메뉴 건너뛰기




Volumn 52, Issue 2, 2014, Pages 257-266

Expression of S6K1 in human visceral adipose tissue is upregulated in obesity and related to insulin resistance and inflammation

Author keywords

Adipose tissue; Inflammation; Insulin resistance; Obesity; S6K1

Indexed keywords

INSULIN; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6 KINASE;

EID: 84939892924     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-014-0632-9     Document Type: Article
Times cited : (38)

References (48)
  • 1
    • 84875657566 scopus 로고    scopus 로고
    • Obesity: the gateway to ill health—an EASO position statement on a rising public health, clinical and scientific challenge in Europe
    • PID: 23548858
    • Frühbeck G, Toplak H, Woodward E, Yumuk V, Maislos M, Oppert JM (2013) Obesity: the gateway to ill health—an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts 6:117–120
    • (2013) Obes Facts , vol.6 , pp. 117-120
    • Frühbeck, G.1    Toplak, H.2    Woodward, E.3    Yumuk, V.4    Maislos, M.5    Oppert, J.M.6
  • 2
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011–2012
    • COI: 1:CAS:528:DC%2BC2cXjvVOhs74%3D, PID: 24570244
    • Ogden CL, Carroll MD, Kit BK, Flegal KM (2014) Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311:806–814
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 3
    • 0037298988 scopus 로고    scopus 로고
    • Control of body weight: a physiologic and transgenic perspective
    • PID: 12627314
    • Frühbeck G, Gómez-Ambrosi J (2003) Control of body weight: a physiologic and transgenic perspective. Diabetologia 46:143–172
    • (2003) Diabetologia , vol.46 , pp. 143-172
    • Frühbeck, G.1    Gómez-Ambrosi, J.2
  • 4
    • 0034987715 scopus 로고    scopus 로고
    • The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
    • PID: 11350765
    • Frühbeck G, Gómez-Ambrosi J, Muruzábal FJ, Burrell MA (2001) The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 280:E827–E847
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , pp. 827-847
    • Frühbeck, G.1    Gómez-Ambrosi, J.2    Muruzábal, F.J.3    Burrell, M.A.4
  • 6
    • 84934434968 scopus 로고    scopus 로고
    • Overview of adipose tissue and its role in obesity and metabolic disorders
    • PID: 18516549
    • Frühbeck G (2008) Overview of adipose tissue and its role in obesity and metabolic disorders. Methods Mol Biol 456:1–22
    • (2008) Methods Mol Biol , vol.456 , pp. 1-22
    • Frühbeck, G.1
  • 7
    • 84857883645 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease
    • PID: 22392865
    • Apovian CM, Gokce N (2012) Obesity and cardiovascular disease. Circulation 125:1178–1182
    • (2012) Circulation , vol.125 , pp. 1178-1182
    • Apovian, C.M.1    Gokce, N.2
  • 9
    • 84874045511 scopus 로고    scopus 로고
    • The origins and drivers of insulin resistance
    • COI: 1:CAS:528:DC%2BC3sXis1Oqs70%3D, PID: 23415219
    • Johnson AM, Olefsky JM (2013) The origins and drivers of insulin resistance. Cell 152:673–684
    • (2013) Cell , vol.152 , pp. 673-684
    • Johnson, A.M.1    Olefsky, J.M.2
  • 10
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • COI: 1:CAS:528:DC%2BC3MXnsVais7Y%3D, PID: 21633179
    • Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121:2111–2117
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 11
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • COI: 1:CAS:528:DC%2BC38XnvFekt7c%3D, PID: 22674330
    • Nicholson JK, Holmes E, Kinross J et al (2012) Host-gut microbiota metabolic interactions. Science 336:1262–1267
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1    Holmes, E.2    Kinross, J.3
  • 12
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • COI: 1:CAS:528:DC%2BC38XjtlSgtrg%3D, PID: 22385956
    • Samuel VT, Shulman GI (2012) Mechanisms for insulin resistance: common threads and missing links. Cell 148:852–871
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 13
    • 7044221791 scopus 로고    scopus 로고
    • Nutrient sensor links obesity with diabetes risk
    • COI: 1:CAS:528:DC%2BD2cXnvFynt7c%3D, PID: 15459705
    • Patti ME, Kahn BB (2004) Nutrient sensor links obesity with diabetes risk. Nat Med 10:1049–1050
    • (2004) Nat Med , vol.10 , pp. 1049-1050
    • Patti, M.E.1    Kahn, B.B.2
  • 14
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • COI: 1:CAS:528:DC%2BD2cXntlGks7g%3D, PID: 15306821
    • Um SH, Frigerio F, Watanabe M et al (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200–205
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3
  • 15
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    • COI: 1:CAS:528:DC%2BD28Xmt1eku7w%3D, PID: 16753575
    • Um SH, D’Alessio D, Thomas G (2006) Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 3:393–402
    • (2006) Cell Metab , vol.3 , pp. 393-402
    • Um, S.H.1    D’Alessio, D.2    Thomas, G.3
  • 16
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • COI: 1:CAS:528:DC%2BD2cXmvFKqsLk%3D, PID: 15314020
    • Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926–1945
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 17
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • COI: 1:CAS:528:DC%2BC38Xls1eguro%3D, PID: 22500797
    • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149:274–293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 18
    • 84880566446 scopus 로고    scopus 로고
    • A growing role for mTOR in promoting anabolic metabolism
    • COI: 1:CAS:528:DC%2BC3sXhtF2msr3K, PID: 23863154
    • Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD (2013) A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans 41:906–912
    • (2013) Biochem Soc Trans , vol.41 , pp. 906-912
    • Howell, J.J.1    Ricoult, S.J.2    Ben-Sahra, I.3    Manning, B.D.4
  • 19
    • 35348832340 scopus 로고    scopus 로고
    • Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
    • COI: 1:CAS:528:DC%2BD2sXhtVWisrvL, PID: 17709744
    • Tremblay F, Brule S, Hee Um S et al (2007) Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci USA 104:14056–14061
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14056-14061
    • Tremblay, F.1    Brule, S.2    Hee Um, S.3
  • 20
    • 0034700456 scopus 로고    scopus 로고
    • Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
    • COI: 1:CAS:528:DC%2BD3MXhslajsA%3D%3D, PID: 11140689
    • Pende M, Kozma SC, Jaquet M et al (2000) Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice. Nature 408:994–997
    • (2000) Nature , vol.408 , pp. 994-997
    • Pende, M.1    Kozma, S.C.2    Jaquet, M.3
  • 21
    • 0028885873 scopus 로고
    • Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
    • COI: 1:CAS:528:DyaK2MXps1alsLo%3D, PID: 7479942
    • Yeh WC, Bierer BE, McKnight SL (1995) Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci USA 92:11086–11090
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11086-11090
    • Yeh, W.C.1    Bierer, B.E.2    McKnight, S.L.3
  • 22
    • 84868089817 scopus 로고    scopus 로고
    • mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases
    • Yang Z, Ming XF (2012) mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases. Obes Rev 2:58–68
    • (2012) Obes Rev , vol.2 , pp. 58-68
    • Yang, Z.1    Ming, X.F.2
  • 23
    • 0242496906 scopus 로고    scopus 로고
    • Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway
    • COI: 1:CAS:528:DC%2BD3sXoslyqtbk%3D, PID: 12960176
    • Lim HK, Choi YA, Park W et al (2003) Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway. J Biol Chem 278:45117–45127
    • (2003) J Biol Chem , vol.278 , pp. 45117-45127
    • Lim, H.K.1    Choi, Y.A.2    Park, W.3
  • 24
    • 84882790100 scopus 로고    scopus 로고
    • Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation
    • Zhang J, Gao Z, Ye J (2013) Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation. Biochim Biophys Acta 2013:1980–1988
    • (2013) Biochim Biophys Acta , vol.2013 , pp. 1980-1988
    • Zhang, J.1    Gao, Z.2    Ye, J.3
  • 25
    • 84055213694 scopus 로고    scopus 로고
    • S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt
    • COI: 1:CAS:528:DC%2BC3MXhs1Cgs7bP, PID: 21906027
    • Di R, Wu X, Chang Z et al (2012) S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. Biochem J 441:199–207
    • (2012) Biochem J , vol.441 , pp. 199-207
    • Di, R.1    Wu, X.2    Chang, Z.3
  • 26
    • 84857058884 scopus 로고    scopus 로고
    • Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity
    • Gómez-Ambrosi J, Silva C, Galofré JC et al (2012) Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes 36:286–294
    • (2012) Int J Obes , vol.36 , pp. 286-294
    • Gómez-Ambrosi, J.1    Silva, C.2    Galofré, J.C.3
  • 27
    • 84859060682 scopus 로고    scopus 로고
    • Clinical usefulness of a new equation for estimating body fat
    • PID: 22179957
    • Gómez-Ambrosi J, Silva C, Catalán V et al (2012) Clinical usefulness of a new equation for estimating body fat. Diabetes Care 35:383–388
    • (2012) Diabetes Care , vol.35 , pp. 383-388
    • Gómez-Ambrosi, J.1    Silva, C.2    Catalán, V.3
  • 28
    • 33645289954 scopus 로고    scopus 로고
    • Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass
    • PID: 16545156
    • Gómez-Ambrosi J, Salvador J, Rotellar F et al (2006) Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass. Obes Surg 16:262–269
    • (2006) Obes Surg , vol.16 , pp. 262-269
    • Gómez-Ambrosi, J.1    Salvador, J.2    Rotellar, F.3
  • 30
    • 84875519919 scopus 로고    scopus 로고
    • Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients
    • PID: 22154272
    • Catalán V, Gómez-Ambrosi J, Rodríguez A et al (2013) Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients. Surg Obes Relat Dis 9:306–314
    • (2013) Surg Obes Relat Dis , vol.9 , pp. 306-314
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3
  • 31
    • 34547632749 scopus 로고    scopus 로고
    • Validation of endogenous control genes in human adipose tissue: relevance to obesity and obesity-associated type 2 diabetes mellitus
    • PID: 17611901
    • Catalán V, Gómez-Ambrosi J, Rotellar F et al (2007) Validation of endogenous control genes in human adipose tissue: relevance to obesity and obesity-associated type 2 diabetes mellitus. Horm Metab Res 39:495–500
    • (2007) Horm Metab Res , vol.39 , pp. 495-500
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rotellar, F.3
  • 32
    • 39749084162 scopus 로고    scopus 로고
    • Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass
    • PID: 18219773
    • Catalán V, Gómez-Ambrosi J, Ramírez B et al (2007) Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg 17:1464–1474
    • (2007) Obes Surg , vol.17 , pp. 1464-1474
    • Catalán, V.1    Gómez-Ambrosi, J.2    Ramírez, B.3
  • 33
    • 1842534924 scopus 로고    scopus 로고
    • Nutrient-induced insulin resistance in human skeletal muscle
    • COI: 1:CAS:528:DC%2BD2cXivF2mtrs%3D, PID: 15078172
    • Krebs M, Roden M (2004) Nutrient-induced insulin resistance in human skeletal muscle. Curr Med Chem 11:901–908
    • (2004) Curr Med Chem , vol.11 , pp. 901-908
    • Krebs, M.1    Roden, M.2
  • 34
    • 34249679614 scopus 로고    scopus 로고
    • mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer
    • COI: 1:CAS:528:DC%2BD2sXmtVGgtb8%3D, PID: 17452018
    • Dann SG, Selvaraj A, Thomas G (2007) mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 13:252–259
    • (2007) Trends Mol Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 35
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
    • COI: 1:CAS:528:DC%2BD2MXitlehtb0%3D, PID: 15604215
    • Khamzina L, Veilleux A, Bergeron S, Marette A (2005) Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146:1473–1481
    • (2005) Endocrinology , vol.146 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 36
    • 84870452466 scopus 로고    scopus 로고
    • Phosphorylated S6K1 (Thr389) is a molecular adipose tissue marker of altered glucose tolerance
    • COI: 1:CAS:528:DC%2BC38XoslKjtrY%3D, PID: 22705322
    • Moreno-Navarrete JM, Ortega F, Sanchez-Garrido MA et al (2013) Phosphorylated S6K1 (Thr389) is a molecular adipose tissue marker of altered glucose tolerance. J Nutr Biochem 24:32–38
    • (2013) J Nutr Biochem , vol.24 , pp. 32-38
    • Moreno-Navarrete, J.M.1    Ortega, F.2    Sanchez-Garrido, M.A.3
  • 37
    • 34249679233 scopus 로고    scopus 로고
    • The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
    • COI: 1:CAS:528:DC%2BD2sXmtlKhsrk%3D, PID: 17329620
    • Krebs M, Brunmair B, Brehm A et al (2007) The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes 56:1600–1607
    • (2007) Diabetes , vol.56 , pp. 1600-1607
    • Krebs, M.1    Brunmair, B.2    Brehm, A.3
  • 38
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • COI: 1:CAS:528:DC%2BD3MXotFOrtbc%3D, PID: 11498541
    • Tremblay F, Marette A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276:38052–38060
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 39
    • 67649854830 scopus 로고    scopus 로고
    • Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85α subunit of phosphatidylinositol 3-kinase and S6K1 kinase
    • COI: 1:CAS:528:DC%2BD1MXisV2gtrY%3D, PID: 18948408
    • Adochio R, Leitner JW, Hedlund R, Draznin B (2009) Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85α subunit of phosphatidylinositol 3-kinase and S6K1 kinase. Endocrinology 150:1165–1173
    • (2009) Endocrinology , vol.150 , pp. 1165-1173
    • Adochio, R.1    Leitner, J.W.2    Hedlund, R.3    Draznin, B.4
  • 40
    • 71949096402 scopus 로고    scopus 로고
    • Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6 K activities in the liver of obese Zucker rats
    • COI: 1:CAS:528:DC%2BD1MXhsFWhur3L, PID: 19801385
    • Zheng Y, Zhang W, Pendleton E et al (2009) Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6 K activities in the liver of obese Zucker rats. J Endocrinol 203:337–347
    • (2009) J Endocrinol , vol.203 , pp. 337-347
    • Zheng, Y.1    Zhang, W.2    Pendleton, E.3
  • 41
    • 84868685585 scopus 로고    scopus 로고
    • The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet
    • COI: 1:CAS:528:DC%2BC38XhsVSltrvM, PID: 22851690
    • Treins C, Alliouachene S, Hassouna R, Xie Y, Birnbaum MJ, Pende M (2012) The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet. Mol Cell Biol 32:4001–4011
    • (2012) Mol Cell Biol , vol.32 , pp. 4001-4011
    • Treins, C.1    Alliouachene, S.2    Hassouna, R.3    Xie, Y.4    Birnbaum, M.J.5    Pende, M.6
  • 42
    • 34547605613 scopus 로고    scopus 로고
    • IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
    • COI: 1:CAS:528:DC%2BD2sXptlyntbw%3D, PID: 17693255
    • Lee DF, Kuo HP, Chen CT et al (2007) IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130:440–455
    • (2007) Cell , vol.130 , pp. 440-455
    • Lee, D.F.1    Kuo, H.P.2    Chen, C.T.3
  • 43
    • 58149094542 scopus 로고    scopus 로고
    • S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2
    • COI: 1:CAS:528:DC%2BD1cXhsVylsr3I, PID: 18952604
    • Zhang J, Gao Z, Yin J, Quon MJ, Ye J (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2. J Biol Chem 283:35375–35382
    • (2008) J Biol Chem , vol.283 , pp. 35375-35382
    • Zhang, J.1    Gao, Z.2    Yin, J.3    Quon, M.J.4    Ye, J.5
  • 44
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
    • COI: 1:CAS:528:DC%2BD38XksVWmsLc%3D, PID: 12039858
    • Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ (2002) Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 16:771–780
    • (2002) FASEB J , vol.16 , pp. 771-780
    • Humar, R.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5
  • 45
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • COI: 1:CAS:528:DC%2BD1cXht1yjtbnI, PID: 18846101
    • Wouters BG, Koritzinsky M (2008) Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 8:851–864
    • (2008) Nat Rev Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 46
    • 0032932912 scopus 로고    scopus 로고
    • MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
    • COI: 1:CAS:528:DyaK1MXksVamsQ%3D%3D, PID: 10048588
    • Yu Y, Sato JD (1999) MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor. J Cell Physiol 178:235–246
    • (1999) J Cell Physiol , vol.178 , pp. 235-246
    • Yu, Y.1    Sato, J.D.2
  • 47
    • 77956185248 scopus 로고    scopus 로고
    • cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXhtFamtrbJ, PID: 20452774
    • Sabio G, Davis RJ (2010) cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance. Trends Biochem Sci 35:490–496
    • (2010) Trends Biochem Sci , vol.35 , pp. 490-496
    • Sabio, G.1    Davis, R.J.2
  • 48
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • COI: 1:CAS:528:DC%2BC3sXjvVCntg%3D%3D, PID: 23223452
    • Han MS, Jung DY, Morel C et al (2013) JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339:218–222
    • (2013) Science , vol.339 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.