Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

Cardiovascular Research

Volumn 108, Issue 3, 2015, Pages 357-366

  Davidson, Sean M ^a   Foote, Kirsty ^a   Kunuthur, Suma ^a   Gosain, Raj ^b   Tan, Noah ^a   Tyser, Richard ^a   Zhao, Yong Juan ^c   Graeff, Richard ^c   Ganesan, A ^d   Duchen, Michael R ^a   Patel, Sandip ^a   Yellon, Derek M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Calcium; Ischaemia; Lysosomes; NAADP; Reperfusion

Indexed keywords

ADENOSINE RECEPTOR BLOCKING AGENT; CYCLOSPORIN A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NED K; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN; TWO PORE CHANNEL 1; TWO PORE CHANNEL 2; UNCLASSIFIED DRUG; 1-(3-((4-(2-FLUOROPHENYL)PIPERAZIN-1-YL)METHYL)-4-METHOXYPHENYL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO(3,4-B)INDOLE-3-CARBOXYLIC ACID; CALCIUM CHANNEL; CARBOLINE DERIVATIVE; CARRIER PROTEIN; NED-K COMPOUND; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PIPERAZINE DERIVATIVE; TPCN1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTAGONIST POTENCY; ARTICLE; CALCIUM SIGNALING; CELL DEATH; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EXCITATION CONTRACTION COUPLING; GENE REPRESSION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; REOXYGENATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIAC MUSCLE CELL; CELL PROTECTION; DEFICIENCY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; HEART MITOCHONDRION; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION SWELLING; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CARBOLINES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NADP; PIPERAZINES; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84950321056     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv226     Document Type: Article

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