Plasmablastic transformation of low-grade b-cell lymphomas: Report on 6 cases

American Journal of Surgical Pathology

Volumn 37, Issue 2, 2013, Pages 272-281

  Martinez, Daniel ^a   Valera, Alexandra ^a   Perez, Nhora Silva ^b   Sua Villegas, Luz Fernanda ^b   Gonzalez Farre, Blanca ^a   Sole, Carla ^a   Gine, Eva ^a   Lopez Guillermo, Armando ^a   Roue, Gaël ^a   Martinez, Salome ^c   Sant, Francesc ^d   Warzocha, Krzysztof ^e   Robak, Tadeusz ^f   Czader, Magdalena ^g   Villamor, Neus ^a   Colomo, Lluis ^a   Campo, Elias ^a   Martinez, Antonio ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b FUNDACIÓN VALLE DEL LILI   (Colombia)

^c HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^d Fundación Althaia   (Spain)

^e INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

^f MEDICAL UNIVERSITY OF LODZ   (Poland)

^g INDIANA UNIVERSITY   (United States)

Author keywords

BCL2; chronic lymphocytic leukemia small lymphocytic lymphoma; follicular lymphoma; MYC; plasma cell differentiation; plasmablastic lymphoma; Richter syndrome

Indexed keywords

DNA;

AGED; ARTICLE; B CELL LYMPHOMA; CASE REPORT; CELL CLONE; CELL TRANSFORMATION; CHROMOSOME ABERRATION; FATALITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HUMAN; MALE; MIDDLE AGED; MORTALITY; PATHOLOGY; PLASMACYTOMA;

AGED; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; CLONE CELLS; DNA, NEOPLASM; FATAL OUTCOME; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; PLASMACYTOMA;

EID: 84872871598     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31826cb1d1     Document Type: Article

References (47)

1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008.
2. Muller-Hermelink HK, Zettl A, Pfeifer W, et al. Pathology of lymphoma progression. Histopathology. 2001;38:285-306.
3. Mukhopadhyay S, Readling J, Cotter PD, et al. Transformation of follicular lymphoma to Burkitt-like lymphoma within a single lymph node. Hum Pathol. 2005;36:571-575.
4. Natkunam Y, Warnke RA, Zehnder JL, et al. Blastic/blastoid transformation of follicular lymphoma: immunohistologic and molecular analyses of five cases. Am J Surg Pathol. 2000;24:525-534.
5. Gradowski JF, Jaffe ES, Warnke RA, et al. Follicular lymphomas with plasmacytic differentiation include two subtypes. Mod Pathol. 2010;23:71-79.
6. Jourdan F, Molina TJ, Le TA, et al. Florid marginal zone differentiation in follicular lymphoma mimicking marginal zone lymphoma of MALT type in the lung. Histopathology. 2006;49:426-429.
7. Nemes Z, Thomazy V, Szeifert G. Follicular centre cell lymphoma with alpha heavy chain disease. A histopathological and immunohistological study. Virchows Arch A Pathol Anat Histol. 1981;394:119-132.
8. Schmid U, Karow J, Lennert K. Follicular malignant non-Hodgkin's lymphoma with pronounced plasmacytic differentiation: a plasmacytoma-like lymphoma. Virchows Arch A Pathol Anat Histopathol. 1985;405:473-481.
9. Vago JF, Hurtubise PE, Redden-Borowski MM, et al. Follicular center-cell lymphoma with plasmacytic differentiation, monoclonal paraprotein, and peripheral blood involvement. Recapitulation of normal B-cell development. Am J Surg Pathol. 1985;9:764-770.
10. Frizzera G, Anaya JS, Banks PM. Neoplastic plasma cells in follicular lymphomas. Clinical and pathologic findings in six cases. Virchows Arch A Pathol Anat Histopathol. 1986;409:149-162.
11. Carlsson M, Totterman TH, Matsson P, et al. Cell cycle progression of B-chronic lymphocytic leukemia cells induced to differentiate by TPA. Blood. 1988;71:415-421.
12. Gordon J, Mellstedt H, Aman P, et al. Phenotypic modulation of chronic lymphocytic leukemia cells by phorbol ester: induction of IgM secretion and changes in the expression of B cell-associated surface antigens. J Immunol. 1984;132:541-547.
13. Okamura J, Letarte M, Stein LD, et al. Modulation of chronic lymphocytic leukemia cells by phorbol ester: increase in Ia expression, IgM secretion and MLR stimulatory capacity. J Immunol. 1982;128:2276-2280.
14. Segel GB, Woodlock TJ, Xu J, et al. Early gene activation in chronic leukemic B lymphocytes induced toward a plasma cell phenotype. Blood Cells Mol Dis. 2003;30:277-287.
15. Totterman TH, Nilsson K, Sundstrom C. Phorbol ester-induced differentiation of chronic lymphocytic leukaemia cells. Nature. 1980;288:176-178.
16. Evans HL, Polski JM, Deshpande V, et al. CD5+true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation: case report and review of the literature. Leuk Lymphoma. 2000;39:625-632.
17. Wong KF, So CC, Chan JC, et al. Gain of chromosome 3/3q in Bcell chronic lymphoproliferative disorder is associated with plasmacytoid differentiation with or without IgM overproduction. Cancer Genet Cytogenet. 2002;136:82-85.
18. Perez-Galan P, Mora-Jensen H, Weniger MA, et al. Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation. Blood. 2011;117:542-552.
19. Foo WC, Huang Q, Sebastian S, et al. Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus. Hum Pathol. 2010;41:1802-1808.
20. Ouansafi I, He B, Fraser C, et al. Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement. Am J Clin Pathol. 2010;134:972-981.
21. Pines A, Ben-Bassat I, Selzer G, et al. Transformation of chronic lymphocytic leukemia to plasmacytoma. Cancer. 1984;54:1904-1907.
22. Ramalingam P, Nayak-Kapoor A, Reid-Nicholson M, et al. Plasmablastic lymphoma with small lymphocytic lymphoma: clinico-pathologic features, and review of the literature. Leuk Lymphoma. 2008;49:1999-2002.
23. Robak T, Urbanska-Rys H, Strzelecka B, et al. Plasmablastic lymphoma in a patient with chronic lymphocytic leukemia heavily pretreated with cladribine (2-CdA): an unusual variant of Richter's syndrome. Eur J Haematol. 2001;67:322-327.
24. Avet-Loiseau H, Gerson F, Magrangeas F, et al. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood. 2001;98:3082-3086.
25. Colomo L, Loong F, Rives S, et al. Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol. 2004;28:736-747.
26. Gabrea A, Martelli ML, Qi Y, et al. Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors. Genes Chromosomes Cancer. 2008;47:573-590.
27. Lee CK, Ma ES, Shek TW, et al. Plasmablastic transformation of multiple myeloma. Hum Pathol. 2003;34:710-714.
28. Montes-Moreno S, Gonzalez-Medina AR, Rodriguez-Pinilla SM, et al. Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotype. Haematologica. 2010;95:1342-1349.
29. Shou Y, Martelli ML, Gabrea A, et al. Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci USA. 2000;97:228-233.
30. Taddesse-Heath L, Meloni-Ehrig A, Scheerle J, et al. Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features. Mod Pathol. 2010;23:991-999.
31. Vega F, Chang CC, Medeiros LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18:806-815.
32. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.
33. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003;348:1764-1775.
34. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910-1916.
35. Valera A, Balague O, Colomo L, et al. IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas. Am J Surg Pathol. 2010;34:1686-1694.
36. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997;89:1413-1420.
37. Banks PM, Keller RH, Li CY, et al. Malignant lymphoma of plasmablastic identity. A neoplasm with both "immunoblastic" and plasma cellular features. Am J Med. 1978;64:906-909.
38. Balague O, Mozos A, Martinez D, et al. Activation of the endoplasmic reticulum stress-associated transcription factor x boxbinding protein-1 occurs in a subset of normal germinal-center B cells and in aggressive B-cell lymphomas with prognostic implications. Am J Pathol. 2009;174:2337-2346.
39. Gine E, Martinez A, Villamor N, et al. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ("accelerated" chronic lymphocytic leukemia) with aggressive clinical behavior. Haematologica. 2010;95:1526-1533.
40. Mao Z, Quintanilla-Martinez L, Raffeld M, et al. IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol. 2007;31:1605-1614.
41. Rossi D, Cerri M, Capello D, et al. Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol. 2008;142:202-215.
42. Timar B, Fulop Z, Csernus B, et al. Relationship between the mutational status of VH genes and pathogenesis of diffuse large B-cell lymphoma in Richter's syndrome. Leukemia. 2004;18: 326-330.
43. Gaidano G, Cerri M, Capello D, et al. Molecular histogenesis of plasmablastic lymphoma of the oral cavity. Br J Haematol. 2002; 119:622-628.
44. Bea S, Lopez-Guillermo A, Ribas M, et al. Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome). Am J Pathol. 2002; 161:957-968.
45. Rossi D, Spina V, Deambrogi C, et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood. 2011;117:3391-3401.
46. Johnson NA, Boyle M, Bashashati A, et al. Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival. Blood. 2009;113:3773-3780.
47. Zelenetz AD, Abramson JS, Advani RH, et al. NCCN Clinical Practice Guidelines in Oncology: non-Hodgkin's lymphomas. J Natl Compr Cancer Netw. 2010;8:288-334.