Blastic/blastoid transformation of follicular lymphoma: Immunohistologic and molecular analyses of five cases

American Journal of Surgical Pathology

Volumn 24, Issue 4, 2000, Pages 525-534

  Natkunam, Yasodha ^a   Warnke, Roger A ^a   Zehnder, James L ^a   Jones, Carol D ^a   Milatovich Cherry, Athena ^a   Cornbleet, P Joanne ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BCL 2; Blastic blastoid transformation; Epstein Barr virus; Follicular lymphoma; Lymphoblastic blastoid; P53; T(14; 18) Translocation

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ARTICLE; BLAST TRANSFORMATION; CLINICAL ARTICLE; CLINICAL FEATURE; EPSTEIN BARR VIRUS; FEMALE; FLOW CYTOMETRY; FOLLICULAR LYMPHOMA; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; PROGNOSIS; PROTEIN EXPRESSION; TREATMENT PLANNING;

ADULT; AGED; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; CYCLIN D1; CYTOGENETICS; DISEASE PROGRESSION; DNA PRIMERS; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, VIRAL; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034029864     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200004000-00006     Document Type: Article

References (61)

1. Agarwal ML, Taylor WR, Chernov MV, Chernova OB, Stark GR. The p53 network. J Biol Chem 1998;273:1-4.
2. Argatoff LH, Connors JM, Klasa RJ, Horsman DE, Gascoyne RD. Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood 1997;89:2067-78.
3. Aventin A, Mecucci C, Guanyabens C, et al. Variant t(2;18) translocation in a Burkitt conversion of follicular lymphoma. Br J Haematol 1990;74:367-9.
4. Bakhshi A, Jensen JP, Goldman P, et al. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985; 41:899-906.
5. Barch M. ACT Cytogenetics Laboratory Manual, 2nd ed. New York, NY: Raven Press, 1991:325-72.
6. Bastion Y, Sebban C, Berger F, et al. Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients. J Clin Oncol 1997;15:1587-94.
7. Bindl JM, Warnke RA. Advantages of detecting monoclonal antibody binding to tissue sections with biotin and avidin reagents in Coplin jars. Am J Clin Pathol 1986;85:490-3.
8. Chan JK, Banks PM, Cleary ML, et al. A revised European-American classification of lymphoid neoplasms proposed by the International Lymphoma Study Group. Am J Clin Pathol 1995; 103:543-60.
9. Cleary ML, Galili N, Sklar J. Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J Exp Med 1986;164:315-20.
10. Cleary ML, Sklar J, Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA 1985;82:7439-43.
11. Cleary ML, Smith SD, Sklar J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobin transcript resulting from the t(14;18) translocation. Cell 1986;47:19-28.
12. Come SE, Jaffe ES, Andersen JC, et al. Non-Hodgkin's lymphomas in leukemic phase: clinicopathologic correlations. Am J Med 1980;69:667-74.
13. Cooper K, Haffajee Z. bcl-2 and p53 protein expression in follicular lymphoma. J Pathol 1997;182:307-10.
14. De Jong D, Voetdijk BM, Beverstock GC, van Ommen GJ, Willemze R, Kluin PM. Activation of the c-myc oncogene in a precursor-C-cell blast crisis of follicular lymphoma, presenting as composite lymphoma. N Engl J Med 1988;318:1373-8.
15. Driscoll DA, Budarf ML, Emanuel BS. A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11. Am J Hum Genet 1992;50:924-33.
16. Driscoll DA, Spinner NB, Budarf ML, et al. Deletions and microdeletions of 22q11.2 in velo-cardio-facial syndrome. Am J Med Genet 1992;44:261-8.
17. Frank TS, Svoboda-Newman SM, Hsi ED. Comparison of methods for extracting DNA from formalin-fixed paraffin sections for nonisotopic PCR. Diagn Mol Pathol 1996;5:220-4.
18. Haldar S, Negrini M, Monne M, Sabbioni S, Croce CM. Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res 1994; 54:2095-7.
19. Henderson S, Rowe M, Gregory C, et al. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 1991;65:1107-15.
20. Hockenberry D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-6.
21. Knutsen T. Cytogenetic mechanisms in the pathogenesis and progression of follicular lymphoma. Cancer Surv 1997;30:163-92.
22. Komatsu H, Iida S, Yamamoto K, et al. A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene. Blood 1994;84:1226-31.
23. Korsmeyer SJ. Chromosomal translocations in lymphoid malignancies reveal novel-proto-oncogenes. Annu Rev Immunol 1992; 10:785-807.
24. Leroux D, Le Marcc'Hadour F, Gressin R, et al. Non-Hodgkin's lymphomas with t(11;14)(q13;q32): a subset of mantle zone/ intermediate lymphocytic lymphoma. Br J Haematol 1991;77: 346-53.
25. Levine EG, Arthur DC, Frizzera G, Peterson BA, Hurd DD, Bloomfield CD. There are differences in cytogenetic abnormalities among histologic subtypes of the non-Hodgkin's lymphomas. Blood 1985;66:1414-22.
26. LoCoco F, Gaidano G, Louis DC, Offit K, Chagnanti RS, Dalla-Favera R. p53 mutations are associated with histologic transformation of follicular lymphoma. Blood 1993;82:2289-95.
27. Louie DC, Offit K, Jaslow R, et al. p53 overexpression as a marker of poor prognosis in mantle cell lymphomas with t(11;14) (q13;q32). Blood 1995;86:2892-9.
28. Matolesy A, Casali P, Warnke RA, Knowles DM. Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene. Blood 1996;88:3937-44.
29. Momose H, Jaffe ES, Shin SS, Chen YY, Weiss LM. Chronic lymphocytic leukemia/small lymphocytic lymphoma with Reed-Sternberg-like cells and possible transformation to Hodgkin's disease. Mediation by Epstein-Barr virus. Am J Surg Pathol 1992;16: 859-67.
30. Nathwani BN, Diamond LW, Winberg CD, et al. Lymphoblastic lymphoma: a clinicopathologic study of 95 patients. Cancer 1981; 48:2347-57.
31. Nguyen PL, Zukerberg LR, Benedict WF, Harris NL. Immunohistochemical detection of p53, bcl-2, and retinoblastoma proteins in follicular lymphoma. Am J Clin Pathol 1996;105:538-43.
32. Nomdedeu JF, Baiget M, Gaidano G, et al. p53 mutation on a case of blastic transformation of follicular lymphoma with double bcl-2 rearrangement (MBR and VCR). Leuk Lymphoma 1998;29:595-605.
33. Norton AJ, Matthews J, Pappa V, et al. Mantle cell lymphoma: natural history defined in a serially biopsied population over a 20-year period. Ann Oncol 1995;6:249-56.
34. Orn M. Lonely no more: p53 finds its kin in a tumor suppressor haven. Cell 1997;90:829-32.
35. Pezzella F, Gatter KC, Mason DY, et al. Bcl-protein expression in a follicular lymphomas in absence of 14;18 translocation. Lancet 1990;336:1510-1.
36. Pezzella F, Morrison H, Jones M, et al. Immunohistochemical detection of p53 and bcl-proteins in non-Hodgkin's lymphoma. Histopathology 1993;22:39-44.
37. Pezzella F, Ralfkiaer E, Gatter KC, Mason DY. The 14;18 translocation in European cases of follicular lymphoma: comparison of Southern blotting and the polymerase chain reaction. Br J Haematol 1990;76:58-64.
38. Pezzella F, Tse AG, Cordell JL, Pulford KA, Gatter KC, Mason DY. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990;137:225-32.
39. Pinyol M, Cobo F, Bea S, et al. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variant of non-Hodgkin's lymphomas. Blood 1998;91:2977-84.
40. Poteat HT, Sklar J. A simplified polymerase chain reactionassay for detection of chromosomal translocations in hematologic malignancies. Diagn Mol Pathol 1997;6:3-9.
41. Prudhomme C, Fenaux P. The clinical significance of mutations of the p53 tumor suppressor gene in haematological malignancies. Br J Haematol 1997;98:502-11.
42. Raghoebier S, Broos L, Kramer MH, et al. Histological conversion of follicular lymphoma with structural alterations of t(14;18) and immunoglobulin genes. Leukemia 1995;9:1748-55.
43. Rimokh R, Berger F, Delsol G, et al. Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias. Blood 1993;81: 3063-7.
44. Rohatiner A, Lister TA. Management of follicular lymphoma. Curr Opin Oncol 1994;6:473-9.
45. Sander CA, Yano T, Clark HM, et al. p53 mutation is associated with progression in follicular lymphomas. Blood 1993;82:1994-2004.
46. Tilly H, Rossi A, Stamatoullas A, et al. Prognostic value of chromosomal abnormalities in follicular lymphoma. Blood 1994;84: 1043-9.
47. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985;228: 1440-3.
48. Tsujimoto Y, Croce CM. Analysis of the structure, transcripts, and protein products of the bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 1986;83:5214-8.
49. Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Corce CM. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 1985;229:1390-3.
50. van de Rijn M, Cleary ML, Variakojis D, Warnke RA, Chang PP, Kamel OW. Epstein-Barr virus clonality in lymphomas occurring in patients with rheumatoid arthritis. Arthritis Rheum 1996;39: 638-42.
51. Vandernberghe E, De Wolf-Peeters C, van den Oord J, et al. Translocation (11;14): a cytogenetic anomaly associated with B-cell lymphomas of non-follicle centre cell lineage. J Pathol 1991;163: 13-8.
52. Villuendas R, Piris MA, Algara P, et al. The expression of p53 protein in non-Hodgkin's lymphomas is not always dependent on p53 gene mutations. Blood 1993;82:3151-6.
53. Warnke R, Weiss LM, Chan JKC, Cleary ML, Dorfman RF. Tumors of the lymph nodes and spleen. 3rd ed. Atlas of Tumor Pathology, vol 14. Washington, DC: Armed Forced Institute of Pathology, 1995.
54. Weisenberger DD, Kim H, Rappaprt H. Mantle-zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer 1982;49:1429-38.
55. Weisenberger DD, Sanger WG, Armitage JO, Putilo DT. Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings. Blood 1987;69:1617-21.
56. Weiss LM, Warnke RA. Follicular lymphoma with blastic conversion: a report of two cases with confirmation by immunoperoxidase studies on bone marrow sections. An J Clin Pathol 1985;83: 681-6.
57. Weiss LM, Warnke RA, Sklar J, Cleary ML. Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas. N Engl J Med 1987;317:1185-9.
58. Williams ME, Swerdlow SH, Rosenberg CL, Arnold A. Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma. Leukemia 1993;7:241-5.
59. Yano T, Jaffe ES, Longo DL, Raffeld M. MYC rearrangements in histologically progressed follicular lymphomas. Blood 1992;80: 758-67.
60. Yuen AR, Kamel OW, Halpern J, Horning SJ. Long-term survival after histologic transformation of low-grade follicular lymphoma. J Clin Oncol 1995;13:1726-33.
61. Yunis JJ, Frizzera G, Oken MM, McKenna J, Theologides A, Arnesen M. Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N Engl J Med 1987;316:79-84.