메뉴 건너뛰기




Volumn 1, Issue 5, 2008, Pages 382-388

Immune reconstitution in the sigmoid colon after long-term HIV therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GAG PROTEIN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA;

EID: 50249123398     PISSN: 19330219     EISSN: None     Source Type: Journal    
DOI: 10.1038/mi.2008.23     Document Type: Article
Times cited : (57)

References (36)
  • 1
    • 36349029905 scopus 로고    scopus 로고
    • December 2006
    • UNAIDS/WHO AIDS epidemic update - December 2006. http://www.unaids.org/ en/HIV_data/epi2006/ (2006).
    • (2006) UNAIDS/WHO AIDS epidemic update
  • 2
    • 35748939690 scopus 로고    scopus 로고
    • HIV disease progression: Immune activation, microbes, and a leaky gut
    • Douek, D. HIV disease progression: Immune activation, microbes, and a leaky gut. Top. HIV Med. 15, 114 (2007).
    • (2007) Top. HIV Med , vol.15 , pp. 114
    • Douek, D.1
  • 3
    • 0027315294 scopus 로고
    • Loss of mucosal CD4 lymphocytes is an early feature of HIV infection
    • Lim, S.G. et al. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection. Clin. Exp. Immunol. 92, 448 (1993).
    • (1993) Clin. Exp. Immunol , vol.92 , pp. 448
    • Lim, S.G.1
  • 4
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of intestinal immunity
    • Mowat, A.M. & Viney, J.L. The anatomical basis of intestinal immunity. Immunol. Rev. 156, 145 (1997).
    • (1997) Immunol. Rev , vol.156 , pp. 145
    • Mowat, A.M.1    Viney, J.L.2
  • 5
    • 4644342929 scopus 로고    scopus 로고
    • CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley, J.M. et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J. Exp. Med. 200, 749 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 749
    • Brenchley, J.M.1
  • 6
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru, S. et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med. 200, 761 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 761
    • Mehandru, S.1
  • 7
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    • Mattapallii, J.J. et al. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434, 1093 (2005).
    • (2005) Nature , vol.434 , pp. 1093
    • Mattapallii, J.J.1
  • 8
    • 17844376742 scopus 로고    scopus 로고
    • Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
    • Li, Q. et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434, 1148 (2005).
    • (2005) Nature , vol.434 , pp. 1148
    • Li, Q.1
  • 9
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
    • Veazey, R.S. et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280, 427 (1998).
    • (1998) Science , vol.280 , pp. 427
    • Veazey, R.S.1
  • 10
    • 33645924682 scopus 로고    scopus 로고
    • HIV disease: Fallout from a mucosal catastrophe?
    • Brenchley, J.M., Price, D.A. & Douek, D.C. HIV disease: Fallout from a mucosal catastrophe? Nat. Immunol. 7, 235 (2006).
    • (2006) Nat. Immunol , vol.7 , pp. 235
    • Brenchley, J.M.1    Price, D.A.2    Douek, D.C.3
  • 11
    • 0034641205 scopus 로고    scopus 로고
    • Immune restoration with antiretroviral therapies: Implications for clinical management
    • Lederman, M.M. & Valdez, H. Immune restoration with antiretroviral therapies: Implications for clinical management. JAMA 284, 223 (2000).
    • (2000) JAMA , vol.284 , pp. 223
    • Lederman, M.M.1    Valdez, H.2
  • 12
    • 0142092389 scopus 로고    scopus 로고
    • Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
    • Guadalupe, M. et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J. Virol. 77, 11708 (2003).
    • (2003) J. Virol , vol.77 , pp. 11708
    • Guadalupe, M.1
  • 13
    • 33845904393 scopus 로고    scopus 로고
    • Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection
    • Mehandru, S. et al. Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS Med. 3, e484 (2006).
    • (2006) PLoS Med , vol.3
    • Mehandru, S.1
  • 14
    • 40549092339 scopus 로고    scopus 로고
    • Persistence of HIV in Gut-associated lymphoid tissue despite long-term antiretroviral therapy
    • Chun, T.W. et al. Persistence of HIV in Gut-associated lymphoid tissue despite long-term antiretroviral therapy. J. Infect. Dis. 197, 714 (2008).
    • (2008) J. Infect. Dis , vol.197 , pp. 714
    • Chun, T.W.1
  • 15
    • 34147108762 scopus 로고    scopus 로고
    • Pathogenesis of HIV in the gastrointestinal tract
    • Dandekar, S. Pathogenesis of HIV in the gastrointestinal tract. Curr. HIV/AIDS Rep. 4, 10 (2007).
    • (2007) Curr. HIV/AIDS Rep , vol.4 , Issue.1 , pp. 10-15
    • Dandekar, S.1
  • 16
    • 22244451393 scopus 로고    scopus 로고
    • Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors
    • Sankaran, S. et al. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc. Natl. Acad. Sci. USA 102 9860 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 9860
    • Sankaran, S.1
  • 17
    • 44649201289 scopus 로고    scopus 로고
    • HIV infection and the gastrointestinal immune system
    • Brenchley, J.M. & Douek, D.C. HIV infection and the gastrointestinal immune system. Mucosal. Immunol. 1, 23 (2007).
    • (2007) Mucosal. Immunol , vol.1 , pp. 23
    • Brenchley, J.M.1    Douek, D.C.2
  • 18
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi, J.V. et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J. Infect. Dis. 179, 859 (1999).
    • (1999) J. Infect. Dis , vol.179 , pp. 859
    • Giorgi, J.V.1
  • 19
    • 0041327667 scopus 로고    scopus 로고
    • Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    • Hazenberg, M.D. et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 17, 1881 (2003).
    • (2003) AIDS , vol.17 , pp. 1881
    • Hazenberg, M.D.1
  • 20
    • 39849096860 scopus 로고    scopus 로고
    • Immune activation and AIDS pathogenesis
    • Sodora, D.L. & Silvestri, G. Immune activation and AIDS pathogenesis. AIDS 22, 439 (2008).
    • (2008) AIDS , vol.22 , pp. 439
    • Sodora, D.L.1    Silvestri, G.2
  • 21
    • 3543098686 scopus 로고    scopus 로고
    • CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific 1 cell immune responses in vitro and are associated with favorable clinical markers of disease status
    • Kinter, A.L. et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific 1 cell immune responses in vitro and are associated with favorable clinical markers of disease status. J. Exp. Med. 200, 331 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 331
    • Kinter, A.L.1
  • 22
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid, Y. & Rouse, B.T. Natural regulatory T cells in infectious disease. Nat. immunol. 6, 353 (2005).
    • (2005) Nat. immunol , vol.6 , pp. 353
    • Belkaid, Y.1    Rouse, B.T.2
  • 23
    • 0033559648 scopus 로고    scopus 로고
    • Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
    • Jin, X. et al. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189, 991 (1999).
    • (1999) J. Exp. Med , vol.189 , pp. 991
    • Jin, X.1
  • 24
    • 33846101731 scopus 로고    scopus 로고
    • CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    • Kiepiela, P. et al. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13, 46 (2007).
    • (2007) Nat. Med , vol.13 , pp. 46
    • Kiepiela, P.1
  • 25
    • 0031664158 scopus 로고    scopus 로고
    • Longitudinal analysis of human immunodeficiency virus type 1 -specific cytotoxic T lymphocyte responses: A predominant gag-specific response is associated with nonprogressive infection
    • Pontesilli, O. et al. Longitudinal analysis of human immunodeficiency virus type 1 -specific cytotoxic T lymphocyte responses: A predominant gag-specific response is associated with nonprogressive infection. J. Infect. Dis. 178, 1008 (1998).
    • (1998) J. Infect. Dis , vol.178 , pp. 1008
    • Pontesilli, O.1
  • 26
    • 0038033158 scopus 로고    scopus 로고
    • Trafficking of human immunodeficiency virus type 1-specific CD8(+) T cells to Gut-associated lymphoid tissue during chronic infection
    • Shacklett, B.L. et al. Trafficking of human immunodeficiency virus type 1-specific CD8(+) T cells to Gut-associated lymphoid tissue during chronic infection. J. Virol. 77, 5621 (2003),
    • (2003) J. Virol , vol.77 , pp. 5621
    • Shacklett, B.L.1
  • 27
    • 33750320502 scopus 로고    scopus 로고
    • Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART
    • Epple, H.J. et al. Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 108, 3072 (2006).
    • (2006) Blood , vol.108 , pp. 3072
    • Epple, H.J.1
  • 28
    • 25844482131 scopus 로고    scopus 로고
    • Perils at mucosal front lines for HIV and SIV and their hosts
    • Haase, A.T. Perils at mucosal front lines for HIV and SIV and their hosts. Nat. Rev Immunol. 5, 783 (2005).
    • (2005) Nat. Rev Immunol , vol.5 , pp. 783
    • Haase, A.T.1
  • 29
    • 0043169683 scopus 로고    scopus 로고
    • High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection
    • George, M.D. et al. High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. Virology 312, 84 (2003).
    • (2003) Virology , vol.312 , pp. 84
    • George, M.D.1
  • 30
    • 33746791047 scopus 로고    scopus 로고
    • Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection
    • Guadalupe, M. et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J. Virol. 80, 8236 (2006).
    • (2006) J. Virol , vol.80 , pp. 8236
    • Guadalupe, M.1
  • 31
    • 0034630946 scopus 로고    scopus 로고
    • Characterization of HIV-1-specific cytotoxic T. lymphocytes expressing the mucosal lymphocyte integrin CD103 in rectal and duodenal lymphoid tissue of HIV-1-infected subjects
    • Shacklett, B.L. et al. Characterization of HIV-1-specific cytotoxic T. lymphocytes expressing the mucosal lymphocyte integrin CD103 in rectal and duodenal lymphoid tissue of HIV-1-infected subjects. Virology 270, 317 (2000).
    • (2000) Virology , vol.270 , pp. 317
    • Shacklett, B.L.1
  • 32
    • 0034622954 scopus 로고    scopus 로고
    • Quantification of HIV-1-specific T-cell responses at the mucosal cervicovaginal surface
    • Shacklett, B.L. et al. Quantification of HIV-1-specific T-cell responses at the mucosal cervicovaginal surface. AIDS 14, 1911 (2000).
    • (2000) AIDS , vol.14 , pp. 1911
    • Shacklett, B.L.1
  • 33
    • 0038205356 scopus 로고    scopus 로고
    • Quantitative ex vivo analysis of functional virus-specific CD8T lymphocytes in the blood and genital tract of HIV-infected women
    • Kaul, R. et al. Quantitative ex vivo analysis of functional virus-specific CD8T lymphocytes in the blood and genital tract of HIV-infected women. AIDS 17, 1139 (2003).
    • (2003) AIDS , vol.17 , pp. 1139
    • Kaul, R.1
  • 34
    • 85185150547 scopus 로고    scopus 로고
    • Shetn, P.M. et al. HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding. J. Immunol. 175, 4789 (2005). 35 Quayle, A.J. et al. Detection of HIV-1-specific CTLs in the semen of HIV infected individuals. J. Immunol. 161, 4406 (1998).
    • Shetn, P.M. et al. HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding. J. Immunol. 175, 4789 (2005). 35 Quayle, A.J. et al. Detection of HIV-1-specific CTLs in the semen of HIV infected individuals. J. Immunol. 161, 4406 (1998).
  • 35
    • 0035077083 scopus 로고    scopus 로고
    • High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: Evidence for impaired CTL effector function
    • Kostense, S. et al. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: Evidence for impaired CTL effector function. Eur. J. Immunol. 31, 677 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 677
    • Kostense, S.1
  • 36
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun, T.W. et al. Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J. Exp. Med. 188, 83 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 83
    • Chun, T.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.