The role of alkaline phosphatase in mineralization

Current Opinion in Orthopaedics

Volumn 18, Issue 5, 2007, Pages 444-448

  Golub, Ellis E ^a   Boesze Battaglia, Kathleen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alkaline phosphatase; Calcification; Matrix vesicle; Mineralization; Pyrophosphate

Indexed keywords

ALKALINE PHOSPHATASE; GLYCOSYLPHOSPHATIDYLINOSITOL; PHOSPHATE; PYROPHOSPHATE;

BONE DISEASE; BONE MATRIX; BONE MINERALIZATION; CALCIFICATION; CARDIOVASCULAR DISEASE; CELL MEMBRANE; ENZYME ACTIVITY; GENE EXPRESSION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

EID: 34547860007     PISSN: 10419918     EISSN: None     Source Type: Journal    
DOI: 10.1097/BCO.0b013e3282630851     Document Type: Review

References (3)

1. Holtz KM, Kantrowitz ER. The mechanism of the alkaline phosphatase reaction: insights from NMR, crystallography and site-specific mutagenesis. FEBS Lett 1999; 462:7-11.
2. Han R, Coleman JE. Dependence of the phosphorylation of alkalinephosphatase by phosphate monoesters on the pk(a) of the leaving group. Biochemistry 1995; 34:4238-4245.
3. Harrison G, Shapiro IM, Golub EE. The phosphatidylinositol-glycolipid anchor on alkaline phosphatase facilitates mineralization initiation in vitro. J Bone Miner Res 1995; 10:568-573.