Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ

Biochemical and Biophysical Research Communications

Volumn 466, Issue 3, 2015, Pages 578-584

  Chen, Chia Ling ^a   Chiang, Tzu Hui ^b   Tseng, Po Chun ^b   Wang, Yu Chih ^c   Lin, Chiou Feng ^c,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

IFN ; PTEN; ROS; SHP2; Signaling

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON REGULATORY FACTOR 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; PTEN PROTEIN, HUMAN; PTPN11 PROTEIN, HUMAN;

A549 CELL LINE; ARTICLE; AS2 CELL LINE; CELL DAMAGE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CANCER CELL LINE; LUNG CARCINOGENESIS; PC14PE6 CELL LINE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ADENOCARCINOMA; ANTAGONISTS AND INHIBITORS; DEFICIENCY; GENETICS; IMMUNOLOGY; LUNG TUMOR; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR ESCAPE;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERFERON-GAMMA; LUNG NEOPLASMS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PTEN PHOSPHOHYDROLASE; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR ESCAPE;

EID: 84952639111     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.09.085     Document Type: Article

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