Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity: Expression of metallothionein and HSP70

Biochemical Pharmacology

Volumn 66, Issue 6, 2003, Pages 917-926

  Andrés, David ^a   Sánchez Reus, Isabel ^a   Bautista, Mirandeli ^a   Cascales, María ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Gadolinium chloride; HSP70; Kupffer cells; Metallothionein; Thioacetamide hepatotoxicity

Indexed keywords

FLAVINE ADENINE NUCLEOTIDE; GADOLINIUM CHLORIDE; HEAT SHOCK PROTEIN 70; METALLOTHIONEIN; MYELOPEROXIDASE; THIOACETAMIDE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; IN VIVO STUDY; INJECTION; KUPFFER CELL; LIPID PEROXIDATION; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; MICROSOME; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE;

EID: 0042261675     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00443-X     Document Type: Article

References (50)

1. Nolan J.P. Endotoxin, reticuloendothelial function and liver injury. Hepatology. 1:1981;458-465.
2. Ishiyama H., Sato M., Matsumara K., Sento M., Ogino K., Hobara T. Proliferation of hepatocytes and attenuation from carbon tetrachloride hepatotoxicity by gadolinium chloride. Pharmacol. Toxicol. 77:1995;293-298.
3. Iimuro Y., Yamamoto M., Kohno H., Itakura J., Fujii H., Matsumoto Y. Blockade of liver macrophages by gadolinium chloride reduces lethality in endotoxemic rats. Analysis of mechanisms of lethality in endotoxemia. J. Leukoc. Biol. 55:1994;723-728.
4. Harstad E.B., Klaassen C.D. Gadolinium chloride pre-treatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice. Toxicol. Appl. Pharmacol. 180:2002;178-185.
5. Iszard M.B., Liu J., Klaassen C.D. Effect of several metallothionein inducers on oxidative stress defence mechanisms in rats. Toxicology. 104:1995;25-33.
6. Bauman J.W., Liu J., Liu Y.P., Klaassen C.D. Increase in metallothionein produced by chemicals that induce oxidative stress. Toxicol. Appl. Pharmacol. 110:1991;347-354.
7. Theocharis S.E., Kanellu H., Margeli A.P., Spiliopoulou C.A., Koutselinis A.S. Metallothionein and heat shock protein expression during acute liver injury and regeneration in rats. Clin. Chem. Lab. Med. 38:2000;1137-1140.
8. Theocharis S.E., Margeli A.P., Karandrea D.N., Tsarpalis K.S., Agapitos E.V., Spiliopoulou C.A., Koutselinis A.S. Liver metallothionein expression in thioacetamide-intoxicated rats. Pathol. Res. Pract. 196:2000;313-319.
9. Andrews G.K. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem. Pharmacol. 59:2000;95-104.
10. Kondoh M., Inoue Y., Atagi S., Futakawa N., Higashimoto M., Sato M. Specific induction of metallothionein synthesis by mitochondrial oxidative stress. Life Sci. 69:2001;2137-2146.
11. Bianchi A., Becuwe P., Collet P., Keller J.M., Domenjoud L., Dauca M. Clofibric acid down-regulation of metallothionein IIA in HepG2 human hepatoma cells. Biochem. Pharmacol. 63:2002;237-245.
12. Sato M., Kondho M. Recent studies on metallothionein: protection against toxicity of heavy metal and oxygen free radicals. Tohoku J. Exp. Med. 196:2002;9-22.
13. Schiaffonati A., Tiberio L. Gene expression in liver after toxic liver injury. Analysis of heat shock response and oxidative stress inducible genes. Liver. 17:1997;183-191.
14. Yamasaki A., Takahashi T., Suzuki T., Fujiwara T., Hirakawa M., Ohmori E., Akagi R. Differential effects of isoflurane and halothane on the induction of heat shock proteins. Biochem. Pharmacol. 62:2001;375-382.
15. Nanji A.A., Griniuviene B., Yacoub L.K., Sadrzadeh S.M., Levitsky S., McCully A. Heat-shock gene expression in alcoholic liver disease in the rat is related to the severity of liver injury and lipid peroxidation. Proc. Soc. Exp. Biol. Med. 210:1995;12-19.
16. Cascales M., Martín-Sanz P., Alvarez A., Sanchez-Pérez M., Díez-Fernández C., Boscá L. Isoenzymes of carbohydrate metabolism in primary cultures of hepatocytes from thioacetamide-induced rat liver necrosis: responses to growth factors. Hepatology. 16:1992;232-240.
17. Cascales M., Martin-Sanz P., Craciunescu D.C., Mayo I., Aguilar A., Robles-Chillida E.M., Cascales C. Alterations in hepatic peroxidation mechanisms in thioacetamide-induced tumors in rats. Effect of a rhodium complex. Carcinogenesis. 12:1991;233-240.
18. Cascales M., Alvarez A., Gascó P., Fernández-Simón L., Sanz N., Boscá L. Cocaine-induced liver injury in mice elicits specific changes in DNA ploidy and induces programmed cell death of hepatocytes. Hepatology. 20:1994;902-1001.
19. Sanz N., Díez-Fernández C., Fernández-Simón L., Alvarez A., Cascales M. Necrogenic and regenerative responses of liver of newly weaned rats. Biochem. Biophys. Acta. 1384:1998;66-78.
20. Dyroff M.C., Neal R.A. Studies of the mechanism of metabolism of thioacetamide-S-oxide by rat liver microsomes. Cancer Res. 41:1981;3430-3445.
21. Sanz N., Díez-Fernández C., Alvarez A.M., Fernández-Simón L., Cascales M. Age-related changes on parameters of experimentally-induced liver injury and regeneration. Toxicol. Appl. Pharmacol. 154:2000;40-49.
22. Zaragoza A., Andrés D., Sarrión D., Cascales M. Potentiation of thioacetamide hepatotoxicity by phenobarbital pretreatment in rats. Inducibility of FAD monooxygenase system and age effect. Chem. Biol. Interact. 124:2000;87-101.
23. Sanz N., Diez-Fernandez C., Andrés D., Cascales M. Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide. Biochim. Biophys. Acta. 1587:2002;12-20.
24. Sanz N., Díez-Fernández C., Alvarez A.M., Cascales M. Age-dependent modifications in rat hepatocyte antioxidant defense systems. J. Hepatol. 27:1997;525-534.
25. Rej R, Horder M. Aspartate aminotransferase. L-Aspartate: 2-oxoglutarate aminotranferase, EC 2.6.2.1, routine UV method. In: Bergmeyer HU, editor. Methods of enzymatic analysis, 3rd ed., vol. III. Weinheim: Verlag Chemie; 1984. p. 416-24.
26. Goldberg DM, Ellis G. Isocitrate dehydrogenase. In: Bergmeyer HU, editor. Methods of enzymatic analysis, 3rd ed., vol. 3. Weinheim: Verlag Chemie; 1986. p. 183-9. Klebanoff SJ. In: Everse J, Everse KE, Grisham MB, editors. Peroxidases in chemistry and biology. Boston: CRC Press; 1991. p. 1-35.
27. Klebanoff SJ. In: Everse J, Everse KE, Grisham MB, editors. Peroxidases in chemistry and biology. Boston: CRC Press; 1991. p. 1-35.
28. Sum C.Y., Kasper C.B. Mixed-function amine oxidase of the rat hepatocyte nuclear envelope. Demonstration and effects of phenobarbital and 3-methylcholantrene. Biochem. Pharmacol. 31:1982;69-72.
29. Deutsch J. Glucose-6-phosphate dehydrogenase. In: Bergmeyer HU, editor. D-Glucose-6-phosphate: NADP+ 1-oxidoreductase, EC 1.1.1.49, 3rd ed, vol. III. Weinheim: Verlag Chemie; 1987. p. 190-7.
30. Outlaw Jr WH, Springer SA. Malic enzyme. In: Bergmeyer HU, editor. L-Malate: NADP+ oxidoreductase (decarboxylating), EC 1.1.1.39, 3rd ed., vol. III. Weinheim: Verlag Chemie; 1987. p. 176-83.
31. Hissin P.J., Hilf R. A fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 126:1976;131-138.
32. Nieaus W.G., Samuelson J.R., Will E.D. Lipid peroxide formation in microsomes. Biochem. J. 113:1969;315-341.
33. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1997;156-159.
34. Amasino R.M. Acceleration of nucleic acid hybridization rate by polyethylene glycol. Anal. Biochem. 152:1986;304-307.
35. Nakagawa I., Suzuki M., Imura N., Naganuma A. Involvement of oxidative stress in paraquat-induced metallothionein synthesis under glutathione depletion. Free Rad. Biol. Med. 24:1998;1390-1395.
36. Bradford M.M. A rapid and sensitive method for the quantification of micrograms quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem. 72:1975;248-254.
37. Abe K., Kogure K., Itogama Y. Rapid and semiquantitative analysis of HSP72 and HSC73 heat shock mRNAs by mimic RT-PCR. Brain Res. 683:1995;251-253.
38. Raff T., van der Giet M., Endemann D., Wiederholt T., Paul M. Design and testing of beta-actin primers for RT-PCR that do not co-amplified processed pseudogenes. Biotechniques. 23:1997;456-460.
39. Brown K.E., Brunt E.M., Heinecke J.W. Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver. Am. J. Pathol. 159:2001;2081-2088.
40. Spolaris Z., Bautista A.P., Spitzer J.J. Primed pentose cycle activity supports production and elimination of superoxide anion in Kupffer cells from rats treated with endotoxin in vivo. Biochim. Biophys. Acta. 1179:1993;134-140.
41. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192:1990;245-261.
42. Cerdán S., Cascales M., Santos-Ruiz A. Effect of thioacetamide on the pentose phosphate pathway and other NADP-linked enzymes of rat liver cytosol: chronology of the perturbations and metabolic significance. Mol. Pharmacol. 19:1981;451-455.
43. Jaeschke H., Smith C.W. Mechanisms of neutrophil-induced parenchymal cell injury. J. Leukoc. Biol. 61:1997;647-653.
44. Essani N.A., Fisher M.A., Farhood A., Manning A.M., Smith C.W., Jaeschke H. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology. 21:1995;1632-1639.
45. Laskin D.L., Pilaro A.M. Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. Toxicol. Appl. Pharmacol. 86:1986;204-215.
46. Hardonk MJ, Dijkhius FWJ, Jonker AM. Selective depletion of Kupffer cells by gadolinium chloride attenuates both acute galactosamine-induced hepatitis and carbon tetrachloride toxicity in rats. In: Wisse E, Knook DL, Wake K, editors. Cells of the hepatic sinusoid. The Netherlands: The Kupffer Cell Foundation; 1995. p. 29-32.
47. Badger D.A., Kuester R.K., Sauer J.M., Sipes I.G. Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity. Toxicology. 121:1997;143-153.
48. Shiratori Y., Kiriyama H., Fukushi Y., Nagura T., Takada H., Hai K., Kamii K. Modulation of ischemia-reperfusion-induced hepatic injury by Kupffer cells. Dig. Dis. Sci. 39:1994;1265-1272.
49. Blazka M.E., Wilmer J.L., Holladay S.D., Wilson R.E., Luster M.I. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 133:1995;43-52.
50. Shi J., Gilbert G.E., Kokubo Y., Ohashi T. Role of the liver in regulating numbers of circulating neutrophils. Blood. 98:2001;1226-1230.