Inducing persistent flow disturbances accelerates atherogenesis and promotes thin cap fibroatheroma development in D374Y-PCSK9 hypercholesterolemic minipigs

Circulation

Volumn 132, Issue 11, 2015, Pages 1003-1012

  Poulsen, Christian Bo ^b   Mehta, Vikram V ^a   Holm, Niels Ramsing ^b   Pareek, Nilesh ^a   Post, Anouk L ^a   Kilic, Ismail Dogu ^c   Banya, Winston A S ^c   Dall'Ara, Gianni ^c   Mattesini, Alessio ^c   Bjørklund, Martin M ^b   Andersen, Niels P ^b   Grøndal, Anna K ^b   Petretto, Enrico ^d   Foin, Nicolas ^e   Davies, Justin E ^a   Di Mario, Carlo ^c   Bentzon, Jacob Fog ^b   Bøtker, Hans Erik ^b   Falk, Erling ^b   Krams, Rob ^a   De Silva, Ranil ^c   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e DEPARTMENT OF CARDIOLOGY   (Singapore)

Author keywords

Atherosclerosis; Atherosclerotic; Biophysics; Endothelium; Hemodynamics; Optical coherence; Plaque; Shear stress; Tomography

Indexed keywords

ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROTIC PLAQUE; BLOOD FLOW VELOCITY; BLOOD VESSEL WALL; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BLOOD FLOW; CORONARY STENT; FLOW RATE; FREQUENCY DOMAIN OPTICAL COHERENCE TOMOGRAPHY; HYPERCHOLESTEROLEMIA; MINIPIG; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; SHEAR MODIFYING STENT; SHEAR STRESS; THIN CAP FIBROATHEROMA; TISSUE SECTION; ANIMAL; ATHEROSCLEROSIS; BLOOD FLOW; COMPLICATION; CORONARY ANGIOGRAPHY; CORONARY BLOOD VESSEL; DISEASE MODEL; GENETICS; HEMODYNAMICS; MECHANICAL STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; PIG; PLAQUE, ATHEROSCLEROTIC; SHEAR STRENGTH; STENT; TIME FACTOR; TRANSGENIC ANIMAL;

SERINE PROTEINASE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ATHEROSCLEROSIS; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY VESSELS; DISEASE MODELS, ANIMAL; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; PLAQUE, ATHEROSCLEROTIC; PROPROTEIN CONVERTASES; REGIONAL BLOOD FLOW; SHEAR STRENGTH; STENTS; STRESS, MECHANICAL; SWINE; SWINE, MINIATURE; TIME FACTORS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84941761475     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.016270     Document Type: Article

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