATSUOKA K, KORETH J, KIM HT et al.: Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med 2013; 5: 179ra143.
-
(2013)
Sci Transl Med
, vol.5
-
-
Matsuoka, K.1
Koreth, J.2
Kim, H.T.3
-
29
-
-
82555196118
-
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis
-
SAADOUN D, ROSENZWAJG M, JOLY F et al.: Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis. N Engl J Med 2011; 365: 2067-77.
-
(2011)
N Engl J Med
, vol.365
, pp. 2067-2077
-
-
Saadoun, D.1
Rosenzwajg, M.2
Joly, F.3
-
30
-
-
58149191877
-
Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells
-
WILSON MS, PESCE JT, RAMALINGAM TR, THOMPSON RW, CHEEVER A, WYNN TA: Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol 2008; 181: 6942-54.
-
(2008)
J Immunol
, vol.181
, pp. 6942-6954
-
-
Wilson, M.S.1
Pesce, J.T.2
Ramalingam, T.R.3
Thompson, R.W.4
Cheever, A.5
Wynn, T.A.6
-
31
-
-
43049174722
-
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
-
TANG Q, ADAMS JY, PENARANDA C et al.: Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 2008; 28: 687-97.
-
(2008)
Immunity
, vol.28
, pp. 687-697
-
-
Tang, Q.1
Adams, J.Y.2
Penaranda, C.3
-
32
-
-
77953297342
-
Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia
-
LIU R, ZHOU Q, LA CAVA A, CAMPAGNOLO DI, VAN KAER L, SHI FD: Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur J Immunol 2010; 40: 1577-89.
-
(2010)
Eur J Immunol
, vol.40
, pp. 1577-1589
-
-
Liu, R.1
Zhou, Q.2
La Cava, A.3
Campagnolo, D.I.4
Van Kaer, L.5
Shi, F.D.6
-
33
-
-
84869791967
-
Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways
-
LEE SY, CHO ML, OH HJ et al.: Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways. Immunology 2012; 137: 305-16.
-
(2012)
Immunology
, vol.137
, pp. 305-316
-
-
Lee, S.Y.1
Cho, M.L.2
Oh, H.J.3
-
34
-
-
33845339257
-
Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease
-
BOYMAN O, SURH CD, SPRENT J: Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease. Expert Opin Biol Ther 2006; 6: 1323-31.
-
(2006)
Expert Opin Biol Ther
, vol.6
, pp. 1323-1331
-
-
Boyman, O.1
Surh, C.D.2
Sprent, J.3
-
35
-
-
53049088033
-
Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines
-
SMITH FO, DOWNEY SG, KLAPPER JA et al.: Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines. Clin Cancer Res 2008; 14: 5610-8.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5610-5618
-
-
Smith, F.O.1
Downey, S.G.2
Klapper, J.A.3
-
36
-
-
48249117436
-
High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006
-
KLAPPER JA, DOWNEY SG, SMITH FO et al.: High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. Cancer 2008; 113: 293-301.
-
(2008)
Cancer
, vol.113
, pp. 293-301
-
-
Klapper, J.A.1
Downey, S.G.2
Smith, F.O.3
-
37
-
-
84885022736
-
The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma
-
KAUFMAN HL, KIRKWOOD JM, HODI FS et al.: The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. Nat Rev Clin Oncol 2013; 10: 588-98.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 588-598
-
-
Kaufman, H.L.1
Kirkwood, J.M.2
Hodi, F.S.3
-
38
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993
-
ATKINS MB, LOTZE MT, DUTCHER JP et al.: High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999; 17: 2105-16.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2105-2116
-
-
Atkins, M.B.1
Lotze, M.T.2
Dutcher, J.P.3
-
39
-
-
0038278831
-
Identification of a protein fragment of interleukin 2 responsible for vasopermeability
-
EPSTEIN AL, MIZOKAMI MM, LI J, HU P, KHAWLI LA: Identification of a protein fragment of interleukin 2 responsible for vasopermeability. J Natl Cancer Inst 2003; 95: 741-9.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 741-749
-
-
Epstein, A.L.1
Mizokami, M.M.2
Li, J.3
Hu, P.4
Khawli, L.A.5
-
40
-
-
14744268262
-
CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2
-
ANTONY PA, RESTIFO NP: CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2. J Immunother 2005; 28: 120-8.
-
(2005)
J Immunother
, vol.28
, pp. 120-128
-
-
Antony, P.A.1
Restifo, N.P.2
-
41
-
-
84907764279
-
Use of enhanced interleukin-2 formulations for improved immunotherapy against cancer
-
ROSALIA RA, ARENAS-RMIREZ N, BOU-CHAUD G, RAEBER ME, BOYMAN O: Use of enhanced interleukin-2 formulations for improved immunotherapy against cancer. Curr Opin Chem Biol 2014; 23: 39-46.
-
(2014)
Curr Opin Chem Biol
, vol.23
, pp. 39-46
-
-
Rosalia, R.A.1
Arenas-Rmirez, N.2
Bou-Chaud, G.3
Raeber, M.E.4
Boyman, O.5
-
42
-
-
0028986977
-
Cytokine-binding proteins: stimulating antagonists
-
KLEIN B, BRAILLY H: Cytokine-binding proteins: stimulating antagonists. Immunol Today 1995; 16: 216-20.
-
(1995)
Immunol Today
, vol.16
, pp. 216-220
-
-
Klein, B.1
Brailly, H.2
-
43
-
-
0027263302
-
Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo
-
SATO TA, WIDMER MB, FINKELMAN FD et al.: Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo. J Immunol 1993; 150: 2717-23.
-
(1993)
J Immunol
, vol.150
, pp. 2717-2723
-
-
Sato, T.A.1
Widmer, M.B.2
Finkelman, F.D.3
-
44
-
-
0027239843
-
Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes
-
FINKELMAN FD, MADDEN KB, MORRIS SC et al.: Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J Immunol 1993; 151: 1235-44.
-
(1993)
J Immunol
, vol.151
, pp. 1235-1244
-
-
Finkelman, F.D.1
Madden, K.B.2
Morris, S.C.3
-
45
-
-
47249097468
-
IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T cell expansion without lymphopenia
-
BOYMAN O, RAMSEY C, KIM DM, SPRENT J, SURH CD: IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T cell expansion without lymphopenia. J Immunol 2008; 180: 7265-75.
-
(2008)
J Immunol
, vol.180
, pp. 7265-7275
-
-
Boyman, O.1
Ramsey, C.2
Kim, D.M.3
Sprent, J.4
Surh, C.D.5
-
46
-
-
33745135757
-
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}
-
RUBINSTEIN MP, KOVAR M, PURTON JF et al.: Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci USA 2006; 103: 9166-71.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9166-9171
-
-
Rubinstein, M.P.1
Kovar, M.2
Purton, J.F.3
-
47
-
-
55949105361
-
Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy
-
VERDEIL G, MARQUARDT K, SURH CD, SHERMAN LA: Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy. Proc Natl Acad Sci USA 2008; 105: 16683-8.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 16683-16688
-
-
Verdeil, G.1
Marquardt, K.2
Surh, C.D.3
Sherman, L.A.4
|