메뉴 건너뛰기




Volumn 907, Issue , 2016, Pages 7-17

A review of chemical gradient systems for cell analysis

Author keywords

Gradient; Lab on a chip; Microfluidics; Review

Indexed keywords

BIOCHEMISTRY; BIOPHYSICS; DISEASES; FLUIDIC DEVICES; GRADIENT METHODS; LAB-ON-A-CHIP; MICROFLUIDICS; PATHOLOGY; REVIEWS; SYNTHESIS (CHEMICAL);

EID: 84951860799     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2015.12.008     Document Type: Review
Times cited : (89)

References (90)
  • 1
    • 81555228395 scopus 로고    scopus 로고
    • An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells
    • Lee J.M., Kim J.E., Kang E., Lee S.H., Chung B.G. An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells. Electrophoresis 2011, 32:3133-3137.
    • (2011) Electrophoresis , vol.32 , pp. 3133-3137
    • Lee, J.M.1    Kim, J.E.2    Kang, E.3    Lee, S.H.4    Chung, B.G.5
  • 2
    • 34548223149 scopus 로고    scopus 로고
    • Cell differentiation guidance using chemical stimulation controlled by a microfluidic device
    • Nakashima Y., Yasuda T. Cell differentiation guidance using chemical stimulation controlled by a microfluidic device. Sens. Actuators A Phys. 2007, 139:252-258.
    • (2007) Sens. Actuators A Phys. , vol.139 , pp. 252-258
    • Nakashima, Y.1    Yasuda, T.2
  • 3
    • 12344282703 scopus 로고    scopus 로고
    • Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies
    • Tourovskaia A., Figueroa-Masot X., Folch A. Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies. Lab Chip 2005, 5:14-19.
    • (2005) Lab Chip , vol.5 , pp. 14-19
    • Tourovskaia, A.1    Figueroa-Masot, X.2    Folch, A.3
  • 4
    • 77957259884 scopus 로고    scopus 로고
    • The signaling mechanisms underlying cell polarity and chemotaxis
    • Wang F. The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb. Perspect. Biol. 2009, 1:1-16.
    • (2009) Cold Spring Harb. Perspect. Biol. , vol.1 , pp. 1-16
    • Wang, F.1
  • 5
    • 72449188591 scopus 로고    scopus 로고
    • Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms
    • Schmidt S., Friedl P. Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res. 2010, 339:83-92.
    • (2010) Cell Tissue Res. , vol.339 , pp. 83-92
    • Schmidt, S.1    Friedl, P.2
  • 6
    • 84868544948 scopus 로고    scopus 로고
    • Overexpression of chemokine ligand 7 is associated with the progression of canine transmissible venereal tumor
    • Chiang H.-C., Wang Y.-S., Chou C.-H., Liao A.T., Chu R.-M., Lin C.-S. Overexpression of chemokine ligand 7 is associated with the progression of canine transmissible venereal tumor. BMC Veterinary Res. 2012, 8:1-7.
    • (2012) BMC Veterinary Res. , vol.8 , pp. 1-7
    • Chiang, H.-C.1    Wang, Y.-S.2    Chou, C.-H.3    Liao, A.T.4    Chu, R.-M.5    Lin, C.-S.6
  • 7
    • 77955981205 scopus 로고    scopus 로고
    • Microfabricated analytical systems for integrated cancer cytomics
    • Wlodkowic D., Cooper J. Microfabricated analytical systems for integrated cancer cytomics. Anal. Bioanal. Chem. 2010, 398:193-209.
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 193-209
    • Wlodkowic, D.1    Cooper, J.2
  • 8
    • 42549096933 scopus 로고    scopus 로고
    • Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing
    • Wang F., Wang H., Wang J., Wang H.Y., Rummel P.L., Garimella S.V., Lu C. Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing. Biotechnol. Bioeng. 2008, 100:150-158.
    • (2008) Biotechnol. Bioeng. , vol.100 , pp. 150-158
    • Wang, F.1    Wang, H.2    Wang, J.3    Wang, H.Y.4    Rummel, P.L.5    Garimella, S.V.6    Lu, C.7
  • 10
    • 12344264742 scopus 로고    scopus 로고
    • Targeting key steps in metastatic tumor progression
    • Eccles S.A. Targeting key steps in metastatic tumor progression. Curr. Opin. Genet. Dev. 2005, 15(1):77-86.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , Issue.1 , pp. 77-86
    • Eccles, S.A.1
  • 11
    • 0030788411 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in cancer metastasis: a review
    • Anderson P.A., Kioller L., Christensen L., Duffy M.J. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int. J. Cancer 1997, 72:1-22.
    • (1997) Int. J. Cancer , vol.72 , pp. 1-22
    • Anderson, P.A.1    Kioller, L.2    Christensen, L.3    Duffy, M.J.4
  • 13
    • 0343841187 scopus 로고
    • The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes
    • Boyden S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J. Exp. Med. 1962, 115:453-466.
    • (1962) J. Exp. Med. , vol.115 , pp. 453-466
    • Boyden, S.1
  • 14
    • 84885173883 scopus 로고    scopus 로고
    • Microfluidic paper-based analytical devices (μPADs) and micro total analysis systems (μTAS): development, applications and future trends
    • Lisowski P., Zarzycki P.K. microfluidic paper-based analytical devices (μPADs) and micro total analysis systems (μTAS): development, applications and future trends. Chromatographia 2013, 76:1201-1214.
    • (2013) Chromatographia , vol.76 , pp. 1201-1214
    • Lisowski, P.1    Zarzycki, P.K.2
  • 15
    • 0017660115 scopus 로고
    • Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors
    • Zigmond S.H. Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J. Cell Biol. 1977, 75:606-616.
    • (1977) J. Cell Biol. , vol.75 , pp. 606-616
    • Zigmond, S.H.1
  • 16
    • 0025788971 scopus 로고
    • A new direct-viewing chemotaxis chamber
    • Zicha D., Dunn G.A., Brown A.F. A new direct-viewing chemotaxis chamber. J. Cell Sci. 1991, 99:769-775.
    • (1991) J. Cell Sci. , vol.99 , pp. 769-775
    • Zicha, D.1    Dunn, G.A.2    Brown, A.F.3
  • 17
    • 25844517613 scopus 로고    scopus 로고
    • Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization
    • Zheng B., Gerdts C.J., Ismagilov R.F. Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization. Curr. Opin. Struct. Biol. 2005, 15:548-555.
    • (2005) Curr. Opin. Struct. Biol. , vol.15 , pp. 548-555
    • Zheng, B.1    Gerdts, C.J.2    Ismagilov, R.F.3
  • 22
    • 79953251836 scopus 로고    scopus 로고
    • Guidelines for accurate EC50/IC50 estimation
    • Sebaugh J.L. Guidelines for accurate EC50/IC50 estimation. Pharm. Stat. 2011, 10:128-134.
    • (2011) Pharm. Stat. , vol.10 , pp. 128-134
    • Sebaugh, J.L.1
  • 23
    • 84883258838 scopus 로고    scopus 로고
    • Generation of a chemical gradient across an array of 256 cell cultures in a single chip
    • Somaweera H., Ibraguimov A., Pappas D. Generation of a chemical gradient across an array of 256 cell cultures in a single chip. Analyst 2013, 138:5566-5571.
    • (2013) Analyst , vol.138 , pp. 5566-5571
    • Somaweera, H.1    Ibraguimov, A.2    Pappas, D.3
  • 24
    • 77955618032 scopus 로고    scopus 로고
    • Microfluidic platforms for single-cell analysis
    • Zare R.N., Kim S. Microfluidic platforms for single-cell analysis. Annu. Rev. Biomed. Eng. 2010, 12:187-201.
    • (2010) Annu. Rev. Biomed. Eng. , vol.12 , pp. 187-201
    • Zare, R.N.1    Kim, S.2
  • 25
    • 84876944333 scopus 로고    scopus 로고
    • A simple and versatile microfluidic cell density gradient generator forquantum dot cytotoxicity assay
    • Wu J., Chen Q., Liu W., Lin Jin-Ming A simple and versatile microfluidic cell density gradient generator forquantum dot cytotoxicity assay. Lab. Chip 2013, 13:1948-1954.
    • (2013) Lab. Chip , vol.13 , pp. 1948-1954
    • Wu, J.1    Chen, Q.2    Liu, W.3    Lin, J.-M.4
  • 26
    • 80051623004 scopus 로고    scopus 로고
    • Ischemia/reperfusion injury of primary porcine cardiomyocytes in a low-shear microfluidic culture and analysis device
    • Khanal G., Chung K., Solis-Wever X., Johnson B., Pappas D. Ischemia/reperfusion injury of primary porcine cardiomyocytes in a low-shear microfluidic culture and analysis device. Analyst 2011, 136:3519-3526.
    • (2011) Analyst , vol.136 , pp. 3519-3526
    • Khanal, G.1    Chung, K.2    Solis-Wever, X.3    Johnson, B.4    Pappas, D.5
  • 27
    • 78049317952 scopus 로고    scopus 로고
    • A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment
    • Amadi O.C., Steinhauser M.L., Nishi Y., Chung S., Kamm R.D., McMahon A.P., Lee R.T. A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed. Microdevices 2010, 12(6):1027-1041.
    • (2010) Biomed. Microdevices , vol.12 , Issue.6 , pp. 1027-1041
    • Amadi, O.C.1    Steinhauser, M.L.2    Nishi, Y.3    Chung, S.4    Kamm, R.D.5    McMahon, A.P.6    Lee, R.T.7
  • 28
    • 84890558023 scopus 로고    scopus 로고
    • A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing
    • Gao Y., Li P., Pappas D. A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing. Biomed. Microdevices 2013, 15:907-915.
    • (2013) Biomed. Microdevices , vol.15 , pp. 907-915
    • Gao, Y.1    Li, P.2    Pappas, D.3
  • 29
    • 84862135163 scopus 로고    scopus 로고
    • Microfluidics for mammalian cell chemotaxis
    • Kim B.J., Wu M. Microfluidics for mammalian cell chemotaxis. Ann. Biomed. Eng. 2012, 40(6):1316-1327.
    • (2012) Ann. Biomed. Eng. , vol.40 , Issue.6 , pp. 1316-1327
    • Kim, B.J.1    Wu, M.2
  • 31
    • 84880472095 scopus 로고    scopus 로고
    • A review of heating and temperature control in microfluidic systems: techniques and applications
    • Miralles V., Huerre A., Malloggi F., Jullien Marie-Caroline A review of heating and temperature control in microfluidic systems: techniques and applications. Diagnostics 2013, 3:33-67.
    • (2013) Diagnostics , vol.3 , pp. 33-67
    • Miralles, V.1    Huerre, A.2    Malloggi, F.3    Jullien, M.-C.4
  • 33
    • 78650766712 scopus 로고    scopus 로고
    • An improved chamber for direct visualisation of chemotaxis
    • Muinonen-Martin A.J., Veltman D.M., Kalna G., Insall R.H. An improved chamber for direct visualisation of chemotaxis. PLoS One 2010, 5(12):e15309.
    • (2010) PLoS One , vol.5 , Issue.12 , pp. e15309
    • Muinonen-Martin, A.J.1    Veltman, D.M.2    Kalna, G.3    Insall, R.H.4
  • 34
    • 0018723691 scopus 로고
    • Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor
    • Gundersen R.W., Barrett J.N. Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor. Science 1979, 206(4422):1079-1080.
    • (1979) Science , vol.206 , Issue.4422 , pp. 1079-1080
    • Gundersen, R.W.1    Barrett, J.N.2
  • 36
    • 0042830855 scopus 로고    scopus 로고
    • Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytes
    • Zadeh a A.D., Seveau S., Halbwachs-Mecarelli L., Keller H.U. Chemotactically-induced redistribution of CD43 as related to polarity and locomotion of human polymorphonuclear leucocytes. Biol. Cell. 2003, 95(5):265-273.
    • (2003) Biol. Cell. , vol.95 , Issue.5 , pp. 265-273
    • Zadeh a, A.D.1    Seveau, S.2    Halbwachs-Mecarelli, L.3    Keller, H.U.4
  • 37
    • 0032911044 scopus 로고    scopus 로고
    • Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
    • Servant G., Weiner O.D., Neptune E.R., Sedat J.W., Bourne H.R. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol. Biol. Cell. 1999, 10(4):1163-1178.
    • (1999) Mol. Biol. Cell. , vol.10 , Issue.4 , pp. 1163-1178
    • Servant, G.1    Weiner, O.D.2    Neptune, E.R.3    Sedat, J.W.4    Bourne, H.R.5
  • 38
    • 24344455528 scopus 로고    scopus 로고
    • Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis
    • Soon L., Mouneimne G., Segall J., Wyckoff J., Condeelis J. Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis. Cell Motil. Cytoskelet. 2005, 62(1):27-34.
    • (2005) Cell Motil. Cytoskelet. , vol.62 , Issue.1 , pp. 27-34
    • Soon, L.1    Mouneimne, G.2    Segall, J.3    Wyckoff, J.4    Condeelis, J.5
  • 40
    • 37349027919 scopus 로고    scopus 로고
    • Biomolecular gradients in cell culture systems
    • Keenan T.M., Folch A. Biomolecular gradients in cell culture systems. Lab. Chip 2008, 8(1):34-57.
    • (2008) Lab. Chip , vol.8 , Issue.1 , pp. 34-57
    • Keenan, T.M.1    Folch, A.2
  • 41
    • 0033773107 scopus 로고    scopus 로고
    • Extracellular matrix and cytokines: a functional unit
    • Schoenherr E., Hausser H.J. Extracellular matrix and cytokines: a functional unit. Immunology 2000, 7:89-101.
    • (2000) Immunology , vol.7 , pp. 89-101
    • Schoenherr, E.1    Hausser, H.J.2
  • 42
    • 69949145647 scopus 로고    scopus 로고
    • Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems
    • Ubersax L., Merkle H.P., Meinel L. Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems. Tissue Eng. Part B Rev. 2009, 15(3):263-289.
    • (2009) Tissue Eng. Part B Rev. , vol.15 , Issue.3 , pp. 263-289
    • Ubersax, L.1    Merkle, H.P.2    Meinel, L.3
  • 43
    • 79959950810 scopus 로고    scopus 로고
    • Cell Guidance by 3D-Gradients in Hydrogel Matrices: Importance for Biomedical Applications
    • Lühmann T., Hall H. Cell Guidance by 3D-Gradients in Hydrogel Matrices: Importance for Biomedical Applications. Materials 2009, 2:1058-1083.
    • (2009) Materials , vol.2 , pp. 1058-1083
    • Lühmann, T.1    Hall, H.2
  • 44
    • 84895434725 scopus 로고    scopus 로고
    • Microfluidic generation of gradient hydrogels to modulate hematopoietic stem cell culture environment
    • Mahadik B.P., Wheeler T.D., Skertich L.J., Kenis P.J.A., Harley B.A.C. Microfluidic generation of gradient hydrogels to modulate hematopoietic stem cell culture environment. Adv. Healthc. Mater 2014, 3:449-458.
    • (2014) Adv. Healthc. Mater , vol.3 , pp. 449-458
    • Mahadik, B.P.1    Wheeler, T.D.2    Skertich, L.J.3    Kenis, P.J.A.4    Harley, B.A.C.5
  • 45
    • 75149149000 scopus 로고    scopus 로고
    • Chitosan-based hydrogels for controlled, localized drug delivery
    • Gunn J., Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv. Drug Deliv. Rev. 2010, 62:83-99.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 83-99
    • Gunn, J.1    Zhang, M.2
  • 46
    • 0042061223 scopus 로고    scopus 로고
    • Hydrogels for tissue engineering: scaffold design variables and applications
    • Drury J.L., Mooney D.J. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 2003, 24(24):4337-4351.
    • (2003) Biomaterials , vol.24 , Issue.24 , pp. 4337-4351
    • Drury, J.L.1    Mooney, D.J.2
  • 47
    • 77951218278 scopus 로고    scopus 로고
    • Engineering hydrogels as extracellular matrix mimics
    • Geckil H., Xu1 F., Zhang X., Moon S., Demirci U. Engineering hydrogels as extracellular matrix mimics. Nanomedicine 2010, 5(3):469-484.
    • (2010) Nanomedicine , vol.5 , Issue.3 , pp. 469-484
    • Geckil, H.1    Xu1, F.2    Zhang, X.3    Moon, S.4    Demirci, U.5
  • 48
    • 84865967452 scopus 로고
    • On the Dynamical Theory of Incompressible Viscous Fluids and the Determination of the Criterion
    • Reynolds O. On the Dynamical Theory of Incompressible Viscous Fluids and the Determination of the Criterion. Phil. Trans. Roy. Soc. Lond. 1894, 56:40-45.
    • (1894) Phil. Trans. Roy. Soc. Lond. , vol.56 , pp. 40-45
    • Reynolds, O.1
  • 49
    • 84898966455 scopus 로고    scopus 로고
    • Engineering microfluidic concentration gradient generators for biological applications
    • Toh A.G.G., Wang A.P., Yang C., Nguyen N.-T. Engineering microfluidic concentration gradient generators for biological applications. Microfluid. Nanofluid 2014, 16:1-18.
    • (2014) Microfluid. Nanofluid , vol.16 , pp. 1-18
    • Toh, A.G.G.1    Wang, A.P.2    Yang, C.3    Nguyen, N.-T.4
  • 50
    • 80054071100 scopus 로고    scopus 로고
    • Interfacial tension measurements with microfluidic tapered channels
    • 2011, 389, 38-42
    • Gu H., Duits M.H.G., Mugele F. Interfacial tension measurements with microfluidic tapered channels. Colloids Surfaces A Physicochem. Eng. Aspects 2011, 389:38-42. 2011, 389, 38-42.
    • (2011) Colloids Surfaces A Physicochem. Eng. Aspects , vol.389 , pp. 38-42
    • Gu, H.1    Duits, M.H.G.2    Mugele, F.3
  • 51
    • 84896284039 scopus 로고    scopus 로고
    • The present and future role of microfluidics in biomedical research
    • Sackmann E.K., Fulton A.L., Beebe D.J. The present and future role of microfluidics in biomedical research. Nature 2014, 507:181-189.
    • (2014) Nature , vol.507 , pp. 181-189
    • Sackmann, E.K.1    Fulton, A.L.2    Beebe, D.J.3
  • 52
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • Wu M.-H., Huang S.-B., Lee G.-B. Microfluidic cell culture systems for drug research. Lab. Chip 2010, 10:939-956.
    • (2010) Lab. Chip , vol.10 , pp. 939-956
    • Wu, M.-H.1    Huang, S.-B.2    Lee, G.-B.3
  • 53
    • 33644659211 scopus 로고    scopus 로고
    • Characterization of a membrane-based gradient generator for use in cell-signaling studies
    • Abhyankar V.V., Lokuta M.A., Huttenlocher A., Beebe D.J. Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab. Chip 2006, 6:389-393.
    • (2006) Lab. Chip , vol.6 , pp. 389-393
    • Abhyankar, V.V.1    Lokuta, M.A.2    Huttenlocher, A.3    Beebe, D.J.4
  • 55
    • 0028922751 scopus 로고
    • On liquid diffusion
    • Fick A. On liquid diffusion. J. Membr. Sci. 1995, 100:33-38.
    • (1995) J. Membr. Sci. , vol.100 , pp. 33-38
    • Fick, A.1
  • 56
    • 33644661720 scopus 로고    scopus 로고
    • A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis
    • Diao J., Young L., Kim S., Fogarty E.A., Heilman S.M., Zhou P., Shuler M.L., Wu M., DeLisa M.P. A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis. Lab. Chip 2006, 6:381-388.
    • (2006) Lab. Chip , vol.6 , pp. 381-388
    • Diao, J.1    Young, L.2    Kim, S.3    Fogarty, E.A.4    Heilman, S.M.5    Zhou, P.6    Shuler, M.L.7    Wu, M.8    DeLisa, M.P.9
  • 57
    • 84862157431 scopus 로고    scopus 로고
    • Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
    • Shin Y., Han S., Jeon J.S., Yamamoto K., Zervantonakis I.K., Sudo R., Kamm R.D., Chung S. Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. Nat. Protoc. 2012, 7(7):1247-1259.
    • (2012) Nat. Protoc. , vol.7 , Issue.7 , pp. 1247-1259
    • Shin, Y.1    Han, S.2    Jeon, J.S.3    Yamamoto, K.4    Zervantonakis, I.K.5    Sudo, R.6    Kamm, R.D.7    Chung, S.8
  • 58
    • 52649129923 scopus 로고    scopus 로고
    • Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging
    • Vickerman V., Blundo J., Chung S., Kamm R.D. Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab. Chip 2008, 8(9):1468-1477.
    • (2008) Lab. Chip , vol.8 , Issue.9 , pp. 1468-1477
    • Vickerman, V.1    Blundo, J.2    Chung, S.3    Kamm, R.D.4
  • 60
    • 81255144070 scopus 로고    scopus 로고
    • Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform
    • Jeong G.S., Han S., Shin Y., Kwon G.H., Kamm R.D., Lee S.H., Chung S. Sprouting angiogenesis under a chemical gradient regulated by interactions with an endothelial monolayer in a microfluidic platform. Anal. Chem. 2011, 83(22):8454-8459.
    • (2011) Anal. Chem. , vol.83 , Issue.22 , pp. 8454-8459
    • Jeong, G.S.1    Han, S.2    Shin, Y.3    Kwon, G.H.4    Kamm, R.D.5    Lee, S.H.6    Chung, S.7
  • 61
    • 84901045133 scopus 로고    scopus 로고
    • Small-molecule axon-polarization studies enabled by a shear-free microfluidic gradient generator
    • Xu H., Ferreira M.M., Heilshorn S.C. Small-molecule axon-polarization studies enabled by a shear-free microfluidic gradient generator. Lab. Chip 2014, 14(12):2047-2056.
    • (2014) Lab. Chip , vol.14 , Issue.12 , pp. 2047-2056
    • Xu, H.1    Ferreira, M.M.2    Heilshorn, S.C.3
  • 62
    • 33744911101 scopus 로고    scopus 로고
    • A microfluidic multi-injector for gradient generation
    • Chung B.G., Lin F., Jeon N.L. A microfluidic multi-injector for gradient generation. Lab. Chip 2006, 6(6):764-768.
    • (2006) Lab. Chip , vol.6 , Issue.6 , pp. 764-768
    • Chung, B.G.1    Lin, F.2    Jeon, N.L.3
  • 65
    • 67349251032 scopus 로고    scopus 로고
    • Fabrication of a microfluidic chip containing dam, weirs and gradient generator for studying cellular response to chemical modulation
    • Ruan J., Wang L., Xu M., Cui D., Zhou X., Liu D. Fabrication of a microfluidic chip containing dam, weirs and gradient generator for studying cellular response to chemical modulation. Mater. Sci. Eng. C 2009, 29:674-679.
    • (2009) Mater. Sci. Eng. C , vol.29 , pp. 674-679
    • Ruan, J.1    Wang, L.2    Xu, M.3    Cui, D.4    Zhou, X.5    Liu, D.6
  • 66
    • 33746431512 scopus 로고    scopus 로고
    • A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis
    • Saadi W., Wang S.-J., Lin F., Jeon N.L. A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis. Biomed. Microdevices 2006, 8:109-118.
    • (2006) Biomed. Microdevices , vol.8 , pp. 109-118
    • Saadi, W.1    Wang, S.-J.2    Lin, F.3    Jeon, N.L.4
  • 68
    • 84906698360 scopus 로고    scopus 로고
    • A polydimethylsiloxane-polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies
    • Chang C.-W., Cheng Y.-J., Tu M., Chen Y.-H., Peng C.-C., Liaoa W.-H., Tung Y.-C. A polydimethylsiloxane-polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies. Lab. Chip 2014, 14:3762-3772.
    • (2014) Lab. Chip , vol.14 , pp. 3762-3772
    • Chang, C.-W.1    Cheng, Y.-J.2    Tu, M.3    Chen, Y.-H.4    Peng, C.-C.5    Liaoa, W.-H.6    Tung, Y.-C.7
  • 69
    • 65749087089 scopus 로고    scopus 로고
    • A Microfluidics-Based Method for Analyzing Leukocyte Migration to Chemoattractant Gradients
    • Lin F. A Microfluidics-Based Method for Analyzing Leukocyte Migration to Chemoattractant Gradients. Methods Enzym. 2009, 461:333-347.
    • (2009) Methods Enzym. , vol.461 , pp. 333-347
    • Lin, F.1
  • 70
    • 84899652386 scopus 로고    scopus 로고
    • Zebrafish on a chip: a novel platform for real-time monitoring of drug-induced developmental toxicity
    • Li Y., Yang F., Chen Z., Shi L., Zhang B., Pan J., Li X., Sun D., Yang H. Zebrafish on a chip: a novel platform for real-time monitoring of drug-induced developmental toxicity. PloS One 2014, 9:94792-94798.
    • (2014) PloS One , vol.9 , pp. 94792-94798
    • Li, Y.1    Yang, F.2    Chen, Z.3    Shi, L.4    Zhang, B.5    Pan, J.6    Li, X.7    Sun, D.8    Yang, H.9
  • 71
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    • Hung P.J., Lee P.J., Sabounchi P., Lin R., Lee L.P. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol. Bioeng. 2005, 89:1-8.
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3    Lin, R.4    Lee, L.P.5
  • 72
    • 3142694728 scopus 로고    scopus 로고
    • Generation of dynamic temporal and spatial concentration gradients using microfluidic devices
    • Lin F., Saadi W., Rhee S.W., Wang Shur-Jen, Mittal S., Li Jeon N. Generation of dynamic temporal and spatial concentration gradients using microfluidic devices. Lab. Chip 2004, 4:164-167.
    • (2004) Lab. Chip , vol.4 , pp. 164-167
    • Lin, F.1    Saadi, W.2    Rhee, S.W.3    Wang, S.-J.4    Mittal, S.5    Li Jeon, N.6
  • 73
    • 0035866594 scopus 로고    scopus 로고
    • Generation of gradients having complex shapes using microfluidic networks
    • Dertinger S.K.W., Chiu D.T., Jeon N.L., Whitesides G.M. Generation of gradients having complex shapes using microfluidic networks. Anal. Chem. 2001, 73:1240-1246.
    • (2001) Anal. Chem. , vol.73 , pp. 1240-1246
    • Dertinger, S.K.W.1    Chiu, D.T.2    Jeon, N.L.3    Whitesides, G.M.4
  • 75
    • 84874154379 scopus 로고    scopus 로고
    • Microfluidic mixing in a Y-junction open channel
    • Tan J.N., Neilda A. Microfluidic mixing in a Y-junction open channel. AIP Adv. 2012, 2:32160-32171.
    • (2012) AIP Adv. , vol.2 , pp. 32160-32171
    • Tan, J.N.1    Neilda, A.2
  • 76
    • 84906819045 scopus 로고    scopus 로고
    • Polymer brushes patterned with micrometer-scale chemical gradients using laminar co-flow
    • Koo H.-J., Waynant K.V., Zhang C., Braun P.V. Polymer brushes patterned with micrometer-scale chemical gradients using laminar co-flow. Appl. Mater. Interface. 2014, 6:14320-14326.
    • (2014) Appl. Mater. Interface. , vol.6 , pp. 14320-14326
    • Koo, H.-J.1    Waynant, K.V.2    Zhang, C.3    Braun, P.V.4
  • 77
    • 59649105005 scopus 로고    scopus 로고
    • A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics
    • Walsh C.L., Babin B.M., Kasinskas R.W., Foster J.A., McGarry M.J., Forbes N.S. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab. Chip 2009, 9(4):545-554.
    • (2009) Lab. Chip , vol.9 , Issue.4 , pp. 545-554
    • Walsh, C.L.1    Babin, B.M.2    Kasinskas, R.W.3    Foster, J.A.4    McGarry, M.J.5    Forbes, N.S.6
  • 78
    • 33646746703 scopus 로고    scopus 로고
    • Universal microfluidic gradient generator
    • Irimia D., Geba D.A., Toner M. Universal microfluidic gradient generator. Anal. Chem. 2006, 78(10):3472-3477.
    • (2006) Anal. Chem. , vol.78 , Issue.10 , pp. 3472-3477
    • Irimia, D.1    Geba, D.A.2    Toner, M.3
  • 79
    • 84864856237 scopus 로고    scopus 로고
    • Spatially selective reagent delivery into cancer cells using a two-layer microfluidic culture system
    • Liu Y., Butler W.B., Pappas D. Spatially selective reagent delivery into cancer cells using a two-layer microfluidic culture system. Anal. Chim. Acta. 2012, 743:125-130.
    • (2012) Anal. Chim. Acta. , vol.743 , pp. 125-130
    • Liu, Y.1    Butler, W.B.2    Pappas, D.3
  • 80
    • 84055207544 scopus 로고    scopus 로고
    • A robust diffusion-based gradient generator for dynamic cell assays A robust diffusion-based gradient generator for dynamic cell assays
    • Atencia J., Cooksey G.A. A robust diffusion-based gradient generator for dynamic cell assays A robust diffusion-based gradient generator for dynamic cell assays. Lab. Chip 2012, 12:309-316.
    • (2012) Lab. Chip , vol.12 , pp. 309-316
    • Atencia, J.1    Cooksey, G.A.2
  • 81
    • 84934878790 scopus 로고    scopus 로고
    • Generation of stable orthogonal gradients of chemical concentration and substrate stiffness in a microfluidic device
    • García S., Sunyer R., Olivares A., Noailly J., Atencia J., Trepat X. Generation of stable orthogonal gradients of chemical concentration and substrate stiffness in a microfluidic device. Lab. Chip 2015, 15:2606-2614.
    • (2015) Lab. Chip , vol.15 , pp. 2606-2614
    • García, S.1    Sunyer, R.2    Olivares, A.3    Noailly, J.4    Atencia, J.5    Trepat, X.6
  • 82
    • 84951765547 scopus 로고    scopus 로고
    • On-chip gradient generation in 256 microfluidic cell cultures: simulation and experimental validation
    • Somaweera H., Haputhanthri S.O., Ibraguimov A., Pappas D. On-chip gradient generation in 256 microfluidic cell cultures: simulation and experimental validation. Analyst 2015, 140(15):5029-5038.
    • (2015) Analyst , vol.140 , Issue.15 , pp. 5029-5038
    • Somaweera, H.1    Haputhanthri, S.O.2    Ibraguimov, A.3    Pappas, D.4
  • 83
    • 80755158890 scopus 로고    scopus 로고
    • Microfluidic static droplet arrays with tuneable gradients in material composition
    • Sun M., Bithi S.S., Vanapalli S.A. Microfluidic static droplet arrays with tuneable gradients in material composition. Lab. Chip 2011, 11:3949-3952.
    • (2011) Lab. Chip , vol.11 , pp. 3949-3952
    • Sun, M.1    Bithi, S.S.2    Vanapalli, S.A.3
  • 84
    • 84874068046 scopus 로고    scopus 로고
    • Generation of chemical concentration gradients in mobile droplet arrays via fragmentation of long immiscible diluting plugs
    • Sun M., Vanapalli S.A. Generation of chemical concentration gradients in mobile droplet arrays via fragmentation of long immiscible diluting plugs. Anal. Chem. 2013, 85(4):2044-2048.
    • (2013) Anal. Chem. , vol.85 , Issue.4 , pp. 2044-2048
    • Sun, M.1    Vanapalli, S.A.2
  • 85
    • 84855405452 scopus 로고    scopus 로고
    • Droplet-based microfluidic flow injection system with large-scale concentration gradient by a single nanoliter-scale injection for enzyme inhibition assay
    • Cai L.F., Zhu Y., Du G.S., Fang Q. Droplet-based microfluidic flow injection system with large-scale concentration gradient by a single nanoliter-scale injection for enzyme inhibition assay. Anal. Chem. 2012, 84(1):446-452.
    • (2012) Anal. Chem. , vol.84 , Issue.1 , pp. 446-452
    • Cai, L.F.1    Zhu, Y.2    Du, G.S.3    Fang, Q.4
  • 86
    • 84898908831 scopus 로고    scopus 로고
    • Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing
    • Wang Y., Wang J. Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing. Analyst 2014, 139(10):2449-2458.
    • (2014) Analyst , vol.139 , Issue.10 , pp. 2449-2458
    • Wang, Y.1    Wang, J.2
  • 87
    • 84864834109 scopus 로고    scopus 로고
    • Temporal gradients in microfluidic systems to probe cellular dynamics: A review
    • Dhumpa R., Roper M.G. Temporal gradients in microfluidic systems to probe cellular dynamics: A review. Anal. Chim. Acta 2012, 743:9-18.
    • (2012) Anal. Chim. Acta , vol.743 , pp. 9-18
    • Dhumpa, R.1    Roper, M.G.2
  • 88
    • 38549084632 scopus 로고    scopus 로고
    • The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae
    • Mettetal J.T., Muzzey D., Gómez-Uribe C., van Oudenaarden A. The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science 2008, 319:482-484.
    • (2008) Science , vol.319 , pp. 482-484
    • Mettetal, J.T.1    Muzzey, D.2    Gómez-Uribe, C.3    van Oudenaarden, A.4
  • 89
    • 77956752516 scopus 로고    scopus 로고
    • Chemical neurostimulation using pulse code modulation (pcm) microfluidic chips
    • Azizi F., Lu H., Chiel H.J., Mastrangelo C.H. Chemical neurostimulation using pulse code modulation (pcm) microfluidic chips. J. Neurosci. Meth. 2010, 192:193-198.
    • (2010) J. Neurosci. Meth. , vol.192 , pp. 193-198
    • Azizi, F.1    Lu, H.2    Chiel, H.J.3    Mastrangelo, C.H.4
  • 90
    • 61449096586 scopus 로고    scopus 로고
    • Microfluidic perfusion system for automated delivery of temporal gradients to biological cells
    • Zhang X., Roper M.G. Microfluidic perfusion system for automated delivery of temporal gradients to biological cells. Anal. Chem. 2009, 81:1162-1168.
    • (2009) Anal. Chem. , vol.81 , pp. 1162-1168
    • Zhang, X.1    Roper, M.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.