High-grade transformation of low-grade B-cell lymphoma

American Journal of Surgical Pathology

Volumn 40, Issue 1, 2016, Pages e1-e16

  Agbay, Rose Lou Marie C ^a   Loghavi, Sanam ^a   Medeiros, L Jeffrey ^a   Khoury, Joseph D ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

B cell lymphoma; DLBCL; Hodgkin; low grade; molecular; transformation

Indexed keywords

TUMOR MARKER;

ADULT; AGED; BIOPSY; CANCER GRADING; CELL TRANSFORMATION; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; MOLECULAR DIAGNOSIS; PATHOLOGY; PHENOTYPE; PREDICTIVE VALUE; RISK ASSESSMENT; RISK FACTOR; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; BIOPSY; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; NEOPLASM GRADING; PHENOTYPE; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT; RISK FACTORS; YOUNG ADULT;

EID: 84952321144     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000561     Document Type: Article

References (114)

1. Armitage JO. How I treat patients with diffuse large B-cell lymphoma. Blood. 2007; 110: 29-36
2. Pfreundschuh M. How I treat elderly patients with diffuse large Bcell lymphoma. Blood. 2010; 116: 5103-5110
3. Parikh SA, Kay NE, Shanafelt TD. How we treat Richter syndrome. Blood. 2014; 123: 1647-1657
4. Fan L, Wang L, Zhang R, et al. Richter transformation in 16 of 149 Chinese patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2012; 53: 1749-1756
5. Bruzzi JF, Macapinlac H, Tsimberidou AM, et al. Detection of Richters transformation of chronic lymphocytic leukemia by PET/CT. J Nucl Med. 2006; 47: 1267-1273
6. Noy A, Schoder H, Gonen M, et al. The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL). Ann Oncol. 2009; 20: 508-512
7. Papajik T, Myslivecek M, Urbanova R, et al. 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomog- raphy examination in patients with chronic lymphocytic leukemia may reveal Richter transformation. Leuk Lymphoma. 2014; 55: 314-319
8. Falchi L, Keating MJ, Marom EM, et al. Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia. Blood. 2014; 123: 2783-2790
9. Tsimberidou AM, Wierda WG, Plunkett W, et al. Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richters syndrome or fludarabinerefractory chronic lymphocytic leukemia. J Clin Oncol. 2008; 26: 196-203
10. Tsimberidou AM, OBrien S, Khouri I, et al. Clinical outcomes and prognostic factors in patients with Richters syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation. J Clin Oncol. 2006; 24: 2343-2351
11. Müller-Hermelink HK, Montserrat E, Catovsky D, et al. Chronic lymphocytic leukaemia/small lymphocytic lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2008: 180-182
12. Lortholary P, Boiron M, Ripault P, et al. Chronic lymphoid leukemia secondarily associated with a malignant reticulopathy: Richters syndrome. Nouv Rev Fr Hematol. 1964; 4: 621-644
13. Richter MN. Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. Am J Pathol. 1928; 4: 285-292. 287
14. Tsimberidou AM, OBrien S, Kantarjian HM, et al. Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. Cancer. 2006; 107: 1294-1302
15. Chigrinova E, Rinaldi A, Kwee I, et al. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome. Blood. 2013; 122: 2673-2682
16. Martinez D, Valera A, Perez NS, et al. Plasmablastic transformation of low-grade B-cell lymphomas report on 6 cases. Am J Surg Pathol. 2013; 37: 272-281
17. Parikh SA, Rabe KG, Call TG, et al. Diffuse large B-cell lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): a cohort study of newly diagnosed patients. Br J Haematol. 2013; 162: 774-782
18. Robak T, Urbanska-Rys H, Strzelecka B, et al. Plasmablastic lymphoma in a patient with chronic lymphocytic leukemia heavily pretreated with cladribine (2-CdA): an unusual variant of Richters syndrome. Eur J Haematol. 2001; 67: 322-327
19. Rossi D, Cerri M, Capello D, et al. Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol. 2008; 142: 202-215
20. Rossi D, Spina V, Deambrogi C, et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood. 2011; 117: 3391-3401
21. Tadmor T, Shvidel L, Goldschmidt N, et al. Hodgkins variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group. Anticancer Res. 2014; 34: 785-790
22. Tsimberidou AM, Keating MJ, Wierda WG. Richters transformation in chronic lymphocytic leukemia. Curr Hematol Malig Rep. 2007; 2: 265-271
23. Robertson LE, Pugh W, OBrien S, et al. Richters syndrome: a report on 39 patients. J Clin Oncol. 1993; 11: 1985-1989
24. Mauro FR, Foa R, Giannarelli D, et al. Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: a single institution study of 204 cases. Blood. 1999; 94: 448-454
25. Rossi D, Gaidano G. Richter syndrome: molecular insights and clinical perspectives. Hematol Oncol. 2009; 27: 1-10
26. Konoplev SN, Fritsche HA, OBrien S, et al. High serum thymidine kinase 1 level predicts poorer survival in patients with chronic lymphocytic leukemia. Am J Clin Pathol. 2010; 134: 472-477
27. Fabbri G, Khiabanian H, Holmes AB, et al. Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. J Exp Med. 2013; 210: 2273-2288
28. Medeiros LJ, Miranda RN, Wang SA, et al. Diagnostic Pathology: Lymph Nodes and Spleen With Extranodal Lymphomas. Altona, Manitoba, Canada: Amirsys Publishing Inc; 2011
29. Mao Z, Quintanilla-Martinez L, Raffeld M, et al. IgVH mutational status and clonality analysis of Richters transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol. 2007; 31: 1605-1614
30. Gine E, Martinez A, Villamor N, et al. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ("accelerated" chronic lymphocytic leukemia) with aggressive clinical behavior. Haematologica. 2010; 95: 1526-1533
31. Aydin S, Rossi D, Bergui L, et al. CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? Blood. 2008; 111: 5646-5653
32. Rasi S, Spina V, Bruscaggin A, et al. A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol. 2011; 152: 284-294
33. Rossi D, Spina V, Cerri M, et al. Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin Cancer Res. 2009; 15: 4415-4422
34. Sun X, Frierson HF, Chen C, et al. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Nat Genet. 2005; 37: 407-412
35. Stankovic T, Weber P, Stewart G, et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet. 1999; 353: 26-29
36. Zenz T, Eichhorst B, Busch R, et al. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol. 2010; 28: 4473-4479
37. Fabbri M, Bottoni A, Shimizu M, et al. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA. 2011; 305: 59-67
38. Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature. 2011; 475: 101-105
39. Rossi D, Fangazio M, Rasi S, et al. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood. 2012; 119: 2854-2862
40. Saito T, Chiba S, Ichikawa M, et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity. 2003; 18: 675-685
41. Szantho E, Bhattoa HP, Csoban M, et al. Serum thymidine kinase activity: analytical performance, age-related reference ranges and validation in chronic lymphocytic leukemia. PLoS One. 2014; 9: e91647
42. Loghavi S, Alayed K, Aladily TN, et al. Stage, age, and EBV status impact outcomes of plasmablastic lymphoma patients: a clinicopathologic analysis of 61 patients. J Hematol Oncol. 2015; 8: 65
43. Pan Z, Xie Q, Repertinger S, et al. Plasmablastic transformation of low-grade CD5+ B-cell lymphoproliferative disorder with MYC gene rearrangements. Hum Pathol. 2013; 44: 2139-2148
44. Parikh SA, Habermann TM, Chaffee KG, et al. Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to De novo Hodgkin lymphoma. Am J Hematol. 2015; 90: 334-338
45. Parikh SA, Rabe KG, Ding W, et al. Hodgkin transformation of chronic lymphocytic leukemia (CLL): Mayo Clinic Experience. Blood. 2013; 122: 1642
46. Bockorny B, Codreanu I, Dasanu C. Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukemia: a retrospective analysis of world literature. Br J Haematol. 2011; 156: 50-66
47. Jamroziak K, Grzybowska-Izydorczyk O, Jesionek-Kupnicka D, et al. Poor prognosis of Hodgkin variant of Richter transformation in chronic lymphocytic leukemia treated with cladribine. Br J Haematol. 2012; 158: 286-288
48. Abruzzo LV, Rosales CM, Medeiros LJ, et al. Epstein-Barr viruspositive B-cell lymphoproliferative disorders arising in immunodeficient patients previously treated with fludarabine for low-grade Bcell neoplasms. Am J Surg Pathol. 2002; 26: 630-636
49. Lossos IS, Gascoyne RD. Transformation of follicular lymphoma. Best Pract Res Clin Haematol. 2011; 24: 147-163
50. Casulo C, Burack WR, Friedberg JW. Transformed follicular non-Hodgkin lymphoma. Blood. 2015; 125: 40-47
51. Mantoto S, Davies AJ, Calaminici M, et al. Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma. J Clin Oncol. 2007; 25: 2426-2433
52. Al-Tourah AJ, Gill KK, Chhanabhai M, et al. Population-based analysis of incidence and outcome of transformed non-Hodgkins lymphoma. J Clin Oncol. 2008; 26: 5165-5169
53. Conconi A, Ponzio C, Lobetti-Bodoni C, et al. Incidence, risk factors and outcome of histological transformation in follicular lymphoma. Br J Haematol. 2012; 157: 188-196
54. Link BK, Maurer MJ, Nowakowski GS, et al. Rates and outcomes of follicular lymphoma transformation in the immunochemotherapy era: a report from the University of Iowa/Mayo Clinic Specialized Program of Research Excellence Molecular Epidemiology Resource. J Clin Oncol. 2013; 31: 3272-3278
55. Bodet-Milin C, Eugene T, Gastinne T, et al. FDG-PET in follicular lymphoma management. J Oncol. 2012; 2012: 370272
56. Maeshima AM, Omatsu M, Nomoto J, et al. Diffuse large B-cell lymphoma after transformation from low-grade follicular lymphoma: morphological, immunohistochemical, and FISH analyses. Cancer Sci. 2008; 99: 1760-1768
57. Bains P, Al Tourah A, Campbell BA, et al. Incidence of transformation to aggressive lymphoma in limited-stage follicular lymphoma treated with radiotherapy. Ann Oncol. 2013; 24: 428-432
58. Alsabeh R, Medeiros LJ, Glackin C, et al. Transformation of follicular lymphoma into CD30 large cell lymphoma with anaplastic cytologic features. Am J Surg Pathol. 1997; 21: 528-536
59. Okosun J, Bodor C, Wang J, et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet. 2014; 46: 176-181
60. Ouansafi I, He B, Fraser C, et al. Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. Am J Clin Pathol. 2010; 134: 972-981
61. Pasqualucci L, Khiabanian H, Fangazio M, et al. Genetics of follicular lymphoma transformation. Cell Rep. 2014; 6: 130-140
62. Sawas A, Diefenbach C, OConnor OA. New therapeutic targets and drugs in non-Hodgkins lymphoma. Curr Opin Hematol. 2011; 18: 280-287
63. Bouska A, McKeithan TW, Deffenbacher KE, et al. Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma. Blood. 2014; 123: 1681-1690
64. Kobayashi H, Ichikawa M, Hangaishi A, et al. Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin. Int J Hematol. 2011; 93: 112-117
65. Yano T, Jaffe ES, Longo DL, et al. MYC rearrangements in histologically progressed follicular lymphomas. Blood. 1992; 80: 758-767
66. Hwang YY, Loong F, Chung LP, et al. Atypical Burkitts lymphoma transforming from follicular lymphoma. Diagn Pathol. 2011; 6: 63
67. Dunn RG, Foot NJ, Ffolkes L, et al. Transformation from follicular lymphoma to biphasic high-grade large B-cell lymphoma with immunophenotypically and genetically distinct diffuse large B cell and Burkitt-like components. J Clin Pathol. 2013; 66: 357-360
68. Geyer JT, Subramaniyam S, Jiang Y, et al. Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients. Hum Pathol. 2015; 46: 260-271
69. Xu X, Zhang L, Wang Y, et al. Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review. Int J Clin Exp Pathol. 2013; 6: 788-794
70. Kanagal-Shamanna R, Medeiros LJ, Lu G, et al. High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequentlt with BCL2 and/or MYC gene rearrangements and a poor prognosis. Histopathology. 2012; 61: 945-954
71. Lin P, Medeiros LJ. The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma. Curr Hematol Malig Rep. 2013; 8: 243-252
72. Vaidyanathan G, Ngamphaiboon N, Hernandez-Ilizaliturru FJ. Clinial spectrum and prognosis of follicular lymphoma with blastoid transformation: case series and a review of the literature. Ann Hematol. 2011; 90: 955-962
73. Ning Y, Foss A, Kimball AS, et al. Characterization of a case of follicular lymphoma transformed into B-lymphoblastic leukemia. Mol Cytogenet. 2013; 6: 34
74. Young KH, Xie QM, Zhou GM, et al. Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event. Am J Clin Pathol. 2008; 129: 157-166
75. Sun X, Gordon LI, Peterson LC. Transformation of follicular lymphoma to acute lymphoblastic leukemia. Arch Pathol Lab Med. 2002; 126: 997-998
76. Natkunam Y, Warnke RA, Zehnder JL, et al. Blastic/blastoid transformation of follicular lymphoma: immunohistologic and molecular analyses of five cases. Am J Surg Pathol. 2000; 24: 525-534
77. Loghavi S, Kutok JL, Jorgensen JL. B-Acute lymphoblastic leukemia/lymphoblastic lymphoma. Am J Clin Pathol. 2015; 144: 393-410
78. Kroft SH, Domiati-Saad R, Finn WG, et al. Precursor Blymphoblastic transformation of grade I follicle center lymphoma. Am J Clin Pathol. 2000; 113: 411-418
79. Kishimoto W, Shirase T, Chihara D, et al. Double-hit lymphoma with a feature of follicular lymphoma concurrent with clonally related B lymphoblastic leukemia: a preference of transformation for the bone marrow. J Clin Exp Hematop. 2012; 52: 113-119
80. Bayerl MG, Bentley G, Bellan C, et al. Lacunar and reedsternberg-like cells in follicular lymphomas are clonally related to the centrocytic and centroblastic cells as demonstrated by laser capture microdissection. Am J Clin Pathol. 2004; 122: 858-864
81. Shin SS, Ben-Ezra J, Burke JS, et al. Reed-Sternberg-like cells in low-grade lymphomas are transformed neoplastic cells of B-cell lineage. Am J Clin Pathol. 1993; 99: 658-662
82. Menon MP, Hutchinson L, Garver J, et al. Transformation of follicular lymphoma to Epstein-Barr virus-related Hodgkin-like lymphoma. J Clin Oncol. 2013; 31: e53-e56
83. Meyer AH, Stroux A, Lerch K, et al. Transformation and additional malignancies are leading risk factors for an adverse course of disease in marginal zone lymphoma. Ann Oncol. 2014; 25: 210-215
84. Xing KH, Kahlon A, Skinnider BF, et al. Outcomes in splenic marginal zone lymphoma: analysis of 107 patients treated in British Columbia. Br J Haematol. 2015; 169: 520-527
85. Camacho FI, Mollejo M, Mateo MS, et al. Progression to large Bcell lymphoma in splenic marginal zone lymphoma: a description of a series of 12 cases. Am J Surg Pathol. 2001; 25: 1268-1276
86. Canelhas A, Comperat E, Le Tourneau A, et al. Marginal zone lymphoma of both spleen and kidney displaying transformation into large B-cell lymphoma. Int Urol Nephrol. 2006; 38: 431-437
87. Lenglet J, Traulle C, Mounier N, et al. Long-term follow-up analysis of 100 patients with splenic marginal zone lymphoma treated with splenectomy as first-line treatment. Leuk Lymphoma. 2014; 55: 1854-1860
88. Sugimoto KJ, Imai H, Shimada A, et al. Diffuse large B-cell lymphoma of the uterus suspected of having transformed from a marginal zone B-cell lymphoma harboring trisomy 18: a case report and review of the literature. Int J Clin Exp Pathol. 2013; 6: 2979-2988
89. Thoennissen NH, Keyvani K, Voelker HU, et al. Splenic marginal zone lymphoma: transformation to diffuse large B-cell lymphoma with isolated cerebral manifestation. J Clin Oncol. 2008; 26: 4509-4511
90. Oka K, Nagayama R, Yonekawa N, et al. Concurrent gastric MALT and Hodgkin lymphoma: a case report. Int J Surg Pathol. 2012; 20: 201-204
91. Fung EK, Neuhauser TS, Thompson LD. Hodgkin-like transformation of a marginal zone B-cell lymphoma of the larynx. Ann Diagn Pathol. 2002; 6: 61-66
92. Heintel D, Streubel B, Welzel N, et al. Burkitt lymphoma following splenic marginal zone lymphoma. evidence for two independent Bcell clones. Cancer Genet Cytogenet. 2003; 141: 86-88
93. Hoehn D, Miranda RN, Kanagal-Shamanna R, et al. Splenic Bcell lymphomas with more than 55% prolymphocytes in blood: evidence for prolymphocytoid transformation. Hum Pathol. 2012; 43: 1828-1838
94. Dungarwalla M, Appiah-Cubi S, Kulkarni S, et al. High-grade transformation in splenic marginal zone lymphoma with circulating villous lymphocytes: the site of transformation influences response to therapy and prognosis. Br J Haematol. 2008; 143: 71-74
95. Stathis A, Chini C, Bertoni F, et al. Long-term outcome following Helicobacter pylori eradication in a retrospective study of 105 patients with localized gastric marginal zone B-cell lymphoma of MALT type. Ann Oncol. 2009; 20: 1086-1093
96. Nakamura S, Sugiyama T, Matsumoto T, et al. Long-term clinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow-up study of 420 patients in Japan. Gut. 2012; 61: 507-513
97. Strunk JE, Schuttler C, Ziebuhr J, et al. Epstein-Barr virus-induced secondary high-grade transformation of Sjogrens syndromerelated mucosa-Associated lymphoid tissue lymphoma. J Clin Oncol. 2013; 31: e265-e268
98. Jiang W, Li L, Tang Y, et al. Expression of FOXP1 in mucosaassociated lymphoid tissue lymphoma suggests a large tumor cell transformation and predicts a poorer prognosis in the positive thyroid patients. Med Oncol. 2012; 29: 3352-3359
99. Martinez-Climent JA, Sanchez-Izquierdo D, Sarsotti E, et al. Genomic abnormalities acquired in the blastic transformation of splenic marginal zone B-cell lymphoma. Leuk Lymphoma. 2003; 44: 459-464
100. Flossbach L, Antoneag E, Buck M, et al. BCL6 gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B-cell lymphoma of mucosa-Associated lymphoid tissue. Int J Cancer. 2011; 129: 70-77
101. Hother C, Rasmussen PK, Joshi T, et al. MicroRNA profiling in ocular adnexal lymphoma: a role for MYC and NFKB1 mediated dysregulation of microRNA expression in aggressive disease. Invest Ophthalmol Vis Sci. 2013; 54: 5169-5175
102. Kiel MJ, Velusamy T, Betz BL, et al. Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. J Exp Med. 2012; 209: 1553-1565
103. Hanzis C, Ojha RP, Hunter Z, et al. Associated malignancies in patients with Waldenstroms macroglobulinemia and their kin. Clin Lymphoma Myeloma Leuk. 2011; 11: 88-92
104. Leleu X, Soumerai J, Roccaro A, et al. Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenstrom macroglobulinemia treated with nucleoside analogs. J Clin Oncol. 2009; 27: 250-255
105. Owen RG, Barrans SL, Richards SJ, et al. Waldenstrom macroglobulinemia. Development of diagnostic criteria and identification of prognostic factors. Am J Clin Pathol. 2001; 116: 420-428
106. Treon SP, Branagan AR, Ioakimidis L, et al. Long-term outcomes to fludarabine and rituximab in Waldenstrom macroglobulinemia. Blood. 2009; 113: 3673-3678
107. Varettoni M, Tedeschi A, Arcaini L, et al. Risk of second cancers in Waldenstrom macroglobulinemia. Ann Oncol. 2012; 23: 411-415
108. Lin P, Mansoor A, Bueso-Ramos C, et al. Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia. Clinicopathologic features of 12 cases. Am J Clin Pathol. 2003; 120: 246-253
109. Tamburini J, Levy V, Chaleteix C, et al. Fludarabine plus cyclophosphamide in Waldenstroms macroglobulinemia: results in 49 patients. Leukemia. 2005; 19: 1831-1834
110. Lin P, Bueso-Ramos C, Wilson CS, et al. Waldenstrom macroglobulinemia involving extramedullary sites: morphologic and immunophenotypic findings in 44 patients. Am J Surg Pathol. 2003; 27: 1104-1113
111. Ling S, Joshua DE, Gibson J, et al. Transformation and progression of Waldenstroms macroglobulinemia following cladribine therapy in two cases: natural evolution or iatrogenic causation? Am J Hematol. 2006; 81: 110-114
112. Shiseki M, Masuda A, Kimura T, et al. Development of diffuse large B-cell lymphoma in a patient with waldenstoms macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. Hematol Rep. 2011; 3: 28-31
113. Rosales CM, Lin P, Mansoor A, et al. Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia associated with Hodgkin disease. A report of two cases. Am J Clin Pathol. 2001; 116: 34-40
114. Peker D, Quigley B, Qin D, et al. Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene. Arch Pathol Lab Med. 2013; 137: 130-133