메뉴 건너뛰기




Volumn 1862, Issue 2, 2016, Pages 274-283

Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain

Author keywords

Aging; Brain; Donepezil; High fat diet; MTOR pathway; Neurodegenerative disorders; Neuroinflammation; Obesity

Indexed keywords

ACETYLCHOLINESTERASE; DONEPEZIL; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN S6;

EID: 84951177051     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.11.002     Document Type: Article
Times cited : (23)

References (57)
  • 1
    • 33748742519 scopus 로고    scopus 로고
    • Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue
    • Cancello R., Clement K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 2006, 113:1141-1147.
    • (2006) BJOG , vol.113 , pp. 1141-1147
    • Cancello, R.1    Clement, K.2
  • 3
    • 11244349747 scopus 로고    scopus 로고
    • Obesity-associated hypertension: new insights into mechanisms
    • Rahmouni K., Correia M.L., Haynes W.G., Mark A.L. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2005, 45:9-14.
    • (2005) Hypertension , vol.45 , pp. 9-14
    • Rahmouni, K.1    Correia, M.L.2    Haynes, W.G.3    Mark, A.L.4
  • 5
    • 84863431784 scopus 로고    scopus 로고
    • Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB
    • Cai D., Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging 2012, 4:98-115.
    • (2012) Aging , vol.4 , pp. 98-115
    • Cai, D.1    Liu, T.2
  • 9
    • 42249107660 scopus 로고    scopus 로고
    • Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis
    • Beydoun M.A., Beydoun H.A., Wang Y. Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes. Rev. 2008, 9:204-218.
    • (2008) Obes. Rev. , vol.9 , pp. 204-218
    • Beydoun, M.A.1    Beydoun, H.A.2    Wang, Y.3
  • 14
    • 84919461635 scopus 로고    scopus 로고
    • Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms
    • Freeman L.R., Haley-Zitlin V., Rosenberger D.S., Granholm A.C. Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutr. Neurosci. 2014, 17:241-251.
    • (2014) Nutr. Neurosci. , vol.17 , pp. 241-251
    • Freeman, L.R.1    Haley-Zitlin, V.2    Rosenberger, D.S.3    Granholm, A.C.4
  • 15
    • 84859428464 scopus 로고    scopus 로고
    • Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet
    • Freeman L.R., Granholm A.C. Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet. J. Cereb. Blood Flow Metab. 2012, 32:643-653.
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 643-653
    • Freeman, L.R.1    Granholm, A.C.2
  • 16
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • Stranahan A.M., Norman E.D., Lee K., Cutler R.G., Telljohann R.S., Egan J.M., Mattson M.P. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008, 18:1085-1088.
    • (2008) Hippocampus , vol.18 , pp. 1085-1088
    • Stranahan, A.M.1    Norman, E.D.2    Lee, K.3    Cutler, R.G.4    Telljohann, R.S.5    Egan, J.M.6    Mattson, M.P.7
  • 17
    • 84885142691 scopus 로고    scopus 로고
    • A recollection of mTOR signaling in learning and memory
    • Graber T.E., McCamphill P.K., Sossin W.S. A recollection of mTOR signaling in learning and memory. Learn. Mem. 2013, 20:518-530.
    • (2013) Learn. Mem. , vol.20 , pp. 518-530
    • Graber, T.E.1    McCamphill, P.K.2    Sossin, W.S.3
  • 18
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • Laplante M., Sabatini D.M. MTOR signaling at a glance. J. Cell Sci. 2009, 122:3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 19
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M., Sabatini D.M. MTOR signaling in growth control and disease. Cell 2012, 149:274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 20
    • 80055115885 scopus 로고    scopus 로고
    • Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?
    • Saha A.K., Xu X.J., Balon T.W., Brandon A., Kraegen E.W., Ruderman N.B. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?. Cell Cycle 2011, 10:3447-3451.
    • (2011) Cell Cycle , vol.10 , pp. 3447-3451
    • Saha, A.K.1    Xu, X.J.2    Balon, T.W.3    Brandon, A.4    Kraegen, E.W.5    Ruderman, N.B.6
  • 21
    • 0041343303 scopus 로고    scopus 로고
    • Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    • An W.L., Cowburn R.F., Li L., Braak H., Alafuzoff I., Iqbal K., Iqbal I.G., Winblad B., Pei J.J. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am. J. Pathol. 2003, 163:591-607.
    • (2003) Am. J. Pathol. , vol.163 , pp. 591-607
    • An, W.L.1    Cowburn, R.F.2    Li, L.3    Braak, H.4    Alafuzoff, I.5    Iqbal, K.6    Iqbal, I.G.7    Winblad, B.8    Pei, J.J.9
  • 22
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: effects on cognitive impairments
    • Caccamo A., Majumder S., Richardson A., Strong R., Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: effects on cognitive impairments. J. Biol. Chem. 2010, 285:13107-13120.
    • (2010) J. Biol. Chem. , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 23
    • 75749114797 scopus 로고    scopus 로고
    • MTOR signaling: at the crossroads of plasticity, memory and disease
    • Hoeffer C.A., Klann E. MTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 2010, 33:67-75.
    • (2010) Trends Neurosci. , vol.33 , pp. 67-75
    • Hoeffer, C.A.1    Klann, E.2
  • 24
    • 23844457609 scopus 로고    scopus 로고
    • Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
    • Li X., Alafuzoff I., Soininen H., Winblad B., Pei J.J. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. FEBS J. 2005, 272:4211-4220.
    • (2005) FEBS J. , vol.272 , pp. 4211-4220
    • Li, X.1    Alafuzoff, I.2    Soininen, H.3    Winblad, B.4    Pei, J.J.5
  • 25
    • 84903362402 scopus 로고    scopus 로고
    • Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology
    • Orr M.E., Salinas A., Buffenstein R., Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol. Aging 2014, 35:1233-1242.
    • (2014) Neurobiol. Aging , vol.35 , pp. 1233-1242
    • Orr, M.E.1    Salinas, A.2    Buffenstein, R.3    Oddo, S.4
  • 26
    • 84928012290 scopus 로고    scopus 로고
    • Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD
    • Tramutola A., Triplett J.C., Di Domenico F., Niedowicz D.M., Murphy M.P., Coccia R., Perluigi M., Butterfield D.A. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. J. Neurochem. 2015, 133:739-749.
    • (2015) J. Neurochem. , vol.133 , pp. 739-749
    • Tramutola, A.1    Triplett, J.C.2    Di Domenico, F.3    Niedowicz, D.M.4    Murphy, M.P.5    Coccia, R.6    Perluigi, M.7    Butterfield, D.A.8
  • 27
    • 84925436842 scopus 로고    scopus 로고
    • MTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy
    • Perluigi M., Di Domenico F., Butterfield D.A. mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy. Neurobiol. Dis. 2015.
    • (2015) Neurobiol. Dis.
    • Perluigi, M.1    Di Domenico, F.2    Butterfield, D.A.3
  • 30
    • 0034535351 scopus 로고    scopus 로고
    • Cholinesterase inhibitors stabilize Alzheimer's disease
    • Giacobini E. Cholinesterase inhibitors stabilize Alzheimer's disease. Ann. N. Y. Acad. Sci. 2000, 920:321-327.
    • (2000) Ann. N. Y. Acad. Sci. , vol.920 , pp. 321-327
    • Giacobini, E.1
  • 31
    • 84888193014 scopus 로고    scopus 로고
    • Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo
    • Kim H.G., Moon M., Choi J.G., Park G., Kim A.J., Hur J., Lee K.T., Oh M.S. Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo. Neurotoxicology 2014, 40:23-32.
    • (2014) Neurotoxicology , vol.40 , pp. 23-32
    • Kim, H.G.1    Moon, M.2    Choi, J.G.3    Park, G.4    Kim, A.J.5    Hur, J.6    Lee, K.T.7    Oh, M.S.8
  • 32
    • 38949164347 scopus 로고    scopus 로고
    • Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice
    • Saxena G., Singh S.P., Agrawal R., Nath C. Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. Eur. J. Pharmacol. 2008, 581:283-289.
    • (2008) Eur. J. Pharmacol. , vol.581 , pp. 283-289
    • Saxena, G.1    Singh, S.P.2    Agrawal, R.3    Nath, C.4
  • 33
    • 33845651380 scopus 로고    scopus 로고
    • The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor
    • Meunier J., Ieni J., Maurice T. The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor. Br. J. Pharmacol. 2006, 149:998-1012.
    • (2006) Br. J. Pharmacol. , vol.149 , pp. 998-1012
    • Meunier, J.1    Ieni, J.2    Maurice, T.3
  • 34
    • 33747044365 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade
    • Takada-Takatori Y., Kume T., Sugimoto M., Katsuki H., Sugimoto H., Akaike A. Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology 2006, 51:474-486.
    • (2006) Neuropharmacology , vol.51 , pp. 474-486
    • Takada-Takatori, Y.1    Kume, T.2    Sugimoto, M.3    Katsuki, H.4    Sugimoto, H.5    Akaike, A.6
  • 35
    • 2942514710 scopus 로고    scopus 로고
    • Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy
    • Wilkinson D.G., Francis P.T., Schwam E., Payne-Parrish J. Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs Aging 2004, 21:453-478.
    • (2004) Drugs Aging , vol.21 , pp. 453-478
    • Wilkinson, D.G.1    Francis, P.T.2    Schwam, E.3    Payne-Parrish, J.4
  • 36
    • 84881219156 scopus 로고    scopus 로고
    • Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice
    • Zhang L., Dasuri K., Fernandez-Kim S.O., Bruce-Keller A.J., Freeman L.R., Pepping J.K., Beckett T.L., Murphy M.P., Keller J.N. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochim. Biophys. Acta 2013, 1832:1456-1462.
    • (2013) Biochim. Biophys. Acta , vol.1832 , pp. 1456-1462
    • Zhang, L.1    Dasuri, K.2    Fernandez-Kim, S.O.3    Bruce-Keller, A.J.4    Freeman, L.R.5    Pepping, J.K.6    Beckett, T.L.7    Murphy, M.P.8    Keller, J.N.9
  • 40
    • 84856021238 scopus 로고    scopus 로고
    • Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity
    • Puig K.L., Floden A.M., Adhikari R., Golovko M.Y., Combs C.K. Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity. PLoS One 2012, 7.
    • (2012) PLoS One , vol.7
    • Puig, K.L.1    Floden, A.M.2    Adhikari, R.3    Golovko, M.Y.4    Combs, C.K.5
  • 41
    • 84874156024 scopus 로고    scopus 로고
    • Regional astrogliosis in the mouse hypothalamus in response to obesity
    • Buckman L.B., Thompson M.M., Moreno H.N., Ellacott K.L. Regional astrogliosis in the mouse hypothalamus in response to obesity. J. Comp. Neurol. 2013, 521:1322-1333.
    • (2013) J. Comp. Neurol. , vol.521 , pp. 1322-1333
    • Buckman, L.B.1    Thompson, M.M.2    Moreno, H.N.3    Ellacott, K.L.4
  • 42
    • 0037298750 scopus 로고    scopus 로고
    • Beta-amyloid aggregation induced by human acetylcholinesterase: inhibition studies
    • Bartolini M., Bertucci C., Cavrini V., Andrisano V. Beta-amyloid aggregation induced by human acetylcholinesterase: inhibition studies. Biochem. Pharmacol. 2003, 65:407-416.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 407-416
    • Bartolini, M.1    Bertucci, C.2    Cavrini, V.3    Andrisano, V.4
  • 43
    • 84919847348 scopus 로고    scopus 로고
    • Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    • Valdearcos M., Robblee M.M., Benjamin D.I., Nomura D.K., Xu A.W., Koliwad S.K. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014, 9:2124-2138.
    • (2014) Cell Rep. , vol.9 , pp. 2124-2138
    • Valdearcos, M.1    Robblee, M.M.2    Benjamin, D.I.3    Nomura, D.K.4    Xu, A.W.5    Koliwad, S.K.6
  • 45
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • Chiang G.G., Abraham R.T. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J. Biol. Chem. 2005, 280:25485-25490.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 47
    • 69549139978 scopus 로고    scopus 로고
    • Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
    • Dello Russo C., Lisi L., Tringali G., Navarra P. Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochem. Pharmacol. 2009, 78:1242-1251.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1242-1251
    • Dello Russo, C.1    Lisi, L.2    Tringali, G.3    Navarra, P.4
  • 48
    • 84856472838 scopus 로고    scopus 로고
    • Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice
    • Park J., Zhang J., Qiu J., Zhu X., Degterev A., Lo E.H., Whalen M.J. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. J. Cereb. Blood Flow Metab. 2012, 32:330-340.
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 330-340
    • Park, J.1    Zhang, J.2    Qiu, J.3    Zhu, X.4    Degterev, A.5    Lo, E.H.6    Whalen, M.J.7
  • 52
    • 71849085520 scopus 로고    scopus 로고
    • Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease
    • Dong H., Yuede C.M., Coughlan C.A., Murphy K.M., Csernansky J.G. Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease. Brain Res. 2009, 1303:169-178.
    • (2009) Brain Res. , vol.1303 , pp. 169-178
    • Dong, H.1    Yuede, C.M.2    Coughlan, C.A.3    Murphy, K.M.4    Csernansky, J.G.5
  • 53
    • 0037622682 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
    • Takada Y., Yonezawa A., Kume T., Katsuki H., Kaneko S., Sugimoto H., Akaike A. Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. J. Pharmacol. Exp. Ther. 2003, 306:772-777.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 772-777
    • Takada, Y.1    Yonezawa, A.2    Kume, T.3    Katsuki, H.4    Kaneko, S.5    Sugimoto, H.6    Akaike, A.7
  • 54
    • 78650653951 scopus 로고    scopus 로고
    • Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model
    • Yoshiyama Y., Kojima A., Ishikawa C., Arai K. Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model. J. Alzheimers Dis. 2010, 22:295-306.
    • (2010) J. Alzheimers Dis. , vol.22 , pp. 295-306
    • Yoshiyama, Y.1    Kojima, A.2    Ishikawa, C.3    Arai, K.4
  • 55
    • 84920763099 scopus 로고    scopus 로고
    • Translational control and autism-like behaviors
    • Gkogkas C.G., Sonenberg N. Translational control and autism-like behaviors. Cell. Logist. 2013, 3.
    • (2013) Cell. Logist. , vol.3
    • Gkogkas, C.G.1    Sonenberg, N.2
  • 56
    • 77951241718 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in aplysia
    • Weatherill D.B., Dyer J., Sossin W.S. Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in aplysia. J. Biol. Chem. 2010, 285:12255-12267.
    • (2010) J. Biol. Chem. , vol.285 , pp. 12255-12267
    • Weatherill, D.B.1    Dyer, J.2    Sossin, W.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.