메뉴 건너뛰기




Volumn 8, Issue 4, 2012, Pages 577-592

Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury

Author keywords

Autophagy; Cardiomyocyte; Diabetes; Hyperglycemia; mTOR; ULK1

Indexed keywords

3 METHYLADENINE; AUTOPHAGY PROTEIN 7; BAFILOMYCIN A1; BECLIN 1; CELL PROTEIN; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 FORM II; SERINE; SHORT HAIRPIN RNA; ULK1 PROTEIN; UNCLASSIFIED DRUG;

EID: 84862287069     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.18980     Document Type: Article
Times cited : (135)

References (69)
  • 1
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • PMID:10938048
    • Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321:405-12; PMID:10938048; http://dx.doi.org/10.1136/bmj.321.7258.405
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3    Matthews, D.R.4    Manley, S.E.5    Cull, C.A.6
  • 2
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • PMID:17592090
    • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation 2007; 115:3213-23; PMID:17592090; http://dx.doi.org/10.1161/CIRCULATIONAHA.106.679597
    • (2007) Circulation , vol.115 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 3
    • 33645280925 scopus 로고    scopus 로고
    • Diabetic cardio-myopathy: The search for a unifying hypothesis
    • PMID:16543510
    • Poornima IG, Parikh P, Shannon RP. Diabetic cardio-myopathy: the search for a unifying hypothesis. Circ Res 2006; 98:596-605; PMID:16543510; http://dx.doi.org/10.1161/01.RES.0000207406.94146.c2
    • (2006) Circ Res , vol.98 , pp. 596-605
    • Poornima, I.G.1    Parikh, P.2    Shannon, R.P.3
  • 4
    • 0035810983 scopus 로고    scopus 로고
    • Glycemic control and heart failure among adult patients with diabetes
    • PMID:11390335
    • Iribarren C, Karter AJ, Go AS, Ferrara A, Liu JY, Sidney S, et al. Glycemic control and heart failure among adult patients with diabetes. Circulation 2001; 103:2668-73; PMID:11390335
    • (2001) Circulation , vol.103 , pp. 2668-2673
    • Iribarren, C.1    Karter, A.J.2    Go, A.S.3    Ferrara, A.4    Liu, J.Y.5    Sidney, S.6
  • 5
    • 23644459089 scopus 로고    scopus 로고
    • Association of poor glycemic control with prolonged hospital stay in patients with diabetes admitted with exacerbation of congestive heart failure
    • PMID:16033717
    • Bhatia V, Wilding GE, Dhindsa G, Bhatia R, Garg RK, Bonner AJ, et al. Association of poor glycemic control with prolonged hospital stay in patients with diabetes admitted with exacerbation of congestive heart failure. Endocr Pract 2004; 10:467-71; PMID:16033717
    • (2004) Endocr Pract , vol.10 , pp. 467-471
    • Bhatia, V.1    Wilding, G.E.2    Dhindsa, G.3    Bhatia, R.4    Garg, R.K.5    Bonner, A.J.6
  • 6
    • 79251478387 scopus 로고    scopus 로고
    • Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: Data from the heart and soul study
    • PMID:20805280
    • van Melle JP, Bot M, de Jonge P, de Boer RA, van Veldhuisen DJ, Whooley MA. Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study. Diabetes Care 2010; 33:2084-9; PMID:20805280; http://dx.doi.org/10.2337/dc10-0286
    • (2010) Diabetes Care , vol.33 , pp. 2084-2089
    • Van Melle, J.P.1    Bot, M.2    De Jonge, P.3    De Boer, R.A.4    Van Veldhuisen, D.J.5    Whooley, M.A.6
  • 7
    • 0036267006 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in mouse myocardium: Mitochondrial cytochrome C-mediated caspase-3 activation pathway
    • PMID:12031984
    • Cai L, Li W, Wang G, Guo L, Jiang Y, Kang YJ. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 2002; 51:1938-48; PMID:12031984; http://dx.doi.org/10.2337/diabetes.51.6.1938
    • (2002) Diabetes , vol.51 , pp. 1938-1948
    • Cai, L.1    Li, W.2    Wang, G.3    Guo, L.4    Jiang, Y.5    Kang, Y.J.6
  • 8
    • 7444220738 scopus 로고    scopus 로고
    • Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats
    • PMID:15522273
    • Fiordaliso F, Bianchi R, Staszewsky L, Cuccovillo I, Doni M, Laragione T, et al. Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats. J Mol Cell Cardiol 2004; 37:959-68; PMID:15522273; http://dx.doi.org/10.1016/j.yjmcc.2004.07.008
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 959-968
    • Fiordaliso, F.1    Bianchi, R.2    Staszewsky, L.3    Cuccovillo, I.4    Doni, M.5    Laragione, T.6
  • 9
    • 14244270061 scopus 로고    scopus 로고
    • PKCepsilon inhibits the hyperglycemia-induced apoptosis signal in adult rat ventricular myocytes
    • PMID:15724450
    • Malhotra A, Kang BP, Hashmi S, Meggs LG. PKCepsilon inhibits the hyperglycemia-induced apoptosis signal in adult rat ventricular myocytes. Mol Cell Biochem 2005; 268:169-73; PMID:15724450; http://dx.doi.org/10.1007/s11010- 005-3858-6
    • (2005) Mol Cell Biochem , vol.268 , pp. 169-173
    • Malhotra, A.1    Kang, B.P.2    Hashmi, S.3    Meggs, L.G.4
  • 10
    • 0036081393 scopus 로고    scopus 로고
    • Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes
    • PMID:11959624
    • Shizukuda Y, Reyland ME, Buttrick PM. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. Am J Physiol Heart Circ Physiol 2002; 282:H1625-34; PMID:11959624
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Shizukuda, Y.1    Reyland, M.E.2    Buttrick, P.M.3
  • 11
    • 0035490419 scopus 로고    scopus 로고
    • Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death
    • PMID:11574421
    • Fiordaliso F, Leri A, Cesselli D, Limana F, Safai B, Nadal-Ginard B, et al. Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 2001; 50:2363-75; PMID:11574421; http://dx.doi.org/10.2337/ diabetes.50.10.2363
    • (2001) Diabetes , vol.50 , pp. 2363-2375
    • Fiordaliso, F.1    Leri, A.2    Cesselli, D.3    Limana, F.4    Safai, B.5    Nadal-Ginard, B.6
  • 12
    • 34547556463 scopus 로고    scopus 로고
    • Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury
    • PMID: 17525155
    • Kobayashi S, Mao K, Zheng H, Wang X, Patterson C, O'Connell TD, et al. Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury. J Biol Chem 2007; 282:21945-52; PMID: 17525155; http://dx.doi.org/10.1074/jbc.M703048200
    • (2007) J Biol Chem , vol.282 , pp. 21945-21952
    • Kobayashi, S.1    Mao, K.2    Zheng, H.3    Wang, X.4    Patterson, C.5    O'Connell, T.D.6
  • 13
    • 46749156297 scopus 로고    scopus 로고
    • Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species
    • PMID:18440987
    • Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res 2008; 79:341-51; PMID:18440987; http://dx.doi.org/10. 1093/cvr/cvn104
    • (2008) Cardiovasc Res , vol.79 , pp. 341-351
    • Yu, T.1    Sheu, S.S.2    Robotham, J.L.3    Yoon, Y.4
  • 14
    • 78650895891 scopus 로고    scopus 로고
    • High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission
    • PMID:20518702
    • Yu T, Jhun BS, Yoon Y. High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission. Antioxid Redox Signal 2011; 14:425-37; PMID:20518702; http://dx.doi.org/10.1089/ars.2010.3284
    • (2011) Antioxid Redox Signal , vol.14 , pp. 425-437
    • Yu, T.1    Jhun, B.S.2    Yoon, Y.3
  • 15
    • 2342563763 scopus 로고    scopus 로고
    • Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes
    • PMID:15111504
    • Ye G, Metreveli NS, Donthi RV, Xia S, Xu M, Carlson EC, et al. Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. Diabetes 2004; 53:1336-43; PMID:15111504; http://dx.doi.org/10.2337/diabetes.53. 5.1336
    • (2004) Diabetes , vol.53 , pp. 1336-1343
    • Ye, G.1    Metreveli, N.S.2    Donthi, R.V.3    Xia, S.4    Xu, M.5    Carlson, E.C.6
  • 16
    • 0036097650 scopus 로고    scopus 로고
    • Overexpression of metallothionein reduces diabetic cardiomyopathy
    • PMID:11756338
    • Liang Q, Carlson EC, Donthi RV, Kralik PM, Shen X, Epstein PN. Overexpression of metallothionein reduces diabetic cardiomyopathy. Diabetes 2002; 51:174-81; PMID:11756338; http://dx.doi.org/10.2337/diabetes.51.1.174
    • (2002) Diabetes , vol.51 , pp. 174-181
    • Liang, Q.1    Carlson, E.C.2    Donthi, R.V.3    Kralik, P.M.4    Shen, X.5    Epstein, P.N.6
  • 17
    • 0036834582 scopus 로고    scopus 로고
    • Effects of vitamin e on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the HOPE study and MICRO-HOPE substudy
    • PMID:12401733
    • Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 2002; 25:1919-27; PMID:12401733; http://dx.doi.org/10.2337/diacare.25.11.1919
    • (2002) Diabetes Care , vol.25 , pp. 1919-1927
    • Lonn, E.1    Yusuf, S.2    Hoogwerf, B.3    Pogue, J.4    Yi, Q.5    Zinman, B.6
  • 18
    • 0345411332 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular events with low-dose aspirin and vitamin e in type 2 diabetic patients: Results of the Primary Prevention Project (PPP) trial
    • PMID:14633812
    • Sacco M, Pellegrini F, Roncaglioni MC, Avanzini F, Tognoni G, Nicolucci A. Primary prevention of cardiovascular events with low-dose aspirin and vitamin E in type 2 diabetic patients: results of the Primary Prevention Project (PPP) trial. Diabetes Care 2003; 26:3264-72; PMID:14633812; http://dx.doi.org/10.2337/ diacare.26.12.3264
    • (2003) Diabetes Care , vol.26 , pp. 3264-3272
    • Sacco, M.1    Pellegrini, F.2    Roncaglioni, M.C.3    Avanzini, F.4    Tognoni, G.5    Nicolucci, A.6
  • 19
    • 27644467802 scopus 로고    scopus 로고
    • Autophagy in cardiac myocyte homeostasis, aging, and pathology
    • PMID:16213475
    • Terman A, Brunk UT. Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res 2005; 68:355-65; PMID:16213475; http://dx.doi.org/10. 1016/j.cardiores.2005.08.014
    • (2005) Cardiovasc Res , vol.68 , pp. 355-365
    • Terman, A.1    Brunk, U.T.2
  • 20
    • 34547914535 scopus 로고    scopus 로고
    • The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart
    • PMID:17627477
    • Takagi H, Matsui Y, Sadoshima J. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal 2007; 9:1373-81; PMID:17627477; http://dx.doi.org/10.1089/ars.2007.1689
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1373-1381
    • Takagi, H.1    Matsui, Y.2    Sadoshima, J.3
  • 21
    • 80052801111 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cardiovascular disease
    • PMID: 21723289
    • Nemchenko A, Chiong M, Turer A, Lavandero S, Hill JA. Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol 2011; 51:584-93; PMID: 21723289; http://dx.doi.org/10.1016/j.yjmcc.2011.06.010
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 584-593
    • Nemchenko, A.1    Chiong, M.2    Turer, A.3    Lavandero, S.4    Hill, J.A.5
  • 22
    • 33846531305 scopus 로고    scopus 로고
    • The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: Apoptosis meets autophagy
    • PMID:17149555
    • Hamacher-Brady A, Brady NR, Gottlieb RA. The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy. Cardiovasc Drugs Ther 2006; 20:445-62; PMID:17149555; http://dx.doi.org/10.1007/s10557-006-0583-7
    • (2006) Cardiovasc Drugs Ther , vol.20 , pp. 445-462
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 23
    • 27644493346 scopus 로고    scopus 로고
    • The pleiotropic role of autophagy: From protein metabolism to bactericide
    • PMID:16247501
    • Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ 2005; 12(Suppl 2):1535-41; PMID:16247501; http://dx.doi.org/10.1038/sj.cdd.4401728
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1535-1541
    • Mizushima, N.1
  • 24
    • 33749570745 scopus 로고    scopus 로고
    • Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    • PMID:16882669
    • Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 2006; 281:29776-87; PMID:16882669; http://dx.doi.org/10.1074/jbc.M603783200
    • (2006) J Biol Chem , vol.281 , pp. 29776-29787
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 25
    • 38049058666 scopus 로고    scopus 로고
    • To be or not to be, the level of autophagy is the question: Dual roles of autophagy in the survival response to starvation
    • PMID:17952023
    • Kang C, Avery L. To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Autophagy 2008; 4:82-4; PMID:17952023
    • (2008) Autophagy , vol.4 , pp. 82-84
    • Kang, C.1    Avery, L.2
  • 26
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMPactivated protein kinase and Beclin 1 in mediating autophagy
    • PMID:17332429
    • Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMPactivated protein kinase and Beclin 1 in mediating autophagy. Circ Res 2007; 100:914-22; PMID:17332429; http://dx.doi.org/10.1161/01.RES.0000261924. 76669.36
    • (2007) Circ Res , vol.100 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3    Abdellatif, M.4    Sakoda, H.5    Asano, T.6
  • 27
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: Apoptosis, autophagy and the cross-talk between them
    • PMID:19325568
    • Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 2009; 16:966-75; PMID:19325568; http://dx.doi.org/10.1038/cdd.2009.33
    • (2009) Cell Death Differ , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.U.3    Kimchi, A.4
  • 28
    • 33749052075 scopus 로고    scopus 로고
    • Signalling and autophagy regulation in health, aging and disease
    • PMID:16973212
    • Meijer AJ, Codogno P. Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med 2006; 27:411-25; PMID:16973212; http://dx.doi.org/10.1016/j.mam.2006.08.002
    • (2006) Mol Aspects Med , vol.27 , pp. 411-425
    • Meijer, A.J.1    Codogno, P.2
  • 29
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • PMID:21258367
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132-41; PMID:21258367; http://dx.doi.org/10.1038/ncb2152
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 30
    • 34548084014 scopus 로고    scopus 로고
    • Macroautophagy: Protector in the diabetes drama?
    • PMID:17534140
    • Meijer AJ, Codogno P. Macroautophagy: protector in the diabetes drama? Autophagy 2007; 3:523-6; PMID:17534140
    • (2007) Autophagy , vol.3 , pp. 523-526
    • Meijer, A.J.1    Codogno, P.2
  • 31
    • 34047179973 scopus 로고    scopus 로고
    • Ubiquitinated-Protein Aggregates Form in Pancreatic {beta}-Cells during Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy
    • PMID:17395740
    • Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH. Ubiquitinated-Protein Aggregates Form in Pancreatic {beta}-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy. Diabetes 2007; 56:930-9; PMID:17395740; http://dx.doi.org/10.2337/db06-1160
    • (2007) Diabetes , vol.56 , pp. 930-939
    • Kaniuk, N.A.1    Kiraly, M.2    Bates, H.3    Vranic, M.4    Volchuk, A.5    Brumell, J.H.6
  • 32
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    • PMID: 18840362
    • Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 2008; 8:318-24; PMID: 18840362; http://dx.doi.org/10. 1016/j.cmet.2008.08.013
    • (2008) Cell Metab , vol.8 , pp. 318-324
    • Jung, H.S.1    Chung, K.W.2    Won Kim, J.3    Kim, J.4    Komatsu, M.5    Tanaka, K.6
  • 33
    • 77957299576 scopus 로고    scopus 로고
    • Role of autophagy in betacell function and mass
    • PMID:21029296
    • Hur KY, Jung HS, Lee MS. Role of autophagy in betacell function and mass. Diabetes Obes Metab 2010; 12 (Suppl 2):20-6; PMID:21029296; http://dx.doi.org/10.1111/j.1463-1326.2010.01278.x
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL. 2 , pp. 20-26
    • Hur, K.Y.1    Jung, H.S.2    Lee, M.S.3
  • 34
    • 0016138942 scopus 로고
    • Hepatic autography in uncontrolled experimental diabetes and its relationships to insulin and glucagon
    • PMID:4834889
    • Amherdt M, Harris V, Renold AE, Orci L, Unger RH. Hepatic autography in uncontrolled experimental diabetes and its relationships to insulin and glucagon. J Clin Invest 1974; 54:188-93; PMID:4834889; http://dx.doi.org/10. 1172/JCI107742
    • (1974) J Clin Invest , vol.54 , pp. 188-193
    • Amherdt, M.1    Harris, V.2    Renold, A.E.3    Orci, L.4    Unger, R.H.5
  • 35
    • 78249232348 scopus 로고    scopus 로고
    • Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inflammation in a rat model of diabetes mellitus
    • PMID:21079355
    • Hagiwara S, Iwasaka H, Koga H, Hasegawa A, Kudo K, Kusaka J, et al. Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inflammation in a rat model of diabetes mellitus. Biomed Res 2010; 31: 263-71; PMID:21079355; http://dx.doi.org/10.2220/biomedres.31.263
    • (2010) Biomed Res , vol.31 , pp. 263-271
    • Hagiwara, S.1    Iwasaka, H.2    Koga, H.3    Hasegawa, A.4    Kudo, K.5    Kusaka, J.6
  • 36
    • 0026575717 scopus 로고
    • Cellular autophagy in proximal tubules of early diabetic rats following insulin treatment and islet transplantation
    • PMID:1349776
    • Han K, Lehringer-Polzin M, Zhou H, Pfeifer U. Cellular autophagy in proximal tubules of early diabetic rats following insulin treatment and islet transplantation. Virchows Arch B Cell Pathol Incl Mol Pathol 1992; 61:367-73; PMID:1349776; http://dx.doi.org/10.1007/BF02890440
    • (1992) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.61 , pp. 367-373
    • Han, K.1    Lehringer-Polzin, M.2    Zhou, H.3    Pfeifer, U.4
  • 37
    • 0030662402 scopus 로고    scopus 로고
    • Inhibition and restimulation by insulin of cellular autophagy in distal tubular cells of the kidney in early diabetic rats
    • PMID:9398032
    • Han K, Zhou H, Pfeifer U. Inhibition and restimulation by insulin of cellular autophagy in distal tubular cells of the kidney in early diabetic rats. Kidney Blood Press Res 1997; 20:258-63; PMID:9398032; http://dx.doi.org/10. 1159/000174155
    • (1997) Kidney Blood Press Res , vol.20 , pp. 258-263
    • Han, K.1    Zhou, H.2    Pfeifer, U.3
  • 38
    • 79959385996 scopus 로고    scopus 로고
    • Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
    • PMID:21562078
    • Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 2011; 60:1770-8; PMID:21562078; http://dx.doi.org/10.2337/db10-0351
    • (2011) Diabetes , vol.60 , pp. 1770-1778
    • Xie, Z.1    Lau, K.2    Eby, B.3    Lozano, P.4    He, C.5    Pennington, B.6
  • 39
    • 79955658311 scopus 로고    scopus 로고
    • Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
    • PMID:21385586
    • Mellor KM, Bell JR, Young MJ, Ritchie RH, Delbridge LM. Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J Mol Cell Cardiol 2011; 50:1035-43; PMID:21385586; http://dx.doi.org/10.1016/j.yjmcc.2011.03.002
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 1035-1043
    • Mellor, K.M.1    Bell, J.R.2    Young, M.J.3    Ritchie, R.H.4    Delbridge, L.M.5
  • 40
    • 80053432592 scopus 로고    scopus 로고
    • Autophagy anomalies in the diabetic myocardium
    • PMID:21814044
    • Mellor KM, Reichelt ME, Delbridge LM. Autophagy anomalies in the diabetic myocardium. Autophagy 2011; 7:1263-7; PMID:21814044; http://dx.doi.org/10.4161/ auto.7.10.17148
    • (2011) Autophagy , vol.7 , pp. 1263-1267
    • Mellor, K.M.1    Reichelt, M.E.2    Delbridge, L.M.3
  • 41
    • 4344624322 scopus 로고    scopus 로고
    • LC3 conjugation system in mammalian autophagy
    • PMID:15325588
    • Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004; 36:2503-18; PMID:15325588; http://dx.doi.org/10.1016/j.biocel.2004.05.009
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2503-2518
    • Tanida, I.1    Ueno, T.2    Kominami, E.3
  • 42
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • PMID:17611390
    • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542-5; PMID:17611390
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 43
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    • PMID:17450150
    • Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007; 13:619-24; PMID:17450150; http://dx.doi.org/ 10.1038/nm1574
    • (2007) Nat Med , vol.13 , pp. 619-624
    • Nakai, A.1    Yamaguchi, O.2    Takeda, T.3    Higuchi, Y.4    Hikoso, S.5    Taniike, M.6
  • 44
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • PMID:17580304
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-45; PMID:17580304; http://dx.doi.org/10.1074/jbc.M702824200
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6
  • 45
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • PMID:18083104
    • Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007; 131:1149-63; PMID:18083104; http://dx.doi.org/10.1016/j.cell.2007.10.035
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5    Hara, T.6
  • 46
    • 78650691023 scopus 로고    scopus 로고
    • Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
    • PMID:20947830
    • Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res 2010; 107:1470-82; PMID:20947830; http://dx.doi.org/10.1161/CIRCRESAHA.110.227371
    • (2010) Circ Res , vol.107 , pp. 1470-1482
    • Hariharan, N.1    Maejima, Y.2    Nakae, J.3    Paik, J.4    Depinho, R.A.5    Sadoshima, J.6
  • 47
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • PMID:17534139
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3:452-60; PMID:17534139
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 48
    • 4344712684 scopus 로고    scopus 로고
    • Methods for monitoring autophagy
    • PMID: 15325587
    • Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol 2004; 36:2491-502; PMID: 15325587; http://dx.doi.org/10.1016/j.biocel.2004.02. 005
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2491-2502
    • Mizushima, N.1
  • 49
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • PMID:17712358
    • Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8:931-7; PMID:17712358; http://dx.doi.org/10.1038/nrm2245
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 931-937
    • Klionsky, D.J.1
  • 50
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • PMID: 15314020
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926-45; PMID: 15314020; http://dx.doi.org/10.1101/gad.1212704
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 51
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • PMID:19225151
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992-2003; PMID:19225151; http://dx.doi.org/10.1091/mbc.E08-12-1249
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5    Cao, J.6
  • 52
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • PMID:20056399
    • Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22:132-9; PMID:20056399; http://dx.doi.org/10.1016/j. ceb.2009.12.004
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 53
    • 0031952669 scopus 로고    scopus 로고
    • Different behaviour of the nonsarcomeric cytoskeleton in neonatal and adult rat cardiomyocytes
    • PMID:9500878
    • Rothen-Rutishauser BM, Ehler E, Perriard E, Messerli JM, Perriard JC. Different behaviour of the nonsarcomeric cytoskeleton in neonatal and adult rat cardiomyocytes. J Mol Cell Cardiol 1998; 30:19-31; PMID:9500878; http://dx.doi.org/10.1006/jmcc.1997.0596
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 19-31
    • Rothen-Rutishauser, B.M.1    Ehler, E.2    Perriard, E.3    Messerli, J.M.4    Perriard, J.C.5
  • 54
    • 84859436566 scopus 로고    scopus 로고
    • Infusion of a Glucose Solution Reduces Autophagy in the Liver after LPS-induced Systemic Inflammation
    • PMID:21384092
    • Hagiwara S, Iwasaka H, Hasegawa A, Kudo K, Kusaka J, Oyama Y, et al. Infusion of a Glucose Solution Reduces Autophagy in the Liver after LPS-induced Systemic Inflammation. Inflammation 2012; 35:249-58; PMID:21384092; http://dx.doi.org/10.1007/s10753-011-9311-y
    • (2012) Inflammation , vol.35 , pp. 249-258
    • Hagiwara, S.1    Iwasaka, H.2    Hasegawa, A.3    Kudo, K.4    Kusaka, J.5    Oyama, Y.6
  • 55
    • 33847024296 scopus 로고    scopus 로고
    • High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells
    • PMID:17259394
    • Mariappan MM, Feliers D, Mummidi S, Choudhury GG, Kasinath BS. High glucose, high insulin, and their combination rapidly induce laminin-beta1 synthesis by regulation of mRNA translation in renal epithelial cells. Diabetes 2007; 56:476-85; PMID:17259394; http://dx.doi.org/10.2337/db05-1334
    • (2007) Diabetes , vol.56 , pp. 476-485
    • Mariappan, M.M.1    Feliers, D.2    Mummidi, S.3    Choudhury, G.G.4    Kasinath, B.S.5
  • 56
    • 12544252740 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
    • PMID:15537654
    • Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem 2005; 280: 2282-93; PMID:15537654; http://dx.doi.org/10.1074/jbc.M412179200
    • (2005) J Biol Chem , vol.280 , pp. 2282-2293
    • Briaud, I.1    Dickson, L.M.2    Lingohr, M.K.3    McCuaig, J.F.4    Lawrence, J.C.5    Rhodes, C.J.6
  • 57
    • 26044444093 scopus 로고    scopus 로고
    • Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function
    • PMID:16135669
    • Li SY, Fang CX, Aberle NS, 2nd, Ren BH, Ceylan-Isik AF, Ren J. Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function. J Endocrinol 2005; 186:491-503; PMID:16135669; http://dx.doi.org/10.1677/joe.1.06168
    • (2005) J Endocrinol , vol.186 , pp. 491-503
    • Li, S.Y.1    Fang, C.X.2    Aberle II, N.S.3    Ren, B.H.4    Ceylan-Isik, A.F.5    Ren, J.6
  • 58
    • 59349105159 scopus 로고    scopus 로고
    • Penumbra imaging as a prognostic indicator for acute myocardial infarction using MDCT
    • PMID:19155384
    • Tsai IC, Liang KW, Lee WL. Penumbra imaging as a prognostic indicator for acute myocardial infarction using MDCT. AJR Am J Roentgenol 2009; 192:W75-6; PMID:19155384; http://dx.doi.org/10.2214/AJR.08.1458
    • (2009) AJR Am J Roentgenol , vol.192
    • Tsai, I.C.1    Liang, K.W.2    Lee, W.L.3
  • 59
    • 58149478492 scopus 로고    scopus 로고
    • mTOR regulates autophagy-associated genes downstream of p73
    • PMID:19001857
    • Rosenbluth JM, Pietenpol JA. mTOR regulates autophagy-associated genes downstream of p73. Autophagy 2009; 5:114-6; PMID:19001857; http://dx.doi.org/10. 4161/auto.5.1.7294
    • (2009) Autophagy , vol.5 , pp. 114-116
    • Rosenbluth, J.M.1    Pietenpol, J.A.2
  • 60
    • 79952129478 scopus 로고    scopus 로고
    • Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis
    • PMID:21245298
    • Rosenbluth JM, Mays DJ, Jiang A, Shyr Y, Pietenpol JA. Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc Natl Acad Sci USA 2011; 108:2076-81; PMID:21245298; http://dx.doi.org/10.1073/ pnas.1011936108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2076-2081
    • Rosenbluth, J.M.1    Mays, D.J.2    Jiang, A.3    Shyr, Y.4    Pietenpol, J.A.5
  • 61
    • 79953211917 scopus 로고    scopus 로고
    • Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
    • PMID:21383122
    • Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci USA 2011; 108:4788-93; PMID:21383122; http://dx.doi.org/10.1073/pnas.1100844108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4788-4793
    • Shang, L.1    Chen, S.2    Du, F.3    Li, S.4    Zhao, L.5    Wang, X.6
  • 62
    • 81155123729 scopus 로고    scopus 로고
    • The serine/threonine kinase ULK1 is a target of multiple phosphorylation events
    • PMID: 21819378
    • Bach M, Larance M, James DE, Ramm G. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J 2011; 440:283-91; PMID: 21819378; http://dx.doi.org/10.1042/BJ20101894
    • (2011) Biochem J , vol.440 , pp. 283-291
    • Bach, M.1    Larance, M.2    James, D.E.3    Ramm, G.4
  • 63
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • PMID:21205641
    • Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331: 456-61; PMID:21205641; http://dx.doi.org/10.1126/science.1196371
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5    Mair, W.6
  • 64
    • 0037418939 scopus 로고    scopus 로고
    • Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter
    • PMID:12623879
    • Sanbe A, Gulick J, Hanks MC, Liang Q, Osinska H, Robbins J. Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res 2003; 92:609-16; PMID:12623879; http://dx.doi.org/10.1161/01. RES.0000065442.64694.9F
    • (2003) Circ Res , vol.92 , pp. 609-616
    • Sanbe, A.1    Gulick, J.2    Hanks, M.C.3    Liang, Q.4    Osinska, H.5    Robbins, J.6
  • 65
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • PMID: 14657337
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100:15077-82; PMID: 14657337; http://dx.doi.org/10.1073/pnas.2436255100
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 66
    • 33847105534 scopus 로고    scopus 로고
    • An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes
    • PMID:17283256
    • Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC, et al. An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation 2007; 115:763-72; PMID:17283256; http://dx.doi.org/10.1161/CIRCULATIONAHA.106.664862
    • (2007) Circulation , vol.115 , pp. 763-772
    • Huang, Y.1    Wright, C.D.2    Merkwan, C.L.3    Baye, N.L.4    Liang, Q.5    Simpson, P.C.6
  • 67
    • 33846225093 scopus 로고    scopus 로고
    • Isolation and culture of adult mouse cardiac myocytes
    • PMID:17172694
    • O'Connell TD, Rodrigo MC, Simpson PC. Isolation and culture of adult mouse cardiac myocytes. Methods Mol Biol 2007; 357:271-96; PMID:17172694
    • (2007) Methods Mol Biol , vol.357 , pp. 271-296
    • O'Connell, T.D.1    Rodrigo, M.C.2    Simpson, P.C.3
  • 68
    • 73649099845 scopus 로고    scopus 로고
    • Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death
    • PMID:19901028
    • Kobayashi S, Volden P, Timm D, Mao K, Xu X, Liang Q. Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. J Biol Chem 2010; 285:793-804; PMID:19901028; http://dx.doi.org/10.1074/jbc.M109.070037
    • (2010) J Biol Chem , vol.285 , pp. 793-804
    • Kobayashi, S.1    Volden, P.2    Timm, D.3    Mao, K.4    Xu, X.5    Liang, Q.6
  • 69
    • 19444382327 scopus 로고    scopus 로고
    • The dynamics of autophagy visualized in live cells: From autophagosome formation to fusion with endo/lysosomes
    • PMID:16874023
    • Bampton ET, Goemans CG, Niranjan D, Mizushima N, Tolkovsky AM. The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy 2005; 1:23-36; PMID:16874023; http://dx.doi.org/10.4161/auto.1.1.1495
    • (2005) Autophagy , vol.1 , pp. 23-36
    • Bampton, E.T.1    Goemans, C.G.2    Niranjan, D.3    Mizushima, N.4    Tolkovsky, A.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.