A human beta cell line with drug inducible excision of immortalizing transgenes

Molecular Metabolism

Volumn 4, Issue 12, 2015, Pages 916-925

  Benazra, Marion ^a,b   Lecomte, Marie José ^a   Colace, Claire ^a,b   Müller, Andreas ^c,d   Machado, Cécile ^a   Pechberty, Severine ^a   Bricout Neveu, Emilie ^a   Grenier Godard, Maud ^a   Solimena, Michele ^c,d,e   Scharfmann, Raphaël ^f   Czernichow, Paul ^a   Ravassard, Philippe ^a,b  

^a INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^e MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^f INSERM   (France)

Author keywords

Cell engineering; Conditional immortalization; Human beta cell function; Human pancreatic beta cell line; Tamoxifen inducible CRE

Indexed keywords

CRE RECOMBINASE; INSULIN; LENTIVIRUS VECTOR; TAMOXIFEN;

ARTICLE; CELL ENGINEERING; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STIMULATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION; GENE TRANSFER; GROWTH INHIBITION; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; STABLE EXPRESSION; TRANSGENE;

EID: 84951826410     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2015.09.008     Document Type: Article

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