메뉴 건너뛰기




Volumn 33, Issue , 2015, Pages D4-D12

Prospects for a globally effective HIV-1 vaccine

Author keywords

Clinical trial; Correlates; Efficacy; HIV 1; Licensure; Public health; Vaccine

Indexed keywords

ANTIGEN; BLOCKING ANTIBODY; EPITOPE; GAG PROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; MIFAMURTIDE; MONOCLONAL ANTIBODY; NEF PROTEIN; NEUTRALIZING ANTIBODY; PARVOVIRUS VECTOR; POL PROTEIN; REV PROTEIN; RV 144 VACCINE; SUBUNIT VACCINE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 84951566775     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.03.059     Document Type: Review
Times cited : (27)

References (154)
  • 1
  • 2
    • 84907958201 scopus 로고    scopus 로고
    • Geneva, Switzerland
    • UNAIDS The Gap report 2014, Geneva, Switzerland.
    • (2014) The Gap report
  • 3
    • 77956871819 scopus 로고    scopus 로고
    • Behavior change interventions to prevent HIV infection among women living in low and middle income countries: a systematic review
    • McCoy S.I., Kangwende R.A., Padian N.S. Behavior change interventions to prevent HIV infection among women living in low and middle income countries: a systematic review. AIDS Behav 2010, 14:469-482.
    • (2010) AIDS Behav , vol.14 , pp. 469-482
    • McCoy, S.I.1    Kangwende, R.A.2    Padian, N.S.3
  • 4
    • 84862524916 scopus 로고    scopus 로고
    • Key harm reduction interventions and their impact on the reduction of risky behavior and HIV incidence among people who inject drugs in low-income and middle-income countries
    • Dutta A., Wirtz A.L., Baral S., Beyrer C., Cleghorn F.R. Key harm reduction interventions and their impact on the reduction of risky behavior and HIV incidence among people who inject drugs in low-income and middle-income countries. Curr Opin HIV AIDS 2012, 7:362-368.
    • (2012) Curr Opin HIV AIDS , vol.7 , pp. 362-368
    • Dutta, A.1    Wirtz, A.L.2    Baral, S.3    Beyrer, C.4    Cleghorn, F.R.5
  • 5
    • 80054689668 scopus 로고    scopus 로고
    • Male circumcision for HIV prevention: current evidence and implementation in sub-Saharan Africa
    • Wamai R.G., Morris B.J., Bailis S.A., Sokal D., Klausner J.D., Appleton R., et al. Male circumcision for HIV prevention: current evidence and implementation in sub-Saharan Africa. J Int AIDS Soc 2011, 14:49.
    • (2011) J Int AIDS Soc , vol.14 , pp. 49
    • Wamai, R.G.1    Morris, B.J.2    Bailis, S.A.3    Sokal, D.4    Klausner, J.D.5    Appleton, R.6
  • 6
    • 84866081248 scopus 로고    scopus 로고
    • Progress, challenges, and new opportunities for the prevention of mother-to-child transmission of HIV under the US President's Emergency Plan for AIDS Relief
    • Chi B.H., Adler M.R., Bolu O., Mbori-Ngacha D., Ekouevi D.K., Gieselman A., et al. Progress, challenges, and new opportunities for the prevention of mother-to-child transmission of HIV under the US President's Emergency Plan for AIDS Relief. J Acquir Immune Defic Syndr 2012, 60(Suppl. 3):S78-S87.
    • (2012) J Acquir Immune Defic Syndr , vol.60 , pp. S78-S87
    • Chi, B.H.1    Adler, M.R.2    Bolu, O.3    Mbori-Ngacha, D.4    Ekouevi, D.K.5    Gieselman, A.6
  • 7
    • 77957147984 scopus 로고    scopus 로고
    • Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities
    • Kim S.C., Becker S., Dieffenbach C., Hanewall B.S., Hankins C., Lo Y.R., et al. Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities. J Int AIDS Soc 2010, 13:24.
    • (2010) J Int AIDS Soc , vol.13 , pp. 24
    • Kim, S.C.1    Becker, S.2    Dieffenbach, C.3    Hanewall, B.S.4    Hankins, C.5    Lo, Y.R.6
  • 8
    • 78650549662 scopus 로고    scopus 로고
    • Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
    • Grant R.M., Lama J.R., Anderson P.L., McMahan V., Liu A.Y., Vargas L., et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010, 363:2587-2599.
    • (2010) N Engl J Med , vol.363 , pp. 2587-2599
    • Grant, R.M.1    Lama, J.R.2    Anderson, P.L.3    McMahan, V.4    Liu, A.Y.5    Vargas, L.6
  • 9
    • 84879000125 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial
    • Choopanya K., Martin M., Suntharasamai P., Sangkum U., Mock P.A., Leethochawalit M., et al. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2013, 381:2083-2090.
    • (2013) Lancet , vol.381 , pp. 2083-2090
    • Choopanya, K.1    Martin, M.2    Suntharasamai, P.3    Sangkum, U.4    Mock, P.A.5    Leethochawalit, M.6
  • 10
    • 84918780163 scopus 로고    scopus 로고
    • ARV-based HIV prevention for women - where we are in 2014
    • Mastro T.D., Sista N., Abdool-Karim Q. ARV-based HIV prevention for women - where we are in 2014. J Int AIDS Soc 2014, 17:19154.
    • (2014) J Int AIDS Soc , vol.17 , pp. 19154
    • Mastro, T.D.1    Sista, N.2    Abdool-Karim, Q.3
  • 11
    • 84866275447 scopus 로고    scopus 로고
    • HIV treatment as prevention: how scientific discovery occurred and translated rapidly into policy for the global response
    • Cohen M.S., Holmes C., Padian N., Wolf M., Hirnschall G., Lo Y.R., et al. HIV treatment as prevention: how scientific discovery occurred and translated rapidly into policy for the global response. Health Aff (Millwood) 2012, 31:1439-1449.
    • (2012) Health Aff (Millwood) , vol.31 , pp. 1439-1449
    • Cohen, M.S.1    Holmes, C.2    Padian, N.3    Wolf, M.4    Hirnschall, G.5    Lo, Y.R.6
  • 12
    • 81355146472 scopus 로고    scopus 로고
    • Promising prevention approaches: tenofovir gel and prophylactic use of antiretroviral medications
    • Krakower D., Mayer K.H. Promising prevention approaches: tenofovir gel and prophylactic use of antiretroviral medications. Curr HIV/AIDS Rep 2011, 8:241-248.
    • (2011) Curr HIV/AIDS Rep , vol.8 , pp. 241-248
    • Krakower, D.1    Mayer, K.H.2
  • 13
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q., Abdool Karim S.S., Frohlich J.A., Grobler A.C., Baxter C., Mansoor L.E., et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010, 329:1168-1174.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3    Grobler, A.C.4    Baxter, C.5    Mansoor, L.E.6
  • 14
    • 84906793896 scopus 로고    scopus 로고
    • Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study
    • Grant R.M., Anderson P.L., McMahan V., Liu A., Amico K.R., Mehrotra M., et al. Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis 2014, 14:820-829.
    • (2014) Lancet Infect Dis , vol.14 , pp. 820-829
    • Grant, R.M.1    Anderson, P.L.2    McMahan, V.3    Liu, A.4    Amico, K.R.5    Mehrotra, M.6
  • 16
    • 84893570591 scopus 로고    scopus 로고
    • Ending AIDS - is an HIV vaccine necessary?
    • Fauci A.S., Marston H.D. Ending AIDS - is an HIV vaccine necessary?. N Engl J Med 2014, 370:495-498.
    • (2014) N Engl J Med , vol.370 , pp. 495-498
    • Fauci, A.S.1    Marston, H.D.2
  • 17
    • 84880331846 scopus 로고    scopus 로고
    • The changing epidemiology of HIV in 2013
    • Beyrer C., Abdool Karim Q. The changing epidemiology of HIV in 2013. Curr Opin HIV AIDS 2013, 8:306-310.
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 306-310
    • Beyrer, C.1    Abdool Karim, Q.2
  • 20
    • 79952414942 scopus 로고    scopus 로고
    • Global trends in molecular epidemiology of HIV-1 during 2000-2007
    • Hemelaar J., Gouws E., Ghys P.D., Osmanov S. Global trends in molecular epidemiology of HIV-1 during 2000-2007. AIDS 2011, 25:679-689.
    • (2011) AIDS , vol.25 , pp. 679-689
    • Hemelaar, J.1    Gouws, E.2    Ghys, P.D.3    Osmanov, S.4
  • 21
    • 84875598818 scopus 로고    scopus 로고
    • Implications of HIV diversity for the HIV-1 pandemic
    • Hemelaar J. Implications of HIV diversity for the HIV-1 pandemic. J Infect 2013, 66:391-400.
    • (2013) J Infect , vol.66 , pp. 391-400
    • Hemelaar, J.1
  • 22
    • 84905469618 scopus 로고    scopus 로고
    • HIV-1 vaccines: challenges and new perspectives
    • Excler J.L., Robb M.L., Kim J.H. HIV-1 vaccines: challenges and new perspectives. Hum Vaccines Immunother 2014, 10:1734-1746.
    • (2014) Hum Vaccines Immunother , vol.10 , pp. 1734-1746
    • Excler, J.L.1    Robb, M.L.2    Kim, J.H.3
  • 23
    • 84883460283 scopus 로고    scopus 로고
    • Novel directions in HIV-1 vaccines revealed from clinical trials
    • Excler J.L., Tomaras G.D., Russell N.D. Novel directions in HIV-1 vaccines revealed from clinical trials. Curr Opin HIV AIDS 2013, 8:421-431.
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 421-431
    • Excler, J.L.1    Tomaras, G.D.2    Russell, N.D.3
  • 24
    • 80053987071 scopus 로고    scopus 로고
    • Moving ahead an HIV vaccine: use both arms to beat HIV
    • Walker B.D., Ahmed R., Plotkin S. Moving ahead an HIV vaccine: use both arms to beat HIV. Nat Med 2011, 17:1194-1195.
    • (2011) Nat Med , vol.17 , pp. 1194-1195
    • Walker, B.D.1    Ahmed, R.2    Plotkin, S.3
  • 25
    • 84894102462 scopus 로고    scopus 로고
    • HIV vaccine efficacy and immune correlates of risk
    • O'Connell R.J., Excler J.L. HIV vaccine efficacy and immune correlates of risk. Curr HIV Res 2013, 11:450-463.
    • (2013) Curr HIV Res , vol.11 , pp. 450-463
    • O'Connell, R.J.1    Excler, J.L.2
  • 26
    • 84856482137 scopus 로고    scopus 로고
    • Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
    • Barouch D.H., Liu J., Li H., Maxfield L.F., Abbink P., Lynch D.M., et al. Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature 2012, 482:89-93.
    • (2012) Nature , vol.482 , pp. 89-93
    • Barouch, D.H.1    Liu, J.2    Li, H.3    Maxfield, L.F.4    Abbink, P.5    Lynch, D.M.6
  • 27
    • 84886778874 scopus 로고    scopus 로고
    • Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys
    • Barouch D.H., Stephenson K.E., Borducchi E.N., Smith K., Stanley K., McNally A.G., et al. Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys. Cell 2013, 155:531-539.
    • (2013) Cell , vol.155 , pp. 531-539
    • Barouch, D.H.1    Stephenson, K.E.2    Borducchi, E.N.3    Smith, K.4    Stanley, K.5    McNally, A.G.6
  • 28
    • 84892786095 scopus 로고    scopus 로고
    • Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
    • Roederer M., Keele B.F., Schmidt S.D., Mason R.D., Welles H.C., Fischer W., et al. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature 2014, 505:502-508.
    • (2014) Nature , vol.505 , pp. 502-508
    • Roederer, M.1    Keele, B.F.2    Schmidt, S.D.3    Mason, R.D.4    Welles, H.C.5    Fischer, W.6
  • 29
    • 84904124681 scopus 로고    scopus 로고
    • A critical question for HIV vaccine development: which antibodies to induce?
    • Zolla-Pazner S. A critical question for HIV vaccine development: which antibodies to induce?. Science 2014, 345:167-168.
    • (2014) Science , vol.345 , pp. 167-168
    • Zolla-Pazner, S.1
  • 30
    • 34548474844 scopus 로고    scopus 로고
    • HIV/AIDS: allied responses
    • Mascola J.R. HIV/AIDS: allied responses. Nature 2007, 449:29-30.
    • (2007) Nature , vol.449 , pp. 29-30
    • Mascola, J.R.1
  • 31
    • 84905651270 scopus 로고    scopus 로고
    • Which antibody functions are important for an HIV vaccine?
    • Su B., Moog C. Which antibody functions are important for an HIV vaccine?. Front Immunol 2014, 5:289.
    • (2014) Front Immunol , vol.5 , pp. 289
    • Su, B.1    Moog, C.2
  • 32
    • 84905663895 scopus 로고    scopus 로고
    • Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccines
    • Excler J.L., Ake J., Robb M.L., Kim J.H., Plotkin S.A. Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccines. Clin Vaccine Immunol 2014, 21:1023-1036.
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 1023-1036
    • Excler, J.L.1    Ake, J.2    Robb, M.L.3    Kim, J.H.4    Plotkin, S.A.5
  • 33
    • 84906084946 scopus 로고    scopus 로고
    • Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1
    • Sarzotti-Kelsoe M., Bailer R.T., Turk E., Lin C.L., Bilska M., Greene K.M., et al. Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1. J Immunol Methods 2014, 409:131-146.
    • (2014) J Immunol Methods , vol.409 , pp. 131-146
    • Sarzotti-Kelsoe, M.1    Bailer, R.T.2    Turk, E.3    Lin, C.L.4    Bilska, M.5    Greene, K.M.6
  • 34
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum P., Gilbert P., Gurwith M., Heyward W., Martin M., van Griensven F., et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis 2006, 194:1661-1671.
    • (2006) J Infect Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3    Heyward, W.4    Martin, M.5    van Griensven, F.6
  • 35
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn N.M., Forthal D.N., Harro C.D., Judson F.N., Mayer K.H., Para M.F. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis 2005, 191:654-665.
    • (2005) J Infect Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3    Judson, F.N.4    Mayer, K.H.5    Para, M.F.6
  • 36
    • 13944250922 scopus 로고    scopus 로고
    • Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
    • Gilbert P.B., Peterson M.L., Follmann D., Hudgens M.G., Francis D.P., Gurwith M., et al. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J Infect Dis 2005, 191:666-677.
    • (2005) J Infect Dis , vol.191 , pp. 666-677
    • Gilbert, P.B.1    Peterson, M.L.2    Follmann, D.3    Hudgens, M.G.4    Francis, D.P.5    Gurwith, M.6
  • 37
    • 24644479045 scopus 로고    scopus 로고
    • HIV-1 virologic and immunologic progression and initiation of antiretroviral therapy among HIV-1-infected subjects in a trial of the efficacy of recombinant glycoprotein 120 vaccine
    • Gilbert P.B., Ackers M.L., Berman P.W., Francis D.P., Popovic V., Hu D.J., et al. HIV-1 virologic and immunologic progression and initiation of antiretroviral therapy among HIV-1-infected subjects in a trial of the efficacy of recombinant glycoprotein 120 vaccine. J Infect Dis 2005, 192:974-983.
    • (2005) J Infect Dis , vol.192 , pp. 974-983
    • Gilbert, P.B.1    Ackers, M.L.2    Berman, P.W.3    Francis, D.P.4    Popovic, V.5    Hu, D.J.6
  • 38
    • 84921350295 scopus 로고    scopus 로고
    • Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection
    • Kim J.H., Excler J.L., Michael N.L. Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection. Annu Rev Med 2015, 66:423-437.
    • (2015) Annu Rev Med , vol.66 , pp. 423-437
    • Kim, J.H.1    Excler, J.L.2    Michael, N.L.3
  • 40
    • 79953019952 scopus 로고    scopus 로고
    • Statistical interpretation of the RV144 HIV vaccine efficacy trial in Thailand: a case study for statistical issues in efficacy trials
    • Gilbert P.B., Berger J.O., Stablein D., Becker S., Essex M., Hammer S.M., et al. Statistical interpretation of the RV144 HIV vaccine efficacy trial in Thailand: a case study for statistical issues in efficacy trials. J Infect Dis 2011, 203:969-975.
    • (2011) J Infect Dis , vol.203 , pp. 969-975
    • Gilbert, P.B.1    Berger, J.O.2    Stablein, D.3    Becker, S.4    Essex, M.5    Hammer, S.M.6
  • 41
    • 84862764447 scopus 로고    scopus 로고
    • Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144
    • Robb M.L., Rerks-Ngarm S., Nitayaphan S., Pitisuttithum P., Kaewkungwal J., Kunasol P., et al. Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144. Lancet Infect Dis 2012, 12:531-537.
    • (2012) Lancet Infect Dis , vol.12 , pp. 531-537
    • Robb, M.L.1    Rerks-Ngarm, S.2    Nitayaphan, S.3    Pitisuttithum, P.4    Kaewkungwal, J.5    Kunasol, P.6
  • 42
    • 34248168722 scopus 로고    scopus 로고
    • Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate
    • Forthal D.N., Gilbert P.B., Landucci G., Phan T. Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate. J Immunol 2007, 178:6596-6603.
    • (2007) J Immunol , vol.178 , pp. 6596-6603
    • Forthal, D.N.1    Gilbert, P.B.2    Landucci, G.3    Phan, T.4
  • 43
    • 73949112038 scopus 로고    scopus 로고
    • The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
    • Cicala C., Martinelli E., McNally J.P., Goode D.J., Gopaul R., Hiatt J., et al. The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1. Proc Natl Acad Sci U S A 2009, 106:20877-20882.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20877-20882
    • Cicala, C.1    Martinelli, E.2    McNally, J.P.3    Goode, D.J.4    Gopaul, R.5    Hiatt, J.6
  • 44
    • 39449098115 scopus 로고    scopus 로고
    • HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    • Arthos J., Cicala C., Martinelli E., Macleod K., Van Ryk D., Wei D., et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 2008, 9:301-309.
    • (2008) Nat Immunol , vol.9 , pp. 301-309
    • Arthos, J.1    Cicala, C.2    Martinelli, E.3    Macleod, K.4    Van Ryk, D.5    Wei, D.6
  • 45
    • 20044364751 scopus 로고    scopus 로고
    • Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX B/E prime-boost HIV-1 vaccine trial in Thailand
    • Karnasuta C., Paris R.M., Cox J.H., Nitayaphan S., Pitisuttithum P., Thongcharoen P., et al. Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX B/E prime-boost HIV-1 vaccine trial in Thailand. Vaccine 2005, 23:2522-2529.
    • (2005) Vaccine , vol.23 , pp. 2522-2529
    • Karnasuta, C.1    Paris, R.M.2    Cox, J.H.3    Nitayaphan, S.4    Pitisuttithum, P.5    Thongcharoen, P.6
  • 46
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • Bonsignori M., Pollara J., Moody M.A., Alpert M.D., Chen X., Hwang K.K., et al. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol 2012, 86:11521-11532.
    • (2012) J Virol , vol.86 , pp. 11521-11532
    • Bonsignori, M.1    Pollara, J.2    Moody, M.A.3    Alpert, M.D.4    Chen, X.5    Hwang, K.K.6
  • 48
    • 84872514448 scopus 로고    scopus 로고
    • Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial
    • Zolla-Pazner S., deCamp A.C., Cardozo T., Karasavvas N., Gottardo R., Williams C., et al. Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial. PLOS ONE 2013, 8:e53629.
    • (2013) PLOS ONE , vol.8 , pp. e53629
    • Zolla-Pazner, S.1    deCamp, A.C.2    Cardozo, T.3    Karasavvas, N.4    Gottardo, R.5    Williams, C.6
  • 49
    • 84868589536 scopus 로고    scopus 로고
    • The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120
    • Karasavvas N., Billings E., Rao M., Williams C., Zolla-Pazner S., Bailer R.T., et al. The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120. AIDS Res Hum Retroviruses 2012, 28:1444-1457.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , pp. 1444-1457
    • Karasavvas, N.1    Billings, E.2    Rao, M.3    Williams, C.4    Zolla-Pazner, S.5    Bailer, R.T.6
  • 50
    • 84895174919 scopus 로고    scopus 로고
    • Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection
    • Zolla-Pazner S., Decamp A., Gilbert P.B., Williams C., Yates N.L., Williams W.T., et al. Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection. PLOS ONE 2014, 9:e87572.
    • (2014) PLOS ONE , vol.9 , pp. e87572
    • Zolla-Pazner, S.1    Decamp, A.2    Gilbert, P.B.3    Williams, C.4    Yates, N.L.5    Williams, W.T.6
  • 52
    • 84884608718 scopus 로고    scopus 로고
    • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial
    • Gottardo R., Bailer R.T., Korber B.T., Gnanakaran S., Phillips J., Shen X., et al. Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. PLOS ONE 2013, 8:e75665.
    • (2013) PLOS ONE , vol.8 , pp. e75665
    • Gottardo, R.1    Bailer, R.T.2    Korber, B.T.3    Gnanakaran, S.4    Phillips, J.5    Shen, X.6
  • 53
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): a double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder S.P., Mehrotra D.V., Duerr A., Fitzgerald D.W., Mogg R., Li D., et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008, 372:1881-1893.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6
  • 54
    • 79959301474 scopus 로고    scopus 로고
    • Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study
    • Gray G.E., Allen M., Moodie Z., Churchyard G., Bekker L.G., Nchabeleng M., et al. Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis 2011, 11:507-515.
    • (2011) Lancet Infect Dis , vol.11 , pp. 507-515
    • Gray, G.E.1    Allen, M.2    Moodie, Z.3    Churchyard, G.4    Bekker, L.G.5    Nchabeleng, M.6
  • 57
    • 84872809067 scopus 로고    scopus 로고
    • Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    • Liao H.X., Bonsignori M., Alam S.M., McLellan J.S., Tomaras G.D., Moody M.A., et al. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity 2013, 38:176-186.
    • (2013) Immunity , vol.38 , pp. 176-186
    • Liao, H.X.1    Bonsignori, M.2    Alam, S.M.3    McLellan, J.S.4    Tomaras, G.D.5    Moody, M.A.6
  • 58
    • 84880310997 scopus 로고    scopus 로고
    • Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees
    • Liu P., Yates N.L., Shen X., Bonsignori M., Moody M.A., Liao H.X., et al. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. J Virol 2013, 87:7828-7836.
    • (2013) J Virol , vol.87 , pp. 7828-7836
    • Liu, P.1    Yates, N.L.2    Shen, X.3    Bonsignori, M.4    Moody, M.A.5    Liao, H.X.6
  • 59
    • 84899087118 scopus 로고    scopus 로고
    • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination
    • Yates N.L., Liao H.X., Fong Y., Decamp A., Vandergrift N.A., Williams W.T., et al. Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Sci Transl Med 2014, 6:228ra39.
    • (2014) Sci Transl Med , vol.6 , pp. 228ra39
    • Yates, N.L.1    Liao, H.X.2    Fong, Y.3    Decamp, A.4    Vandergrift, N.A.5    Williams, W.T.6
  • 60
    • 84899105650 scopus 로고    scopus 로고
    • Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines
    • Chung A.W., Ghebremichael M., Robinson H., Brown E., Choi I., Lane S., et al. Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines. Sci Transl Med 2014, 6(228):ra38.
    • (2014) Sci Transl Med , vol.6 , Issue.228 , pp. ra38
    • Chung, A.W.1    Ghebremichael, M.2    Robinson, H.3    Brown, E.4    Choi, I.5    Lane, S.6
  • 61
    • 84909633945 scopus 로고    scopus 로고
    • The HIV-1 gp120 V1V2 loop: structure, function and importance for vaccine development
    • O'Connell R.J., Kim J.H., Excler J.L. The HIV-1 gp120 V1V2 loop: structure, function and importance for vaccine development. Expert Rev Vaccines 2014, 1-12.
    • (2014) Expert Rev Vaccines , pp. 1-12
    • O'Connell, R.J.1    Kim, J.H.2    Excler, J.L.3
  • 62
    • 84861057293 scopus 로고    scopus 로고
    • Nomenclature for immune correlates of protection after vaccination
    • Plotkin S.A., Gilbert P.B. Nomenclature for immune correlates of protection after vaccination. Clin Infect Dis 2012, 54:1615-1617.
    • (2012) Clin Infect Dis , vol.54 , pp. 1615-1617
    • Plotkin, S.A.1    Gilbert, P.B.2
  • 63
    • 84951573276 scopus 로고    scopus 로고
    • Investigation of antibody responses induced in RV305 a late boost vaccination of HIV-1 uninfected volunteers that participated in RV144, a Thai trial
    • Karasavvas N., Karnasuta C., Ngauy V., Vasan S., Tricharavoj R., de Souza M.S., et al. Investigation of antibody responses induced in RV305 a late boost vaccination of HIV-1 uninfected volunteers that participated in RV144, a Thai trial. P03.68LB, AIDS Vaccine 2013 2013.
    • (2013) P03.68LB, AIDS Vaccine 2013
    • Karasavvas, N.1    Karnasuta, C.2    Ngauy, V.3    Vasan, S.4    Tricharavoj, R.5    de Souza, M.S.6
  • 67
    • 84861963478 scopus 로고    scopus 로고
    • The mechanism of action of MF59 - an innately attractive adjuvant formulation
    • O'Hagan D.T., Ott G.S., De Gregorio E., Seubert A. The mechanism of action of MF59 - an innately attractive adjuvant formulation. Vaccine 2012, 30:4341-4348.
    • (2012) Vaccine , vol.30 , pp. 4341-4348
    • O'Hagan, D.T.1    Ott, G.S.2    De Gregorio, E.3    Seubert, A.4
  • 68
    • 77957357557 scopus 로고    scopus 로고
    • Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three adjuvant systems
    • Leroux-Roels I., Koutsoukos M., Clement F., Steyaert S., Janssens M., Bourguignon P., et al. Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three adjuvant systems. Vaccine 2010, 28:7016-7024.
    • (2010) Vaccine , vol.28 , pp. 7016-7024
    • Leroux-Roels, I.1    Koutsoukos, M.2    Clement, F.3    Steyaert, S.4    Janssens, M.5    Bourguignon, P.6
  • 69
    • 79955086319 scopus 로고    scopus 로고
    • Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems
    • Garcon N., Van Mechelen M. Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems. Expert Rev Vaccines 2011, 10:471-486.
    • (2011) Expert Rev Vaccines , vol.10 , pp. 471-486
    • Garcon, N.1    Van Mechelen, M.2
  • 70
    • 84951573279 scopus 로고    scopus 로고
    • Adjuvant dependent mucosal V2 responses and RAS activation in vaccine induced protection from SIVmac251 acquisition
    • Vaccari M., Gordon S.N., Fourati S., Schifanella L., Cameron M., Keele B.F., et al. Adjuvant dependent mucosal V2 responses and RAS activation in vaccine induced protection from SIVmac251 acquisition. OA25.01. HIV R4P 2014.
    • (2014) OA25.01. HIV R4P
    • Vaccari, M.1    Gordon, S.N.2    Fourati, S.3    Schifanella, L.4    Cameron, M.5    Keele, B.F.6
  • 71
    • 0029422476 scopus 로고
    • Selection of potent immunological adjuvants for vaccine construction
    • McElrath M.J. Selection of potent immunological adjuvants for vaccine construction. Semin Cancer Biol 1995, 6:375-385.
    • (1995) Semin Cancer Biol , vol.6 , pp. 375-385
    • McElrath, M.J.1
  • 73
    • 79951899834 scopus 로고    scopus 로고
    • Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
    • Moon J.J., Suh H., Bershteyn A., Stephan M.T., Liu H., Huang B., et al. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater 2011, 10:243-251.
    • (2011) Nat Mater , vol.10 , pp. 243-251
    • Moon, J.J.1    Suh, H.2    Bershteyn, A.3    Stephan, M.T.4    Liu, H.5    Huang, B.6
  • 75
    • 79956079578 scopus 로고    scopus 로고
    • Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
    • Nutt S.L., Tarlinton D.M. Germinal center B and follicular helper T cells: siblings, cousins or just good friends?. Nat Immunol 2011, 12:472-477.
    • (2011) Nat Immunol , vol.12 , pp. 472-477
    • Nutt, S.L.1    Tarlinton, D.M.2
  • 76
    • 0029656045 scopus 로고    scopus 로고
    • Inter- and intraclade neutralization of human immunodeficiency virus type 1: genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes
    • Moore J.P., Cao Y., Leu J., Qin L., Korber B., Ho D.D. Inter- and intraclade neutralization of human immunodeficiency virus type 1: genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes. J Virol 1996, 70:427-444.
    • (1996) J Virol , vol.70 , pp. 427-444
    • Moore, J.P.1    Cao, Y.2    Leu, J.3    Qin, L.4    Korber, B.5    Ho, D.D.6
  • 77
    • 0029813738 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 neutralizing antibody serotyping using serum pools and an infectivity reduction assay
    • Mascola J.R., Louder M.K., Surman S.R., Vancott T.C., Yu X.F., Bradac J., et al. Human immunodeficiency virus type 1 neutralizing antibody serotyping using serum pools and an infectivity reduction assay. AIDS Res Hum Retroviruses 1996, 12:1319-1328.
    • (1996) AIDS Res Hum Retroviruses , vol.12 , pp. 1319-1328
    • Mascola, J.R.1    Louder, M.K.2    Surman, S.R.3    Vancott, T.C.4    Yu, X.F.5    Bradac, J.6
  • 78
    • 0027957892 scopus 로고
    • Two antigenically distinct subtypes of human immunodeficiency virus type 1: viral genotype predicts neutralization serotype
    • Mascola J.R., Louwagie J., McCutchan F.E., Fischer C.L., Hegerich P.A., Wagner K.F., et al. Two antigenically distinct subtypes of human immunodeficiency virus type 1: viral genotype predicts neutralization serotype. J Infect Dis 1994, 169:48-54.
    • (1994) J Infect Dis , vol.169 , pp. 48-54
    • Mascola, J.R.1    Louwagie, J.2    McCutchan, F.E.3    Fischer, C.L.4    Hegerich, P.A.5    Wagner, K.F.6
  • 79
    • 0029839390 scopus 로고    scopus 로고
    • Multivariate analysis of human immunodeficiency virus type 1 neutralization data
    • Nyambi P.N., Nkengasong J., Lewi P., Andries K., Janssens W., Fransen K., et al. Multivariate analysis of human immunodeficiency virus type 1 neutralization data. J Virol 1996, 70:6235-6243.
    • (1996) J Virol , vol.70 , pp. 6235-6243
    • Nyambi, P.N.1    Nkengasong, J.2    Lewi, P.3    Andries, K.4    Janssens, W.5    Fransen, K.6
  • 80
    • 10244249213 scopus 로고    scopus 로고
    • Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization
    • Weber J., Fenyo E.M., Beddows S., Kaleebu P., Bjorndal A. Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization. J Virol 1996, 70:7827-7832.
    • (1996) J Virol , vol.70 , pp. 7827-7832
    • Weber, J.1    Fenyo, E.M.2    Beddows, S.3    Kaleebu, P.4    Bjorndal, A.5
  • 81
    • 84907993259 scopus 로고    scopus 로고
    • Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies
    • Hraber P., Korber B.T., Lapedes A.S., Bailer R.T., Seaman M.S., Gao H., et al. Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies. J Virol 2014, 88:12623-12643.
    • (2014) J Virol , vol.88 , pp. 12623-12643
    • Hraber, P.1    Korber, B.T.2    Lapedes, A.S.3    Bailer, R.T.4    Seaman, M.S.5    Gao, H.6
  • 82
    • 84861986980 scopus 로고    scopus 로고
    • HIV vaccine development: challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem
    • Koff W.C. HIV vaccine development: challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem. Vaccine 2012, 30:4310-4315.
    • (2012) Vaccine , vol.30 , pp. 4310-4315
    • Koff, W.C.1
  • 83
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: understanding nature's pathways
    • Mascola J.R., Haynes B.F. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev 2013, 254:225-244.
    • (2013) Immunol Rev , vol.254 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 84
    • 84902081656 scopus 로고    scopus 로고
    • Lessons from babies: inducing HIV-1 broadly neutralizing antibodies
    • Tomaras G.D., Haynes B.F. Lessons from babies: inducing HIV-1 broadly neutralizing antibodies. Nat Med 2014, 20:583-585.
    • (2014) Nat Med , vol.20 , pp. 583-585
    • Tomaras, G.D.1    Haynes, B.F.2
  • 85
    • 84902131373 scopus 로고    scopus 로고
    • Early development of broadly neutralizing antibodies in HIV-1-infected infants
    • Goo L., Chohan V., Nduati R., Overbaugh J. Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nat Med 2014, 20:655-658.
    • (2014) Nat Med , vol.20 , pp. 655-658
    • Goo, L.1    Chohan, V.2    Nduati, R.3    Overbaugh, J.4
  • 86
    • 67650453747 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
    • Simek M.D., Rida W., Priddy F.H., Pung P., Carrow E., Laufer D.S., et al. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J Virol 2009, 83:7337-7348.
    • (2009) J Virol , vol.83 , pp. 7337-7348
    • Simek, M.D.1    Rida, W.2    Priddy, F.H.3    Pung, P.4    Carrow, E.5    Laufer, D.S.6
  • 87
    • 69149083668 scopus 로고    scopus 로고
    • Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
    • Stamatatos L., Morris L., Burton D.R., Mascola J.R. Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?. Nat Med 2009, 15:866-870.
    • (2009) Nat Med , vol.15 , pp. 866-870
    • Stamatatos, L.1    Morris, L.2    Burton, D.R.3    Mascola, J.R.4
  • 88
    • 33144486096 scopus 로고    scopus 로고
    • Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1
    • Moore P.L., Crooks E.T., Porter L., Zhu P., Cayanan C.S., Grise H., et al. Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1. J Virol 2006, 80:2515-2528.
    • (2006) J Virol , vol.80 , pp. 2515-2528
    • Moore, P.L.1    Crooks, E.T.2    Porter, L.3    Zhu, P.4    Cayanan, C.S.5    Grise, H.6
  • 89
    • 84873506978 scopus 로고    scopus 로고
    • Designing tomorrow's vaccines
    • Nabel G.J. Designing tomorrow's vaccines. N Engl J Med 2013, 368:551-560.
    • (2013) N Engl J Med , vol.368 , pp. 551-560
    • Nabel, G.J.1
  • 90
    • 73949154006 scopus 로고    scopus 로고
    • Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L
    • Hessell A.J., Rakasz E.G., Tehrani D.M., Huber M., Weisgrau K.L., Landucci G., et al. Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. J Virol 2010, 84:1302-1313.
    • (2010) J Virol , vol.84 , pp. 1302-1313
    • Hessell, A.J.1    Rakasz, E.G.2    Tehrani, D.M.3    Huber, M.4    Weisgrau, K.L.5    Landucci, G.6
  • 91
    • 79960585840 scopus 로고    scopus 로고
    • Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody
    • Burton D.R., Hessell A.J., Keele B.F., Klasse P.J., Ketas T.A., Moldt B., et al. Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody. Proc Natl Acad Sci U S A 2011, 108:11181-11186.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 11181-11186
    • Burton, D.R.1    Hessell, A.J.2    Keele, B.F.3    Klasse, P.J.4    Ketas, T.A.5    Moldt, B.6
  • 92
    • 84904497424 scopus 로고    scopus 로고
    • Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
    • Pegu A., Yang Z.Y., Boyington J.C., Wu L., Ko S.Y., Schmidt S.D., et al. Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med 2014, 6:243ra88.
    • (2014) Sci Transl Med , vol.6 , pp. 243ra88
    • Pegu, A.1    Yang, Z.Y.2    Boyington, J.C.3    Wu, L.4    Ko, S.Y.5    Schmidt, S.D.6
  • 93
    • 84907971356 scopus 로고    scopus 로고
    • Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo
    • Rudicell R.S., Kwon Y.D., Ko S.Y., Pegu A., Louder M.K., Georgiev I.S., et al. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J Virol 2014, 88:12669-12682.
    • (2014) J Virol , vol.88 , pp. 12669-12682
    • Rudicell, R.S.1    Kwon, Y.D.2    Ko, S.Y.3    Pegu, A.4    Louder, M.K.5    Georgiev, I.S.6
  • 94
    • 84869232528 scopus 로고    scopus 로고
    • Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
    • Moldt B., Rakasz E.G., Schultz N., Chan-Hui P.Y., Swiderek K., Weisgrau K.L., et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci U S A 2012, 109:18921-18925.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 18921-18925
    • Moldt, B.1    Rakasz, E.G.2    Schultz, N.3    Chan-Hui, P.Y.4    Swiderek, K.5    Weisgrau, K.L.6
  • 95
    • 84951573281 scopus 로고    scopus 로고
    • Structure-based stabilization of the prefusion closed HIV-1 env trimer [SY05.03]
    • Kwong P.D. Structure-based stabilization of the prefusion closed HIV-1 env trimer [SY05.03]. HIV R4P 2014.
    • (2014) HIV R4P
    • Kwong, P.D.1
  • 96
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • Scheid J.F., Mouquet H., Ueberheide B., Diskin R., Klein F., Oliveira T.Y., et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 2011, 333:1633-1637.
    • (2011) Science , vol.333 , pp. 1633-1637
    • Scheid, J.F.1    Mouquet, H.2    Ueberheide, B.3    Diskin, R.4    Klein, F.5    Oliveira, T.Y.6
  • 98
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies
    • Kwong P.D., Mascola J.R. Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity 2012, 37:412-425.
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 99
    • 80053132436 scopus 로고    scopus 로고
    • Broad neutralization coverage of HIV by multiple highly potent antibodies
    • Walker L.M., Huber M., Doores K.J., Falkowska E., Pejchal R., Julien J.P., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 2011, 477:466-470.
    • (2011) Nature , vol.477 , pp. 466-470
    • Walker, L.M.1    Huber, M.2    Doores, K.J.3    Falkowska, E.4    Pejchal, R.5    Julien, J.P.6
  • 100
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker L.M., Phogat S.K., Chan-Hui P.Y., Wagner D., Phung P., Goss J.L., et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 2009, 326:285-289.
    • (2009) Science , vol.326 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.Y.3    Wagner, D.4    Phung, P.5    Goss, J.L.6
  • 101
    • 77954920017 scopus 로고    scopus 로고
    • Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    • Wu X., Yang Z.Y., Li Y., Hogerkorp C.M., Schief W.R., Seaman M.S., et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 2010, 329:856-861.
    • (2010) Science , vol.329 , pp. 856-861
    • Wu, X.1    Yang, Z.Y.2    Li, Y.3    Hogerkorp, C.M.4    Schief, W.R.5    Seaman, M.S.6
  • 102
    • 84905672117 scopus 로고    scopus 로고
    • Immunologic basis for long HCDR3s in broadly neutralizing antibodies against HIV-1
    • Yu L., Guan Y. Immunologic basis for long HCDR3s in broadly neutralizing antibodies against HIV-1. Front Immunol 2014, 5:250.
    • (2014) Front Immunol , vol.5 , pp. 250
    • Yu, L.1    Guan, Y.2
  • 103
    • 84917691102 scopus 로고    scopus 로고
    • HIV antibodies, antigen modification regulates competition of broad and narrow neutralizing HIV antibodies
    • McGuire A.T., Dreyer A.M., Carbonetti S., Lippy A., Glenn J., Scheid J.F., et al. HIV antibodies, antigen modification regulates competition of broad and narrow neutralizing HIV antibodies. Science 2014, 346:1380-1383.
    • (2014) Science , vol.346 , pp. 1380-1383
    • McGuire, A.T.1    Dreyer, A.M.2    Carbonetti, S.3    Lippy, A.4    Glenn, J.5    Scheid, J.F.6
  • 104
    • 79953316880 scopus 로고    scopus 로고
    • Comparison of antibody repertoires produced by HIV-1 infection, other chronic and acute infections, and systemic autoimmune disease
    • Breden F., Lepik C., Longo N.S., Montero M., Lipsky P.E., Scott J.K. Comparison of antibody repertoires produced by HIV-1 infection, other chronic and acute infections, and systemic autoimmune disease. PLOS ONE 2011, 6:e16857.
    • (2011) PLOS ONE , vol.6 , pp. e16857
    • Breden, F.1    Lepik, C.2    Longo, N.S.3    Montero, M.4    Lipsky, P.E.5    Scott, J.K.6
  • 105
    • 63849131879 scopus 로고    scopus 로고
    • Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
    • Scheid J.F., Mouquet H., Feldhahn N., Seaman M.S., Velinzon K., Pietzsch J., et al. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature 2009, 458:636-640.
    • (2009) Nature , vol.458 , pp. 636-640
    • Scheid, J.F.1    Mouquet, H.2    Feldhahn, N.3    Seaman, M.S.4    Velinzon, K.5    Pietzsch, J.6
  • 106
    • 84923850343 scopus 로고    scopus 로고
    • Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties
    • Guenaga J., de Val N., Tran K., Feng Y., Satchwell K., Ward A.B., et al. Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties. PLOS Pathog 2015, 11:e1004570.
    • (2015) PLOS Pathog , vol.11 , pp. e1004570
    • Guenaga, J.1    de Val, N.2    Tran, K.3    Feng, Y.4    Satchwell, K.5    Ward, A.B.6
  • 107
    • 84923172318 scopus 로고    scopus 로고
    • A native-like SOSIP.664 trimer based on a HIV-1 subtype B env gene
    • Pugach P., Ozorowski G., Cupo A., Ringe R., Yasmeen A., de Val N., et al. A native-like SOSIP.664 trimer based on a HIV-1 subtype B env gene. J Virol 2015, 89:3380-3395.
    • (2015) J Virol , vol.89 , pp. 3380-3395
    • Pugach, P.1    Ozorowski, G.2    Cupo, A.3    Ringe, R.4    Yasmeen, A.5    de Val, N.6
  • 108
  • 109
    • 84874561170 scopus 로고    scopus 로고
    • Neutralizing antibodies to HIV-1 induced by immunization
    • McCoy L.E., Weiss R.A. Neutralizing antibodies to HIV-1 induced by immunization. J Exp Med 2013, 210:209-223.
    • (2013) J Exp Med , vol.210 , pp. 209-223
    • McCoy, L.E.1    Weiss, R.A.2
  • 110
    • 84855343161 scopus 로고    scopus 로고
    • Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction
    • Huang X., Jin W., Hu K., Luo S., Du T., Griffin G.E., et al. Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction. Virology 2012, 423:97-106.
    • (2012) Virology , vol.423 , pp. 97-106
    • Huang, X.1    Jin, W.2    Hu, K.3    Luo, S.4    Du, T.5    Griffin, G.E.6
  • 111
    • 84875343247 scopus 로고    scopus 로고
    • Neutralizing antibody responses in macaques induced by human immunodeficiency virus type 1 monovalent or trivalent envelope glycoproteins
    • Quinnan G.V., Zhang P., Dong M., Chen H., Feng Y.R., Lewis M., et al. Neutralizing antibody responses in macaques induced by human immunodeficiency virus type 1 monovalent or trivalent envelope glycoproteins. PLOS ONE 2013, 8:e59803.
    • (2013) PLOS ONE , vol.8 , pp. e59803
    • Quinnan, G.V.1    Zhang, P.2    Dong, M.3    Chen, H.4    Feng, Y.R.5    Lewis, M.6
  • 112
    • 84864365540 scopus 로고    scopus 로고
    • HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120
    • Kovacs J.M., Nkolola J.P., Peng H., Cheung A., Perry J., Miller C.A., et al. HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120. Proc Natl Acad Sci U S A 2012, 109:12111-12116.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 12111-12116
    • Kovacs, J.M.1    Nkolola, J.P.2    Peng, H.3    Cheung, A.4    Perry, J.5    Miller, C.A.6
  • 113
    • 84922969997 scopus 로고    scopus 로고
    • A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component
    • Bricault C.A., Kovacs J.M., Nkolola J.P., Yusim K., Giorgi E.E., Shields J.L., et al. A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component. J Virol 2015, 89:2507-2519.
    • (2015) J Virol , vol.89 , pp. 2507-2519
    • Bricault, C.A.1    Kovacs, J.M.2    Nkolola, J.P.3    Yusim, K.4    Giorgi, E.E.5    Shields, J.L.6
  • 114
    • 84860837935 scopus 로고    scopus 로고
    • Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens
    • Santra S., Muldoon M., Watson S., Buzby A., Balachandran H., Carlson K.R., et al. Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens. Virology 2012, 428:121-127.
    • (2012) Virology , vol.428 , pp. 121-127
    • Santra, S.1    Muldoon, M.2    Watson, S.3    Buzby, A.4    Balachandran, H.5    Carlson, K.R.6
  • 116
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao H.X., Lynch R., Zhou T., Gao F., Alam S.M., Boyd S.D., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 2013, 496:469-476.
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.X.1    Lynch, R.2    Zhou, T.3    Gao, F.4    Alam, S.M.5    Boyd, S.D.6
  • 118
    • 84877609579 scopus 로고    scopus 로고
    • Rational HIV immunogen design to target specific germline B cell receptors
    • Jardine J., Julien J.P., Menis S., Ota T., Kalyuzhniy O., McGuire A., et al. Rational HIV immunogen design to target specific germline B cell receptors. Science 2013, 340:711-716.
    • (2013) Science , vol.340 , pp. 711-716
    • Jardine, J.1    Julien, J.P.2    Menis, S.3    Ota, T.4    Kalyuzhniy, O.5    McGuire, A.6
  • 119
    • 68349150945 scopus 로고    scopus 로고
    • Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    • Johnson P.R., Schnepp B.C., Zhang J., Connell M.J., Greene S.M., Yuste E., et al. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med 2009, 15:901-906.
    • (2009) Nat Med , vol.15 , pp. 901-906
    • Johnson, P.R.1    Schnepp, B.C.2    Zhang, J.3    Connell, M.J.4    Greene, S.M.5    Yuste, E.6
  • 120
    • 84898540554 scopus 로고    scopus 로고
    • Adeno-associated virus delivery of broadly neutralizing antibodies
    • Schnepp B.C., Johnson P.R. Adeno-associated virus delivery of broadly neutralizing antibodies. Curr Opin HIV AIDS 2014, 9:250-256.
    • (2014) Curr Opin HIV AIDS , vol.9 , pp. 250-256
    • Schnepp, B.C.1    Johnson, P.R.2
  • 121
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • Balazs A.B., Chen J., Hong C.M., Rao D.S., Yang L., Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 2012, 481:81-84.
    • (2012) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3    Rao, D.S.4    Yang, L.5    Baltimore, D.6
  • 122
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    • Balazs A.B., Ouyang Y., Hong C.M., Chen J., Nguyen S.M., Rao D.S., et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med 2014, 20:296-300.
    • (2014) Nat Med , vol.20 , pp. 296-300
    • Balazs, A.B.1    Ouyang, Y.2    Hong, C.M.3    Chen, J.4    Nguyen, S.M.5    Rao, D.S.6
  • 123
    • 84908242690 scopus 로고    scopus 로고
    • Challenges in the design of a T cell vaccine in the context of HIV-1 diversity
    • Tongo M., Burgers W.A. Challenges in the design of a T cell vaccine in the context of HIV-1 diversity. Viruses 2014, 6:3968-3990.
    • (2014) Viruses , vol.6 , pp. 3968-3990
    • Tongo, M.1    Burgers, W.A.2
  • 124
    • 84862744172 scopus 로고    scopus 로고
    • CD8(+) T cells in preventing HIV infection and disease
    • McDermott A.B., Koup R.A. CD8(+) T cells in preventing HIV infection and disease. AIDS 2012, 26:1281-1292.
    • (2012) AIDS , vol.26 , pp. 1281-1292
    • McDermott, A.B.1    Koup, R.A.2
  • 125
    • 84859919465 scopus 로고    scopus 로고
    • Lessons learned from HIV-1 vaccine trials: new priorities and directions
    • McMichael A.J., Haynes B.F. Lessons learned from HIV-1 vaccine trials: new priorities and directions. Nat Immunol 2012, 13:423-427.
    • (2012) Nat Immunol , vol.13 , pp. 423-427
    • McMichael, A.J.1    Haynes, B.F.2
  • 126
    • 69249211230 scopus 로고    scopus 로고
    • T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces
    • Korber B.T., Letvin N.L., Haynes B.F. T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces. J Virol 2009, 83:8300-8314.
    • (2009) J Virol , vol.83 , pp. 8300-8314
    • Korber, B.T.1    Letvin, N.L.2    Haynes, B.F.3
  • 127
    • 84883400877 scopus 로고    scopus 로고
    • Development of replication-competent viral vectors for HIV vaccine delivery
    • Parks C.L., Picker L.J., King C.R. Development of replication-competent viral vectors for HIV vaccine delivery. Curr Opin HIV AIDS 2013, 8:402-411.
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 402-411
    • Parks, C.L.1    Picker, L.J.2    King, C.R.3
  • 128
    • 77955272708 scopus 로고    scopus 로고
    • Replicating viral vectors as HIV vaccines: summary report from the IAVI-sponsored satellite symposium at the AIDS vaccine 2009 conference
    • Excler J.L., Parks C.L., Ackland J., Rees H., Gust I.D., Koff W.C. Replicating viral vectors as HIV vaccines: summary report from the IAVI-sponsored satellite symposium at the AIDS vaccine 2009 conference. Biologicals 2010, 38:511-521.
    • (2010) Biologicals , vol.38 , pp. 511-521
    • Excler, J.L.1    Parks, C.L.2    Ackland, J.3    Rees, H.4    Gust, I.D.5    Koff, W.C.6
  • 129
    • 78650598765 scopus 로고    scopus 로고
    • The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors
    • Koup R.A., Graham B.S., Douek D.C. The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors. Nat Rev Immunol 2011, 11:65-70.
    • (2011) Nat Rev Immunol , vol.11 , pp. 65-70
    • Koup, R.A.1    Graham, B.S.2    Douek, D.C.3
  • 130
    • 58149267963 scopus 로고    scopus 로고
    • Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
    • Liu J., O'Brien K.L., Lynch D.M., Simmons N.L., La Porte A., Riggs A.M., et al. Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature 2009, 457:87-91.
    • (2009) Nature , vol.457 , pp. 87-91
    • Liu, J.1    O'Brien, K.L.2    Lynch, D.M.3    Simmons, N.L.4    La Porte, A.5    Riggs, A.M.6
  • 131
    • 56649114351 scopus 로고    scopus 로고
    • HIV-1 vaccine-induced immunity in the test-of-concept step study: a case-cohort analysis
    • McElrath M.J., De Rosa S.C., Moodie Z., Dubey S., Kierstead L., Janes H., et al. HIV-1 vaccine-induced immunity in the test-of-concept step study: a case-cohort analysis. Lancet 2008, 372:1894-1905.
    • (2008) Lancet , vol.372 , pp. 1894-1905
    • McElrath, M.J.1    De Rosa, S.C.2    Moodie, Z.3    Dubey, S.4    Kierstead, L.5    Janes, H.6
  • 133
    • 79952324470 scopus 로고    scopus 로고
    • An Ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: results from a randomized placebo-controlled trial (the step study)
    • Fitzgerald D.W., Janes H., Robertson M., Coombs R., Frank I., Gilbert P., et al. An Ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: results from a randomized placebo-controlled trial (the step study). J Infect Dis 2011, 203:765-772.
    • (2011) J Infect Dis , vol.203 , pp. 765-772
    • Fitzgerald, D.W.1    Janes, H.2    Robertson, M.3    Coombs, R.4    Frank, I.5    Gilbert, P.6
  • 134
    • 79958726847 scopus 로고    scopus 로고
    • Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study
    • Li F., Finnefrock A.C., Dubey S.A., Korber B.T., Szinger J., Cole S., et al. Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study. PLOS ONE 2011, 6:e20479.
    • (2011) PLOS ONE , vol.6 , pp. e20479
    • Li, F.1    Finnefrock, A.C.2    Dubey, S.A.3    Korber, B.T.4    Szinger, J.5    Cole, S.6
  • 135
    • 84862026563 scopus 로고    scopus 로고
    • A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge
    • Reynolds M.R., Weiler A.M., Piaskowski S.M., Piatak M., Robertson H.T., Allison D.B., et al. A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge. Vaccine 2012, 30:4465-4475.
    • (2012) Vaccine , vol.30 , pp. 4465-4475
    • Reynolds, M.R.1    Weiler, A.M.2    Piaskowski, S.M.3    Piatak, M.4    Robertson, H.T.5    Allison, D.B.6
  • 136
    • 84863116109 scopus 로고    scopus 로고
    • Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb Step trial of a similar HIV-1 vaccine
    • Qureshi H., Ma Z.M., Huang Y., Hodge G., Thomas M.A., DiPasquale J., et al. Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb Step trial of a similar HIV-1 vaccine. J Virol 2012, 86:2239-2250.
    • (2012) J Virol , vol.86 , pp. 2239-2250
    • Qureshi, H.1    Ma, Z.M.2    Huang, Y.3    Hodge, G.4    Thomas, M.A.5    DiPasquale, J.6
  • 137
    • 79955680409 scopus 로고    scopus 로고
    • Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys
    • Letvin N.L., Rao S.S., Montefiori D.C., Seaman M.S., Sun Y., Lim S.Y., et al. Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys. Sci Transl Med 2011, 3:81ra36.
    • (2011) Sci Transl Med , vol.3 , pp. 81ra36
    • Letvin, N.L.1    Rao, S.S.2    Montefiori, D.C.3    Seaman, M.S.4    Sun, Y.5    Lim, S.Y.6
  • 138
    • 80053948074 scopus 로고    scopus 로고
    • Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania
    • Bakari M., Aboud S., Nilsson C., Francis J., Buma D., Moshiro C., et al. Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania. Vaccine 2011, 29:8417-8428.
    • (2011) Vaccine , vol.29 , pp. 8417-8428
    • Bakari, M.1    Aboud, S.2    Nilsson, C.3    Francis, J.4    Buma, D.5    Moshiro, C.6
  • 139
    • 84866858197 scopus 로고    scopus 로고
    • Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens
    • Ratto-Kim S., Currier J.R., Cox J.H., Excler J.L., Valencia-Micolta A., Thelian D., et al. Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens. PLOS ONE 2012, 7:e45840.
    • (2012) PLOS ONE , vol.7 , pp. e45840
    • Ratto-Kim, S.1    Currier, J.R.2    Cox, J.H.3    Excler, J.L.4    Valencia-Micolta, A.5    Thelian, D.6
  • 140
    • 77949264937 scopus 로고    scopus 로고
    • Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
    • Santra S., Liao H.X., Zhang R., Muldoon M., Watson S., Fischer W., et al. Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med 2010, 16:324-328.
    • (2010) Nat Med , vol.16 , pp. 324-328
    • Santra, S.1    Liao, H.X.2    Zhang, R.3    Muldoon, M.4    Watson, S.5    Fischer, W.6
  • 141
    • 77949263061 scopus 로고    scopus 로고
    • Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
    • Barouch D.H., O'Brien K.L., Simmons N.L., King S.L., Abbink P., Maxfield L.F., et al. Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys. Nat Med 2010, 16:319-323.
    • (2010) Nat Med , vol.16 , pp. 319-323
    • Barouch, D.H.1    O'Brien, K.L.2    Simmons, N.L.3    King, S.L.4    Abbink, P.5    Maxfield, L.F.6
  • 143
  • 144
    • 71949099413 scopus 로고    scopus 로고
    • Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses
    • Liu Y., McNevin J., Rolland M., Zhao H., Deng W., Maenza J., et al. Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses. J Infect Dis 2009, 200:1825-1833.
    • (2009) J Infect Dis , vol.200 , pp. 1825-1833
    • Liu, Y.1    McNevin, J.2    Rolland, M.3    Zhao, H.4    Deng, W.5    Maenza, J.6
  • 145
    • 84908389330 scopus 로고    scopus 로고
    • HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques
    • Kulkarni V., Valentin A., Rosati M., Rolland M., Mullins J.I., Pavlakis G.N., et al. HIV-1 conserved elements p24CE DNA vaccine induces humoral immune responses with broad epitope recognition in macaques. PLOS ONE 2014, 9:e111085.
    • (2014) PLOS ONE , vol.9 , pp. e111085
    • Kulkarni, V.1    Valentin, A.2    Rosati, M.3    Rolland, M.4    Mullins, J.I.5    Pavlakis, G.N.6
  • 146
    • 84869020041 scopus 로고    scopus 로고
    • Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys
    • Stephenson K.E., SanMiguel A., Simmons N.L., Smith K., Lewis M.G., Szinger J.J., et al. Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys. J Virol 2012, 86:11434-11440.
    • (2012) J Virol , vol.86 , pp. 11434-11440
    • Stephenson, K.E.1    SanMiguel, A.2    Simmons, N.L.3    Smith, K.4    Lewis, M.G.5    Szinger, J.J.6
  • 147
    • 84927797395 scopus 로고    scopus 로고
    • Optimizing parallel induction of HIV type 1-specific antibody and T-cell responses by multicomponent subunit vaccines
    • Clutton G., Carpov A., Parks C.L., Dean H.J., Montefiori D.C., Hanke T. Optimizing parallel induction of HIV type 1-specific antibody and T-cell responses by multicomponent subunit vaccines. AIDS 2014, 28:2495-2504.
    • (2014) AIDS , vol.28 , pp. 2495-2504
    • Clutton, G.1    Carpov, A.2    Parks, C.L.3    Dean, H.J.4    Montefiori, D.C.5    Hanke, T.6
  • 148
    • 84914692091 scopus 로고    scopus 로고
    • Characterization of T-cell responses to conserved regions of the HIV-1 proteome in BALB/c mice
    • Ondondo B., Abdul-Jawad S., Bridgeman A., Hanke T. Characterization of T-cell responses to conserved regions of the HIV-1 proteome in BALB/c mice. Clin Vaccine Immunol 2014, 21:1565-1572.
    • (2014) Clin Vaccine Immunol , vol.21 , pp. 1565-1572
    • Ondondo, B.1    Abdul-Jawad, S.2    Bridgeman, A.3    Hanke, T.4
  • 149
    • 84888301911 scopus 로고    scopus 로고
    • DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge
    • Koopman G., Beenhakker N., Nieuwenhuis I., Doxiadis G., Mooij P., Drijfhout J.W., et al. DNA/long peptide vaccination against conserved regions of SIV induces partial protection against SIVmac251 challenge. AIDS 2013, 27:2841-2851.
    • (2013) AIDS , vol.27 , pp. 2841-2851
    • Koopman, G.1    Beenhakker, N.2    Nieuwenhuis, I.3    Doxiadis, G.4    Mooij, P.5    Drijfhout, J.W.6
  • 150
    • 84903954106 scopus 로고    scopus 로고
    • Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial
    • Hayton E.J., Rose A., Ibrahimsa U., Del Sorbo M., Capone S., Crook A., et al. Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial. PLOS ONE 2014, 9:e101591.
    • (2014) PLOS ONE , vol.9 , pp. e101591
    • Hayton, E.J.1    Rose, A.2    Ibrahimsa, U.3    Del Sorbo, M.4    Capone, S.5    Crook, A.6
  • 151
    • 84895904764 scopus 로고    scopus 로고
    • Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1
    • Borthwick N., Ahmed T., Ondondo B., Hayes P., Rose A., Ebrahimsa U., et al. Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1. Mol Ther 2014, 22:464-475.
    • (2014) Mol Ther , vol.22 , pp. 464-475
    • Borthwick, N.1    Ahmed, T.2    Ondondo, B.3    Hayes, P.4    Rose, A.5    Ebrahimsa, U.6
  • 152
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen S.G., Ford J.C., Lewis M.S., Ventura A.B., Hughes C.M., Coyne-Johnson L., et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 2011, 473:523-527.
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3    Ventura, A.B.4    Hughes, C.M.5    Coyne-Johnson, L.6
  • 154
    • 84911499033 scopus 로고    scopus 로고
    • Accelerating HIV-1 vaccine efficacy trials
    • Barouch D.H., Michael N.L. Accelerating HIV-1 vaccine efficacy trials. Cell 2014, 159:969-972.
    • (2014) Cell , vol.159 , pp. 969-972
    • Barouch, D.H.1    Michael, N.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.