Structure and energetics of allosteric regulation of HCN2 ion channels by cyclic nucleotides

Journal of Biological Chemistry

Volumn 291, Issue 1, 2016, Pages 371-381

  DeBerg, Hannah A ^a   Brzovic, Peter S ^a   Flynn, Galen E ^a   Zagotta, William N ^a   Stoll, Stefan ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; BIOLOGICAL MEMBRANES; BRAIN; CHEMICAL ACTIVATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHYSIOLOGY; MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; PARAMAGNETIC RESONANCE; RECONFIGURABLE HARDWARE;

ALLOSTERIC MECHANISMS; ALLOSTERIC REGULATION; CONFORMATIONAL CHANGE; CYCLIC NUCLEOTIDE BINDING DOMAIN; ELECTRICAL ACTIVITIES; ELECTRON PARAMAGNETIC RESONANCES (EPR); NUCLEAR MAGNETIC RESONANCE(NMR); STRUCTURE AND ENERGETICS;

NUCLEOTIDES;

CYCLIC AMP; CYCLIC CMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; AMINO ACID; HCN2 PROTEIN, MOUSE; POTASSIUM CHANNEL;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ELECTROPHYSIOLOGY; FEMALE; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; ANIMAL; ANISOTROPY; CHEMISTRY; DRUG EFFECTS; ELECTRON; FLUORESCENCE; METABOLISM; MOLECULAR MODEL; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

ALLOSTERIC REGULATION; AMINO ACIDS; ANIMALS; ANISOTROPY; ELECTRONS; FLUORESCENCE; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; ION CHANNEL GATING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; NUCLEOTIDES, CYCLIC; POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS;

EID: 84952889325     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.696450     Document Type: Article

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