A cell-based phenotypic assay to identify cardioprotective agents

Circulation Research

Volumn 110, Issue 7, 2012, Pages 948-957

  Guo, Stephanie ^a   Olm Shipman, Adam ^b   Walters, Andrew ^a   Urciuoli, William R ^b   Devito, Stefanie ^b   Nadtochiy, Sergiy M ^b   Wojtovich, Andrew P ^b   Brookes, Paul S ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

cell culture; chemical screen; library; metabolism; myocardial infarction; myocardial ischemia; stroke

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 7 HYDROXYFLAVONE; ADENOSINE; APIIN; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CLORSULON; CLOXIQUINE; COMPACTIN; CYCLOSPORIN A; DIAZOXIDE; DIOXYBENZONE; LINOLEIC ACID; METHAPYRILENE; OLEIC ACID; PROPOXUR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CELL ASSAY; CELL DEATH; CONTROLLED STUDY; DIAGNOSTIC VALUE; GAS FLOW; GENOTYPING TECHNIQUE; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; ISOLATED HEART; MALE; MOLECULAR LIBRARY; NONHUMAN; OXYGEN TENSION; PH MEASUREMENT; PHENOTYPE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RESPIROMETRY; VALIDATION STUDY;

ANIMALS; CARDIOTONIC AGENTS; CELL DEATH; CELL LINE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN-ION CONCENTRATION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 84859432015     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.263715     Document Type: Article

References (54)

1. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics: 2011 update: a report from the American Heart Association. Circulation. 2011;123:e18-e209.
2. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74:1124-1136. (Pubitemid 17174962)
3. Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz W, Weichert A, Scholkens BA. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res. 1995;29:260-268.
4. Jain D, Dasgupta P, Hughes LO, Lahiri A, Raftery EB. Ranolazine (RS-43285): a preliminary study of a new anti-anginal agent with selective effect on ischaemic myocardium. Eur J Clin Pharmacol. 1990;38:111-114. (Pubitemid 20097312)
5. Griffiths EJ, Halestrap AP. Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. J Mol Cell Cardiol. 1993;25:1461-1469. (Pubitemid 24049454)
6. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159-163. (Pubitemid 15192863)
7. Swain JL, Hines JJ, Sabina RL, Holmes EW. Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis. Circ Res. 1982;51:102-105. (Pubitemid 12092395)
8. Shimshak TM, Preuss KC, Gross GJ, Brooks HL, Warltier DC. Recovery of contractile function in post-ischaemic reperfused myocardium of conscious dogs: influence of nicorandil, a new antianginal agent. Cardiovasc Res. 1986;20:621-626. (Pubitemid 16053587)
9. Pagel PS, Hettrick DA, Lowe D, Tessmer JP, Warltier DC. Desflurane and isoflurane exert modest beneficial actions on left ventricular diastolic function during myocardial ischemia in dogs. Anesthesiology. 1995;83: 1021-1035.
10. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest. 2005;115:1232-1240. (Pubitemid 40629041)
11. Chowdrey HS, Curtis MJ, Hearse DJ. Effects of atrial natriuretic peptide on ischaemia-induced arrhythmias in the rat heart: arrhythmogen or endogenous antiarrhythmic agent? J Cardiovasc Pharmacol. 1989;13:451-454. (Pubitemid 19068351)
12. Downey JM, Cohen MV. Why do we still not have cardioprotective drugs? Circ J. 2009;73:1171-1177.
13. Tompkins AJ, Burwell LS, Digerness SB, Zaragoza C, Holman WL, Brookes PS. Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition. Biochim Biophys Acta. 2006;1762:223-231. (Pubitemid 43006028)
14. Nadtochiy SM, Burwell LS, Ingraham CA, Spencer CM, Friedman AE, Pinkert CA, Brookes PS. In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine. J Mol Cell Cardiol. 2009;46:960-968.
15. Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, Brand MD. Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem. 2009;81:6868-6878.
16. Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation. 1991;84:350-356.
17. Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ. Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+channels: possible mechanism of cardioprotection. Circ Res. 1997;81:1072-1082. (Pubitemid 27514958)
18. Brennan JP, Southworth R, Medina RA, Davidson SM, Duchen MR, Shattock MJ. Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Cardiovasc Res. 2006;72:313-321. (Pubitemid 44511914)
19. Nadtochiy SM, Zhu Q, Urciuoli W, Rafikov R, Black SM, Brookes PS. Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1. J Biol Chem. 2012;287:3573-3580.
20. Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 2005;434:658-662. (Pubitemid 40488559)
21. Kainkaryam RM, Woolf PJ. Pooling in high-throughput drug screening. Curr Opin Drug Discov Devel. 2009;12:339-350.
22. Lundholt BK, Scudder KM, Pagliaro L. A simple technique for reducing edge effect in cell-based assays. J Biomol Screen. 2003;8:566-570.
23. Ghose AK, Viswanadhan VN, Wendoloski JJ. A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery, 1: a qualitative and quantitative characterization of known drug databases. J Comb Chem. 1999;1:55-68.
24. Gouras GK, Beal MF. Metal chelator decreases Alzheimer beta-amyloid plaques. Neuron. 2001;30:641-642. (Pubitemid 32607325)
25. Park MH, Lee SJ, Byun HR, Kim Y, Oh YJ, Koh JY, Hwang JJ. Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore. Neurobiol Dis. 2011;42:242-251.
26. Gottlieb RA, Finley KD, Mentzer RM Jr. Cardioprotection requires taking out the trash. Basic Res Cardiol. 2009;104:169-180.
27. Valen G, Kaszaki J, Szabo I, Nagy S, Vaage J. Histamine release and its effects in ischaemia-reperfusion injury of the isolated rat heart. Acta Physiol Scand. 1994;150:413-424. (Pubitemid 24231183)
28. Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. Nutrientsensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol. 2010;28:249-255.
29. Amin-Hanjani S, Stagliano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke. 2001;32:980-986.
30. Scalia R, Gooszen ME, Jones SP, Hoffmeyer M, Rimmer DM III, Trocha SD, Huang PL, Smith MB, Lefer AM, Lefer DJ. Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice. Circulation. 2001;103:2598-2603. (Pubitemid 32521971)
31. Bergmann MW, Rechner C, Freund C, Baurand A, El JA, Dietz R. Statins inhibit reoxygenation-induced cardiomyocyte apoptosis: role for glycogen synthase kinase 3beta and transcription factor beta-catenin. J Mol Cell Cardiol. 2004;37:681-690. (Pubitemid 39194560)
32. Szarszoi O, Maly J, Ostadal P, Netuka I, Besik J, Kolar F, Ostadal B. Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart. Physiol Res. 2008;57:793-796.
33. Lefer AM, Campbell B, Shin YK, Scalia R, Hayward R, Lefer DJ. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. Circulation. 1999;100:178-184. (Pubitemid 29330017)
34. Efthymiou CA, Mocanu MM, Yellon DM. Atorvastatin and myocardial reperfusion injury: new pleiotropic effect implicating multiple prosurvival signaling. J Cardiovasc Pharmacol. 2005;45:247-252. (Pubitemid 40328147)
35. D'Annunzio V, Donato M, Erni L, Miksztowicz V, Buchholz B, Carrion CL, Schreier L, Wikinski R, Gelpi RJ, Berg G, Basso N. Rosuvastatin given during reperfusion decreases infarct size and inhibits matrix metalloproteinase-2 activity in normocholesterolemic and hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 2009;53:137-144.
36. Schulman MD, Ostlind DA, Valentino D. Mechanism of action of MK-401 against Fasciola hepatica: inhibition of phosphoglycerate kinase. Mol Biochem Parasitol. 1982;5:133-145.
37. Priel A, Silberberg SD. Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol. 2004;123:281-293. (Pubitemid 38282976)
38. Hu B, Mei QB, Yao XJ, Smith E, Barry WH, Liang BT. A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor. FASEB J. 2001;15:2739-2741.
39. Calderone V, Chericoni S, Martinelli C, Testai L, Nardi A, Morelli I, Breschi MC, Martinotti E. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 2004;370:290-298. (Pubitemid 40063828)
40. Redel A, Lange M, Jazbutyte V, Lotz C, Smul TM, Roewer N, Kehl F. Activation of mitochondrial large-conductance calcium-activated K+channels via protein kinase A mediates desflurane-induced preconditioning. Anesth Analg. 2008;106:384-391. (Pubitemid 351156658)
41. Cao CM, Xia Q, Gao Q, Chen M, Wong TM. Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning. J Pharmacol Exp Ther. 2005;312:644-650. (Pubitemid 40189562)
42. Whittle SR, Turner AJ. Anti-convulsants and brain aldehyde metabolism: inhibitory characteristics of ox brain aldehyde reductase. Biochem Pharmacol. 1981;30:1191-1196. (Pubitemid 11117807)
43. Macias AT, Hernandez RJ, Mehta AK, MacKerell AD Jr, Ticku MK, Coop A. 3-Chloropropanoic acid (UMB66): a ligand for the gammahydroxybutyric acid receptor lacking a 4-hydroxyl group. Bioorg Med Chem. 2004;12:1643-1647. (Pubitemid 38340761)
44. Lee JE, Safe S. 3,4-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells. Toxicol Sci. 2000;58:235-242. (Pubitemid 32042422)
45. Barrowman MM, Marriner SE, Bogan JA. The fumarate reductase system as a site of anthelmintic attack in Ascaris suum. Biosci Rep. 1984;4: 879-883. (Pubitemid 15178108)
46. Wojtovich AP, Brookes PS. The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Res Cardiol. 2009;104:121-129.
47. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008;321:1493-1495.
48. Burwell LS, Nadtochiy SM, Brookes PS. Cardioprotection by metabolic shut-down and gradual wake-up. J Mol Cell Cardiol. 2009;46:804-810.
49. Karmazyn M. The role of the myocardial sodium-hydrogen exchanger in mediating ischemic and reperfusion injury: from amiloride to cariporide. Ann N Y Acad Sci. 1999;874:326-334. (Pubitemid 29351954)
50. Hausenloy DJ, Tsang A, Yellon DM. The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med. 2005;15:69-75. (Pubitemid 40693390)
51. Yamanaka N, Imanari T, Tamura Z, Yagi K. Uncoupling of oxidative phosphorylation of rat liver mitochondria by chinoform. J Biochem. 1973;73:993-998.
52. Futagawa H, Kakinuma Y, Takahashi H. The role of cholinergic and noncholinergic mechanisms in the cardiorespiratory failure produced by N-methylcarbamate cholinesterase inhibitors in rabbits. Toxicol Appl Pharmacol. 2000;165:27-36. (Pubitemid 30346457)
53. Riou B, Ruel P, Hanouz JL, Langeron O, Lecarpentier Y, Viars P. In vitro effects of eltanolone on rat myocardium. Anesthesiology. 1995;83:792-798.
54. Sear JW, Prys-Roberts C, Dye J. Cardiovascular studies during induction with minaxolone. Acta Anaesth Belg. 1979;30(Suppl):161-168. (Pubitemid 10084420)