In search of a surrogate: Engineering human beta cell lines for therapy

Trends in Endocrinology and Metabolism

Volumn 25, Issue 8, 2014, Pages 378-380

  Newby, Brittney N ^a   Terada, Naohiro ^a   Mathews, Clayton E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Beta cells; Embryonic stem cell; Induced pluripotent stem cell; Islet cell transplantation; Type 1 diabetes

Indexed keywords

CELL LINE; CELL THERAPY; CELL TRANSPLANTATION; DIABETIC PATIENT; DONOR; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NOTE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; CYTOLOGY; DIABETES MELLITUS, TYPE 1; PANCREAS ISLET TRANSPLANTATION; PROCEDURES; TRANSPLANTATION;

CELL LINE; DIABETES MELLITUS, TYPE 1; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION;

EID: 84904734275     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.05.006     Document Type: Note

References (16)

1. Atkinson M.A., et al. Type 1 diabetes. Lancet 2014, 383:69-82.
2. Staeva T.P., et al. Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes 2013, 62:9-17.
3. Feutren G., et al. Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet 1986, 2:119-124.
4. Planas R., et al. Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Clin. Exp. Immunol. 2010, 159:23-44.
5. Scharfmann R., et al. Concise review: in search of unlimited sources of functional human pancreatic beta cells. Stem Cells Transl. Med. 2013, 2:61-67.
6. Lightfoot Y.L., et al. Immune-mediated beta-cell death in type 1 diabetes: lessons from human beta-cell lines. Eur. J. Clin. Invest. 2012, 42:1244-1251.
7. Lightfoot Y.L., et al. Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic beta cell line betaLox5. PLoS ONE 2011, 6:e20617.
8. Vasu S., et al. Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4. Biochim. Biophys. Acta 2014, 1840:136-145.
9. Ravassard P., et al. A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion. J. Clin. Invest. 2011, 121:3589-3597.
10. Scharfmann R., et al. Development of a conditionally immortalized human pancreatic beta cell line. J. Clin. Invest. 2014, 124:2087-2098.
11. Schulz T.C., et al. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS ONE 2012, 7:e37004.
12. Bouwens L., et al. The use of stem cells for pancreatic regeneration in diabetes mellitus. Nat. Rev. Endocrinol. 2013, 9:598-606.
13. Bilic J., Izpisua Belmonte J.C. Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart?. Stem Cells 2012, 30:33-41.
14. Kelly O.G., et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat. Biotechnol. 2011, 29:750-756.
15. Yamada M., et al. Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature 2014, 10.1038/nature13287.
16. Pagliuca F.W., Melton D.A. How to make a functional beta-cell. Development 2013, 140:2472-2483.