Movement of the C-helix during the gating of cyclic nucleotide-gated channels

Biophysical Journal

Volumn 83, Issue 6, 2002, Pages 3283-3295

  Mazzolini, Monica ^a   Punta, Marco ^a   Torre, Vincent ^a  

^a SISSA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 TRIMETHYLAMMONIOETHYLMETHANE THIOSULFONATE; ASPARTIC ACID; CADMIUM; COPPER PHENANTHROLINE; CYCLIC GMP; CYCLIC NUCLEOTIDE; LEUCINE; OXIDIZING AGENT; PHENANTHROLINE DERIVATIVE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; CATTLE; CHANNEL GATING; CONTROLLED STUDY; MUTATION; NONHUMAN;

BOS TAURUS; BOVINAE;

EID: 0036924162     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75329-0     Document Type: Article

References (56)

1. Akabas, M. H., D. A. Stauffer, M. Xu, and A. Karlin. 1992. Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science. 258:307-310.
2. Altenhofen, W., J. Ludwig, E. Eismann, W. Kraus, W. Bönigk, and U. B. Kaupp. 1991. Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium. Proc. Natl. Acad. Sci. U.S.A. 88:9868-9872.
3. Becchetti, A., K. Gamel, and V. Torre. 1999. Cyclic nucleotide-gated channels. Pore topology studied through the accessibility of receptor cysteines. J. Gen. Physiol. 114:377-392.
4. 2+ of substituted cysteine residues within the P-loop. Pflügers Arch. 440:556-565.
5. Beniath, J. P., G. F. Toaselli, and E. Marban. 1996. Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 93:7373-7396.
6. Berman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. 2000. The Protein Data Bank. Nucleic Acids Res. 28:235-242.
7. Biel, M., X. Zong, and F. Hofmann. 1995. Molecular diversity of cyclic nucleotide-gated cation channels. Naunyn Schmiedebergs Arch. Pharmacol. 353:1-10.
8. Bradley, J., S. Frings, K.-W. Yau, and R. Randall. 2001. Nomenclature for ion channel subunits. Science. 294:2095-2096.
9. Bucossi, G., M. Nizzari, and V. Torre. 1997. Single-channel properties of ionic channels by cyclic nucleotides. Biophys. J. 72:1165-1181.
10. Careaga, C. L., and J. J. Falke. 1992. Thermal motions of surface alphahelices in the D-galactose chemosensory receptor. J. Mol. Biol. 226:1219-1235.
11. Cook, N. J., W. Hanke, and U. B. Kaupp. 1987. Identification, purification, and functional reconstitution of the cyclic GMP-dependent channel from rod photoreceptors. Proc. Natl. Acad. Sci. U.S.A. 84:585-589.
12. Ermler, U., W. Grabarse, S. Shima, M. Goubeaud, and R. K. Thauer. 1998. Active sites of transition metals enzymes with a focus on nickel. Curr. Opin. Struct. Biol. 8:749-758.
13. Dhallan, R. S., K. W. Yau, K. A. Schrader, and R. R. Reed. 1990. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 347:18-27.
14. Finn, J. T., M. E. Grunwald, and K-W. Yau. 1996. Cyclic nucleotide-gated ion channels: An extended family with diverse functions. Annu. Rev. Physiol. 58:395-426.
15. Glusker, J. P. 1991. Structural aspects of metal liganding to functional groups in proteins. Adv. Protein Chem. 42:1-76.
16. Gordon, S. E., and W. N. Zagotta. 1995. Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels. Neuron. 14:857-864.
17. Hamill, O. P., A. Martin, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85-100.
18. Hastrup, H., A. Karlin, and J. A. Javvitch. 2001. Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment. PNAS. 98:10055-10060.
19. He, Y., M. L. Ruiz, and J. W. Karpen. 2000. Constraining the subunit order of rod cyclic nucleotide-gated channels reveals a diagonal arrangement of like subunits. Proc. Natl. Acad. Sci. U.S.A. 97:895-900.
20. Henn, D. K., A. Baumann, and U. B. Kaupp. 1995. Probing the transmembrane topology of cyclic nucleotide-gated ion channels with a gene fusion approach. Proc. Natl. Acad. Sci. U.S.A. 92:7425-7429.
21. Higgins, M. K., D. Weitz, T. Warne, G. F. Schertler, and U. B. Kaupp. 2002. Molecular architecture of a retinal cGMP-gated channels: The arrangement of a cytoplasmic domain. EMBO J. 21:2087-2094.
22. Holmgren, M., K. S. Shin, and G. Yellen. 1998. The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge. Neuron. 21:617-621.
23. Johnson, J. P., and W. N. Zagotta. 2001. Rotation movement during cyclic nucleotide-gated channel opening. Nature. 412:917-921.
24. Karlin, A., and M. H. Akabas. 1998. Substituted-cysteine accessibility method. Methods Enzymol. 293:123-145.
25. Kaupp, U. B. 1995. Family of cyclic nucleotide gated ion channels. Curr. Opin. Neurobiol. 5:434-442.
26. Kaupp, U. B., T. Niidome, T. Tanabe, S. Terada, W. Bönigk, W. Stühmer, N. J. Cook, K. Kangawa, H. Matsuo, T. Hirose, T. Miyata, and S. Numa. 1989. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature. 342:762-766.
27. Körschen, H. G., M. Illing, R. Seifert, F. Sesti, A. Williams, S. Gotzes, C. Colville, F. Müller, A. Dosé, M. Godde, L. Molday, U. B. Kaupp, and R. S. Molday. 1995. A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Neuron. 15:627-636.
28. Krovetz, H. S., H. M. A. VanDongen, and A. M. J. VanDongen. 1997. Atomic distances estimates from disulfides and high-affinity metal-binding sites in a K channel pore. Biophys. J. 72:117-126.
29. Li, J., and H. A. Lester. 1999. Functional roles of aromatic residues in the ligand-binding domain of cyclic nucleotide-gated channels. Mol. Pharmacol. 55:873-882.
30. Liu, D. T., G. R. Tibbs, and S. A. Siegelbaum. 1996. Subunit stoichiometry of cyclic nucleotide-gated channels and effects of subunit order on channel function. Neuron. 16:983-990.
31. Loussouarn, G., E. N. Makhina, T. Rose, and C. G. Nichols. 2000. Structure and dynamic of the pore of inwardly rectifying Katp channels. J. Biol. Chem. 275:1137-1144.
32. Maroney, M. J. 1999. Structure/function relationships in nickel metallobiochemistry. Curr. Opin. Chem. Biol. 3:188-199.
33. Matulef, K., G. E. Flynn, and W. N. Zagotta. 1999. Molecular rearrangements in the ligand-binding domain of cyclic nucleotide-gated channels. Neuron. 24:443-452.
34. Matulef, K., and W. N. Zagotta. 2002. Probing the quaternary structure of cyclic nucleotide-gated channels. Biophys. J. 82:276a. (Abstr.).
35. Menini, A. 1995. Cyclic nucleotide-gated channels in visual and olfactory transduction. Biophys. Chem. 55:185-196.
36. Miledi, R., I. Parker, and H. P. Zhu. 1984. Extracellular ions and excitation-contraction coupling in frog twitch muscle fibers. J. Physiol. 351:687-710.
37. Molday, R. S., L. L. Molday, A. Dose, I. Clark-Lewis, M. Illing, N. J. Cook, E. F. Eismann, and U. B. Kaupp. 1991. The cGMP-gated channels of the rod photoreceptor cell characterization and orientation of the amino terminus. J. Biol. Chem. 266:21917-21922.
38. Nakamura, T., and G. H. Gold. 1987. A cyclic nucleotide-gated conductance in olfactory receptor cilia. Nature. 325:442-444.
39. Nizzari, M., F. Sesti, M. T. Giraudo, C. Virginio, A. Cattaneo, and V. Torre. 1993. Single-channel properties of cloned cGMP-activated channels from retinal rods. Proc. R. Soc. Lond. 254:69-74.
40. Passner, J. M., S. C. Schultz, and T. A. Steitz. 2000. Modeling the cAMP-induced allosteric transition using the crystal structure of CAP-cAMP at 2.1 A resolution. J. Mol. Biol. 304:847-859.
41. Ponta, M., A. Cavalli, V. Torre. and P. Carloni. 2002. Molecular modeling studies on CNG channel from bovine retinal rod: A structural model of the cyclic nucleotide binding domain. Proteins Struct. Funct. Genet. In press.
42. Roncaglia, P., and A. Becchetti. 2001. Cyclic-nucleotide-gated channels: Pore topology in desensitizing E19A mutants. Pflugers Arch. 441:772-780.
43. Scott, S. P., and J. C. Tanaka. 1998. Three residues predicted by molecular modeling to interact with the purine moiety alter ligand binding and channel gating in cyclic nucleotide-gated channels. Biochemistry. 37:17239-17252.
44. Scott, S. P., I. T. Weber, R. W. Harrison, J. Carey, J. C., and Tanaka. 2001. A functioning chimera of the cyclic nucleotide-binding domain from the bovine retinal rod ion channel and the DNA-binding domain from catabolite gene-activating protein. Biochemistry. 40:7464-7473.
45. Sesti, F., E. Eismann, U. B. Kaupp, M. Nizzari, and V. Torre. 1995. The multi-ion nature of the cGMP-gated channel from vertebrate rods. J. Physiol. 487:17-36.
46. Shammat, I. M., and S. E. Gordon. 1999. Stoichiometry and arrangement of subunits in rod cyclic nucleotide-gated channels. Neuron. 23:809-819.
47. Srinivasan, N., R. Sowdhamini, C. Ramakrishnan, and P. Balaram. 1989. Conformations of disulfide bridges in proteins. Int. J. Peptide Res. 36:147-155.
48. Su, Y., W. R. G. Dostmann, F. W. Herberg, K. Durick, N. H. Xuong, L. Ten Eyck, S. S. Taylor, and K. I. Varughese. 1995. Regulatory subunit of protein kinase A: Structure of deletion mutant with cAMP binding domains. Science. 269:807-813.
49. Sun, Z. P., M. H. Akabas, E. H. Goulding, A. Karlin, and S. A. Siegelbaum. 1996. Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating. Neuron. 16:141-149.
50. Tibbs, G. R., D. T. Liu, B. G. Leypold, and S. A. Siegelbaum. 1998. A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site. J. Biol. Chem. 273:4497-4505.
51. Varnum, M. D., K. D. Black, and W. N. Zagotta. 1995. Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels. Neuron. 15:619-625.
52. Weber, I. T., and T. A. Steitz. 1987. Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution. J. Mol. Biol. 198:311-326.
53. Yau, K. W., and D. A. Baylor. 1989. Cyclic GMP-activated conductance of retinal photoreceptor cells. Annu. Rev. Neurosci. 12:289-327.
54. Zagotta, W. N. 1996. Molecular mechanisms of cyclic nucleotide-gated channels. J. Bioenerg. Biomembr. 28:269-278.
55. Zagotta, W. N., and S. A. Siegelbaum. 1996. Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 19:235-263.
56. Zimmerman, A. L. 1995. Cyclic nucleotide-gated channels. Curr. Opin. Neurobiol. 5:296-303.