The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes after Ischemia Through Induction of Autophagy

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 21, Issue 1, 2016, Pages 70-81

  Huang, Ling ^a   Dai, Kai ^b   Chen, Manhua ^a   Zhou, Wenping ^a   Wang, Xiaoling ^a   Chen, Jing ^b   Zhou, Wei ^a  

^a CENTRAL HOSPITAL OF WUHAN   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

AMPK; autophagy; cardiomyocyte; ischemia; mTOR

Indexed keywords

2 CHLORO 5 [[5 [[5 (4,5 DIMETHYL 2 NITROPHENYL) 2 FURANYL]METHYLENE] 4,5 DIHYDRO 4 OXO 2 THIAZOLYL]AMINO]BENZOIC ACID; 3 [4 (1,3 BENZODIOXOL 5 YL) 2 OXO 3 BUTEN 1 YL] 3 HYDROXY 1,3 DIHYDRO 2H INDOL 2 ONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTECTIVE AGENT; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; 2-CHLORO-5-((5-((5-(4,5-DIMETHYL-2-NITROPHENYL)-2-FURANYL)METHYLENE)-4,5-DIHYDRO-4-OXO-2-THIAZOLYL)AMINO)BENZOIC ACID; 3 AMINOBENZOIC ACID DERIVATIVE; 3-(4-(BENZO(D)(1,3)DIOXOL-5-YL)-2-OXOBUT-3-EN-1-YL)-3-HYDROXYINDOLIN-2-ONE; GLUCOSE; INDOLE DERIVATIVE; MTOR PROTEIN, MOUSE; OXYGEN; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIAC MUSCLE CELL; CELL CULTURE; CELL HYPOXIA; CELL PROTECTION; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; AUTOPHAGY; BENZODIOXOLES; CELL HYPOXIA; CELLS, CULTURED; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GLUCOSE; INDOLES; MALE; META-AMINOBENZOATES; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; OXYGEN; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; THIAZOLES; TOR SERINE-THREONINE KINASES;

EID: 84951274163     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248415581177     Document Type: Article

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