Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt. Calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex

Journal of Biological Chemistry

Volumn 278, Issue 33, 2003, Pages 30821-30827

  Takahashi, Satoru ^b   Mendelsohn, Michael E ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; CELL CULTURE; ENZYME KINETICS; GROWTH KINETICS;

PHOSPHORYALTION;

PROTEINS;

CALCIUM ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; NITRIC OXIDE SYNTHASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AORTA; CALCIUM; CATTLE; CELLS, CULTURED; DRUG SYNERGISM; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HSP90 HEAT-SHOCK PROTEINS; HYPOGLYCEMIC AGENTS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; BOVINAE;

EID: 0043234527     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304471200     Document Type: Article

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