메뉴 건너뛰기




Volumn 40, Issue 3, 2015, Pages 167-172

Duligotuzumab: Human anti-EGFR/anti-HER3 MAb colorectal cancer therapy head and neck cancer therapy

Author keywords

Anti EGFR; Anti HER3 ErbB3; Colorectal cancer; Duligotuzumab; Head and neck cancer; MEHD 7945A

Indexed keywords

CETUXIMAB; DULIGOTUZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; MONOCLONAL ANTIBODY;

EID: 84930536940     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2015.040.03.2312450     Document Type: Article
Times cited : (5)

References (18)
  • 1
    • 84878834722 scopus 로고    scopus 로고
    • Two-in-One antibodies with dual action Fabs
    • Eigenbrot, C., Fuh, G. Two-in-One antibodies with dual action Fabs. Curr Opin Chem Biol 2013, 17(3): 400-5.
    • (2013) Curr Opin Chem Biol , vol.17 , Issue.3 , pp. 400-405
    • Eigenbrot, C.1    Fuh, G.2
  • 2
    • 62849095162 scopus 로고    scopus 로고
    • Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
    • Bostrom, J., Yu, S.F., Kan, D. et al. Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science 2009, 323(5921): 1610-4.
    • (2009) Science , vol.323 , Issue.5921 , pp. 1610-1614
    • Bostrom, J.1    Yu, S.F.2    Kan, D.3
  • 3
    • 80054765331 scopus 로고    scopus 로고
    • A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
    • Schaefer, G., Haber, L., Crocker, L.M. et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell 2011, 20(4): 472-86.
    • (2011) Cancer Cell , vol.20 , Issue.4 , pp. 472-486
    • Schaefer, G.1    Haber, L.2    Crocker, L.M.3
  • 7
    • 84872525097 scopus 로고    scopus 로고
    • Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation
    • Huang, S., Li, C., Armstrong, E.A. et al. Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation. Cancer Res 2013, 73(2): 824-33.
    • (2013) Cancer Res , vol.73 , Issue.2 , pp. 824-833
    • Huang, S.1    Li, C.2    Armstrong, E.A.3
  • 11
    • 84928567346 scopus 로고    scopus 로고
    • Assessing signal modulation in preclinical models and tumor tissue from patients enrolled in a phase 1 study of the HER3/EGFR dual action antibody, MEHD7945A (MEHD), as an exploratory pharmacodynamic (PD) analysis
    • Penuel, E.M., Burton, L., Stern, H., Mark, L., Pirzkall, A., Amler, L., Schaefer, G. Assessing signal modulation in preclinical models and tumor tissue from patients enrolled in a phase 1 study of the HER3/EGFR dual action antibody, MEHD7945A (MEHD), as an exploratory pharmacodynamic (PD) analysis. 104th Annu Meet Am Assoc Cancer Res (AACR) (April 6-10, Washington, D.C.) 2013, Abst 3527.
    • 104th Annu Meet Am Assoc Cancer Res (AACR) (April 6-10, Washington, D.C.) 2013
    • Penuel, E.M.1    Burton, L.2    Stern, H.3    Mark, L.4    Pirzkall, A.5    Amler, L.6    Schaefer, G.7
  • 12
    • 84859802154 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose
    • Kamath, A.V., Lu, D., Gupta, P. et al. Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose. Cancer Chemother Pharmacol 2012, 69(4): 1063-9.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.4 , pp. 1063-1069
    • Kamath, A.V.1    Lu, D.2    Gupta, P.3
  • 13
    • 84928563193 scopus 로고    scopus 로고
    • Pharmacodynamic (PD) assessment of drug activity in tumor tissue from patients (pts) enrolled in a Phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual action antibody, in pts with locally advanced or metastatic epithelial tumors
    • Juric, D., Dienstmann, R., Cervantes, A., et al. Pharmacodynamic (PD) assessment of drug activity in tumor tissue from patients (pts) enrolled in a Phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual action antibody, in pts with locally advanced or metastatic epithelial tumors. 104th Annu Meet Am Assoc Cancer Res (AACR) (April 6-10, Washington, D.C.) 2013, Abst 3363.
    • 104th Annu Meet Am Assoc Cancer Res (AACR) (April 6-10, Washington, D.C.) 2013
    • Juric, D.1    Dienstmann, R.2    Cervantes, A.3
  • 14
    • 84928534552 scopus 로고    scopus 로고
    • Human pharmacokinetic (PK) characterization of the novel dual-action anti-HER3/EGFR antibody MEHD7945A (MEHD) in patients with refractory/recurrent epithelial tumors
    • Hidalgo, M., Calles, A., Juric, D., et al. Human pharmacokinetic (PK) characterization of the novel dual-action anti-HER3/EGFR antibody MEHD7945A (MEHD) in patients with refractory/recurrent epithelial tumors. 48th Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2012, Abst 2567.
    • 48th Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2012
    • Hidalgo, M.1    Calles, A.2    Juric, D.3
  • 15
    • 84928521635 scopus 로고    scopus 로고
    • Phase 1b study of MEHD7945A (MEHD) plus cisplatin/fluorouracil (cis/5FU) or carboplatin/paclitaxel (carbo/pac) for 1st-line treatment of recurrent/metastatic squamous cell carcinoma of head and neck (RMSCCHN)
    • Clement, P., Machiels, J., Wirth, L., et al. Phase 1b study of MEHD7945A (MEHD) plus cisplatin/fluorouracil (cis/5FU) or carboplatin/paclitaxel (carbo/pac) for 1st-line treatment of recurrent/metastatic squamous cell carcinoma of head and neck (RMSCCHN). 39th Eur Soc Med Oncol (ESMO) Congr (September 26-30, Madrid) 2014, Abst 989PD.
    • 39th Eur Soc Med Oncol (ESMO) Congr (September 26-30, Madrid) 2014
    • Clement, P.1    Machiels, J.2    Wirth, L.3
  • 17
    • 84928579538 scopus 로고    scopus 로고
    • A Phase 1 study of MEHD7945A (MEHD), a first-in-class EGFR/HER3 dual action antibody, in patients (pts) with locally advanced or metastatic epithelial tumors
    • Juric, D., Dienstmann, R., Messersmith, W., et al. A Phase 1 study of MEHD7945A (MEHD), a first-in-class EGFR/HER3 dual action antibody, in patients (pts) with locally advanced or metastatic epithelial tumors. 103rd Annu Meet Am Assoc Cancer Res (AACR) (March 31-April 4, Chicago) 2012, Abst CT-08.
    • 103rd Annu Meet Am Assoc Cancer Res (AACR) (March 31-April 4, Chicago) 2012
    • Juric, D.1    Dienstmann, R.2    Messersmith, W.3
  • 18
    • 84928534370 scopus 로고    scopus 로고
    • Randomized phase II study of MEHD7945A (MEHD) vs cetuximab (Cet) in greater than or equal to 2nd-line recurrent/metastatic squamous cell carcinoma of the head and neck (RMSCCHN) progressive on/after platinum-based chemotherapy (PtCT)
    • Fayette, J., Wirth, L., Oprean, C., et al. Randomized phase II study of MEHD7945A (MEHD) vs cetuximab (Cet) in greater than or equal to 2nd-line recurrent/metastatic squamous cell carcinoma of the head and neck (RMSCCHN) progressive on/after platinum-based chemotherapy (PtCT). 39th Eur Soc Med Oncol (ESMO) Congr (September 26-30, Madrid) 2014, Abst 9860.
    • 39th Eur Soc Med Oncol (ESMO) Congr (September 26-30, Madrid) 2014
    • Fayette, J.1    Wirth, L.2    Oprean, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.