Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 1, 2016, Pages L40-L49

  Afolayan, Adeleye J ^a   Eis, Annie ^a   Alexander, Maxwell ^a   Michalkiewicz, Teresa ^a   Teng, Ru Jeng ^a   Lakshminrusimha, Satyan ^b   Konduri, Girija G ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Biogenesis; ENOS; Mitochondria; Oxidative stress; SOD2

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; DELTANONOATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOCHONDRIAL DNA; NITRIC OXIDE; NITRIC OXIDE DONOR; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE 2; SIRTUIN 1; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

AIRWAY PRESSURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTERY CONSTRICTION; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DUCTUS ARTERIOSUS; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FEMALE; FETUS; GENE DOSAGE; GENE EXPRESSION; GENE SILENCING; HYPEROXIA; LUNG PARENCHYMA; MITOCHONDRIAL BIOGENESIS; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN BREATHING; OXYGENATION; PERSISTENT PULMONARY HYPERTENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; RESPIRATORY CHAIN; WEANING; ANIMAL; IMMUNOLOGY; METABOLISM; MITOCHONDRION; NEWBORN; PREGNANCY; PULMONARY HYPERTENSION; SHEEP;

ANIMALS; ANIMALS, NEWBORN; ENDOTHELIAL CELLS; FEMALE; FETUS; HYPERTENSION, PULMONARY; MITOCHONDRIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PERSISTENT FETAL CIRCULATION SYNDROME; PREGNANCY; SHEEP;

EID: 84953297007     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00392.2014     Document Type: Article

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