메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages 243-252

The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma

Author keywords

8q24; Activated B cell type (ABC); Aggressive B cell lymphoma; BCL2; BCL6; Burkitt lymphoma; Cell of origin; Diffuse large B cell lymphoma; Double hit lymphoma; Fluorescence in situ hybridization; Gene expression profile; Germinal center B cell type (GCB); Gray zone lymphoma; High grade B cell lymphoma; IGH; IGL; Immunohistochemistry; International prognostic index (IPI); Ki 67; MYC; Non IG; Prognosis; R CHOP; Triple hit lymphoma

Indexed keywords

CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; IMMUNOGLOBULIN HEAVY CHAIN; KI 67 ANTIGEN; METHOTREXATE; MYC PROTEIN; PREDNISOLONE; PROTEIN BCL 2; PROTEIN BCL 6; RITUXIMAB; VINCRISTINE; VINCRISTINE SULFATE; ANTINEOPLASTIC AGENT;

EID: 84883893621     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-013-0169-y     Document Type: Article
Times cited : (28)

References (65)
  • 1
    • 77952477025 scopus 로고    scopus 로고
    • Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era
    • 20385988 10.1200/JCO.2009.26.2493 1:CAS:528:DC%2BC3cXnsFOntrs%3D
    • Ziepert M, Hasenclever D, Kuhnt E, et al. Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era. J Clin Oncol. 2010;28:2373-80.
    • (2010) J Clin Oncol , vol.28 , pp. 2373-2380
    • Ziepert, M.1    Hasenclever, D.2    Kuhnt, E.3
  • 2
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • 12075054 10.1056/NEJMoa012914 Gene expression profiling identified two principal subgroups of DLBCL, GCB vs. ABC types, with different prognosis and patterns of oncogenic pathway activation
    • •• Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:1937-47. Gene expression profiling identified two principal subgroups of DLBCL, GCB vs. ABC types, with different prognosis and patterns of oncogenic pathway activation.
    • (2002) N Engl J Med , vol.346 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3
  • 3
    • 9144237554 scopus 로고    scopus 로고
    • Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
    • 14504078 10.1182/blood-2003-05-1545 1:CAS:528:DC%2BD2cXhsFGhsA%3D%3D
    • Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275-82.
    • (2004) Blood , vol.103 , pp. 275-282
    • Hans, C.P.1    Weisenburger, D.D.2    Greiner, T.C.3
  • 4
    • 68549124173 scopus 로고    scopus 로고
    • A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy
    • 19706817 10.1158/1078-0432.CCR-09-0113 1:CAS:528:DC%2BD1MXhtVOntrnK
    • Choi WW, Weisenburger DD, Greiner TC, et al. A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res. 2009;15:5494-502.
    • (2009) Clin Cancer Res , vol.15 , pp. 5494-5502
    • Choi, W.W.1    Weisenburger, D.D.2    Greiner, T.C.3
  • 5
    • 79951990286 scopus 로고    scopus 로고
    • Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab
    • 21135273 10.1200/JCO.2010.30.0368
    • Meyer PN, Fu K, Greiner TC, et al. Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab. J Clin Oncol. 2011;29:200-7.
    • (2011) J Clin Oncol , vol.29 , pp. 200-207
    • Meyer, P.N.1    Fu, K.2    Greiner, T.C.3
  • 6
    • 84865865930 scopus 로고    scopus 로고
    • Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: A report from the International DLBCL Rituximab-CHOP Consortium Program Study
    • 22437443 10.1038/leu.2012.83 1:CAS:528:DC%2BC38XhtlWqsr%2FE
    • Visco C, Li Y, Xu-Monette ZY, et al. Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study. Leukemia. 2012;26:2103-13.
    • (2012) Leukemia , vol.26 , pp. 2103-2113
    • Visco, C.1    Li, Y.2    Xu-Monette, Z.Y.3
  • 7
    • 80755143466 scopus 로고    scopus 로고
    • The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: A bio-CORAL study
    • 21947824 10.1200/JCO.2011.35.4423
    • Thieblemont C, Briere J, Mounier N, et al. The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a bio-CORAL study. J Clin Oncol. 2011;29:4079-87.
    • (2011) J Clin Oncol , vol.29 , pp. 4079-4087
    • Thieblemont, C.1    Briere, J.2    Mounier, N.3
  • 8
    • 70449589073 scopus 로고    scopus 로고
    • MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy
    • 19704118 10.1182/blood-2009-05-220095 1:CAS:528:DC%2BD1MXhtlyjsr3E
    • Savage KJ, Johnson NA, Ben-Neriah S, et al. MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood. 2009;114:3533-7.
    • (2009) Blood , vol.114 , pp. 3533-3537
    • Savage, K.J.1    Johnson, N.A.2    Ben-Neriah, S.3
  • 9
    • 77954752069 scopus 로고    scopus 로고
    • Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab
    • 20498406 10.1200/JCO.2009.26.3947 1:CAS:528:DC%2BC3cXhtVajurvL
    • Barrans S, Crouch S, Smith A, et al. Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. J Clin Oncol. 2010;28:3360-5.
    • (2010) J Clin Oncol , vol.28 , pp. 3360-3365
    • Barrans, S.1    Crouch, S.2    Smith, A.3
  • 10
    • 70349575802 scopus 로고    scopus 로고
    • Lymphomas with concurrent BCL2 and MYC translocations: The critical factors associated with survival
    • 19597184 10.1182/blood-2009-03-212191 1:CAS:528:DC%2BD1MXhtFOgtrfJ
    • Johnson NA, Savage KJ, Ludkovski O, et al. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood. 2009;114:2273-9.
    • (2009) Blood , vol.114 , pp. 2273-2279
    • Johnson, N.A.1    Savage, K.J.2    Ludkovski, O.3
  • 11
    • 60149087553 scopus 로고    scopus 로고
    • Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: A historical review of cytogenetics in the light of todays knowledge
    • 18923440 10.1038/leu.2008.281 1:CAS:528:DC%2BD1MXhs1Ols70%3D
    • Boerma EG, Siebert R, Kluin PM, Baudis M. Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge. Leukemia. 2009;23:225-34.
    • (2009) Leukemia , vol.23 , pp. 225-234
    • Boerma, E.G.1    Siebert, R.2    Kluin, P.M.3    Baudis, M.4
  • 12
    • 57849149430 scopus 로고    scopus 로고
    • Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
    • 18754028 10.1038/leu.2008.230 1:CAS:528:DC%2BD1cXhsFWjtb7E
    • Klapper W, Stoecklein H, Zeynalova S, et al. Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Leukemia. 2008;22:2226-9.
    • (2008) Leukemia , vol.22 , pp. 2226-2229
    • Klapper, W.1    Stoecklein, H.2    Zeynalova, S.3
  • 13
    • 73349091840 scopus 로고    scopus 로고
    • Nodal diffuse large B-cell lymphomas in children and adolescents: Immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome
    • 19816150 10.1097/PAS.0b013e3181bb9a18
    • Gualco G, Weiss LM, Harrington Jr WJ, Bacchi CE. Nodal diffuse large B-cell lymphomas in children and adolescents: immunohistochemical expression patterns and c-MYC translocation in relation to clinical outcome. Am J Surg Pathol. 2009;33:1815-22.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1815-1822
    • Gualco, G.1    Weiss, L.M.2    Harrington, Jr.W.J.3    Bacchi, C.E.4
  • 14
    • 64049093008 scopus 로고    scopus 로고
    • BCL2, BCL6, MYC, MALT 1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: A multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome
    • 19144384 10.1016/j.humpath.2008.06.032 1:CAS:528:DC%2BD1MXktl2isrs%3D
    • Tibiletti MG, Martin V, Bernasconi B, et al. BCL2, BCL6, MYC, MALT 1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: a multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome. Hum Pathol. 2009;40:645-52.
    • (2009) Hum Pathol , vol.40 , pp. 645-652
    • Tibiletti, M.G.1    Martin, V.2    Bernasconi, B.3
  • 15
    • 67650767035 scopus 로고    scopus 로고
    • Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocations
    • 19535347 10.3324/haematol.2008.005355 1:CAS:528:DC%2BD1MXhtVGitrrM
    • Tomita N, Tokunaka M, Nakamura N, et al. Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocations. Haematologica. 2009;94:935-43.
    • (2009) Haematologica , vol.94 , pp. 935-943
    • Tomita, N.1    Tokunaka, M.2    Nakamura, N.3
  • 16
    • 77649230092 scopus 로고    scopus 로고
    • B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma
    • 20118770 10.1097/PAS.0b013e3181cd3aeb
    • Snuderl M, Kolman OK, Chen YB, et al. B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma. Am J Surg Pathol. 2010;34:327-40.
    • (2010) Am J Surg Pathol , vol.34 , pp. 327-340
    • Snuderl, M.1    Kolman, O.K.2    Chen, Y.B.3
  • 17
    • 80051904741 scopus 로고    scopus 로고
    • Fluorescence in situ hybridisation analysis of formalin-fixed paraffin-embedded tissue sections in the diagnostic work-up of non-Burkitt high grade B-cell non-Hodgkin's lymphoma: A single centre's experience
    • 21593346 10.1136/jclinpath-2011-200015 1:CAS:528:DC%2BC3MXht1yju73N
    • Foot NJ, Dunn RG, Geoghegan H, Wilkins BS, Neat MJ. Fluorescence in situ hybridisation analysis of formalin-fixed paraffin-embedded tissue sections in the diagnostic work-up of non-Burkitt high grade B-cell non-Hodgkin's lymphoma: a single centre's experience. J Clin Pathol. 2011;64:802-8.
    • (2011) J Clin Pathol , vol.64 , pp. 802-808
    • Foot, N.J.1    Dunn, R.G.2    Geoghegan, H.3    Wilkins, B.S.4    Neat, M.J.5
  • 18
    • 80052385495 scopus 로고    scopus 로고
    • Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immunohistochemical profiles
    • 21659362 10.3324/haematol.2011.042531
    • Horn H, Schmelter C, Leich E, et al. Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immunohistochemical profiles. Haematologica. 2011;96:1327-34.
    • (2011) Haematologica , vol.96 , pp. 1327-1334
    • Horn, H.1    Schmelter, C.2    Leich, E.3
  • 19
    • 80054045437 scopus 로고    scopus 로고
    • BCL2 and MYC dual-hit lymphoma/leukemia
    • 10.3960/jslrt.51.7
    • Tomita N. BCL2 and MYC dual-hit lymphoma/leukemia. J Clin Exp Hematopathol. 2011;51:7-12.
    • (2011) J Clin Exp Hematopathol , vol.51 , pp. 7-12
    • Tomita, N.1
  • 20
    • 84865339813 scopus 로고    scopus 로고
    • Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab
    • 22213394 10.1002/cncr.27396 1:CAS:528:DC%2BC38Xht1WrsbzL
    • Akyurek N, Uner A, Benekli M, Barista I. Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab. Cancer. 2012;118:4173-83.
    • (2012) Cancer , vol.118 , pp. 4173-4183
    • Akyurek, N.1    Uner, A.2    Benekli, M.3    Barista, I.4
  • 21
    • 84861211721 scopus 로고    scopus 로고
    • MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation
    • 22408263 10.1182/blood-2012-01-406033 1:CAS:528:DC%2BC38XnsVKhur8%3D
    • Cuccuini W, Briere J, Mounier N, et al. MYC+ diffuse large B-cell lymphoma is not salvaged by classical R-ICE or R-DHAP followed by BEAM plus autologous stem cell transplantation. Blood. 2012;119:4619-24.
    • (2012) Blood , vol.119 , pp. 4619-4624
    • Cuccuini, W.1    Briere, J.2    Mounier, N.3
  • 22
    • 84867060272 scopus 로고    scopus 로고
    • Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    • 22665537 10.1200/JCO.2011.41.4342 1:CAS:528:DC%2BC38XhslSksrfJ Immunohistochemistry for MYC and BCL2 can be used as a surragate for MYC and BCL2 gene aberrations to identify high-risk patients
    • • Green TM, Young KH, Visco C, et al. Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012;30:3460-7. Immunohistochemistry for MYC and BCL2 can be used as a surragate for MYC and BCL2 gene aberrations to identify high-risk patients.
    • (2012) J Clin Oncol , vol.30 , pp. 3460-3467
    • Green, T.M.1    Young, K.H.2    Visco, C.3
  • 23
    • 84855345481 scopus 로고    scopus 로고
    • B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18) (q32;q21): An aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome
    • 22002575 10.1038/modpathol.2011.147 1:CAS:528:DC%2BC38Xjs1Srtg%3D%3D A full decription of morphologic spectrum of MYC/BCL2 double hit lymphoma
    • • Li S, Lin P, Fayad LE, et al. B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome. Mod Pathol. 2012;25:145-56. A full decription of morphologic spectrum of MYC/BCL2 double hit lymphoma.
    • (2012) Mod Pathol , vol.25 , pp. 145-156
    • Li, S.1    Lin, P.2    Fayad, L.E.3
  • 24
    • 84862118460 scopus 로고    scopus 로고
    • Biology of double-hit B-cell lymphomas
    • 22504522 10.1097/MOH.0b013e328353bbbd
    • Lindsley RC, LaCasce AS. Biology of double-hit B-cell lymphomas. Curr Opin Hematol. 2012;19:299-304.
    • (2012) Curr Opin Hematol , vol.19 , pp. 299-304
    • Lindsley, R.C.1    Lacasce, A.S.2
  • 25
    • 0032211147 scopus 로고    scopus 로고
    • Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma
    • 9787151 1:CAS:528:DyaK1cXntFCqsLY%3D
    • Kramer MH, Hermans J, Wijburg E, et al. Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood. 1998;92:3152-62.
    • (1998) Blood , vol.92 , pp. 3152-3162
    • Kramer, M.H.1    Hermans, J.2    Wijburg, E.3
  • 26
    • 84862569374 scopus 로고    scopus 로고
    • Double-hit BCL2/MYC translocations in a consecutive cohort of patients with large B-cell lymphoma - A single centre's experience
    • 22510149 10.1111/j.1600-0609.2012.01787.x
    • Pedersen MO, Gang AO, Poulsen TS, et al. Double-hit BCL2/MYC translocations in a consecutive cohort of patients with large B-cell lymphoma - a single centre's experience. Eur J Haematol. 2012;89:63-71.
    • (2012) Eur J Haematol , vol.89 , pp. 63-71
    • Pedersen, M.O.1    Gang, A.O.2    Poulsen, T.S.3
  • 27
    • 84878030010 scopus 로고    scopus 로고
    • MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma
    • 23335369 10.1182/blood-2012-06-435842 1:CAS:528:DC%2BC3sXltVyqt7o%3D Confirms MYC rearrangement as a negative prognostic marker in a prospective unselected study using R-CHOP as therapy. Confirms the value of the IHC in defining MYC/BCL2 double hit lymphoma. Proposed a scoring system based on FISH and IHC that is able to identify 15 % of patients with dismal prognosis within the IPI-high-risk subgroup
    • •• Horn H, Ziepert M, Becher C, et al. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood. 2013;121:2253-63. Confirms MYC rearrangement as a negative prognostic marker in a prospective unselected study using R-CHOP as therapy. Confirms the value of the IHC in defining MYC/BCL2 double hit lymphoma. Proposed a scoring system based on FISH and IHC that is able to identify 15 % of patients with dismal prognosis within the IPI-high-risk subgroup.
    • (2013) Blood , vol.121 , pp. 2253-2263
    • Horn, H.1    Ziepert, M.2    Becher, C.3
  • 28
    • 79952154009 scopus 로고    scopus 로고
    • Double-hit B-cell lymphomas
    • 21119107 10.1182/blood-2010-09-297879 1:CAS:528:DC%2BC3MXjsVWns7k%3D
    • Aukema SM, Siebert R, Schuuring E, et al. Double-hit B-cell lymphomas. Blood. 2011;117:2319-31.
    • (2011) Blood , vol.117 , pp. 2319-2331
    • Aukema, S.M.1    Siebert, R.2    Schuuring, E.3
  • 29
    • 84873998338 scopus 로고    scopus 로고
    • Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas
    • 23348205 10.1097/PAS.0b013e31826cebad
    • Pillai RK, Sathanoori M, Van Oss SB, Swerdlow SH. Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas. Am J Surg Pathol. 2013;37:323-32.
    • (2013) Am J Surg Pathol , vol.37 , pp. 323-332
    • Pillai, R.K.1    Sathanoori, M.2    Van Oss, S.B.3    Swerdlow, S.H.4
  • 30
    • 11144271969 scopus 로고    scopus 로고
    • Atypical Burkitt lymphoma arising from follicular lymphoma: Demonstration by polymerase chain reaction following laser capture microdissection and by fluorescence in situ hybridization on paraffin-embedded tissue sections
    • 15613866 10.1097/01.pas.0000146027.76706.50
    • Tomita N, Nakamura N, Kanamori H, et al. Atypical Burkitt lymphoma arising from follicular lymphoma: demonstration by polymerase chain reaction following laser capture microdissection and by fluorescence in situ hybridization on paraffin-embedded tissue sections. Am J Surg Pathol. 2005;29:121-4.
    • (2005) Am J Surg Pathol , vol.29 , pp. 121-124
    • Tomita, N.1    Nakamura, N.2    Kanamori, H.3
  • 31
    • 32844456419 scopus 로고    scopus 로고
    • Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis
    • 16258503 10.1038/modpathol.3800500 1:CAS:528:DC%2BD2MXhtlSqu7zI
    • Kanungo A, Medeiros LJ, Abruzzo LV, Lin P. Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol. 2006;19:25-33.
    • (2006) Mod Pathol , vol.19 , pp. 25-33
    • Kanungo, A.1    Medeiros, L.J.2    Abruzzo, L.V.3    Lin, P.4
  • 32
    • 84877259599 scopus 로고    scopus 로고
    • Double-hit lymphoma with a feature of follicular lymphoma concurrent with clonally related B lymphoblastic leukemia: A preference of transformation for the bone marrow
    • 10.3960/jslrt.52.113
    • Kishimoto W, Shirase T, Chihara D, et al. Double-hit lymphoma with a feature of follicular lymphoma concurrent with clonally related B lymphoblastic leukemia: a preference of transformation for the bone marrow. J Clin Exp Hematopathol. 2012;52:113-9.
    • (2012) J Clin Exp Hematopathol , vol.52 , pp. 113-119
    • Kishimoto, W.1    Shirase, T.2    Chihara, D.3
  • 33
    • 0024237192 scopus 로고
    • Evolution of B-cell malignancy: Pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene
    • 3186743 10.1073/pnas.85.22.8548 1:CAS:528:DyaL1MXjsVKmtQ%3D%3D
    • Gauwerky CE, Haluska FG, Tsujimoto Y, Nowell PC, Croce CM. Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene. Proc Natl Acad Sci USA. 1988;85:8548-52.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8548-8552
    • Gauwerky, C.E.1    Haluska, F.G.2    Tsujimoto, Y.3    Nowell, P.C.4    Croce, C.M.5
  • 34
    • 39749134145 scopus 로고    scopus 로고
    • C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator?
    • 18297523 10.1080/10428190701836845 1:CAS:528:DC%2BD1cXit1Cmsbk%3D
    • Christie L, Kernohan N, Levison D, et al. C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator? Leuk Lymphoma. 2008;49:470-6.
    • (2008) Leuk Lymphoma , vol.49 , pp. 470-476
    • Christie, L.1    Kernohan, N.2    Levison, D.3
  • 35
    • 33645279862 scopus 로고    scopus 로고
    • Molecular diagnosis of Burkitt's lymphoma
    • 16760443 10.1056/NEJMoa055759 1:CAS:528:DC%2BD28XlsVaisro%3D
    • Dave SS, Fu K, Wright GW, et al. Molecular diagnosis of Burkitt's lymphoma. N Engl J Med. 2006;354:2431-42.
    • (2006) N Engl J Med , vol.354 , pp. 2431-2442
    • Dave, S.S.1    Fu, K.2    Wright, G.W.3
  • 36
    • 33744960411 scopus 로고    scopus 로고
    • A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling
    • 16760442 10.1056/NEJMoa055351 1:CAS:528:DC%2BD28XlsVajur0%3D
    • Hummel M, Bentink S, Berger H, et al. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med. 2006;354:2419-30.
    • (2006) N Engl J Med , vol.354 , pp. 2419-2430
    • Hummel, M.1    Bentink, S.2    Berger, H.3
  • 37
    • 70349691319 scopus 로고    scopus 로고
    • B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma
    • S.H. Swerdlow E.H.N. Campo E.S. Jaffe S.A. Pileri H. Stein (eds) et al. IARC Lyon, France
    • Kluin PM HN, Stein H. B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma. In: Swerdlow SH, Campo EHN, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO classification of Tumours of Hematopoietic and Lymphoid Tissue. Lyon, France: IARC; 2008.
    • (2008) WHO Classification of Tumours of Hematopoietic and Lymphoid Tissue
    • Kluin Pm, H.N.1    Stein, H.2
  • 38
    • 79955868541 scopus 로고    scopus 로고
    • The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective
    • 21482997 10.1200/JCO.2010.32.8385
    • Salaverria I, Siebert R. The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective. J Clin Oncol. 2011;29:1835-43.
    • (2011) J Clin Oncol , vol.29 , pp. 1835-1843
    • Salaverria, I.1    Siebert, R.2
  • 39
    • 84860320692 scopus 로고    scopus 로고
    • Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
    • 22374697 10.1182/blood-2011-05-349662 1:CAS:528:DC%2BC38XmslWmsL4%3D
    • Deffenbacher KE, Iqbal J, Sanger W, et al. Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling. Blood. 2012;119:3757-66.
    • (2012) Blood , vol.119 , pp. 3757-3766
    • Deffenbacher, K.E.1    Iqbal, J.2    Sanger, W.3
  • 40
    • 80054908342 scopus 로고    scopus 로고
    • Composite diffuse large B-cell lymphoma and precursor B lymphoblastic lymphoma presenting as a double-hit lymphoma with MYC and BCL2 translocation
    • 21778297 10.1136/jclinpath-2011-200143
    • Nanua S, Bartlett NL, Hassan A, et al. Composite diffuse large B-cell lymphoma and precursor B lymphoblastic lymphoma presenting as a double-hit lymphoma with MYC and BCL2 translocation. J Clin Pathol. 2011;64:1032-4.
    • (2011) J Clin Pathol , vol.64 , pp. 1032-1034
    • Nanua, S.1    Bartlett, N.L.2    Hassan, A.3
  • 41
    • 36348992574 scopus 로고    scopus 로고
    • High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: A neoplasm of germinal center immunophenotype with poor prognosis
    • 18024366 10.3324/haematol.11263 1:CAS:528:DC%2BD2sXht12rurrF
    • Lin P, Medeiros LJ. High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis. Haematologica. 2007;92:1297-301.
    • (2007) Haematologica , vol.92 , pp. 1297-1301
    • Lin, P.1    Medeiros, L.J.2
  • 42
    • 84868008393 scopus 로고    scopus 로고
    • High-grade B cell lymphoma, unclassifiable, with blastoid features: An unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis
    • 22804688 10.1111/j.1365-2559.2012.04301.x
    • Kanagal-Shamanna R, Medeiros LJ, Lu G, et al. High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis. Histopathology. 2012;61:945-54.
    • (2012) Histopathology , vol.61 , pp. 945-954
    • Kanagal-Shamanna, R.1    Medeiros, L.J.2    Lu, G.3
  • 43
    • 0032921751 scopus 로고    scopus 로고
    • Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: Cytogenetics predict outcome and reflect clinical presentation
    • 10334544 1:STN:280:DyaK1M3msFOisQ%3D%3D
    • Macpherson N, Lesack D, Klasa R, et al. Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation. J Clin Oncol. 1999;17:1558-67.
    • (1999) J Clin Oncol , vol.17 , pp. 1558-1567
    • Macpherson, N.1    Lesack, D.2    Klasa, R.3
  • 44
    • 33644792286 scopus 로고    scopus 로고
    • Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior
    • 16327438 10.1097/01.pas.0000180442.87022.08
    • McClure RF, Remstein ED, Macon WR, et al. Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior. Am J Surg Pathol. 2005;29:1652-60.
    • (2005) Am J Surg Pathol , vol.29 , pp. 1652-1660
    • McClure, R.F.1    Remstein, E.D.2    Macon, W.R.3
  • 45
    • 64849083856 scopus 로고    scopus 로고
    • Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations
    • 19151788 10.1038/leu.2008.344 1:CAS:528:DC%2BD1MXks1Sitbg%3D
    • Niitsu N, Okamoto M, Miura I, Hirano M. Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations. Leukemia. 2009;23:777-83.
    • (2009) Leukemia , vol.23 , pp. 777-783
    • Niitsu, N.1    Okamoto, M.2    Miura, I.3    Hirano, M.4
  • 46
    • 84883875506 scopus 로고    scopus 로고
    • MYC rearrangements are useful for predicting outcomes following rituximab and chemotherapy: Multicenter analysis of Japanese patients with diffuse large B-cell lymphoma
    • Kojima M, Nishikii H, Takizawa J, et al. MYC rearrangements are useful for predicting outcomes following rituximab and chemotherapy: multicenter analysis of Japanese patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2013.
    • (2013) Leuk Lymphoma
    • Kojima, M.1    Nishikii, H.2    Takizawa, J.3
  • 47
    • 36349025294 scopus 로고    scopus 로고
    • The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement
    • 18024371 10.3324/haematol.11305
    • Le Gouill S, Talmant P, Touzeau C, et al. The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica. 2007;92:1335-42.
    • (2007) Haematologica , vol.92 , pp. 1335-1342
    • Le Gouill, S.1    Talmant, P.2    Touzeau, C.3
  • 48
    • 84879070639 scopus 로고    scopus 로고
    • B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and burkitt lymphoma: Study of 39 cases
    • Perry AM, Crockett D, Dave BJ, et al. B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and burkitt lymphoma: study of 39 cases. Br J Haematol. 2013.
    • (2013) Br J Haematol
    • Perry, A.M.1    Crockett, D.2    Dave, B.J.3
  • 49
    • 84863230289 scopus 로고    scopus 로고
    • Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
    • 21882178 10.1002/cncr.26433 1:CAS:528:DC%2BC38XjtFyhsb4%3D
    • Lin P, Dickason TJ, Fayad LE, et al. Prognostic value of MYC rearrangement in cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Cancer. 2012;118:1566-73.
    • (2012) Cancer , vol.118 , pp. 1566-1573
    • Lin, P.1    Dickason, T.J.2    Fayad, L.E.3
  • 50
    • 55249105997 scopus 로고    scopus 로고
    • A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial)
    • 18612102 10.1182/blood-2008-03-145128 1:CAS:528:DC%2BD1cXhtFCrurjJ
    • Mead GM, Barrans SL, Qian W, et al. A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial). Blood. 2008;112:2248-60.
    • (2008) Blood , vol.112 , pp. 2248-2260
    • Mead, G.M.1    Barrans, S.L.2    Qian, W.3
  • 51
    • 84870390243 scopus 로고    scopus 로고
    • Does the proliferation fraction help identify mature B cell lymphomas with double- and triple-hit translocations?
    • 23171357 10.1111/j.1365-2559.2012.04351.x
    • Mationg-Kalaw E, Tan LH, Tay K, et al. Does the proliferation fraction help identify mature B cell lymphomas with double- and triple-hit translocations? Histopathology. 2012;61:1214-8.
    • (2012) Histopathology , vol.61 , pp. 1214-1218
    • Mationg-Kalaw, E.1    Tan, L.H.2    Tay, K.3
  • 52
    • 79551473158 scopus 로고    scopus 로고
    • Burkitt lymphoma and atypical Burkitt or Burkitt-like lymphoma: Should these be treated as different diseases?
    • 21191675 10.1007/s11899-010-0076-4
    • Thomas DA, O'Brien S, Faderl S, et al. Burkitt lymphoma and atypical Burkitt or Burkitt-like lymphoma: should these be treated as different diseases? Curr Hematol Malig Rep. 2011;6:58-66.
    • (2011) Curr Hematol Malig Rep , vol.6 , pp. 58-66
    • Thomas, D.A.1    O'Brien, S.2    Faderl, S.3
  • 53
    • 79952430906 scopus 로고    scopus 로고
    • Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    • 21390126 10.1038/nature09730 1:CAS:528:DC%2BC3MXivFyqt7w%3D
    • Pasqualucci L, Dominguez-Sola D, Chiarenza A, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011;471:189-95.
    • (2011) Nature , vol.471 , pp. 189-195
    • Pasqualucci, L.1    Dominguez-Sola, D.2    Chiarenza, A.3
  • 54
    • 80052269038 scopus 로고    scopus 로고
    • Analysis of the coding genome of diffuse large B-cell lymphoma
    • 21804550 10.1038/ng.892 1:CAS:528:DC%2BC3MXpsFKqsLk%3D
    • Pasqualucci L, Trifonov V, Fabbri G, et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet. 2011;43:830-7.
    • (2011) Nat Genet , vol.43 , pp. 830-837
    • Pasqualucci, L.1    Trifonov, V.2    Fabbri, G.3
  • 55
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
    • 21796119 10.1038/nature10351 1:CAS:528:DC%2BC3MXhtVOku7zO
    • Morin RD, Mendez-Lago M, Mungall AJ, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011;476:298-303.
    • (2011) Nature , vol.476 , pp. 298-303
    • Morin, R.D.1    Mendez-Lago, M.2    Mungall, A.J.3
  • 56
    • 77950640767 scopus 로고    scopus 로고
    • Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma
    • 20378577 10.3324/haematol.2009.012864 1:CAS:528:DC%2BC3cXhtlWjsL7I
    • Stasik CJ, Nitta H, Zhang W, et al. Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma. Haematologica. 2010;95:597-603.
    • (2010) Haematologica , vol.95 , pp. 597-603
    • Stasik, C.J.1    Nitta, H.2    Zhang, W.3
  • 57
    • 80051576860 scopus 로고    scopus 로고
    • Gains of MYC locus and outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP
    • 21488860 10.1111/j.1365-2141.2011.08675.x 1:CAS:528:DC%2BC3MXhsVOksLbP
    • Testoni M, Kwee I, Greiner TC, et al. Gains of MYC locus and outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP. Br J Haematol. 2011;155:274-7.
    • (2011) Br J Haematol , vol.155 , pp. 274-277
    • Testoni, M.1    Kwee, I.2    Greiner, T.C.3
  • 58
    • 84867088456 scopus 로고    scopus 로고
    • Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
    • 22851565 10.1200/JCO.2011.41.0985 1:CAS:528:DC%2BC38XhslSksrfI
    • Johnson NA, Slack GW, Savage KJ, et al. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol. 2012;30:3452-9.
    • (2012) J Clin Oncol , vol.30 , pp. 3452-3459
    • Johnson, N.A.1    Slack, G.W.2    Savage, K.J.3
  • 59
    • 84867077586 scopus 로고    scopus 로고
    • Growing importance of MYC/BCL2 immunohistochemistry in diffuse large B-cell lymphomas
    • 22949148 10.1200/JCO.2012.44.4729 1:CAS:528:DC%2BC38XhslSksrfM
    • Pfreundschuh M. Growing importance of MYC/BCL2 immunohistochemistry in diffuse large B-cell lymphomas. J Clin Oncol. 2012;30:3433-5.
    • (2012) J Clin Oncol , vol.30 , pp. 3433-3435
    • Pfreundschuh, M.1
  • 60
    • 84879385620 scopus 로고    scopus 로고
    • MYC/BCL2 protein co-expression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: A report from the International DLBCL Rituximab-CHOP Consortium Program Study
    • Proposed that the poor prognosis of ABC type was related to MYC expression rather than stage of cell differentiation or cell of origin per se
    • • Hu S, Xu-Monette ZY, Tzankov A, et al. MYC/BCL2 protein co-expression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program Study. Blood. 2013. Proposed that the poor prognosis of ABC type was related to MYC expression rather than stage of cell differentiation or cell of origin per se.
    • (2013) Blood
    • Hu, S.1    Xu-Monette, Z.Y.2    Tzankov, A.3
  • 61
    • 84869786887 scopus 로고    scopus 로고
    • Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP
    • 23018644 10.1182/blood-2012-05-428466 1:CAS:528:DC%2BC38XhslOqu7%2FF
    • Gupta M, Maurer MJ, Wellik LE, et al. Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP. Blood. 2012;120:4400-6.
    • (2012) Blood , vol.120 , pp. 4400-4406
    • Gupta, M.1    Maurer, M.J.2    Wellik, L.E.3
  • 62
    • 84867010006 scopus 로고    scopus 로고
    • C-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    • 23021216 10.1016/j.cell.2012.08.033 1:CAS:528:DC%2BC38XhsValtrvM
    • Nie Z, Hu G, Wei G, et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell. 2012;151:68-79.
    • (2012) Cell , vol.151 , pp. 68-79
    • Nie, Z.1    Hu, G.2    Wei, G.3
  • 63
    • 84874789573 scopus 로고    scopus 로고
    • Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies
    • 22484426 10.1038/onc.2012.117 1:CAS:528:DC%2BC38Xlt1ahsbw%3D
    • Leskov I, Pallasch CP, Drake A, et al. Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies. Oncogene. 2013;32:1066-72.
    • (2013) Oncogene , vol.32 , pp. 1066-1072
    • Leskov, I.1    Pallasch, C.P.2    Drake, A.3
  • 64
    • 77954243397 scopus 로고    scopus 로고
    • Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas
    • 20348878 10.1038/modpathol.2010.76 1:CAS:528:DC%2BC3cXotlWgsr8%3D
    • Seegmiller AC, Garcia R, Huang R, Maleki A, Karandikar NJ, Chen W. Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas. Mod Pathol. 2010;23:909-20.
    • (2010) Mod Pathol , vol.23 , pp. 909-920
    • Seegmiller, A.C.1    Garcia, R.2    Huang, R.3    Maleki, A.4    Karandikar, N.J.5    Chen, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.