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Volumn 238, Issue 2, 2016, Pages 257-266

Large animal models of atherosclerosis - New tools for persistent problems in cardiovascular medicine

Author keywords

animal models; atherosclerosis; genetically modified animals; pathology

Indexed keywords

ANIMAL MODEL; ATHEROSCLEROSIS; DIABETES MELLITUS; DIAGNOSTIC IMAGING; DISEASE COURSE; DRUG DEVELOPMENT; HUMAN; HYPERTENSION; LIPOPROTEIN METABOLISM; MINIPIG; MOUSE MODEL; NONHUMAN; PATHOGENESIS; PORCINE MODEL; PRIMATE MODEL; PRIORITY JOURNAL; RABBIT MODEL; REVIEW; SPONTANEOUS MUTATION; TRANSLATIONAL RESEARCH; ANIMAL; DISEASE MODEL; FORECASTING; GENETIC ENGINEERING; MOUSE; PIG; PRECLINICAL STUDY; PROCEDURES; RABBIT; TRANSGENIC ANIMAL;

EID: 84951270901     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4646     Document Type: Review
Times cited : (62)

References (66)
  • 2
    • 84880938203 scopus 로고    scopus 로고
    • Molecular biology of atherosclerosis
    • Hopkins PN,. Molecular biology of atherosclerosis. Physiol Rev 2013; 93: 1317-1542.
    • (2013) Physiol Rev , vol.93 , pp. 1317-1542
    • Hopkins, P.N.1
  • 3
    • 84899112104 scopus 로고    scopus 로고
    • Reduction of low-density lipoprotein cholesterol by monoclonal antibody inhibition of PCSK9
    • Stein EA, Raal F,. Reduction of low-density lipoprotein cholesterol by monoclonal antibody inhibition of PCSK9. Annu Rev Med 2014; 65: 417-431.
    • (2014) Annu Rev Med , vol.65 , pp. 417-431
    • Stein, E.A.1    Raal, F.2
  • 4
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK,. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473: 317-325.
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 5
    • 62549162170 scopus 로고    scopus 로고
    • Genomics and cardiovascular drug development
    • Plump AS, Lum PY,. Genomics and cardiovascular drug development. J Am Coll Cardiol 2009; 53: 1089-1100.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1089-1100
    • Plump, A.S.1    Lum, P.Y.2
  • 6
    • 59649103078 scopus 로고    scopus 로고
    • Limitations of the Framingham risk score are now much clearer
    • Schlendorf KH, Nasir K, Blumenthal RS,. Limitations of the Framingham risk score are now much clearer. Prev Med 2009; 48: 115-116.
    • (2009) Prev Med , vol.48 , pp. 115-116
    • Schlendorf, K.H.1    Nasir, K.2    Blumenthal, R.S.3
  • 8
    • 84890461947 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society
    • Nordestgaard BG, Chapman MJ, Humphries SE, et al., Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. Eur Heart J 2013; 34: 3478-3490.
    • (2013) Eur Heart J , vol.34 , pp. 3478-3490
    • Nordestgaard, B.G.1    Chapman, M.J.2    Humphries, S.E.3
  • 9
    • 84871055775 scopus 로고    scopus 로고
    • A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lim SS, Vos T, Flaxman AD, et al., A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2224-2260.
    • (2012) Lancet , vol.380 , pp. 2224-2260
    • Lim, S.S.1    Vos, T.2    Flaxman, A.D.3
  • 10
    • 4444382796 scopus 로고    scopus 로고
    • Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study
    • Yusuf S, Hawken S, Ounpuu S, et al., Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 937-952.
    • (2004) Lancet , vol.364 , pp. 937-952
    • Yusuf, S.1    Hawken, S.2    Ounpuu, S.3
  • 11
    • 50349090959 scopus 로고    scopus 로고
    • Evidence mandating earlier and more aggressive treatment of hypercholesterolemia
    • Steinberg D, Glass CK, Witztum JL,. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation 2008; 118: 672-677.
    • (2008) Circulation , vol.118 , pp. 672-677
    • Steinberg, D.1    Glass, C.K.2    Witztum, J.L.3
  • 12
    • 37349021003 scopus 로고    scopus 로고
    • Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
    • Tabas I, Williams KJ, Borén J,. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 2007; 116: 1832-1844.
    • (2007) Circulation , vol.116 , pp. 1832-1844
    • Tabas, I.1    Williams, K.J.2    Borén, J.3
  • 13
    • 79251580687 scopus 로고    scopus 로고
    • Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity
    • Miller YI, Choi SH, Wiesner P, et al., Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res 2011; 108: 235-248.
    • (2011) Circ Res , vol.108 , pp. 235-248
    • Miller, Y.I.1    Choi, S.H.2    Wiesner, P.3
  • 14
    • 84902192302 scopus 로고    scopus 로고
    • Inflammation and its resolution as determinants of acute coronary syndromes
    • Libby P, Tabas I, Fredman G, et al., Inflammation and its resolution as determinants of acute coronary syndromes. Circ Res 2014; 114: 1867-1879.
    • (2014) Circ Res , vol.114 , pp. 1867-1879
    • Libby, P.1    Tabas, I.2    Fredman, G.3
  • 15
    • 66349100479 scopus 로고    scopus 로고
    • The LDL modification hypothesis of atherogenesis: An update
    • Steinberg D,. The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 2009; 50 (suppl): S376-381.
    • (2009) J Lipid Res , vol.50 , pp. S376-S381
    • Steinberg, D.1
  • 16
    • 84902131678 scopus 로고    scopus 로고
    • Mechanisms of plaque formation and rupture
    • Bentzon JF, Otsuka F, Virmani R, et al., Mechanisms of plaque formation and rupture. Circ Res 2014; 114: 1852-1866.
    • (2014) Circ Res , vol.114 , pp. 1852-1866
    • Bentzon, J.F.1    Otsuka, F.2    Virmani, R.3
  • 17
    • 84874885965 scopus 로고    scopus 로고
    • Update on acute coronary syndromes: The pathologists' view
    • Falk E, Nakano M, Bentzon JF, et al., Update on acute coronary syndromes: the pathologists' view. Eur Heart J 2013; 34: 719-728.
    • (2013) Eur Heart J , vol.34 , pp. 719-728
    • Falk, E.1    Nakano, M.2    Bentzon, J.F.3
  • 18
    • 33644850224 scopus 로고    scopus 로고
    • Diet and murine atherosclerosis
    • Getz GS,. Diet and murine atherosclerosis. Arterioscler Thromb Vasc Biol 2005; 26: 242-249.
    • (2005) Arterioscler Thromb Vasc Biol , vol.26 , pp. 242-249
    • Getz, G.S.1
  • 19
    • 0035405575 scopus 로고    scopus 로고
    • Diabetes-induced accelerated atherosclerosis in swine
    • Gerrity RG, Natarajan R, Nadler JL, et al., Diabetes-induced accelerated atherosclerosis in swine. Diabetes 2001; 50: 1654-1665.
    • (2001) Diabetes , vol.50 , pp. 1654-1665
    • Gerrity, R.G.1    Natarajan, R.2    Nadler, J.L.3
  • 20
    • 77957583441 scopus 로고    scopus 로고
    • Atherosclerotic lesions in mouse and man: Is it the same disease?
    • Bentzon JF, Falk E,. Atherosclerotic lesions in mouse and man: is it the same disease? Curr Opin Lipidol 2010; 21: 434-440.
    • (2010) Curr Opin Lipidol , vol.21 , pp. 434-440
    • Bentzon, J.F.1    Falk, E.2
  • 23
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump AS, Smith JD, Hayek T, et al., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992; 71: 343-353.
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3
  • 24
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein e
    • Zhang SH, Reddick RL, Piedrahita JA, et al., Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992; 258: 468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3
  • 25
    • 0028345073 scopus 로고
    • Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    • Ishibashi S, Goldstein JL, Brown MS, et al., Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest 1994; 93: 1885-1893.
    • (1994) J Clin Invest , vol.93 , pp. 1885-1893
    • Ishibashi, S.1    Goldstein, J.L.2    Brown, M.S.3
  • 26
    • 79956022523 scopus 로고    scopus 로고
    • SiRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids
    • Tadin-Strapps M, Peterson LB, Cumiskey A-M, et al., siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids. J Lipid Res 2011; 52: 1084-1097.
    • (2011) J Lipid Res , vol.52 , pp. 1084-1097
    • Tadin-Strapps, M.1    Peterson, L.B.2    Cumiskey, A.-M.3
  • 27
    • 77953958749 scopus 로고    scopus 로고
    • Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control
    • Herbert B, Patel D, Waddington SN, et al., Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control. Arterioscler Thromb Vasc Biol 2010; 30: 1333-1339.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1333-1339
    • Herbert, B.1    Patel, D.2    Waddington, S.N.3
  • 28
    • 84901449412 scopus 로고    scopus 로고
    • Induction of atherosclerosis in mice and hamsters without germline genetic engineering
    • Bjørklund MM, Hollensen AK, Hagensen MK, et al., Induction of atherosclerosis in mice and hamsters without germline genetic engineering. Circ Res 2014; 114: 1684-1689.
    • (2014) Circ Res , vol.114 , pp. 1684-1689
    • Bjørklund, M.M.1    Hollensen, A.K.2    Hagensen, M.K.3
  • 30
    • 26244463577 scopus 로고    scopus 로고
    • Atherosclerotic plaque progression and vulnerability to rupture: Angiogenesis as a source of intraplaque hemorrhage
    • Virmani R, Kolodgie FD, Burke AP, et al., Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 2005; 25: 2054-2061.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2054-2061
    • Virmani, R.1    Kolodgie, F.D.2    Burke, A.P.3
  • 31
    • 0035573652 scopus 로고    scopus 로고
    • Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice
    • Zhou J, Møller J, Danielsen CC, et al., Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2001; 21: 1470-1476.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1470-1476
    • Zhou, J.1    Møller, J.2    Danielsen, C.C.3
  • 32
    • 0018887237 scopus 로고
    • Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit)
    • Watanabe Y., Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit). Atherosclerosis 1980; 36: 261-268.
    • (1980) Atherosclerosis , vol.36 , pp. 261-268
    • Watanabe, Y.1
  • 33
    • 0033377246 scopus 로고    scopus 로고
    • Apolipoprotein B overproduction by the perfused liver of the St. Thomas' mixed hyperlipidemic (SMHL) rabbit
    • Ardern HA, Benson GM, Suckling KE, et al., Apolipoprotein B overproduction by the perfused liver of the St. Thomas' mixed hyperlipidemic (SMHL) rabbit. J Lipid Res 1999; 40: 2234-2243.
    • (1999) J Lipid Res , vol.40 , pp. 2234-2243
    • Ardern, H.A.1    Benson, G.M.2    Suckling, K.E.3
  • 34
    • 84941620269 scopus 로고    scopus 로고
    • Efficient creation of an APOE knockout rabbit
    • Ji D, Zhao G, Songstad A, et al., Efficient creation of an APOE knockout rabbit. Transgen Res 2014; 24: 227-235.
    • (2014) Transgen Res , vol.24 , pp. 227-235
    • Ji, D.1    Zhao, G.2    Songstad, A.3
  • 35
    • 0027275282 scopus 로고
    • The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation
    • Bocan TM, Mueller SB, Mazur MJ, et al., The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation. Atherosclerosis 1993; 102: 9-22.
    • (1993) Atherosclerosis , vol.102 , pp. 9-22
    • Bocan, T.M.1    Mueller, S.B.2    Mazur, M.J.3
  • 36
    • 0038448027 scopus 로고    scopus 로고
    • Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit)
    • Shiomi M., Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit). Arterioscler Thromb Vasc Biol 2003; 23: 1239-1244.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1239-1244
    • Shiomi, M.1
  • 37
    • 0033397013 scopus 로고    scopus 로고
    • Status, stress, and atherosclerosis: The role of environment and individual behavior
    • Kaplan JR, Manuck SB,. Status, stress, and atherosclerosis: the role of environment and individual behavior. Ann N Y Acad Sci 1999; 896: 145-161.
    • (1999) Ann N y Acad Sci , vol.896 , pp. 145-161
    • Kaplan, J.R.1    Manuck, S.B.2
  • 38
    • 84894081986 scopus 로고    scopus 로고
    • Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
    • Niu Y, Bin Shen, Cui Y, et al., Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 2014; 156: 836-843.
    • (2014) Cell , vol.156 , pp. 836-843
    • Niu, Y.1    Shen, B.2    Cui, Y.3
  • 39
    • 84872013355 scopus 로고    scopus 로고
    • Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant
    • Al-Mashhadi RH, Sorensen CB, Kragh PM, et al., Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med 2013; 5: 166ra1.
    • (2013) Sci Transl Med , vol.5 , pp. 166ra1
    • Al-Mashhadi, R.H.1    Sorensen, C.B.2    Kragh, P.M.3
  • 40
    • 77957589333 scopus 로고    scopus 로고
    • Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: A model for preclinical studies
    • Thim T, Hagensen MK, Drouet L, et al., Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies. EuroIntervention 2010; 6: 261-268.
    • (2010) EuroIntervention , vol.6 , pp. 261-268
    • Thim, T.1    Hagensen, M.K.2    Drouet, L.3
  • 41
    • 84898657735 scopus 로고    scopus 로고
    • Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs
    • e93457.
    • Davis BT, Wang X-J, Rohret JA, et al., Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs. PLoS One 2014; 9: e93457.
    • (2014) PLoS One , vol.9
    • Davis, B.T.1    Wang, X.-J.2    Rohret, J.A.3
  • 42
    • 84872051225 scopus 로고    scopus 로고
    • Mighty minipig in fight against cardiovascular disease
    • Agarwala A, Billheimer J, Rader DJ,. Mighty minipig in fight against cardiovascular disease. Sci Transl Med 2013; 5: 166fs1.
    • (2013) Sci Transl Med , vol.5 , pp. 166fs1
    • Agarwala, A.1    Billheimer, J.2    Rader, D.J.3
  • 43
    • 84880178319 scopus 로고    scopus 로고
    • Porcine models of accelerated coronary atherosclerosis: Role of diabetes mellitus and hypercholesterolemia
    • Hamamdzic D, Wilensky RL,. Porcine models of accelerated coronary atherosclerosis: role of diabetes mellitus and hypercholesterolemia. J Diabetes Res 2013; 2013: 761415.
    • (2013) J Diabetes Res , vol.2013 , pp. 761415
    • Hamamdzic, D.1    Wilensky, R.L.2
  • 44
    • 0025909020 scopus 로고
    • Development of complex atherosclerotic lesions in pigs with inherited hyper-LDL cholesterolemia bearing mutant alleles for apolipoprotein B
    • Prescott MF, McBride CH, Hasler-Rapacz J, et al., Development of complex atherosclerotic lesions in pigs with inherited hyper-LDL cholesterolemia bearing mutant alleles for apolipoprotein B. Am J Pathol 1991; 139: 139-147.
    • (1991) Am J Pathol , vol.139 , pp. 139-147
    • Prescott, M.F.1    McBride, C.H.2    Hasler-Rapacz, J.3
  • 45
    • 0032513567 scopus 로고    scopus 로고
    • Identification of a mutation in the low density lipoprotein receptor gene associated with recessive familial hypercholesterolemia in swine
    • Hasler-Rapacz J, Ellegren H, Fridolfsson AK, et al., Identification of a mutation in the low density lipoprotein receptor gene associated with recessive familial hypercholesterolemia in swine. Am J Med Genet 1998; 76: 379-386.
    • (1998) Am J Med Genet , vol.76 , pp. 379-386
    • Hasler-Rapacz, J.1    Ellegren, H.2    Fridolfsson, A.K.3
  • 46
    • 53549093853 scopus 로고    scopus 로고
    • Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
    • Wilensky RL, Shi Y, Mohler ER, et al., Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med 2008; 14: 1059-1066.
    • (2008) Nat Med , vol.14 , pp. 1059-1066
    • Wilensky, R.L.1    Shi, Y.2    Mohler, E.R.3
  • 47
    • 77953124838 scopus 로고    scopus 로고
    • Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: A serial, in vivo intravascular ultrasound study
    • Koskinas KC, Feldman CL, Chatzizisis YS, et al., Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound study. Circulation 2010; 121: 2092-2101.
    • (2010) Circulation , vol.121 , pp. 2092-2101
    • Koskinas, K.C.1    Feldman, C.L.2    Chatzizisis, Y.S.3
  • 48
    • 84879069306 scopus 로고    scopus 로고
    • Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress
    • Koskinas KC, Sukhova GK, Baker AB, et al., Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Arterioscler Thromb Vasc Biol 2013; 33: 1494-1504.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1494-1504
    • Koskinas, K.C.1    Sukhova, G.K.2    Baker, A.B.3
  • 49
    • 84872923119 scopus 로고    scopus 로고
    • Subsequent development of fibroatheromas with inflamed fibrous caps can be predicted by intracoronary near infrared spectroscopy
    • Patel D, Hamamdzic D, Llano R, et al., Subsequent development of fibroatheromas with inflamed fibrous caps can be predicted by intracoronary near infrared spectroscopy. Arterioscler Thromb Vasc Biol 2013; 33: 347-353.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 347-353
    • Patel, D.1    Hamamdzic, D.2    Llano, R.3
  • 50
    • 84937523810 scopus 로고    scopus 로고
    • Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs
    • Al-Mashhadi RH, Bjørklund MM, Mortensen MB, et al., Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs. Diabetologia 2015; 58: 1926-1936.
    • (2015) Diabetologia , vol.58 , pp. 1926-1936
    • Al-Mashhadi, R.H.1    Bjørklund, M.M.2    Mortensen, M.B.3
  • 51
    • 0021930664 scopus 로고
    • Production of transgenic rabbits, sheep and pigs by microinjection
    • Hammer RE, Pursel VG, Rexroad CE, et al., Production of transgenic rabbits, sheep and pigs by microinjection. Nature 1985; 315: 680-683.
    • (1985) Nature , vol.315 , pp. 680-683
    • Hammer, R.E.1    Pursel, V.G.2    Rexroad, C.E.3
  • 52
    • 0037039771 scopus 로고    scopus 로고
    • Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • Lai L, Kolber-Simonds D, Park K-W, et al., Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089-1092.
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.-W.3
  • 53
    • 0036009120 scopus 로고    scopus 로고
    • Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs
    • Dai Y, Vaught TD, Boone J, et al., Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol 2002; 20: 251-255.
    • (2002) Nat Biotechnol , vol.20 , pp. 251-255
    • Dai, Y.1    Vaught, T.D.2    Boone, J.3
  • 54
    • 79957923056 scopus 로고    scopus 로고
    • Unexpected roles for PCSK9 in lipid metabolism
    • Soutar AK,. Unexpected roles for PCSK9 in lipid metabolism. Curr Opin Lipidol 2011; 22: 192-196.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 192-196
    • Soutar, A.K.1
  • 55
    • 84906790793 scopus 로고    scopus 로고
    • Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: A systematic review
    • Ekeløf S, Rosenberg J, Jensen JS, et al., Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: a systematic review. J Cardiovasc Transl Res 2014; 7: 570-580.
    • (2014) J Cardiovasc Transl Res , vol.7 , pp. 570-580
    • Ekeløf, S.1    Rosenberg, J.2    Jensen, J.S.3
  • 56
    • 79952240166 scopus 로고    scopus 로고
    • Atherosclerosis and thrombosis: Insights from large animal models
    • Vilahur G, Padro T, Badimon L,. Atherosclerosis and thrombosis: insights from large animal models. J Biomed Biotechnol 2011; 2011: 907575.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 907575
    • Vilahur, G.1    Padro, T.2    Badimon, L.3
  • 57
  • 58
    • 84941761475 scopus 로고    scopus 로고
    • Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs
    • Pedigri RM, Poulsen CB, Mehta VV, et al., Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs. Circulation 2015; 132: 1003-1012.
    • (2015) Circulation , vol.132 , pp. 1003-1012
    • Pedigri, R.M.1    Poulsen, C.B.2    Mehta, V.V.3
  • 59
    • 84863805532 scopus 로고    scopus 로고
    • Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: The PREDICTION study
    • Stone PH, Saito S, Takahashi S, et al., Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION study. Circulation 2012; 126: 172-181.
    • (2012) Circulation , vol.126 , pp. 172-181
    • Stone, P.H.1    Saito, S.2    Takahashi, S.3
  • 60
    • 0037159282 scopus 로고    scopus 로고
    • Coronary plaque classification with intravascular ultrasound radiofrequency data analysis
    • Nair A., Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation 2002; 106: 2200-2206.
    • (2002) Circulation , vol.106 , pp. 2200-2206
    • Nair, A.1
  • 61
    • 51549094936 scopus 로고    scopus 로고
    • Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system
    • Gardner CM, Tan H, Hull EL, et al., Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system. JACC Cardiovasc Imaging 2008; 1: 638-648.
    • (2008) JACC Cardiovasc Imaging , vol.1 , pp. 638-648
    • Gardner, C.M.1    Tan, H.2    Hull, E.L.3
  • 62
    • 77955487856 scopus 로고    scopus 로고
    • Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease
    • Thim T, Hagensen MK, Wallace-Bradley D, et al., Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease. Circ Cardiovasc Imaging 2010; 3: 384-391.
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 384-391
    • Thim, T.1    Hagensen, M.K.2    Wallace-Bradley, D.3
  • 63
    • 84899718423 scopus 로고    scopus 로고
    • Darapladib for preventing ischemic events in stable coronary heart disease
    • Investigators.
    • The STABILITY, Investigators. Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med 2014; 370: 1702-1711.
    • (2014) N Engl J Med , vol.370 , pp. 1702-1711
    • The, S.1
  • 64
    • 79952321373 scopus 로고    scopus 로고
    • Atherosclerosis drug development in jeopardy: The need for predictive biomarkers of treatment response
    • Fryburg DA, Vassileva MT,. Atherosclerosis drug development in jeopardy: the need for predictive biomarkers of treatment response. Sci Transl Med 2011; 3: 72cm6.
    • (2011) Sci Transl Med , vol.3 , pp. 72cm6
    • Fryburg, D.A.1    Vassileva, M.T.2
  • 65
    • 77952692199 scopus 로고    scopus 로고
    • Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: Ready for prime time?
    • Rudd JHF, Narula J, Strauss HW, et al., Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time? J Am Coll Cardiol 2010; 55: 2527-2535.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2527-2535
    • Rudd, J.H.F.1    Narula, J.2    Strauss, H.W.3
  • 66
    • 84897594300 scopus 로고    scopus 로고
    • One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
    • Hai T, Teng F, Guo R, et al., One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Nature 2014; 24: 372-375.
    • (2014) Nature , vol.24 , pp. 372-375
    • Hai, T.1    Teng, F.2    Guo, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.