Bispecific Monoclonal Antibody Complexes Facilitate Erythrocyte Binding and Liver Clearance of a Prototype Particulate Pathogen in a Monkey Model

Journal of Immunology

Volumn 159, Issue 8, 1997, Pages 4035-4044

  Taylor, Ronald P ^a   Martin, Edward N ^a   Reinagel, Michele L ^a   Nardin, Alessandra ^a   Craig, Maria ^a   Choice, Quincy ^a   Schlimgen, Ryan ^a   Greenbaum, Stephen ^a   Incardona, Nino L ^b   Ochs, Hans D ^c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPECIFIC ANTIBODY; COMPLEMENT COMPONENT C3B RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; VIRUS ANTIBODY;

ANIMAL; ARTICLE; BACTERIOPHAGE PHI X 174; BIOLOGICAL MODEL; ERYTHROCYTE; IMMUNE ADHERENCE; IMMUNOLOGY; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MACACA; METABOLISM; PHYSIOLOGY; VIRION; VIROLOGY;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BACTERIOPHAGE PHI X 174; ERYTHROCYTES; IMMUNE ADHERENCE REACTION; IMMUNOGLOBULIN FC FRAGMENTS; INFUSIONS, INTRAVENOUS; LIVER; MACACA; MACACA FASCICULARIS; MODELS, BIOLOGICAL; RECEPTORS, COMPLEMENT 3B; VIRION;

EID: 0031572506     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. 32-labelled Escherichia coli and staphylococci by the reticuloendothelial system. J. Exp. Med. 119:27.
2. Brown, E. J., S. W. Hosea, C. H. Hammer, C. G. Burch, and M. M. Frank. 1982. A quantitative analysis of the interaction of antipneumoccocal antibody and complement in experimental bacteremia. J. Clin. Invest. 69:85.
3. Ochs, H. D., S. Nonoyama, Q. Zhu, M. Farrington, and R. J. Wedgwood. 1993. Regulation of antibody responses: the role of complement and adhesion molecules. Clin. Immunol. Immunopathol. 67:S33.
4. Smith, T. J. 1995. Antibody recognition of viruses. Semin. Virol. 6:217.
5. Fearon, D. T. 1980. Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte. J. Exp. Med. 152:20.
6. Cornacoff, J. B., L. A. Hebert, W. L. Smead, M. E. Van Aman, D. J. Birmingham, and F. J. Waxman. 1983. Primate erythrocyte-immune complex-clearing mechanism. J. Clin. Invest. 71:236.
7. Hebert, L. A., and F. G. Cosio. 1987. The erythrocyte-immune complex-glomerulonephritis connection in man. Kidney Int. 31:877.
8. Schifferli, J. A., and R. P. Taylor. 1989. Physiological and pathological aspects of circulating immune complexes. Kidney Int. 35:993.
9. Kimberly, R. P., J. C. Edberg, L. T. Merriam, S. B. Clarkson, J. C. Unkeless, and R. P. Taylor. 1989. In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees. J. Clin. Invest. 84:962.
10. Davies, K. A., V. Hird, S. Stewart, G. B. Sivolapenko, P. Jose, A. A. Epenetos, and M. J. Walport. 1990. A study of in vivo immune complex formation and clearance in man. J. Immunol. 144:4613.
11. Davies, K. A., A. M. Peters, H. L. C. Benyon, and M. Walport. 1992. Immune complex processing in patients with systemic lupus erythematosus. J. Clin. Invest. 90:2075.
12. Nelson, R. A. 1953. The immune adherence phenomenon: an immunologically specific reaction between micro-organisms and erythrocytes leading to enhanced phagocytosis. Science 118:733.
13. Taylor, R. P., W. M. Sutherland, C. J. Reist, D. J. Webb, E. L. Wright, and R. H. Labugen. 1991. Use of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes: a potential therapeutic treatment. Proc. Natl. Acad. Sci. USA 88:3305.
14. Reist, C. J., J. Combs, B. Y. Croft, and R. P. Taylor. 1993. Antigens pre-bound to the primate erythrocyte complement receptor via cross-linked bispecific monoclonal antibody heteropolymers are rapidly cleared from the circulation. Eur. J. Immunol. 23:3021.
15. Taylor, R. P., and P. J. Ferguson. 1995. Primate erythrocyte complement receptor (CR1) as an anchor site for bispecific-based therapies to clear pathogens or autoantibodies safely from the from the circulation. J. Hematother. 4:357.
16. Taylor, R. P., W. M. Sutherland, E. N. Martin, P. J. Ferguson, M. L. Reinagel, E. Gilbert, K. Lopez, N. L. Incardona, and H. D. Ochs. 1997. Bispecific monoclonal antibody complexes bound to primate erythrocyte complement receptor 1 facilitate virus clearance in a monkey model. J. Immunol. 158:842.
17. Farr, R. S. 1958. A quantitative immunochemical measure of the primary interaction between I-BSA and antibody. J. Infect. Dis. 103:239.
18. Hombeck, P. 1991. Assays for antibody production. Curr. Prot. Immunol. 1:2.1.1.
19. Pedersen, S. E., R. P. Taylor, K. W. Morley, and E. L. Wright. 1980. Stability of DNA/Anti-DNA complexes. IV. Complement fixation. J. Immunol. Methods. 38: 269.
20. Ferguson, P. J., E. N. Martin, K. L. Greene, S. Kuhn, D. S. Cafiso, G. Addona, and R. P. Taylor. 1995. Antigen-based heteropolymers facilitate, via primate erythrocyte complement receptor type 1, rapid erythrocyte binding of an autoantibody and its clearance form the circulation in rhesus monkeys. J. Immunol. 155:339.
21. Hogg, N., G. D. Ross, D. B. Jones, M. Slusarenko, M. J. Walport, and P. J. Lachmann. 1984. Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). Eur. J. Immunol. 14:236.
22. Ferguson, P. J., C. J. Reist, E. N. Martin, C. Johnson, K. L. Greene, S. Kuhn, J. Niebur, W. Emlen, and R. P. Taylor. 1995. Antigen-based heteropolymers: a potential therapy to bind and clear autoantibodies via erythrocyte CR1. Arthritis Rheum. 38:190.
23. Taylor, R. P., P. J. Ferguson, E. N. Martin, J. Cooke, K. L. Greene, K. Grinspun, M. Guttman, and S. Kuhn. Immune complexes bound to the primate erythrocyte complement receptor (CR1) via anti-CR1 mAbs are cleared simultaneously with loss of CR1 in a concerted reaction in a rhesus monkey model. Clin. Immunol. Immunopathol. 82:49.
24. Cosio, F. G., S. Xiao-Ping, D. J. Birmingham, M. Van Aman, and L. A. Hebert. 1990. Evaluation of the mechanisms responsible for the reduction in erythrocyte complement receptors when immune complexes form in vivo in primates. J. Immunol. 145:4198.
25. Madi, N., J. P. Paccaud, G. Steiger, and J. A. Schifferli. 1989. Immune adherence of nascent hepatitis B surface antigen-antibody complexes in vivo in humans. Clin. Exp. Immunol. 78:201.
26. Edberg, J. C., L. Tosic, E. L. Wright, W. M. Sutherland, and R. P. Taylor. 1988. Quantitative analyses of the relationship between C3 consumption, C3b capture and immune adherence of complement-fixing antibody/DNA immune complexes. J. Immunol. 141:4258.
27. Edberg, J. C., R. P. Kimberly, and R. P. Taylor. 1992. Functional characterization of non-human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic system. Eur. J. Immunol. 22:1333.
28. Hourcade, D., V. M. Holers, and J. P. Atkinson. The regulators of complement activation (RCA) gene cluster. Adv. Immunol. 45:381.
29. Taylor, R. P., C. J. Reist, W. M. Sutherland, A. Otto, R. H. Labuguen, and E. L. Wright. 1992. In vivo binding and clearance of circulating antigen by bispecific heteropolymer-mediated binding to primate erythrocyte complement receptor. J. Immunol. 148:2462.
30. Finbloom, D. S., and P. H. Plotz. 1979. Studies of reticuloendothelial function in the mouse with model immune complexes. II. Serum clearance, tissue uptake, and reticuloendothelial saturation in NZB/W mice. J. Immunol. 123:1600.
31. Mathison, J. C., R. J. Ulevitch, J. R. Fletcher, and C. G. Cochrane. 1980. The distribution of lipopolysaccharide in normocomplementemic and C3-depleted rabbits and rhesus monkeys. Am. J. Pathol. 101:245.
32. Yousaf, N., J. C. Howard, and B. D. Williams. 1988. Studies in the rat of antibody-sensitized and N-ethylmaleimide-treated erythrocyte clearance by the liver: effects of immune complex infusion and complement activation. Immunology 64:193.
33. Edberg, J. C., L. Tosic, and R. P. Taylor. 1989. Immune adherence and the processing of soluble complement-fixing antibody/DNA immune complexes in mice. Clin. Immunol. Immunopathol. 51:118.
34. Reist, C. J., H. Y. Liang, D. Denny, E. N. Martin, W. M. Scheld, and R. P. Taylor. 1994. Cross-linked bispecific monoclonal antibody heteropolymers facilitate the clearance of human IgM from the circulation of squirrel monkeys. Eur. J. Immunol. 24:2018.
35. Schorlemmer, H. U., and A. C. Allison. 1976. Effects of activated complement components on enzyme secretion by macrophages. Immunology 31:781.
36. Ross, G. D., W. J. Yount, M. J. Walport, J. B. Winfield, C. J. Parker, C. R. Fuller, R. P. Taylor, B. L. Myones, and P. J. Lachmann. 1985. Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation. J. Immunol. 135:2005.
37. Adams, D. O., K.-J. Kao, R. Farb, and S. V. Pizzo. Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted proteases. J. Immunol. 124: 293.
38. Hawkins, D. 1972. Neutrophilic leukocytes in immunologic reactions: evidence for the selective release of lysosomal constituents. J. Immunol. 108:319.
39. Willis, H. E., B. Browder, A. J. Feister, T. Mohankumar, and S. Ruddy. 1988. Monoclonal antibody to human IgG Fc receptors: cross-linking of receptors induces enzyme release and superoxide generation by neutrophils. J. Immunol. 140:234.
40. Adams, D. O., and T. A. Hamilton. 1992. Macrophages as destructive cells in host defense. In Inflammation: Basic Principles and Clinical Correlates, 2nd Ed. J. A. Gallin, I. M. Goldstein, and R. Snyderman, eds. Raven Press, New York, p. 637.