Microfabricated analytical systems for integrated cancer cytomics

Analytical and Bioanalytical Chemistry

Volumn 398, Issue 1, 2010, Pages 193-209

  Wlodkowic, Donald ^a   Cooper, Jonathan M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cell sorting; Cytometry; Cytomics; Lab on a chip; Microfluidics; Real time cell assays

Indexed keywords

BIOCHIPS; CONTROLLED DRUG DELIVERY; COST EFFECTIVENESS; DISEASES; FLOW OF FLUIDS; LAB-ON-A-CHIP; LABORATORIES; REYNOLDS NUMBER; TARGETED DRUG DELIVERY;

CELL ASSAYS; CELL SORTING; CELL-TO-CELL VARIABILITY; COMPUTATIONAL MODELLING; CYTOMETRY; CYTOMICS; LAB-ON-A-CHIP TECHNOLOGY; MICROFLUIDIC TECHNOLOGIES;

MICROFLUIDICS;

EID: 77955981205     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-3722-8     Document Type: Review

References (123)

1. J Foo F Michor 2010 Evolution of resistance to anti-cancer therapy during general dosing schedules J Theor Biol 263 2 179 188
2. TJ Perkins PS Swain 2009 Strategies for cellular decision-making Mol Syst Biol 5 326
3. KL Roach KR King BE Uygun IS Kohane ML Yarmush M Toner 2009 Biotechnol Prog 25 6 1772 9
4. M Perc M Rupnik M Gosak M Marhl 2009 Prevalence of stochasticity in experimentally observed responses of pancreatic acinar cells to acetylcholine Chaos 19 3 037113
5. ED Hawkins JF Markham LP McGuinness PD Hodgkin 2009 A single-cell pedigree analysis of alternative stochastic lymphocyte fates Proc Natl Acad Sci U S A 106 32 13457 62
6. H Fakir WY Tan L Hlatky P Hahnfeldt RK Sachs 2009 Stochastic population dynamic effects for lung cancer progression Radiat Res 172 3 383 93
7. H Enderling AR Anderson MA Chaplain A Beheshti L Hlatky P Hahnfeldt 2009 Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics Cancer Res 69 22 8814 21
8. IN Lavrik R Eils N Fricker C Pforr PH Krammer 2009 Understanding apoptosis by systems biology approaches Mol Biosyst 5 10 1105 11
9. S Raychaudhuri J Skommer K Henty N Birch T Brittain 2010 Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death Apoptosis 15 4 401 411
10. L Milas WN Hittelman 2009 Cancer stem cells and tumor response to therapy: current problems and future prospects Semin Radiat Oncol 19 2 96 105
11. AJ Davis JF Tannock 2000 Repopulation of tumour cells between cycles of chemotherapy: a neglected factor Lancet Oncol 1 86 93
12. N Stavreva P Stavrev BG Fallone 2009 Probability dynamics of a repopulating tumor in case of fractionated external radiotherapy Phys Med 25 4 181 91
13. A Tárnok J Bocsi G Brockhoff 2006 Cytomics-importance of multimodal analysis of cell function and proliferation in oncology Cell Prolif 39 6 495 505
14. A Tárnok GK Valet F Emmrich 2006 Systems biology and clinical cytomics: the 10th Leipziger Workshop and the 3rd International Workshop on Slide-Based Cytometry, Leipzig, Germany, April 2005 Cytometry A 69 1 36 40
15. S Faley K Seale J Hughey DK Schaffer S VanCompernolle B McKinney F Baudenbacher D Unutmaz JP Wikswo 2008 Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel Lab Chip 8 10 1700 12
16. D Wlodkowic S Faley M Zagnoni JP Wikswo JM Cooper 2009 Microfluidic single-cell array cytometry for the analysis of tumor apoptosis Anal Chem 81 13 5517 23
17. Y Yang SJ Adelstein AI Kassis 2009 Target discovery from data mining approaches Drug Discov Today 14 3-4 147 54
18. YS Kim P Maruvada JA Milner 2008 Metabolomics in biomarker discovery: future uses for cancer prevention Future Oncol 4 1 93 102
19. SL Faley M Copland D Wlodkowic W Kolch KT Seale JP Wikswo JM Cooper 2009 Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells Lab Chip 9 18 2659 64
20. D Wlodkowic J Skommer D McGuinness S Faley W Kolch Z Darzynkiewicz JM Cooper 2009 Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells Anal Chem 81 16 6952 6959
21. Z Darzynkiewicz G Juan X Li W Gorczyca T Murakami F Traganos 1997 Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis) Cytometry 27 1 1 20
22. Z Darzynkiewicz E Bedner F Traganos 2001 Difficulties and pitfalls in analysis of apoptosis Methods Cell Biol 63 527 46
23. MR Melamed 2001 A brief history of flow cytometry and sorting Methods Cell Biol 63 3 17
24. JP Robinson 2006 Multispectral cytometry: the next generation Biophotonics Int 10 36 40
25. L Bonetta 2005 Flow cytometry smaller and better Nat Methods 2 785 95
26. H Shapiro 2004 The evolution of cytometers Cytometry A 58 13 7
27. TC George DA Basiji BE Hall DH Lynch WE Ortyn DJ Perry MJ Seo CA Zimmerman PJ Morrissey 2004 Distinguishing modes of cell death using the ImageStream multispectral imaging flow cytometer Cytometry A 59 2 237 45
28. EK Zuba-Surma M Kucia A Abdel-Latif JW Lillard Jr MZ Ratajczak 2007 The imagestream system: a key step to a new era in imaging Folia Histochem Cytobiol 45 4 279 90
29. LA Kamentsky LD Kamentsky 1991 Microscope-based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data Cytometry 12 381 7
30. G Janossy H Shapiro 2008 Simplified cytometry for routine monitoring of infectious diseases Cytometry B Clin Cytom 74 Suppl 1 S6 10
31. BS Manian 2008 Affordable diagnostics-changing the paradigm in India Cytometry B Clin Cytom 74 Suppl 1 S117 22
32. LL Baum S Crowe AL Landay 2007 Advances in CD4 cell enumeration in resource-poor countries Curr Opin HIV AIDS 2 3 234 40
33. LM Mayr D Bojanic 2009 Novel trends in high-throughput screening Curr Opin Pharmacol 9 5 580 8
34. EF Schmid R Ashkenazy J Merson DA Smith 2009 Will biomedical innovation change the future of healthcare? Drug Discov Today 14 21-22 1037 44
35. KS Zaenker F Entschladen 2009 Paving roads for new drugs in oncology Recent Pat Anticancer Drug Discov 4 2 137 45
36. A Manz PS Dittrich 2006 Lab-on-a-chip: microfluidics in drug discovery Nat Rev Drug Discov 5 210 8
37. J Hong JB Edel AJ deMello 2009 Micro-and nanofluidic systems for high-throughput biological screening Drug Discov Today 14 3-4 134 46
38. L Kang BG Chung R Langer A Khademhosseini 2008 Microfluidics for drug discovery and development: from target selection to product lifecycle management Drug Discov Today 13 1-2 1 13
39. J Deeken 2009 The Affymetrix DMET platform and pharmacogenetics in drug development Curr Opin Mol Ther 11 3 260 8
40. TW Gant SD Zhang EL Taylor 2009 Novel genomic methods for drug discovery and mechanism-based toxicological assessment Curr Opin Drug Discov Devel 12 1 72 80
41. VS Gomase S Tagore KV Kale 2008 Microarray: an approach for current drug targets Curr Drug Metab 9 3 221 31
42. RL Camp V Neumeister DL Rimm 2008 A decade of tissue microarrays: progress in the discovery and validation of cancer biomarkers J Clin Oncol 26 34 5630 7
43. H Ma KY Horiuchi 2006 Chemical microarray: a new tool for drug screening and discovery Drug Discov Today 11 13-14 661 8
44. J Sobek K Bartscherer A Jacob JD Hoheisel P Angenendt 2006 Microarray technology as a universal tool for high-throughput analysis of biological systems Comb Chem High Throughput Screen 9 5 365 80
45. M Uttamchandani SQ Yao 2008 Peptide microarrays: next generation biochips for detection, diagnostics and high-throughput screening Curr Pharm Des 14 24 2428 38
46. GM Whitesides 2006 The origins and the future of microfluidics Nature 442 368 72
47. J El-Ali PK Sorger KF Jensen 2006 Cells on chips Nature 442 403 11
48. CE Sims NL Allbritton 2007 Analysis of single mammalian cells on-chip Lab Chip 7 423 40
49. J Wang L Ren L Li W Liu J Zhou W Yu D Tong S Chen 2009 Microfluidics: a new cosset for neurobiology Lab Chip 9 5 644 52
50. FB Myers LP Lee 2008 Innovations in optical microfluidic technologies for point-of-care diagnostics Lab Chip 8 12 2015 31
51. MG Mauk BL Ziober Z Chen JA Thompson HH Bau 2007 Lab-on-a-chip technologies for oral-based cancer screening and diagnostics: capabilities, issues, and prospects Ann N Y Acad Sci 1098 467 75
52. B Weigl G Domingo P Labarre J Gerlach 2008 Towards non-and minimally instrumented, microfluidics-based diagnostic devices Lab Chip 8 12 1999 2014
53. FL Kiechle CA Holland 2009 Point-of-care testing and molecular diagnostics: miniaturization required Clin Lab Med 29 3 555 60
54. TG Fernandes MM Diogo DS Clark JS Dordick JM Cabral 2009 High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research Trends Biotechnol 27 6 342 9
55. Wheeler DB, Carpenter AE, Sabatini DM (2005) Cell microarrays and RNA interference chip away at gene function. Nat Genet 37 Suppl:25-30
56. JH Doroshow RE Parchment 2008 Oncologic phase 0 trials incorporating clinical pharmacodynamics: from concept to patient Clin Cancer Res 14 12 3658 63
57. EK Rowinsky 2004 Curtailing the high rate of late-stage attrition of investigational therapeutics against unprecedented targets in patients with lung and other malignancies Clin Cancer Res 10 12 Pt 2 4220 6
58. SW Fesik 2005 Promoting apoptosis as a strategy for cancer drug discovery Nat Rev Cancer 5 11 876 85
59. AC Mita MM Mita EK Rowinsky 2004 Development of rationally designed, target-based agents for the treatment of advanced colorectal cancer Clin Colorectal Cancer 4 2 107 23
60. D Wlodkowic J Skommer D McGuinness C Hillier Z Darzynkiewicz 2009 ER-Golgi network-a future target for anti-cancer therapy Leuk Res 33 11 1440 7
61. BB Hyde G Twig OS Shirihai 2010 Organellar vs cellular control of mitochondrial dynamics Semin Cell Dev Biol 10.1016/j.semcdb.2010.01.003
62. Y Tokimitsu H Kishi S Kondo R Honda K Tajiri K Motoki T Ozawa S Kadowaki T Obata S Fujiki C Tateno H Takaishi K Chayama K Yoshizato E Tamiya T Sugiyama A Muraguchi 2007 Single lymphocyte analysis with a microwell array chip Cytometry A 71 12 1003 10
63. K Tajiri H Kishi Y Tokimitsu S Kondo T Ozawa K Kinoshita A Jin S Kadowaki T Sugiyama A Muraguchi 2007 Cell-microarray analysis of antigen-specific B-cells: single cell analysis of antigen receptor expression and specificity Cytometry A 71 11 961 7
64. S Yamamura H Kishi Y Tokimitsu S Kondo R Honda SR Rao M Omori E Tamiya A Muraguchi 2005 Single-cell microarray for analyzing cellular response Anal Chem 77 24 8050 6
65. JR Rettig A Folch 2005 Large-scale single-cell trapping and imaging using microwell arrays Anal Chem 77 17 5628 34
66. S Lindström M Eriksson T Vazin J Sandberg J Lundeberg J Frisén H Andersson-Svahn 2009 High-density microwell chip for culture and analysis of stem cells PLoS ONE 4 9 e6997
67. S Lindström K Mori T Ohashi H Andersson-Svahn 2009 A microwell array device with integrated microfluidic components for enhanced single-cell analysis Electrophoresis 30 24 4166 71
68. RS Thomas H Morgan NG Green 2009 Negative DEP traps for single cell immobilisation Lab Chip 9 11 1534 40
69. M Bocchi M Lombardini A Faenza L Rambelli L Giulianelli N Pecorari R Guerrieri 2009 Dielectrophoretic trapping in microwells for manipulation of single cells and small aggregates of particles Biosens Bioelectron 24 5 1177 83
70. J Voldman ML Gray M Toner MA Schmidt 2002 A Microfabrication-based dynamic array cytometer Anal Chem 74 3984 90
71. SK Sia GM Whitesides 2003 Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies Electrophoresis 24 21 3563 76
72. S Takayama E Ostuni P LeDuc K Naruse DE Ingber GM Whitesides 2001 Subcellular positioning of small molecules Nature 411 6841 1016
73. S Takayama E Ostuni P LeDuc K Naruse DE Ingber GM Whitesides 2003 Selective chemical treatment of cellular microdomains using multiple laminar streams Chem Biol 10 2 123 30
74. N Klauke G Smith JM Cooper 2009 Local regional stimulation of single isolated ventricular myocytes using microfluidics Anal Chem 10.1021/ac9008429
75. PJ Hung PJ Lee P Sabounchi N Aghdam R Lin LP Lee 2005 A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array Lab Chip 5 44 8
76. KR King S Wang D Irimia A Jayaraman M Toner ML Yarmush 2007 A high-throughput microfluidic real-time gene expression living cell array Lab Chip 7 77 85
77. D Di Carlo LY Wu LP Lee 2006 Dynamic single cell culture array Lab Chip 6 11 1445 9
78. Z Wang MC Kim M Marquez T Thorsen 2007 High-density microfluidic arrays for cell cytotoxicity analysis Lab Chip 7 740 5
79. M Miyake T Yoshikawa S Fujita J Miyake 2009 Transfection microarray and the applications Mol Biosyst 5 5 444 9
80. SD Chan G Luedke M Valer C Buhlmann T Preckel 2003 Cytometric analysis of protein expression and apoptosis in human primary cells with a novel microfluidic chip-based system Cytometry A 55 2 119 25
81. D Huh W Gu Y Kamotani JB Grotberg S Takayama 2005 Microfluidics for flow cytometric analysis of cells and particles Physiol Meas 26 3 73 98
82. A Wolff IR Perch-Nielsen UD Larsen P Friis G Goranovic CR Poulsen JP Kutter P Telleman 2003 Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter Lab Chip 3 1 22 7
83. MM Wang E Tu DE Raymond JM Yang H Zhang N Hagen B Dees EM Mercer AH Forster I Kariv PJ Marchand WF Butler 2005 Microfluidic sorting of mammalian cells by optical force switching Nat Biotechnol 23 1 83 7
84. AY Fu HP Chou C Spence FH Arnold SR Quake 2002 An integrated microfabricated cell sorter Anal Chem 74 11 2451 7
85. H Sugino K Ozaki Y Shirasaki T Arakawa S Shoji T Funatsu 2009 On-chip microfluidic sorting with fluorescence spectrum detection and multiway separation Lab Chip 9 9 1254 60
86. JD Adams U Kim HT Soh 2008 Multitarget magnetic activated cell sorter Proc Natl Acad Sci U S A 105 47 18165 70
87. D Wlodkowic J Skommer S Faley Z Darzynkiewicz JM Cooper 2009 Dynamic analysis of apoptosis using cyanine SYTO probes: from classical to microfluidic cytometry Exp Cell Res 315 10 1706 14
88. K Takeda F Jimma 2009 Maintenance free biosafety flowcytometer using disposable microfluidic chip (FISHMAN-R) Cytometry B 76B 405 6
89. Takao M, Jimma F, Takeda K (2009) Expanded applications of new-designed microfluidic flow cytometer (FISHMAN-R). Cytometry B 76B;405
90. TD Chung HC Kim 2007 Recent advances in miniaturized microfluidic flow cytometry for clinical use Electrophoresis 28 24 4511 20
91. N Watkins BM Venkatesan M Toner W Rodriguez R Bashir 2009 A robust electrical microcytometer with 3-dimensional hydrofocusing Lab Chip 9 3177 84
92. X Mao SCS Lin C Dong TJ Huang 2009 Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing Lab Chip 9 1583 9
93. A Kummrow J Theisen M Frankowski A Tuchscheerer H Yildirim K Brattke M Schmidt J Neukammer 2009 Microfluidic structures for flow cytometric analysis of hydrodynamically focussed blood cells fabricated by ultraprecision micromachining Lab Chip 9 972 81
94. R Rodriguez-Trujillo O Castillo-Fernandez M Garrido M Arundell A Valencia G Gomila 2008 High-speed particle detection in a micro-Coulter counter with two-dimensional adjustable aperture Biosens Bioelectron 24 290 6
95. R Scott P Sethu CK Harnett 2008 Three-dimensional hydrodynamic focusing in a microfluidic Coulter counter Rev Sci Instrum 79 046104
96. S Zheng M Liu YC Tai 2008 Micro coulter counters with platinum black electroplated electrodes for human blood cell sensing Biomed Microdevices 10 221 31
97. D Holmes D Pettigrew CH Reccius JD Gwyer C van Berkel J Holloway DE Davies H Morgan 2009 Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry Lab Chip 9 2881 9
98. Piacentini N, Demarchi D, Civera P, Knaflitz M (2008) Blood cell counting by means of impedance measurements in a microsystem device. Conf Proc IEEE Eng Med Biol Soc 4824-7
99. X Wang FF Becker PRC Gascoyne 2002 Membrane dielectric changes indicate induced apoptosis in HL-60 cells more sensitively than surface phosphatidylserine expression or DNA fragmentation Biochim Biophys Acta 1564 412 20
100. K Cheung S Gawad P Renaud 2005 Impedance spectroscopy flow cytometry: on-chip label-free cell differentiation Cytometry A 65 124 32
101. LL Sohn OA Saleh GR Facer AJ Beavis RS Allan DA Notterman 2000 Capacitance cytometry: measuring biological cells one by one Proc Natl Acad Sci U S A 97 10687 90
102. JM Atienza J Zhu X Wang X Xu Y Abassi 2005 Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays J Biomol Screen 10 795 805
103. H Zhang E Tu ND Hagen CA Schnabel MJ Paliotti WS Hoo PM Nguyen JR Kohrumel WF Butler M Chachisvillis PJ Marchand 2004 Time-of-flight optophoresis analysis of live whole cells in microfluidic channels Biomed Microdevices 6 11 21
104. AH Forster MM Wang WF Butler M Chachisvilis TD Chung SC Esener JM Hall O Kibar K Lykstad PJ Marchand EM Mercer LM Pestana S Sur E Tu R Yang H Zhang I Kariv 2004 Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model Anal Biochem 327 14 22
105. M Nerenberg I Kariv P McNeeley P Marchand S Sur J Diver S Riccitelli J Nieva A Saven 2006 Use of optophoresis as an in vitro predictor of cell response to chemotherapy for chronic lymphocytic leukemia Leuk Lymphoma 47 2194 202
106. E Tamaki A Hibara M Tokeshi T Kitamori 2003 Microchannel-assisted thermal-lens spectrometry for microchip analysis J Chromatogr A 987 197 204
107. E Tamaki A Hibara M Tokeshi T Kitamori 2005 Tunable thermal lens spectrometry utilizing microchannel-assisted thermal lens spectrometry Lab Chip 5 129 31
108. S Balslev AM Jorgensen B Bilenberg KB Mogensen D Snakenborg O Geschke JP Kutter A Kristensen 2006 Lab-on-a-chip with integrated optical transducers Lab Chip 6 213 7
109. P Chen X Feng W Du BF Liu 2008 Microfluidic chips for cell sorting Front Biosci 13 2464 83
110. HS Kim OT Son KH Kim SH Kim S Maeng HI Jung 2007 Separation of apoptotic cells using a microfluidic device Biotechnol Lett 29 11 1659 63
111. N Xia TP Hunt BT Mayers E Alsberg GM Whitesides RM Westervelt DE Ingber 2006 Combined microfluidic-micromagnetic separation of living cells in continuous flow Biomed Microdevices 8 4 299 308
112. BY Qu ZY Wu F Fang ZM Bai DZ Yang SK Xu 2008 A glass microfluidic chip for continuous blood cell sorting by a magnetic gradient without labeling Anal Bioanal Chem 392 7-8 1317 24
113. N Pamme 2007 Continuous flow separations in microfluidic devices Lab Chip 7 12 1644 59
114. N Pamme 2006 Magnetism and microfluidics Lab Chip 6 1 24 38
115. N Pamme C Wilhelm 2006 Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis Lab Chip 6 8 974 80
116. AY Lau LP Lee JW Chan 2008 An integrated optofluidic platform for Raman-activated cell sorting Lab Chip 8 1116 20
117. CW Yung J Fiering AJ Muellerb DE Ingber 2009 Micromagnetic-microfluidic blood cleansing device Lab Chip 9 1171 7
118. S Nagrath LV Sequist S Maheswaran DW Bell D Irimia L Ulkus MR Smith EL Kwak S Digumarthy A Muzikansky P Ryan UJ Balis RG Tompkins DA Haber M Toner 2007 Isolation of rare circulating tumour cells in cancer patients by microchip technology Nature 450 7173 1235 9
119. JT Nevill R Cooper M Dueck DN Breslauer LP Lee 2007 Integrated microfluidic cell culture and lysis on a chip Lab Chip 7 1689 95
120. R Gomez-Sjoberg AA Leyrat DM Pirone CS Chen SR Quake 2007 Versatile, fully automated, microfluidic cell culture system Anal Chem 79 8557 63
121. KC Chaw M Manimaran EH Tayad S Swaminathan 2007 Multi-step microfluidic device for studying cancer metastasis Lab Chip 7 1041 7
122. M Deutsch A Deutsch O Shirihai I Hurevich E Afrimzon Y Shafrana N Zurgila 2006 A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells Lab Chip 6 995 1000
123. A Revzin K Sekine A Sin RG Tompkins M Toner 2005 Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes Lab Chip 5 30 7