-
1
-
-
0027438710
-
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α
-
DOI 10.1002/art.1780361206
-
Elliott MJ, Maini RN, Feldmann M, et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum 1993; 36(12): 1681-90 (Pubitemid 23360007)
-
(1993)
Arthritis and Rheumatism
, vol.36
, Issue.12
, pp. 1681-1690
-
-
Elliott, M.J.1
Maini, R.N.2
Feldmann, M.3
Long-Fox, A.4
Charles, P.5
Katsikis, P.6
Brennan, F.M.7
Walker, J.8
Bijl, H.9
Ghrayeb, J.10
Woody, J.N.11
-
2
-
-
77955489317
-
Anti-TNF therapy, from rationale to standard of care: What lessons has it taught us?
-
Feldmann M, Maini RN. Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us? J Immunol 2010; 185(2): 791-4
-
(2010)
J Immunol
, vol.185
, Issue.2
, pp. 791-794
-
-
Feldmann, M.1
Maini, R.N.2
-
3
-
-
34548229364
-
FcRn: The neonatal Fc receptor comes of age
-
DOI 10.1038/nri2155, PII NRI2155
-
Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007; 7(9): 715-25 (Pubitemid 47327396)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.9
, pp. 715-725
-
-
Roopenian, D.C.1
Akilesh, S.2
-
4
-
-
34248655131
-
Tunable pharmacokinetics: Modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment
-
DOI 10.1038/nprot.2006.322, PII NPROT.2006.322
-
Olafsen T, Kenanova VE, Wu AM. Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment. Nat Protoc 2006; 1(4): 2048-60 (Pubitemid 46773329)
-
(2006)
Nature Protocols
, vol.1
, Issue.4
, pp. 2048-2060
-
-
Olafsen, T.1
Kenanova, V.E.2
Wu, A.M.3
-
5
-
-
33749860977
-
Post-translational modifications in the context of therapeutic proteins
-
DOI 10.1038/nbt1252, PII NBT1252
-
Walsh G, Jefferis R. Post-translational modifications in the context of therapeutic proteins. Nat Biotechnol 2006; 24(10): 1241-52 (Pubitemid 44564769)
-
(2006)
Nature Biotechnology
, vol.24
, Issue.10
, pp. 1241-1252
-
-
Walsh, G.1
Jefferis, R.2
-
6
-
-
27144432842
-
Engineered antibody fragments and the rise of single domains
-
DOI 10.1038/nbt1142, PII N1142
-
Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotechnol 2005; 23(9): 1126-36 (Pubitemid 41486394)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.9
, pp. 1126-1136
-
-
Holliger, P.1
Hudson, P.J.2
-
7
-
-
51549092094
-
The impact of PEGylation on biological therapies
-
Veronese FM, Mero A. The impact of PEGylation on biological therapies. BioDrugs 2008; 22(5): 315-29
-
(2008)
BioDrugs
, vol.22
, Issue.5
, pp. 315-329
-
-
Veronese, F.M.1
Mero, A.2
-
8
-
-
33846987785
-
PEGylation of native disulfide bonds in proteins
-
Brocchini S, Balan S, Godwin A, et al. PEGylation of native disulfide bonds in proteins. Nat Protoc 2006; 1(5): 2241-52
-
(2006)
Nat Protoc
, vol.1
, Issue.5
, pp. 2241-2252
-
-
Brocchini, S.1
Balan, S.2
Godwin, A.3
-
9
-
-
29344448254
-
A new generation of protein display scaffolds for molecular recognition
-
DOI 10.1110/ps.051817606
-
Hosse RJ, Rothe A, Power BE. A new generation of protein display scaffolds for molecular recognition. Protein Sci 2006; 15(1): 14-27 (Pubitemid 43004229)
-
(2006)
Protein Science
, vol.15
, Issue.1
, pp. 14-27
-
-
Hosse, R.J.1
Rothe, A.2
Power, B.E.3
-
10
-
-
3442885115
-
A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate
-
DOI 10.1136/ard.2003.016014
-
Cohen SB, Moreland LW, Cush JJ, et al. A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate. Ann Rheum Dis 2004; 63(9): 1062-8 (Pubitemid 39120355)
-
(2004)
Annals of the Rheumatic Diseases
, vol.63
, Issue.9
, pp. 1062-1068
-
-
Cohen, S.B.1
Moreland, L.W.2
Cush, J.J.3
Greenwald, M.W.4
Block, S.5
Shergy, W.J.6
Hanrahan, P.S.7
Khraishi, M.M.8
Patel, A.9
Sun, G.10
Bear, M.B.11
-
11
-
-
0013511183
-
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
-
DOI 10.1056/NEJM199707173370301
-
Moreland LW, Baumgartner SW, Schiff MH, et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 1997; 337(3): 141-7 (Pubitemid 27306284)
-
(1997)
New England Journal of Medicine
, vol.337
, Issue.3
, pp. 141-147
-
-
Moreland, L.W.1
Baumgartner, S.W.2
Schiff, M.H.3
Tindall, E.A.4
Fleischmann, R.M.5
Weaver, A.L.6
Ettlinger, R.E.7
Cohen, S.8
Koopman, W.J.9
Mohler, K.10
Widmer, M.B.11
Blosch, C.M.12
-
12
-
-
0034918211
-
TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice
-
DOI 10.1038/89782
-
Wang H, Marsters SA, Baker T, et al. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol 2001; 2(7): 632-7 (Pubitemid 32677631)
-
(2001)
Nature Immunology
, vol.2
, Issue.7
, pp. 632-637
-
-
Wang, H.1
Marsters, S.A.2
Baker, T.3
Chan, B.4
Lee, W.P.5
Fu, L.6
Tumas, D.7
Yan, M.8
Dixit, V.M.9
Ashkenazi, A.10
Grewal, I.S.11
-
13
-
-
79959856423
-
Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial
-
van Vollenhoven RF, Kinnman N, Vincent E, et al. Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial. Arthritis Rheum 2011; 63(7): 1782-92
-
(2011)
Arthritis Rheum
, vol.63
, Issue.7
, pp. 1782-1792
-
-
Van Vollenhoven, R.F.1
Kinnman, N.2
Vincent, E.3
-
14
-
-
77957361348
-
Development trends for human monoclonal antibody therapeutics
-
Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 2010; 9(10): 767-74
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.10
, pp. 767-774
-
-
Nelson, A.L.1
Dhimolea, E.2
Reichert, J.M.3
-
15
-
-
27144532832
-
Human antibodies from transgenic animals
-
DOI 10.1038/nbt1135, PII N1135
-
Lonberg N. Human antibodies from transgenic animals. Nat Biotechnol 2005; 23(9): 1117-25 (Pubitemid 41486393)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.9
, pp. 1117-1125
-
-
Lonberg, N.1
-
16
-
-
27144431943
-
Selecting and screening recombinant antibody libraries
-
DOI 10.1038/nbt1126, PII N1126
-
Hoogenboom HR. Selecting and screening recombinant antibody libraries. Nat Biotechnol 2005; 23(9): 1105-16 (Pubitemid 41486392)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.9
, pp. 1105-1116
-
-
Hoogenboom, H.R.1
-
17
-
-
33749328523
-
In vitro display technologies reveal novel biopharmaceutics
-
DOI 10.1096/fj.05-5650rev
-
Rothe A, Hosse RJ, Power BE. In vitro display technologies reveal novel biopharmaceutics. Faseb J 2006; 20(10): 1599-610 (Pubitemid 44943797)
-
(2006)
FASEB Journal
, vol.20
, Issue.10
, pp. 1599-1610
-
-
Rothe, A.1
Hosse, R.J.2
Power, B.E.3
-
18
-
-
3142685154
-
In-vitro protein evolution by ribosome display and mRNA display
-
DOI 10.1016/j.jim.2004.04.008, PII S0022175904001309
-
Lipovsek D, Pluckthun A. In-vitro protein evolution by ribosome display and mRNA display. J Immunol Methods 2004; 290(1-2): 51-67 (Pubitemid 38917130)
-
(2004)
Journal of Immunological Methods
, vol.290
, Issue.1-2
, pp. 51-67
-
-
Lipovsek, D.1
Pluckthun, A.2
-
19
-
-
1642369949
-
Antibody affinity maturation by chain shuffling
-
Marks JD. Antibody affinity maturation by chain shuffling. Methods Mol Biol 2004; 248: 327-43
-
(2004)
Methods Mol Biol
, vol.248
, pp. 327-343
-
-
Marks, J.D.1
-
20
-
-
0345829975
-
Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone: Improved affinity results from small structural changes within the variable domains
-
DOI 10.1074/jbc.M208392200
-
Valjakka J, Hemminki A, Niemi S, et al. Crystal structure of an in vitro affinityand specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains. J Biol Chem 2002; 277(46): 44021-7 (Pubitemid 36157828)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 44021-44027
-
-
Valjakka, J.1
Hemminki, A.2
Niemi, S.3
Soderlund, H.4
Takkinen, K.5
Rouvinen, J.6
-
21
-
-
0242495115
-
Generation and Characterization of LymphoStat-B, a Human Monoclonal Antibody That Antagonizes the Bioactivities of B Lymphocyte Stimulator
-
DOI 10.1002/art.11299
-
Baker KP, Edwards BM, Main SH, et al. Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis Rheum 2003; 48(11): 3253-65 (Pubitemid 37409340)
-
(2003)
Arthritis and Rheumatism
, vol.48
, Issue.11
, pp. 3253-3265
-
-
Baker, K.P.1
Edwards, B.M.2
Main, S.H.3
Choi, G.H.4
Wager, R.E.5
Halpern, W.G.6
Lappin, P.B.7
Riccobene, T.8
Abramian, D.9
Sekut, L.10
Sturm, B.11
Poortman, C.12
Minter, R.R.13
Dobson, C.L.14
Williams, E.15
Carmen, S.16
Smith, R.17
Roschke, V.18
Hilbert, D.M.19
Vaughan, T.J.20
Albert, V.R.21
more..
-
22
-
-
84872191194
-
Belimumab-an anti-blys human monoclonal antibody for rheumatoid arthritis
-
Jin X, Ding C. Belimumab-an anti-BLyS human monoclonal antibody for rheumatoid arthritis. Expert Opin Biol Ther 2013; 13(2): 315-22
-
(2013)
Expert Opin Biol Ther
, vol.13
, Issue.2
, pp. 315-322
-
-
Jin, X.1
Ding, C.2
-
23
-
-
13444271918
-
High-throughput antibody production
-
DOI 10.1016/j.cbpa.2004.10.011
-
Chambers RS. High-throughput antibody production. Curr Opin Chem Biol 2005; 9(1): 46-50 (Pubitemid 40208623)
-
(2005)
Current Opinion in Chemical Biology
, vol.9
, Issue.1
, pp. 46-50
-
-
Chambers, R.S.1
-
24
-
-
33846708242
-
Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: Optimal pharmacokinetics for therapy
-
DOI 10.1158/0008-5472.CAN-06-0454
-
Kenanova V, Olafsen T, Williams LE, et al. Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy. Cancer Res 2007; 67(2): 718-26 (Pubitemid 46192212)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 718-726
-
-
Kenanova, V.1
Olafsen, T.2
Williams, L.E.3
Ruel, N.H.4
Longmate, J.5
Yazaki, P.J.6
Shively, J.E.7
Colcher, D.8
Raubitschek, A.A.9
Wu, A.M.10
-
25
-
-
33847257777
-
Pharmacokinetics of rituximab and its clinical use: Thought for the best use?
-
DOI 10.1016/j.critrevonc.2006.09.004, PII S1040842806002009
-
Cartron G, Blasco H, Paintaud G, et al. Pharmacokinetics of rituximab and its clinical use: thought for the best use? Crit Rev Oncol Hematol 2007; 62(1): 43-52 (Pubitemid 46330791)
-
(2007)
Critical Reviews in Oncology/Hematology
, vol.62
, Issue.1
, pp. 43-52
-
-
Cartron, G.1
Blasco, H.2
Paintaud, G.3
Watier, H.4
Le Guellec, C.5
-
26
-
-
0036796777
-
Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: A phase II double-blinded, randomized, dose-escalating trial
-
Choy EH, Hazleman B, Smith M, et al. Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatology (Oxford) 2002; 41(10): 1133-7 (Pubitemid 35203540)
-
(2002)
Rheumatology
, vol.41
, Issue.10
, pp. 1133-1137
-
-
Choy, E.H.S.1
Hazleman, B.2
Smith, M.3
Moss, K.4
Lisi, L.5
Scott, D.G.I.6
Patel, J.7
Sopwith, M.8
Isenberg, D.A.9
-
27
-
-
67449124634
-
Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: The RAPID 2 study. A randomised controlled trial
-
Smolen J, Landewe RB, Mease P, et al. Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial. Ann Rheum Dis 2009; 68(6): 797-804
-
(2009)
Ann Rheum Dis
, vol.68
, Issue.6
, pp. 797-804
-
-
Smolen, J.1
Landewe, R.B.2
Mease, P.3
-
28
-
-
33646696885
-
Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
-
DOI 10.1001/jama.295.19.2275
-
Bongartz T, Sutton AJ, Sweeting MJ, et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006; 295(19): 2275-85 (Pubitemid 43736578)
-
(2006)
Journal of the American Medical Association
, vol.295
, Issue.19
, pp. 2275-2285
-
-
Bongartz, T.1
Sutton, A.J.2
Sweeting, M.J.3
Buchan, I.4
Matteson, E.L.5
Montori, V.6
-
29
-
-
84942918614
-
The innate immune system in SLE
-
Wallace DJ, Hahn BH, et al. editors, 8th edition, Elsevier, Philadelphia, PA
-
Bossaller L, Marshak-Rothstein A. The innate immune system in SLE. In: Wallace DJ, Hahn BH, et al. editors, Dubois' lupus erthematosus and related syndromes. 8th edition, Elsevier, Philadelphia, PA; 2013. p. 75-61
-
(2013)
Dubois' Lupus Erthematosus and Related Syndromes
, pp. 75-61
-
-
Bossaller, L.1
Marshak-Rothstein, A.2
-
30
-
-
84859832981
-
2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
-
Singh JA, Furst DE, Bharat A, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 2012; 64(5): 625-39
-
(2008)
Arthritis Care Res (Hoboken)
, vol.64
, Issue.5
, pp. 625-639
-
-
Singh, J.A.1
Furst, D.E.2
Bharat, A.3
-
31
-
-
70049108310
-
Short-and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis
-
Rehnberg M, Amu S, Tarkowski A, et al. Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis. Arthritis Res Ther 2009; 11(4): R123
-
(2009)
Arthritis Res Ther
, vol.11
, Issue.4
-
-
Rehnberg, M.1
Amu, S.2
Tarkowski, A.3
-
32
-
-
47249109393
-
Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: The B-cell roadblock hypothesis
-
DOI 10.1111/j.1600-065X.2008.00627.x
-
Silverman GJ, Boyle DL. Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis. Immunol Rev 2008; 223: 175-85 (Pubitemid 351986172)
-
(2008)
Immunological Reviews
, vol.223
, Issue.1
, pp. 175-185
-
-
Silverman, G.J.1
Boyle, D.L.2
-
33
-
-
76749123764
-
Autoantibody-positive rheumatoid arthritis (RA) patients have enhanced clinical response to rituximab when compared to seronegative patients
-
Isaacs J, Olech E, Tak P, et al. Autoantibody-positive rheumatoid arthritis (RA) patients have enhanced clinical response to rituximab when compared to seronegative patients. Ann Rheum Dis 2009; 68(3): 442
-
(2009)
Ann Rheum Dis
, vol.68
, Issue.3
, pp. 442
-
-
Isaacs, J.1
Olech, E.2
Tak, P.3
-
34
-
-
33847068351
-
Drug insight: The mechanism of action of rituximab in autoimmune disease - The immune complex decoy hypothesis
-
Taylor RP, Lindorfer MA. Drug insight: the mechanism of action of rituximab in autoimmune disease-the immune complex decoy hypothesis. Nat Clin Pract Rheumatol 2007; 3(2): 86-95
-
(2007)
Nat Clin Pract Rheumatol
, vol.3
, Issue.2
, pp. 86-95
-
-
Taylor, R.P.1
Lindorfer, M.A.2
-
35
-
-
80052795550
-
Mechanisms of inhibition of joint destruction by rituximab in rheumatoid arthritis
-
Bourmans M, Thurlings R, Vos K, et al. Mechanisms of inhibition of joint destruction by rituximab in rheumatoid arthritis. Arthritis Rheum 2010; 62(10): 761
-
(2010)
Arthritis Rheum
, vol.62
, Issue.10
, pp. 761
-
-
Bourmans, M.1
Thurlings, R.2
Vos, K.3
-
36
-
-
66549130454
-
Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: A report of 57 cases from the Research on Adverse Drug Events and Reports project
-
Carson KR, Evens AM, Richey EA, et al. Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood 2009; 113(20): 4834-40
-
(2009)
Blood
, vol.113
, Issue.20
, pp. 4834-4840
-
-
Carson, K.R.1
Evens, A.M.2
Richey, E.A.3
-
37
-
-
58149162030
-
Type II (tositumomab) anti-CD20 monoclonal antibody out performs type i (rituximab-like) reagents in B-cell depletion regardless of complement activation
-
Beers SA, Chan CH, James S, et al. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood 2008; 112(10): 4170-7
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 4170-4177
-
-
Beers, S.A.1
Chan, C.H.2
James, S.3
-
38
-
-
84863435547
-
The advent of biosimilar therapies in rheumatology-"O brave new world"
-
Scheinberg MA, Kay J. The advent of biosimilar therapies in rheumatology-"O brave new world". Nat Rev Rheumatol 2012; 8(7): 430-6
-
(2012)
Nat Rev Rheumatol
, vol.8
, Issue.7
, pp. 430-436
-
-
Scheinberg, M.A.1
Kay, J.2
-
39
-
-
56149114691
-
Pharmacokinetic and pharmacodynamic properties of TRU-015, a CD20-directed small modular immunopharmaceutical protein therapeutic, in patients with rheumatoid arthritis: A Phase I, open-label, dose-escalation clinical study
-
Burge DJ, Bookbinder SA, Kivitz AJ, et al. Pharmacokinetic and pharmacodynamic properties of TRU-015, a CD20-directed small modular immunopharmaceutical protein therapeutic, in patients with rheumatoid arthritis: a Phase I, open-label, dose-escalation clinical study. Clin Ther 2008; 30(10): 1806-16
-
(2008)
Clin Ther
, vol.30
, Issue.10
, pp. 1806-1816
-
-
Burge, D.J.1
Bookbinder, S.A.2
Kivitz, A.J.3
-
41
-
-
79251570884
-
Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors
-
de Weers M, Tai YT, van der Veer MS, et al. Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J Immunol 2011; 186(3): 1840-8
-
(2011)
J Immunol
, vol.186
, Issue.3
, pp. 1840-1848
-
-
De Weers, M.1
Tai, Y.T.2
Van Der Veer, M.S.3
-
42
-
-
77958120721
-
Regulation of the B cell receptor repertoire and self-reactivity by BAFF
-
Ota M, Duong BH, Torkamani A, et al. Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol 2010; 185(7): 4128-36
-
(2010)
J Immunol
, vol.185
, Issue.7
, pp. 4128-4136
-
-
Ota, M.1
Duong, B.H.2
Torkamani, A.3
-
43
-
-
33646844797
-
Belimumab Human Genome Sciences/Cambridge Antibody Technology/ GlaxoSmithKline
-
Ding C, Jones G. Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline. Curr Opin Investig Drugs 2006; 7(5): 464-72 (Pubitemid 43772987)
-
(2006)
Current Opinion in Investigational Drugs
, vol.7
, Issue.5
, pp. 464-472
-
-
Ding, C.1
Jones, G.2
-
44
-
-
84876889502
-
Efficacy and safety of belimumab in patients with rheumatoid arthritis: A phase II, randomized, double-blind, placebo-controlled, dose-ranging study
-
Stohl W, Merrill JT, McKay JD, et al. Efficacy and safety of belimumab in patients with rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled, dose-ranging study. J Rheumatol 2013; 40(5): 579-89
-
(2013)
J Rheumatol
, vol.40
, Issue.5
, pp. 579-589
-
-
Stohl, W.1
Merrill, J.T.2
McKay, J.D.3
-
45
-
-
84863850571
-
Belimumab in the treatment of systemic lupus erythematosus: High disease activity predictors of response
-
van Vollenhoven RF, Petri MA, Cervera R, et al. Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response. Ann Rheum Dis 2012; 71(8): 1343-9
-
(2012)
Ann Rheum Dis
, vol.71
, Issue.8
, pp. 1343-1349
-
-
Van Vollenhoven, R.F.1
Petri, M.A.2
Cervera, R.3
-
46
-
-
37049017404
-
Anti-BR3 antibodies: A new class of B-cell immunotherapy combining cellular depletion and survival blockade
-
DOI 10.1182/blood-2007-04-088088
-
Lin WY, Gong Q, Seshasayee D, et al. Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade. Blood 2007; 110(12): 3959-67 (Pubitemid 350248451)
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 3959-3967
-
-
Wei, Y.L.1
Gong, Q.2
Seshasayee, D.3
Lin, Z.4
Ou, Q.5
Ye, S.6
Suto, E.7
Shu, J.8
Wyne, P.L.9
Lee, C.-W.V.10
Fuh, G.11
Leabman, M.12
Iyer, S.13
Howell, K.14
Gelzleichter, T.15
Beyer, J.16
Danilenko, D.17
Yeh, S.18
DeForge, L.E.19
Ebens, A.20
Thompson, J.S.21
Ambrose, C.22
Balazs, M.23
Starovasnik, M.A.24
Martin, F.25
more..
-
50
-
-
65349185047
-
The clinical utility of inhibiting CD28-mediated costimulation
-
Linsley PS, Nadler SG. The clinical utility of inhibiting CD28-mediated costimulation. Immunol Rev 2009; 229(1): 307-21
-
(2009)
Immunol Rev
, vol.229
, Issue.1
, pp. 307-321
-
-
Linsley, P.S.1
Nadler, S.G.2
-
51
-
-
77956410939
-
Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells
-
Platt AM, Gibson VB, Patakas A, et al. Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells. J Immunol 2010; 185(3): 1558-67
-
(2010)
J Immunol
, vol.185
, Issue.3
, pp. 1558-1567
-
-
Platt, A.M.1
Gibson, V.B.2
Patakas, A.3
-
52
-
-
20044386299
-
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
-
DOI 10.1111/j.1600-6143.2005.00749.x
-
Larsen CP, Pearson TC, Adams AB, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005; 5(3): 443-53 (Pubitemid 40313335)
-
(2005)
American Journal of Transplantation
, vol.5
, Issue.3
, pp. 443-453
-
-
Larsen, C.P.1
Pearson, T.C.2
Adams, A.B.3
Tso, P.4
Shirasugi, N.5
Strobert, E.6
Anderson, D.7
Cowan, S.8
Price, K.9
Naemura, J.10
Emswiler, J.11
Greene, J.12
Turk, L.A.13
Bajorath, J.14
Townsend, R.15
Hagerty, D.16
Linsley, P.S.17
Peach, R.J.18
-
53
-
-
84873411673
-
Clinical targeting of the TNF and TNFR superfamilies
-
Croft M, Benedict CA, Ware CF. Clinical targeting of the TNF and TNFR superfamilies. Nat Rev Drug Discov 2013; 12(2): 147-68
-
(2013)
Nat Rev Drug Discov
, vol.12
, Issue.2
, pp. 147-168
-
-
Croft, M.1
Benedict, C.A.2
Ware, C.F.3
-
54
-
-
33845882484
-
Biologic therapies in rheumatology: Lessons learned, future directions
-
DOI 10.1038/nrd2196, PII NRD2196
-
Strand V, Kimberly R, Isaacs JD. Biologic therapies in rheumatology: lessons learned, future directions. Nat Rev Drug Discov 2007; 6(1): 75-92 (Pubitemid 46020288)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.1
, pp. 75-92
-
-
Strand, V.1
Kimberly, R.2
Isaacs, J.D.3
-
55
-
-
3543140687
-
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy
-
DOI 10.1084/jem.20040165
-
Ehrenstein MR, Evans JG, Singh A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004; 200(3): 277-85 (Pubitemid 39031247)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.3
, pp. 277-285
-
-
Ehrenstein, M.R.1
Evans, J.G.2
Singh, A.3
Moore, S.4
Warnes, G.5
Isenberg, D.A.6
Mauri, C.7
-
56
-
-
84855275896
-
Observational studies on the risk of cancer associated with tumor necrosis factor inhibitors in rheumatoid arthritis: A review of their methodologies and results
-
Solomon DH, Mercer E, Kavanaugh A. Observational studies on the risk of cancer associated with tumor necrosis factor inhibitors in rheumatoid arthritis: a review of their methodologies and results. Arthritis Rheum 2012; 64(1): 21-32
-
(2012)
Arthritis Rheum
, vol.64
, Issue.1
, pp. 21-32
-
-
Solomon, D.H.1
Mercer, E.2
Kavanaugh, A.3
-
57
-
-
78649381672
-
BSR and BHPR rheumatoid arthritis guidelines on safety of anti-TNF therapies
-
Ding T, Ledingham J, Luqmani R, et al. BSR and BHPR rheumatoid arthritis guidelines on safety of anti-TNF therapies. Rheumatology (Oxford) 2010; 49(11): 2217-19
-
(2010)
Rheumatology (Oxford)
, vol.49
, Issue.11
, pp. 2217-2219
-
-
Ding, T.1
Ledingham, J.2
Luqmani, R.3
-
58
-
-
40449090323
-
Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
-
DOI 10.1158/0008-5472.CAN-07-5704
-
Egberts JH, Cloosters V, Noack A, et al. Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 2008; 68(5): 1443-50 (Pubitemid 351346852)
-
(2008)
Cancer Research
, vol.68
, Issue.5
, pp. 1443-1450
-
-
Egberts, J.-H.1
Cloosters, V.2
Noack, A.3
Schniewind, B.4
Thon, L.5
Klose, S.6
Kettler, B.7
Von Forstner, C.8
Kneitz, C.9
Tepel, J.10
Adam, D.11
Wajant, H.12
Kalthoff, H.13
Trauzold, A.14
-
59
-
-
78649658557
-
Anti-TNFalpha domain antibody construct CEP-37247: Full antibody functionality at half the size
-
Gay RD, Clarke AW, Elgundi Z, et al. Anti-TNFalpha domain antibody construct CEP-37247: full antibody functionality at half the size. MAbs 2010; 2(6): 625-38
-
(2010)
MAbs
, vol.2
, Issue.6
, pp. 625-638
-
-
Gay, R.D.1
Clarke, A.W.2
Elgundi, Z.3
-
60
-
-
48149104295
-
Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs
-
Holt LJ, Basran A, Jones K, et al. Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs. Protein Eng Des Sel 2008; 21(5): 283-8
-
(2008)
Protein Eng des Sel
, vol.21
, Issue.5
, pp. 283-288
-
-
Holt, L.J.1
Basran, A.2
Jones, K.3
-
61
-
-
77954636621
-
Anti-serum albumin domain antibodies in the development of highly potent efficacious and long-acting interferon
-
Walker A, Dunlevy G, Rycroft D, et al. Anti-serum albumin domain antibodies in the development of highly potent, efficacious and long-acting interferon. Protein Eng Des Sel 2010; 23(4): 271-8
-
(2010)
Protein Eng des Sel
, vol.23
, Issue.4
, pp. 271-278
-
-
Walker, A.1
Dunlevy, G.2
Rycroft, D.3
-
62
-
-
79955477738
-
The growth factor progranulin binds to tnf receptors and is therapeutic against inflammatory arthritis in mice
-
Tang W, Lu Y, Tian QY, et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 2011; 332(6028): 478-84
-
(2011)
Science
, vol.332
, Issue.6028
, pp. 478-484
-
-
Tang, W.1
Lu, Y.2
Tian, Q.Y.3
-
63
-
-
73849134001
-
Blocking interleukin-1 in rheumatic diseases
-
Goldbach-Mansky R. Blocking interleukin-1 in rheumatic diseases. Ann NY Acad Sci 2009; 1182: 111-23
-
(2009)
Ann NY Acad Sci
, vol.1182
, pp. 111-123
-
-
Goldbach-Mansky, R.1
-
64
-
-
84864545087
-
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
-
Dinarello CA, Simon A, van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 2012; 11(8): 633-52
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.8
, pp. 633-652
-
-
Dinarello, C.A.1
Simon, A.2
Van Der Meer, J.W.3
-
65
-
-
84871316266
-
A new era in the treatment of systemic juvenile idiopathic arthritis
-
Sandborg C, Mellins ED. A new era in the treatment of systemic juvenile idiopathic arthritis. N Engl J Med 2012; 367(25): 2439-40
-
(2012)
N Engl J Med
, vol.367
, Issue.25
, pp. 2439-2440
-
-
Sandborg, C.1
Mellins, E.D.2
-
66
-
-
84873893352
-
Update on biologicals for treatment of juvenile idiopathic arthritis
-
Horneff G. Update on biologicals for treatment of juvenile idiopathic arthritis. Expert Opin Biol Ther 2013; 13(3): 361-76
-
(2013)
Expert Opin Biol Ther
, vol.13
, Issue.3
, pp. 361-376
-
-
Horneff, G.1
-
67
-
-
80052189130
-
Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: Results of a 12-week, Phase II, dose-finding study
-
Alten R, Gomez-Reino J, Durez P, et al. Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study. BMC Musculoskelet Disord 2011; 12: 153
-
(2011)
BMC Musculoskelet Disord
, vol.12
, pp. 153
-
-
Alten, R.1
Gomez-Reino, J.2
Durez, P.3
-
69
-
-
84878237993
-
Activation and regulation of the inflammasomes
-
Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol 2013; 13(6): 397-411
-
(2013)
Nat Rev Immunol
, vol.13
, Issue.6
, pp. 397-411
-
-
Latz, E.1
Xiao, T.S.2
Stutz, A.3
-
70
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
DOI 10.1038/nature04516, PII N04516
-
Martinon F, Petrilli V, Mayor A, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440(7081): 237-41 (Pubitemid 43372104)
-
(2006)
Nature
, vol.440
, Issue.7081
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
71
-
-
84877275257
-
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
-
Gabay C, Emery P, van Vollenhoven R, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 2013; 381(9877): 1541-50
-
(2013)
Lancet
, vol.381
, Issue.9877
, pp. 1541-1550
-
-
Gabay, C.1
Emery, P.2
Van Vollenhoven, R.3
-
72
-
-
84872858296
-
Which are the antibodies to watch in 2013?
-
Reichert JM. Which are the antibodies to watch in 2013? MAbs 2013; 5(1): 1-4
-
(2013)
MAbs
, vol.5
, Issue.1
, pp. 1-4
-
-
Reichert, J.M.1
-
74
-
-
79960182099
-
Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study
-
Xu Z, Bouman-Thio E, Comisar C, et al. Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study. Br J Clin Pharmacol 2011; 72(2): 270-81
-
(2011)
Br J Clin Pharmacol
, vol.72
, Issue.2
, pp. 270-281
-
-
Xu, Z.1
Bouman-Thio, E.2
Comisar, C.3
-
75
-
-
84862783578
-
A phase II double-blind randomised placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate
-
Mease P, Strand V, Shalamberidze L, et al. A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate. Ann Rheum Dis 2012; 71(7): 1183-9
-
(2012)
Ann Rheum Dis
, vol.71
, Issue.7
, pp. 1183-1189
-
-
Mease, P.1
Strand, V.2
Shalamberidze, L.3
-
76
-
-
74849112402
-
Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis
-
von Delwig A, Locke J, Robinson JH, Ng WF. Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum 2010; 62(1): 143-9
-
(2010)
Arthritis Rheum
, vol.62
, Issue.1
, pp. 143-149
-
-
Von Delwig, A.1
Locke, J.2
Robinson, J.H.3
Ng, W.F.4
-
77
-
-
68849125507
-
Type 17 T helper cells-origins, features and possible roles in rheumatic disease
-
Annunziato F, Cosmi L, Liotta F, et al. Type 17 T helper cells-origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol 2009; 5(6): 325-31
-
(2009)
Nat Rev Rheumatol
, vol.5
, Issue.6
, pp. 325-331
-
-
Annunziato, F.1
Cosmi, L.2
Liotta, F.3
-
78
-
-
84877603562
-
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II dose-finding double-blind randomised placebo controlled study
-
Genovese MC, Durez P, Richards HB, et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann Rheum Dis 2013; 72(6): 863-9
-
(2013)
Ann Rheum Dis
, vol.72
, Issue.6
, pp. 863-869
-
-
Genovese, M.C.1
Durez, P.2
Richards, H.B.3
-
79
-
-
84859073115
-
Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
-
Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012; 366(13): 1190-9
-
(2012)
N Engl J Med
, vol.366
, Issue.13
, pp. 1190-1199
-
-
Leonardi, C.1
Matheson, R.2
Zachariae, C.3
-
80
-
-
84859017988
-
Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
-
Papp KA, Leonardi C, Menter A, et al. Brodalumab, an anti-interleukin-17- receptor antibody for psoriasis. N Engl J Med 2012; 366(13): 1181-9
-
(2012)
N Engl J Med
, vol.366
, Issue.13
, pp. 1181-1189
-
-
Papp, K.A.1
Leonardi, C.2
Menter, A.3
-
81
-
-
77950535421
-
LY2439821 a humanized anti-interleukin-17 monoclonal antibody in the treatment of patients with rheumatoid arthritis: A phase i randomized double-blind placebo-controlled proof-of-concept study
-
Genovese MC, Van den Bosch F, Roberson SA, et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum 2010; 62(4): 929-39
-
(2010)
Arthritis Rheum
, vol.62
, Issue.4
, pp. 929-939
-
-
Genovese, M.C.1
Van Den Bosch, F.2
Roberson, S.A.3
-
82
-
-
84881506110
-
-
ACR/ARHO 11; Chicago
-
Mark C, Genovese MWG, Cho CS, et al. A Phase 2 study of multiple subcutaneous doses of LY2439821, an anti-il-17 monoclonal antibody, in patients with rheumatoid arthritis in two populations: naïve to biologic therapy or inadequate responders to tumor necrosis factor alpha inhibitors. ACR/ARHO 11; Chicago: 2011
-
(2011)
A Phase 2 Study of Multiple Subcutaneous Doses of LY2439821, An anti-il-17 Monoclonal Antibody, in Patients with Rheumatoid Arthritis in Two Populations: Naïve to Biologic Therapy or Inadequate Responders to Tumor Necrosis Factor Alpha Inhibitors
-
-
Mark, C.1
Genovese, M.W.G.2
Cho, C.S.3
-
83
-
-
84887412452
-
A Randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG 827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate
-
Pavelka K, Yun C, Richard N, et al. A Randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG 827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Rheum 2012; 64(Suppl 10): 831
-
(2012)
Arthritis Rheum
, vol.64
, Issue.SUPPL. 10
, pp. 831
-
-
Pavelka, K.1
Yun, C.2
Richard, N.3
-
84
-
-
34547555571
-
Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis
-
DOI 10.1038/ncprheum0559, PII NCPRHEUM0559
-
Lainer-Carr D, Brahn E. Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis. Nat Clin Pract Rheumatol 2007; 3(8): 434-42 (Pubitemid 47193549)
-
(2007)
Nature Clinical Practice Rheumatology
, vol.3
, Issue.8
, pp. 434-442
-
-
Lainer-Carr, D.1
Brahn, E.2
-
85
-
-
29244480303
-
Anti-TNF-α antibody Infliximab and glucocorticoids reduce serum vascular endothelial growth factor levels in patients with rheumatoid arthritis: A pilot study
-
DOI 10.1007/s00296-005-0619-5
-
Strunk J, Bundke E, Lange U. Anti-TNF-alpha antibody Infliximab and glucocorticoids reduce serum vascular endothelial growth factor levels in patients with rheumatoid arthritis: a pilot study. Rheumatol Int 2006; 26(3): 252-6 (Pubitemid 41830984)
-
(2006)
Rheumatology International
, vol.26
, Issue.3
, pp. 252-256
-
-
Strunk, J.1
Bundke, E.2
Lange, U.3
-
86
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
DOI 10.1073/pnas.172398299
-
Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002; 99(17): 11393-8 (Pubitemid 34920936)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.17
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.D.4
Ho, L.5
Russell, M.6
Boland, P.7
Leidich, R.8
Hylton, D.9
Burova, E.10
Ioffe, E.11
Huang, T.12
Radziejewski, C.13
Bailey, K.14
Fandl, J.P.15
Daly, T.16
Wiegand, S.J.17
Yancopoulos, G.D.18
Rudge, J.S.19
-
87
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
DOI 10.1056/NEJMoa032691
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350(23): 2335-42 (Pubitemid 38702844)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
88
-
-
84866552180
-
Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
-
Kanakaraj P, Puffer BA, Yao XT, et al. Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. MAbs 2012; 4(5): 600-13
-
(2012)
MAbs
, vol.4
, Issue.5
, pp. 600-613
-
-
Kanakaraj, P.1
Puffer, B.A.2
Yao, X.T.3
-
89
-
-
75649113035
-
Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis
-
Schwager K, Kaspar M, Bootz F, et al. Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis. Arthritis Res Ther 2009; 11(5): R142
-
(2009)
Arthritis Res Ther
, vol.11
, Issue.5
-
-
Schwager, K.1
Kaspar, M.2
Bootz, F.3
-
90
-
-
84908029359
-
COVA301: A highly potent bispecific inhibitor of IL17A and TNFa
-
Silacci M, Baenziger-Tobler N, Batey S, et al. COVA301: a highly potent bispecific inhibitor of IL17A and TNFa. mAbs 2011; 4(1): 16
-
(2011)
MAbs
, vol.4
, Issue.1
, pp. 16
-
-
Silacci, M.1
Baenziger-Tobler, N.2
Batey, S.3
-
91
-
-
84929998441
-
A novel individualised treatment approach in open-label extension study of ozoralizumab (ATN-103) in subjects with rheumatoid arthritis on a background of methotrexate
-
Fleischmann RM, De Bruyn S, Duby C, et al. A novel individualised treatment approach in open-label extension study of ozoralizumab (ATN-103) in subjects with rheumatoid arthritis on a background of methotrexate. ACR Meeting Report; 2012
-
(2012)
ACR Meeting Report
-
-
Fleischmann, R.M.1
De Bruyn, S.2
Duby, C.3
-
92
-
-
84881499963
-
Preclinical development of ALX-0061, an Anti-IL-6R nanobody for therapeutic use in rheumatoid arthritis with a high in vitro affinity and potency and a competitive in vivo pharmacological profile
-
Maarten Van Roy HU, Rossenu S, Jacobs S, et al. Preclinical development of ALX-0061, an Anti-IL-6R nanobody for therapeutic use in rheumatoid arthritis with a high in vitro affinity and potency and a competitive in vivo pharmacological profile. ACR Meeting Report; 2012
-
(2012)
ACR Meeting Report
-
-
Maarten Van Roy, H.U.1
Rossenu, S.2
Jacobs, S.3
-
93
-
-
33749009030
-
Mechanisms of disease: The link between RANKL and arthritic bone disease
-
Schett G, Hayer S, Zwerina J, et al. Mechanisms of disease: the link between RANKL and arthritic bone disease. Nat Clin Pract Rheumatol 2005; 1(1): 47-54
-
(2005)
Nat Clin Pract Rheumatol
, vol.1
, Issue.1
, pp. 47-54
-
-
Schett, G.1
Hayer, S.2
Zwerina, J.3
-
94
-
-
79953751008
-
Osteoporosis: Now and the future
-
Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet 2011; 377(9773): 1276-87
-
(2011)
Lancet
, vol.377
, Issue.9773
, pp. 1276-1287
-
-
Rachner, T.D.1
Khosla, S.2
Hofbauer, L.C.3
-
95
-
-
84867582660
-
Et al.Superiority of denosumab to zoledronic acid for prevention of skeletal- related events: a combined analysis of 3 pivotal, randomised, phase 3 trials
-
Lipton A, Fizazi K, Stopeck AT, Henry DH, Brown JE, Yardley DA, et al.Superiority of denosumab to zoledronic acid for prevention of skeletal- related events: a combined analysis of 3 pivotal, randomised, phase 3 trials. Eur J Cancer 2012; 48(16): 3082-92
-
(2012)
Eur J Cancer
, vol.48
, Issue.16
, pp. 3082-3092
-
-
Lipton, A.1
Fizazi, K.2
Stopeck, A.T.3
Henry, D.H.4
Brown, J.E.5
Yardley, D.A.6
-
96
-
-
43949139580
-
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
-
DOI 10.1002/art.23417
-
Cohen SB, Dore RK, Lane NE, et al. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum 2008; 58(5): 1299-309 (Pubitemid 351705919)
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.5
, pp. 1299-1309
-
-
Cohen, S.B.1
Dore, R.K.2
Lane, N.E.3
Ory, P.A.4
Peterfy, C.G.5
Sharp, J.T.6
Van Der Heijde, D.7
Zhou, L.8
Tsuji, W.9
Newmark, R.10
-
97
-
-
34249867399
-
Emerging targets of biologic therapies for rheumatoid arthritis
-
DOI 10.1038/ncprheum0506, PII NCPRHEUM0506
-
Tarner IH, Muller-Ladner U, Gay S. Emerging targets of biologic therapies for rheumatoid arthritis. Nat Clin Pract Rheumatol 2007; 3(6): 336-45 (Pubitemid 46864888)
-
(2007)
Nature Clinical Practice Rheumatology
, vol.3
, Issue.6
, pp. 336-345
-
-
Tarner, I.H.1
Muller-Ladner, U.2
Gay, S.3
-
98
-
-
0014977146
-
Lactate dehydrogenase in the synovial tissue in rheumatoid arthritis: Total activity and isoenzyme composition
-
Lindy S, Uitto J, Turto H, et al. Lactate dehydrogenase in the synovial tissue in rheumatoid arthritis: total activity and isoenzyme composition. Clin Chim Acta 1971; 31(1): 19-23
-
(1971)
Clin Chim Acta
, vol.31
, Issue.1
, pp. 19-23
-
-
Lindy, S.1
Uitto, J.2
Turto, H.3
-
99
-
-
33845951211
-
DAMPs, PAMPs and alarmins: All we need to know about danger
-
DOI 10.1189/jlb.0306164
-
Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007; 81(1): 1-5 (Pubitemid 46028489)
-
(2007)
Journal of Leukocyte Biology
, vol.81
, Issue.1
, pp. 1-5
-
-
Bianchi, M.E.1
-
100
-
-
79955551778
-
Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis
-
Tamaki Y, Takakubo Y, Hirayama T, et al. Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis. J Rheumatol 2011; 38(5): 810-20
-
(2011)
J Rheumatol
, vol.38
, Issue.5
, pp. 810-820
-
-
Tamaki, Y.1
Takakubo, Y.2
Hirayama, T.3
-
101
-
-
0038681182
-
Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
-
DOI 10.1002/art.11161
-
Kokkola R, Li J, Sundberg E, et al. Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity. Arthritis Rheum 2003; 48(7): 2052-8 (Pubitemid 36828701)
-
(2003)
Arthritis and Rheumatism
, vol.48
, Issue.7
, pp. 2052-2058
-
-
Kokkola, R.1
Li, J.2
Sundberg, E.3
Aveberger, A.-C.4
Palmblad, K.5
Yang, H.6
Tracey, K.J.7
Andersson, U.8
Erlandsson Harris, H.9
-
102
-
-
84858764021
-
Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models
-
Schierbeck H, Lundback P, Palmblad K, et al. Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models. Mol Med 2011; 17(9-10): 1039-44
-
(2011)
Mol Med
, vol.17
, Issue.9-10
, pp. 1039-1044
-
-
Schierbeck, H.1
Lundback, P.2
Palmblad, K.3
-
103
-
-
21844457408
-
Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis
-
DOI 10.1016/S0140-6736(05)66827-4, PII S0140673605668274
-
Kamphuis S, Kuis W, de Jager W, et al. Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet 2005; 366(9479): 50-6 (Pubitemid 40956530)
-
(2005)
Lancet
, vol.366
, Issue.9479
, pp. 50-56
-
-
Kamphuis, S.1
Kuis, W.2
De Jager, W.3
Teklenburg, G.4
Massa, M.5
Gordon, G.6
Boerhof, M.7
Rijkers, G.T.8
Uiterwaal, C.S.9
Otten, H.G.10
Sette, A.11
Albani, S.12
Prakken, B.J.13
-
104
-
-
70350521825
-
Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial
-
Koffeman EC, Genovese M, Amox D, et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial. Arthritis Rheum 2009; 60(11): 3207-16
-
(2009)
Arthritis Rheum
, vol.60
, Issue.11
, pp. 3207-3216
-
-
Koffeman, E.C.1
Genovese, M.2
Amox, D.3
-
105
-
-
34447525439
-
Beneficial suicide: Why neutrophils die to make NETs
-
DOI 10.1038/nrmicro1710, PII NRMICRO1710
-
Brinkmann V, Zychlinsky A. Beneficial suicide: why neutrophils die to make NETs. Nat Rev Microbiol 2007; 5(8): 577-82 (Pubitemid 47074113)
-
(2007)
Nature Reviews Microbiology
, vol.5
, Issue.8
, pp. 577-582
-
-
Brinkmann, V.1
Zychlinsky, A.2
-
106
-
-
1542287347
-
Neutrophil Extracellular Traps Kill Bacteria
-
DOI 10.1126/science.1092385
-
Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303(5663): 1532-5 (Pubitemid 38314426)
-
(2004)
Science
, vol.303
, Issue.5663
, pp. 1532-1535
-
-
Brinkmann, V.1
Reichard, U.2
Goosmann, C.3
Fauler, B.4
Uhlemann, Y.5
Weiss, D.S.6
Weinrauch, Y.7
Zychlinsky, A.8
-
107
-
-
84876104421
-
NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis
-
Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A, et al. NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med 2013; 5(178): 178ra40
-
(2013)
Sci Transl Med
, vol.5
, Issue.178
-
-
Khandpur, R.1
Carmona-Rivera, C.2
Vivekanandan-Giri, A.3
-
108
-
-
77954647644
-
Nucleic acid sensing receptors in systemic lupus erythematosus: Development of novel DNA- and/or RNA-like analogues for treating lupus
-
Lenert P. Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus. Clin Exp Immunol 2010; 161(2): 208-22
-
(2010)
Clin Exp Immunol
, vol.161
, Issue.2
, pp. 208-222
-
-
Lenert, P.1
-
109
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
-
Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9(2): 102-14
-
(2008)
Nat Rev Genet
, vol.9
, Issue.2
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
110
-
-
79958053053
-
The inhibitory effect of MicroRNA-146a expression on bone destruction in collagen-induced arthritis
-
Nakasa T, Shibuya H, Nagata Y, et al. The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 2011; 63(6): 1582-90
-
(2011)
Arthritis Rheum
, vol.63
, Issue.6
, pp. 1582-1590
-
-
Nakasa, T.1
Shibuya, H.2
Nagata, Y.3
-
111
-
-
34047210698
-
Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents
-
Lin HS, Hu CY, Chan HY, et al. Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br J Pharmacol 2007; 150(7): 862-72
-
(2007)
Br J Pharmacol
, vol.150
, Issue.7
, pp. 862-872
-
-
Lin, H.S.1
Hu, C.Y.2
Chan, H.Y.3
-
112
-
-
84857233842
-
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating MRNA decay
-
Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA. Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. Ann Rheum Dis 2012; 71(3): 424-31
-
(2012)
Ann Rheum Dis
, vol.71
, Issue.3
, pp. 424-431
-
-
Grabiec, A.M.1
Korchynskyi, O.2
Tak, P.P.3
Reedquist, K.A.4
-
113
-
-
5644239630
-
WAF1/Cip1 expression
-
DOI 10.1002/art.20709
-
Nishida K, Komiyama T, Miyazawa S, et al. Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expression. Arthritis Rheum 2004; 50(10): 3365-76 (Pubitemid 39372015)
-
(2004)
Arthritis and Rheumatism
, vol.50
, Issue.10
, pp. 3365-3376
-
-
Nishida, K.1
Komiyama, T.2
Miyazawa, S.-I.3
Shen, Z.-N.4
Furumatsu, T.5
Doi, H.6
Yoshida, A.7
Yamana, J.8
Yamamura, M.9
Ninomiya, Y.10
Inoue, H.11
Asahara, H.12
-
114
-
-
84864716411
-
Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
-
Fleischmann R, Kremer J, Cush J, et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 2012; 367(6): 495-507
-
(2012)
N Engl J Med
, vol.367
, Issue.6
, pp. 495-507
-
-
Fleischmann, R.1
Kremer, J.2
Cush, J.3
-
115
-
-
84879835300
-
A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study
-
Hirata S, Dirven L, Shen Y, et al. A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study. Rheumatology (Oxford) 2013
-
(2013)
Rheumatology (Oxford)
-
-
Hirata, S.1
Dirven, L.2
Shen, Y.3
-
116
-
-
2342551979
-
Combination Therapy with Etanercept and Anakinra in the Treatment of Patients with Rheumatoid Arthritis Who Have Been Treated Unsuccessfully with Methotrexate
-
DOI 10.1002/art.20221
-
Genovese MC, Cohen S, Moreland L, et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum 2004; 50(5): 1412-19 (Pubitemid 38608062)
-
(2004)
Arthritis and Rheumatism
, vol.50
, Issue.5
, pp. 1412-1419
-
-
Genovese, M.C.1
Cohen, S.2
Moreland, L.3
Lium, D.4
Robbins, S.5
Newmark, R.6
Bekker, P.7
-
117
-
-
79953718761
-
Evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis: Results from a randomized controlled trial
-
Greenwald MW, Shergy WJ, Kaine JL, et al. Evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis: results from a randomized controlled trial. Arthritis Rheum 2011; 63(3): 622-32
-
(2011)
Arthritis Rheum
, vol.63
, Issue.3
, pp. 622-632
-
-
Greenwald, M.W.1
Shergy, W.J.2
Kaine, J.L.3
-
118
-
-
0034121235
-
Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins
-
DOI 10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B
-
MacGregor AJ, Snieder H, Rigby AS, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000; 43(1): 30-7 (Pubitemid 30368210)
-
(2000)
Arthritis and Rheumatism
, vol.43
, Issue.1
, pp. 30-37
-
-
MacGregor, A.J.1
Snieder, H.2
Rigby, A.S.3
Koskenvuo, M.4
Kaprio, J.5
Aho, K.6
Silman, A.J.7
-
119
-
-
70249138036
-
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
Bauernfeind FG, Horvath G, Stutz A, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009; 183(2): 787-91
-
(2009)
J Immunol
, vol.183
, Issue.2
, pp. 787-791
-
-
Bauernfeind, F.G.1
Horvath, G.2
Stutz, A.3
|