Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

EMBO Journal

Volumn 34, Issue 13, 2015, Pages 1743-1758

  Ruas, Margarida ^a   Davis, Lianne C ^a   Chen, Cheng Chang ^b   Morgan, Anthony J ^a   Chuang, Kai Ting ^a,d   Walseth, Timothy F ^c   Grimm, Christian ^b   Garnham, Clive ^a   Powell, Trevor ^a   Platt, Nick ^a   Platt, Frances M ^a   Biel, Martin ^b   Wahl Schott, Christian ^b   Parrington, John ^a   Galione, Antony ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF MINNESOTA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Ca2+; electrophysiology; endo lysosome; NAADP; TPC

Indexed keywords

CALCIUM CHANNEL; MESSENGER RNA; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,5 BIPHOSPHATE; TWO PORE CHANNEL 1; TWO PORE CHANNEL 2; UNCLASSIFIED DRUG; CALCIUM; ISOPROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TPCN1 PROTEIN, MOUSE; TPCN2 PROTEIN, MOUSE;

ADULT; ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; LYSOSOME; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PATCH CLAMP TECHNIQUE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVERSAL POTENTIAL; SINGLE CELL ANALYSIS; TECHNOLOGY; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; DRUG EFFECTS; EVOKED RESPONSE; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PH; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELLS, CULTURED; EVOKED POTENTIALS; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MICE; MICE, KNOCKOUT; NADP; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION;

EID: 84933674860     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490009     Document Type: Article

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