Spatiotemporal release of BMP-2 and VEGF enhances osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells co-encapsulated in a patterned hydrogel

Journal of Controlled Release

Volumn 223, Issue , 2016, Pages 126-136

  Barati, Danial ^a   Shariati, Seyed Ramin Pajoum ^a   Moeinzadeh, Seyedsina ^a   Melero Martin, Juan M ^b   Khademhosseini, Ali ^c,d,e,f   Jabbari, Esmaiel ^a  

^a University of South Carolina   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e HARVARD UNIVERSITY   (United States)

^f Konkuk University   (South Korea)

Author keywords

Dual protein delivery; ECFC; Human MSC; Nanogel grafting; Osteogenesis; Patterned hydrogel; rhBMP 2; Vasculogenesis; VEGF

Indexed keywords

BONE; CELL CULTURE; CELL ENGINEERING; CELLS; CHAINS; CYTOLOGY; GRAFTING (CHEMICAL); HYDROGELS; MICROCHANNELS; NANOSTRUCTURED MATERIALS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYETHYLENES; PROTEINS; RECOMBINANT PROTEINS; STEM CELLS;

DUAL PROTEINS; ECFC; HUMAN MSC; NANOGELS; OSTEOGENESIS; RHBMP-2; VASCULOGENESIS; VEGF;

ENDOTHELIAL CELLS;

CALCIUM; CARBENE; CD31 ANTIGEN; GLYCOLIDE; HYDROGEN; LACTIDE; MACROGOL; MONOMER; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT VASCULOTROPIN; SUCCINIMIDE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN 2; CADHERIN; DNA; HYDROGEL; LEUKOCYTE ANTIGEN; MACROGOL DERIVATIVE; MESSENGER RNA; POLYESTER; POLYGLYCOLIC ACID; POLYLACTIDE; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; RUNX2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL ENCAPSULATION; COLONY FORMING CELL; CONTROLLED STUDY; DNA CONTENT; DRUG RELEASE; ENDOTHELIAL COLONY FORMING CELL; ENDOTHELIAL PROGENITOR CELL; HUMAN; HUMAN CELL; HYDROGEL; MESENCHYMAL STEM CELL; OSSIFICATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SCANNING ELECTRON MICROSCOPY; VASCULARIZATION; ZETA POTENTIAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; STEM CELL; VASCULAR ENDOTHELIUM;

ANTIGENS, CD; ANTIGENS, CD31; BONE MORPHOGENETIC PROTEIN 2; CADHERINS; CELL DIFFERENTIATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGELS; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS; POLYESTERS; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; RECOMBINANT PROTEINS; RNA, MESSENGER; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84953339834     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.12.031     Document Type: Article

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