Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in apoE-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 9, 2001, Pages 1470-1476

  Zhou, Ji ^a   Møller, Jan ^a   Danielsen, Carl C ^b   Bentzon, Jacob ^a   Ravn, Hanne B ^a   Austin, Richard C ^c   Falk, Erling ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

ApoE deficient mouse; Atherosclerosis; Homocysteine; Plaque rupture

Indexed keywords

APOLIPOPROTEIN E; DRINKING WATER; HOMOCYSTEINE; METHIONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ROOT; ARTERY RUPTURE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL SIZE; COLLAGEN METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; FIBROSIS; HISTOPATHOLOGY; HYPERHOMOCYSTEINEMIA; HYPERLIPOPROTEINEMIA TYPE 3; MECHANICAL STRESS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RISK FACTOR; TENDON; THROMBOSIS; THROMBUS;

EID: 0035573652     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0901.096582     Document Type: Article

References (39)

1. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
2. Blood levels of homocysteine and increased risks of cardiovascular disease: Causal or casual?
3. Plasma homocysteine levels and mortality in patients with coronary artery disease
4. Plaque pathology and coronary thrombosis in the pathogenesis of acute coronary syndromes
5. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques: Potential role of matrix-degrading metalloproteinases and implications for plaque rupture
6. Regulation of lysyl oxidase by interferon-γ in rat aortic smooth muscle cells
7. Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues: Implications for homocystinuria
8. Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: Implications for atherosclerosis
9. Reaction of aortic lysyl oxidase with β-aminopropionitrile
10. A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine, 3: Accumulation of acid soluble collagen with a high hydroxylysine content in bone
11. A collagen defect in homocystinuria
12. Homocysteine as a risk factor for vascular disease: Enhanced collagen production and accumulation by smooth muscle cells
13. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
14. Homocysteine increases cyclin-dependent kinase in aortic rat tissue
15. Effects of ingestion of high protein or excess methionine diets by rats for two years
16. Homocysteine in plasma: Stabilization of blood samples with fluoride
17. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
18. Quantitative assessment of atherosclerotic lesions in mice
19. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
20. Mechanical properties of rat tail tendon in relation to proximal-distal sampling position and age
21. Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine β-synthase-deficient mice
22. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia
23. Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys
24. Vitamin B-6 deficiency vs folate deficiency: Comparison of responses to methionine loading in rats
25. Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine
26. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model
27. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree
28. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
29. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats
30. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
31. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
32. Induction of monocyte tissue factor expression by homocysteine: A possible mechanism for thrombosis
33. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia
34. Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys
35. Fibrinogen deficiency is compatible with the development of atherosclerosis in mice
36. Absence of P-selectin delays fatty streak formation in mice
37. Advanced atherosclerotic lesions in the innominate artery of the apoE knockout mouse
38. Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse