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Volumn 1628, Issue , 2015, Pages 343-350

Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS)

Author keywords

ALS; Neuroprotection; Stem cells; Transplantation

Indexed keywords

GLUTAMATE TRANSPORTER; NEUROTROPHIC FACTOR; RILUZOLE;

EID: 84952638866     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.06.035     Document Type: Review
Times cited : (37)

References (59)
  • 1
    • 84886804048 scopus 로고    scopus 로고
    • Tracking immune cells in vivo using magnetic resonance imaging
    • E.T. Ahrens, and J.W. Bulte Tracking immune cells in vivo using magnetic resonance imaging Nat. Rev. Immunol. 13 2013 755 763
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 755-763
    • Ahrens, E.T.1    Bulte, J.W.2
  • 2
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • D.R. Beers, and et al. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. USA 103 2006 16021 16026
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16021-16026
    • Beers, D.R.1
  • 3
    • 0028097839 scopus 로고
    • A controlled trial of Riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
    • G. Bensimon, L. Lacomblez, and V Meininger A controlled trial of Riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group N. Engl. J. Med. 330 1994 585 591
    • (1994) N. Engl. J. Med. , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 4
    • 33744798774 scopus 로고    scopus 로고
    • Onset and progression in inherited ALS determined by motor neurons and microglia
    • S. Boillee, and et al. Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 2006 1389 1392
    • (2006) Science , vol.312 , pp. 1389-1392
    • Boillee, S.1
  • 5
    • 9244244699 scopus 로고    scopus 로고
    • Iron oxide MR contrast agents for molecular and cellular imaging
    • J.W. Bulte, and D.L. Kraitchman Iron oxide MR contrast agents for molecular and cellular imaging NMR Biomed. 17 2004 484 499
    • (2004) NMR Biomed. , vol.17 , pp. 484-499
    • Bulte, J.W.1    Kraitchman, D.L.2
  • 6
    • 84902134581 scopus 로고    scopus 로고
    • Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons
    • H. Chen, and et al. Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons Cell Stem Cell 14 2014 796 809
    • (2014) Cell Stem Cell , vol.14 , pp. 796-809
    • Chen, H.1
  • 7
    • 34249674380 scopus 로고    scopus 로고
    • Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model
    • S. Corti, and et al. Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model Brain 130 2007 1289 1305
    • (2007) Brain , vol.130 , pp. 1289-1305
    • Corti, S.1
  • 8
    • 80054832080 scopus 로고    scopus 로고
    • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
    • M. DeJesus-Hernandez, and et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS Neuron 72 2011 245 256
    • (2011) Neuron , vol.72 , pp. 245-256
    • DeJesus-Hernandez, M.1
  • 9
    • 34247473080 scopus 로고    scopus 로고
    • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
    • F.P. Di Giorgio, and et al. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat. Neurosci. 10 2007 608 614
    • (2007) Nat. Neurosci. , vol.10 , pp. 608-614
    • Di Giorgio, F.P.1
  • 10
    • 84897997188 scopus 로고    scopus 로고
    • Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes
    • E.L. Feldman, and et al. Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes Ann. Neurol. 75 2014 363 373
    • (2014) Ann. Neurol. , vol.75 , pp. 363-373
    • Feldman, E.L.1
  • 11
    • 84861919329 scopus 로고    scopus 로고
    • Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: Results of a phase i trial in 12 patients
    • J.D. Glass, and et al. Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients Stem Cells 30 2012 1144 1151
    • (2012) Stem Cells , vol.30 , pp. 1144-1151
    • Glass, J.D.1
  • 12
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
    • M.E. Gurney, and et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation Science 264 1994 1772 1775
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1
  • 13
    • 80052783545 scopus 로고    scopus 로고
    • Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
    • A.M. Haidet-Phillips, and et al. Astrocytes from familial and sporadic ALS patients are toxic to motor neurons Nat. Biotechnol. 29 2011 824 828
    • (2011) Nat. Biotechnol. , vol.29 , pp. 824-828
    • Haidet-Phillips, A.M.1
  • 14
    • 84920879541 scopus 로고    scopus 로고
    • Human glial progenitor engraftment and gene expression is independent of the ALS environment
    • A.M. Haidet-Phillips, and et al. Human glial progenitor engraftment and gene expression is independent of the ALS environment Exp. Neurol. 264C 2014 188 199
    • (2014) Exp. Neurol. , vol.264 C , pp. 188-199
    • Haidet-Phillips, A.M.1
  • 15
    • 70350167840 scopus 로고    scopus 로고
    • Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice
    • D.H. Hwang, and et al. Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice Gene Ther. 16 2009 1234 1244
    • (2009) Gene Ther. , vol.16 , pp. 1234-1244
    • Hwang, D.H.1
  • 16
    • 39849103473 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    • D. Jaarsma, and et al. Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice J. Neurosci. 28 2008 2075 2088
    • (2008) J. Neurosci. , vol.28 , pp. 2075-2088
    • Jaarsma, D.1
  • 17
    • 78449269355 scopus 로고    scopus 로고
    • NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration
    • S.H. Kang, and et al. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration Neuron 68 2010 668 681
    • (2010) Neuron , vol.68 , pp. 668-681
    • Kang, S.H.1
  • 18
    • 77957964299 scopus 로고    scopus 로고
    • Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    • D. Karussis, and et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis Arch. Neurol. 67 2010 1187 1194
    • (2010) Arch. Neurol. , vol.67 , pp. 1187-1194
    • Karussis, D.1
  • 19
    • 84914098789 scopus 로고    scopus 로고
    • Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1
    • E. Kiskinis, and et al. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1 Cell Stem Cell 14 2014 781 795
    • (2014) Cell Stem Cell , vol.14 , pp. 781-795
    • Kiskinis, E.1
  • 20
    • 18444381777 scopus 로고    scopus 로고
    • GDNF delivery using human neural progenitor cells in a rat model of ALS
    • S.M. Klein, and et al. GDNF delivery using human neural progenitor cells in a rat model of ALS Hum. Gene Ther. 16 2005 509 521
    • (2005) Hum. Gene Ther. , vol.16 , pp. 509-521
    • Klein, S.M.1
  • 21
    • 84924219720 scopus 로고    scopus 로고
    • Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice
    • T. Kondo, and et al. Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice Stem Cell Rep. 3 2014 242 249
    • (2014) Stem Cell Rep. , vol.3 , pp. 242-249
    • Kondo, T.1
  • 22
    • 54949126674 scopus 로고    scopus 로고
    • Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
    • A.C. Lepore, and et al. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease Nat. Neurosci. 11 2008 1294 1301
    • (2008) Nat. Neurosci. , vol.11 , pp. 1294-1301
    • Lepore, A.C.1
  • 23
    • 80053608707 scopus 로고    scopus 로고
    • Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS
    • A.C. Lepore, and et al. Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS PLoS One 6 2011 e25968
    • (2011) PLoS One , vol.6 , pp. e25968
    • Lepore, A.C.1
  • 24
    • 0037096354 scopus 로고    scopus 로고
    • Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease
    • M.M. Lino, C. Schneider, and P. Caroni Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease J. Neurosci. 22 2002 4825 4832
    • (2002) J. Neurosci. , vol.22 , pp. 4825-4832
    • Lino, M.M.1    Schneider, C.2    Caroni, P.3
  • 25
    • 75149132873 scopus 로고    scopus 로고
    • Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells
    • R. Lopez-Gonzalez, P. Kunckles, and I. Velasco Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells Cell Transplant. 18 2009 1171 1181
    • (2009) Cell Transplant. , vol.18 , pp. 1171-1181
    • Lopez-Gonzalez, R.1    Kunckles, P.2    Velasco, I.3
  • 26
    • 35848930793 scopus 로고    scopus 로고
    • Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice
    • L.J. Martin, and Z. Liu Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice J. Neuropathol. Exp. Neurol. 66 2007 1002 1018
    • (2007) J. Neuropathol. Exp. Neurol. , vol.66 , pp. 1002-1018
    • Martin, L.J.1    Liu, Z.2
  • 27
    • 34247475338 scopus 로고    scopus 로고
    • Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    • M. Nagai, and et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Nat. Neurosci. 10 2007 615 622
    • (2007) Nat. Neurosci. , vol.10 , pp. 615-622
    • Nagai, M.1
  • 28
    • 84875175026 scopus 로고    scopus 로고
    • Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis
    • N.L. Nichols, and et al. Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis Am. J. Respir. Crit. Care Med. 187 2013 535 542
    • (2013) Am. J. Respir. Crit. Care Med. , vol.187 , pp. 535-542
    • Nichols, N.L.1
  • 29
    • 78149467339 scopus 로고    scopus 로고
    • Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells
    • M. Nizzardo, and et al. Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells Cell Mol. Life Sci. 67 2010 3837 3847
    • (2010) Cell Mol. Life Sci. , vol.67 , pp. 3837-3847
    • Nizzardo, M.1
  • 30
    • 84895798799 scopus 로고    scopus 로고
    • Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model
    • M. Nizzardo, and et al. Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model Hum. Mol. Genet. 23 2014 342 354
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 342-354
    • Nizzardo, M.1
  • 31
    • 68049110630 scopus 로고    scopus 로고
    • Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice
    • S. Park, and et al. Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice Exp. Mol. Med. 41 2009 487 500
    • (2009) Exp. Mol. Med. , vol.41 , pp. 487-500
    • Park, S.1
  • 32
    • 79952070300 scopus 로고    scopus 로고
    • Programming embryonic stem cells to neuronal subtypes
    • M. Peljto, and H. Wichterle Programming embryonic stem cells to neuronal subtypes Curr. Opin. Neurobiol. 21 2011 43 51
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 43-51
    • Peljto, M.1    Wichterle, H.2
  • 33
    • 0035873076 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
    • A. Pramatarova, and et al. Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J. Neurosci. 21 2001 3369 3374
    • (2001) J. Neurosci. , vol.21 , pp. 3369-3374
    • Pramatarova, A.1
  • 34
    • 0031213730 scopus 로고    scopus 로고
    • Glial-restricted precursors are derived from multipotent neuroepithelial stem cells
    • M.S. Rao, and M. Mayer-Proschel Glial-restricted precursors are derived from multipotent neuroepithelial stem cells Dev. Biol. 188 1997 48 63
    • (1997) Dev. Biol. , vol.188 , pp. 48-63
    • Rao, M.S.1    Mayer-Proschel, M.2
  • 35
    • 0032584071 scopus 로고    scopus 로고
    • A tripotential glial precursor cell is present in the developing spinal cord
    • M.S. Rao, M. Noble, and M. Mayer-Proschel A tripotential glial precursor cell is present in the developing spinal cord Proc. Natl. Acad. Sci. USA 95 1998 3996 4001
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3996-4001
    • Rao, M.S.1    Noble, M.2    Mayer-Proschel, M.3
  • 36
    • 79551553440 scopus 로고    scopus 로고
    • Cervical multilevel intraspinal stem cell therapy: Assessment of surgical risks in Gottingen minipigs
    • B. Raore, and et al. Cervical multilevel intraspinal stem cell therapy: assessment of surgical risks in Gottingen minipigs Spine 36 2011 E164 E171
    • (2011) Spine , vol.36 , pp. E164-E171
    • Raore, B.1
  • 37
    • 84895508213 scopus 로고    scopus 로고
    • Necroptosis drives motor neuron death in models of both sporadic and familial ALS
    • D.B. Re, and et al. Necroptosis drives motor neuron death in models of both sporadic and familial ALS Neuron 81 2014 1001 1008
    • (2014) Neuron , vol.81 , pp. 1001-1008
    • Re, D.B.1
  • 38
    • 80054837386 scopus 로고    scopus 로고
    • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
    • A.E. Renton, and et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD Neuron 72 2011 257 268
    • (2011) Neuron , vol.72 , pp. 257-268
    • Renton, A.E.1
  • 39
    • 84926168917 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from ALS patients for disease modeling
    • J.P. Richard, and N.J. Maragakis Induced pluripotent stem cells from ALS patients for disease modeling Brain Res. 1607 2014 15 25
    • (2014) Brain Res. , vol.1607 , pp. 15-25
    • Richard, J.P.1    Maragakis, N.J.2
  • 40
    • 70349730271 scopus 로고    scopus 로고
    • Cervical spinal cord therapeutics delivery: Preclinical safety validation of a stabilized microinjection platform
    • discussion 761-2
    • J. Riley, and et al. Cervical spinal cord therapeutics delivery: preclinical safety validation of a stabilized microinjection platform Neurosurgery 65 2009 754 761 discussion 761-2
    • (2009) Neurosurgery , vol.65 , pp. 754-761
    • Riley, J.1
  • 41
    • 84929237446 scopus 로고    scopus 로고
    • Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: A phase i safety trial, technical note, and lumbar safety outcomes
    • discussion 416
    • J. Riley, and et al. Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I safety trial, technical note, and lumbar safety outcomes Neurosurgery 71 2012 405 416 discussion 416
    • (2012) Neurosurgery , vol.71 , pp. 405-416
    • Riley, J.1
  • 42
    • 84891836716 scopus 로고    scopus 로고
    • Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: A phase i trial, cervical microinjection, and final surgical safety outcomes
    • J. Riley, and et al. Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I trial, cervical microinjection, and final surgical safety outcomes Neurosurgery 74 2014 77 87
    • (2014) Neurosurgery , vol.74 , pp. 77-87
    • Riley, J.1
  • 43
    • 80955166181 scopus 로고    scopus 로고
    • Platform and cannula design improvements for spinal cord therapeutics delivery
    • J.P. Riley, and et al. Platform and cannula design improvements for spinal cord therapeutics delivery Neurosurgery 69 2011 147 155
    • (2011) Neurosurgery , vol.69 , pp. 147-155
    • Riley, J.P.1
  • 44
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • J.D. Rothstein, L.J. Martin, and R.W. Kuncl Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis N. Engl. J. Med. 326 1992 1464 1468
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 45
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • J.D. Rothstein, and et al. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann. Neurol. 38 1995 73 84
    • (1995) Ann. Neurol. , vol.38 , pp. 73-84
    • Rothstein, J.D.1
  • 46
    • 77952273950 scopus 로고    scopus 로고
    • Isolation, characterization and preclinical development of human glial-restricted progenitor cells for treatment of neurological disorders
    • R.W. Sandrock, and et al. Isolation, characterization and preclinical development of human glial-restricted progenitor cells for treatment of neurological disorders Regen. Med. 5 2010 381 394
    • (2010) Regen. Med. , vol.5 , pp. 381-394
    • Sandrock, R.W.1
  • 47
    • 37549065020 scopus 로고    scopus 로고
    • GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS
    • M. Suzuki, and et al. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS PLoS One 2 2007 e689
    • (2007) PLoS One , vol.2 , pp. e689
    • Suzuki, M.1
  • 48
    • 56749154435 scopus 로고    scopus 로고
    • Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS
    • M. Suzuki, and et al. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS Mol. Ther. 16 2008 2002 2010
    • (2008) Mol. Ther. , vol.16 , pp. 2002-2010
    • Suzuki, M.1
  • 49
    • 84924907889 scopus 로고    scopus 로고
    • Analysis of graft survival in a trial of stem cell transplant in ALS
    • T. Tadesse, and et al. Analysis of graft survival in a trial of stem cell transplant in ALS Ann. Clin. Transl. Neurol. 1 2014 900 908
    • (2014) Ann. Clin. Transl. Neurol. , vol.1 , pp. 900-908
    • Tadesse, T.1
  • 50
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 51
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • K. Takahashi, and et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 52
    • 84871497430 scopus 로고    scopus 로고
    • Multimodal actions of neural stem cells in a mouse model of ALS: A meta-analysis
    • Y.D. Teng, and et al. Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis Sci. Transl. Med. 4 2012 164 165
    • (2012) Sci. Transl. Med. , vol.4 , pp. 164-165
    • Teng, Y.D.1
  • 53
    • 84911408927 scopus 로고    scopus 로고
    • Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex
    • G.M. Thomsen, and et al. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex J. Neurosci. 34 2014 15587 15600
    • (2014) J. Neurosci. , vol.34 , pp. 15587-15600
    • Thomsen, G.M.1
  • 54
    • 84898034713 scopus 로고    scopus 로고
    • Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
    • B.J. Wainger, and et al. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons Cell Rep. 7 2014 1 11
    • (2014) Cell Rep. , vol.7 , pp. 1-11
    • Wainger, B.J.1
  • 55
    • 34548233140 scopus 로고    scopus 로고
    • Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    • Q. Xiao, and et al. Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia J. Neurochem. 102 2007 2008 2019
    • (2007) J. Neurochem. , vol.102 , pp. 2008-2019
    • Xiao, Q.1
  • 56
    • 33749872454 scopus 로고    scopus 로고
    • Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
    • L. Xu, and et al. Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats Transplantation 82 2006 865 875
    • (2006) Transplantation , vol.82 , pp. 865-875
    • Xu, L.1
  • 57
    • 79954421954 scopus 로고    scopus 로고
    • Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats
    • L. Xu, and et al. Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats Neurosci. Lett. 494 2011 222 226
    • (2011) Neurosci. Lett. , vol.494 , pp. 222-226
    • Xu, L.1
  • 58
    • 39749188753 scopus 로고    scopus 로고
    • Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    • K. Yamanaka, and et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Nat. Neurosci. 11 2008 251 253
    • (2008) Nat. Neurosci. , vol.11 , pp. 251-253
    • Yamanaka, K.1
  • 59
    • 33847663410 scopus 로고    scopus 로고
    • Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
    • J. Yan, and et al. Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord PLoS Med. 4 2007 e39
    • (2007) PLoS Med. , vol.4 , pp. e39
    • Yan, J.1


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