BMP2 and VEGF promote angiogenesis but retard terminal differentiation of osteoblasts in bone regeneration by up-regulating Id1

Acta Biochimica et Biophysica Sinica

Volumn 43, Issue 10, 2011, Pages 796-804

  Song, Xiaobin ^a   Liu, Shaohua ^a,b   Qu, Xun ^b   Hu, Yingwei ^a,b   Zhang, Xiaoying ^a,b   Wang, Tao ^a,b   Wei, Fengcai ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

angiogenesis; BMP2; bone tissue engineering; Id1; VEGF

Indexed keywords

ANGIOGENIC FACTOR; BONE MORPHOGENETIC PROTEIN 2; ID1 PROTEIN, RAT; INHIBITOR OF DIFFERENTIATION 1; VASCULOTROPIN A;

ANIMAL; ARTICLE; BONE REGENERATION; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; METHODOLOGY; OSTEOBLAST; PATHOLOGY; RAT; TISSUE ENGINEERING; UPREGULATION; WISTAR RAT;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; INHIBITOR OF DIFFERENTIATION PROTEIN 1; MALE; OSTEOBLASTS; RATS; RATS, WISTAR; TISSUE ENGINEERING; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ADENOVIRIDAE; RATTUS;

EID: 80053471860     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmr074     Document Type: Article

References (35)

1. Gazit D, Turgeman G, Kelley P, Wang E, Jalenak M, Zilberman Y and Moutsatsos I. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: A novel cell-mediated gene therapy. J Gene Med 1999, 1: 121-133. (Pubitemid 129631069)
2. Gamradt SC and Lieberman JR. Genetic modification of stem cells to enhance bone repair. Ann Biomed Eng 2004, 32: 136-147.
3. Ferrara N, Gerber HP and LeCouter J. The biology of VEGF and its receptors. Nat Med 2003, 9: 669-676. (Pubitemid 36749215)
4. Goulet JA, Senunas LE, DeSilva GL and Greenfield ML. Autogenous iliac crest bone graft. Complications and functional assessment. Clin Orthop Relat Res 1997, 339: 76-81. (Pubitemid 27250717)
5. Kneser U, Schaefer DJ, Polykandriotis E and Horch RE. Tissue engineering of bone: The reconstructive surgeon's point of view. J Cell Mol Med 2006, 10: 7-19. (Pubitemid 44882940)
6. Bruder SP, Fink DJ and Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994, 56: 283-294. (Pubitemid 24360045)
7. Wu N, Zhao Y, Yin Y, Zhang Y and Luo J. Identification and analysis of type II TGF-b receptors in BMP-9-inducedosteogenic differentiation of C3H10T1/2 mesenchymal stem cells. Acta Biochim Biophys Sin 2010, 42: 699-708.
8. Peterson B, Zhang J, Iglesias R, Kabo M, Hedrick M, Benhaim P and Lieberman JR. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng 2005, 11: 120-129. (Pubitemid 40515180)
9. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T and Witzenbichler B, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275: 964-967. (Pubitemid 27087709)
10. Hur J, Yoon CH, Kim HS, Choi JH, Kang HJ, Hwang KK and Oh BH, et al. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 2004, 24: 288-293. (Pubitemid 38197580)
11. Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M and Li T, et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000, 97: 3422-3427. (Pubitemid 30183318)
12. Murasawa S and Asahara T. Gene modified cell transplantation for vascular regeneration. Curr Gene Ther 2007, 7: 1-6. (Pubitemid 46322285)
13. Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S and Silver M, et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002, 105: 732-738. (Pubitemid 34157378)
14. Grellier M, Bordenave L and Amedee J. Cell-to-cell communication between osteogenic and endothelial lineages: Implications for tissue engineering. Trends Biotechnol 2009, 27: 562-571.
15. Kempen DH, Lu L, Heijink A, Hefferan TE, Creemers LB, Maran A and Yaszemski MJ, et al. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 2009, 30: 2816-2825.
16. Henrich D, Seebach C, Kaehling C, Scherzed A, Wilhelm K, Tewksbury R and Powerski M, et al. Simultaneous cultivation of human endotheliallike differentiated precursor cells and human marrow stromal cells on betatricalcium phosphate. Tissue Eng C Methods 2009, 15: 551-560.
17. Steinert AF, Palmer GD, Pilapil C, Nö th U, Evans CH and Ghivizzani SC. Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng A 2009, 15: 1127-1139.
18. Fei Q, Guo C, Xu X, Gao J, Zhang J, Chen T and Cui D. Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A. Acta Biochim Biophys Sin 2010, 42: 801-806.
19. Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT and De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004, 56: 549-580. (Pubitemid 39658463)
20. Kanczler JM and Oreffo RO. Osteogenesis and angiogenesis: The potential for engineering bone. Eur Cell Mater 2008, 15: 100-114. (Pubitemid 351955734)
21. Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K and Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008, 319: 195-198.
22. Carano RA and Filvaroff EH. Angiogenesis and bone repair. Drug Discov Today 2003, 8: 980-989. (Pubitemid 37474243)
23. Pearson JD. Endothelial progenitor cells-an evolving story. Microvasc Res 2010, 79: 162-168.
24. Wang H, Yu Y, Guo RW, Shi YK, Song MB, Chen JF and Yu SY, et al. Inhibitor of DNA binding-1 promotes the migration and proliferation of endothelial progenitor cells in vitro. Mol Cell Biochem 2010, 335: 19-27.
25. Ciarrocchi A, Jankovic V, Shaked Y, Nolan DJ, Mittal V, Kerbel RS and Nimer SD, et al. Id1 restrains p21 expression to control endothelial progenitor cell formation. PLoS One 2007, 2: E1338.
26. Dragoo JL, Choi JY, Lieberman JR, Huang J, Zuk PA, Zhang J and Hedrick MH, et al. Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res 2003, 21: 622-629. (Pubitemid 36758206)
27. Nakashima A, Katagiri T and Tamura M. Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts. J Biol Chem 2005, 280: 37660-37668. (Pubitemid 41642374)
28. Unger RE, Sartoris A, Peters K, Motta A, Migliaresi C, Kunkel M and Bulnheim U, et al. Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials. Biomaterials 2007, 28: 3965-3976. (Pubitemid 47048370)
29. Rouwkema J, de Boer J and Van Blitterswijk CA. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng 2006, 12: 2685-2693. (Pubitemid 46141291)
30. Seebach C, Henrich D, Kahling C, Wilhelm K, Tami AE, Alini M and Marzi I. Endothelial progenitor cells and mesenchymal stem cells seeded onto beta-TCP granules enhance early vascularization and bone healing in a critical-sized bone defect in rats. Tissue Eng A 2010, 16: 1961-1970.
31. Guillotin B, Bourget C, Remy-Zolgadri M, Bareille R, Fernandez P, Conrad V and Amedee-Vilamitjana J. Human primary endothelial cells stimulate human osteoprogenitor cell differentiation. Cell Physiol Biochem 2004, 14: 325-332. (Pubitemid 39179201)
32. Rivron NC, Liu JJ, Rouwkema J, de Boer J and van Blitterswijk CA. Engineering vascularised tissues in vitro. Eur Cell Mater 2008, 15: 27-40. (Pubitemid 351955730)
33. Raida M, Heymann AC, Gunther C and Niederwieser D. Role of bone morphogenetic protein 2 in the crosstalk between endothelial progenitor cells and mesenchymal stem cells. Int J Mol Med 2006, 18: 735-739.
34. Geiger F, Bertram H, Berger I, Lorenz H, Wall O, Eckhardt C and Simank HG, et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 2005, 20: 2028-2035. (Pubitemid 41532788)
35. Peng H, Usas A, Olshanski A, Ho AM, Gearhart B, Cooper GM and Huard J. VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res 2005, 20: 2017-2027. (Pubitemid 41532787)