Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

Toxicology and Applied Pharmacology

Volumn 291, Issue , 2016, Pages 38-45

  Won, Young Suk ^a   Song, Ji Won ^b   Lim, Jong Hwan ^c   Lee, Mee Young ^d   Moon, Og Sung ^a   Kim, Hyoung Chin ^a   Son, Hwa Young ^b   Kwon, Hyo Jung ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Botanical Drug Research Team Huons Co Ltd   (South Korea)

^d Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Hepatotoxicity; ob ob; Oxidative stress; Thioacetamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; THIOACETAMIDE; TRIACYLGLYCEROL;

ACUTE LIVER FAILURE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; LETHAL DOSE; LIVER TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PLASMA CLEARANCE; SINGLE DRUG DOSE; SURVIVAL RATE; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION; ANIMAL; C57BL MOUSE; DRUG-INDUCED LIVER INJURY; GENETICS; LD50; METABOLISM; MOUSE MUTANT;

ANIMALS; DRUG-INDUCED LIVER INJURY; LETHAL DOSE 50; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; THIOACETAMIDE;

EID: 84951789452     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.12.001     Document Type: Article

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